# FCU_adenylylCyclase

### About this model

This is a Functional Cell Unit for adenylyl cyclase metabolism in the cardiac cell.

This is a composite module, composed of several individual modules, and merged together in a modular fashion.

INPUTS:

- Ligands for beta-1 adrenergic and muscarinic receptors.
OUTPUTS:

- Change in molar amount of cyclic AMP.

### Model status

The current CellML implementation runs in OpenCOR.

### Model overview

All components are presented in bond-graph form. Components are made by converting an existing kinetic model and translating into bond-graph form.

A description of the process to find bond-graph parameter is shown in the folder parameter_finder, which relies on the:

- stoichiometry of system
- kinetic constants for forward/reverse reactions

- If not already, all reactions are made reversible by assigning a small value to the reverse direction.

Here, this solve process is performed in Python.

### Modular description

#### Components

CellML divides the mathematical model into distinct components, which are able to be re-used in other composite models. These CellML components are:

- beta-1 adrenergic receptor and Gs protein (GPCR-
*β*1AR) - muscarinic receptor and Gi Protein (GPCR-M2) (M2)
- cyclic AMP (cAMP)

Source | Components |
---|---|

Saucerman et al. | GPCR-β 1AR, cAMP |

Iancu et al. | GPCR-M2 |

Each of these blocks is itself a CellML model, complete with bond-graph parameters appropriate for the isolated system.