<?xml version='1.0' encoding='UTF-8'?>
<model cmeta:id="jafri_rice_winslow_1998_version02" name="jafri_rice_winslow_1998_version02" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<units name="ms">
<unit prefix="milli" units="second"/>
</units>
<units name="per_ms">
<unit exponent="-1" prefix="milli" units="second"/>
</units>
<units name="per_mm">
<unit exponent="-1" prefix="milli" units="metre"/>
</units>
<units name="mV">
<unit prefix="milli" units="volt"/>
</units>
<units name="per_mV">
<unit exponent="-1" prefix="milli" units="volt"/>
</units>
<units name="per_mV_ms">
<unit exponent="-1" units="mV"/>
<unit exponent="-1" units="ms"/>
</units>
<units name="mS_per_mm2">
<unit prefix="milli" units="siemens"/>
<unit exponent="-2" prefix="milli" units="metre"/>
</units>
<units name="mm2">
<unit exponent="2" prefix="milli" units="metre"/>
</units>
<units name="mM">
<unit prefix="nano" units="mole"/>
<unit exponent="-3" prefix="milli" units="metre"/>
</units>
<units name="mM_per_ms">
<unit units="mM"/>
<unit exponent="-1" units="ms"/>
</units>
<units name="per_mM_per_ms">
<unit exponent="-1" units="mM"/>
<unit exponent="-1" units="ms"/>
</units>
<units name="per_mM3_per_ms">
<unit exponent="-3" units="mM"/>
<unit exponent="-1" units="ms"/>
</units>
<units name="per_mM4_per_ms">
<unit exponent="-4" units="mM"/>
<unit exponent="-1" units="ms"/>
</units>
<units name="uF_per_mm2">
<unit prefix="micro" units="farad"/>
<unit exponent="-2" prefix="milli" units="metre"/>
</units>
<units name="uA_per_mm2">
<unit prefix="micro" units="ampere"/>
<unit exponent="-2" prefix="milli" units="metre"/>
</units>
<units name="uA_per_mmcu">
<unit prefix="micro" units="ampere"/>
<unit exponent="-3" prefix="milli" units="metre"/>
</units>
<units name="mm_per_ms">
<unit prefix="milli" units="metre"/>
<unit exponent="-1" prefix="milli" units="second"/>
</units>
<units name="gas_constant_units">
<unit prefix="pico" units="joule"/>
<unit exponent="-1" prefix="nano" units="mole"/>
<unit exponent="-1" units="kelvin"/>
</units>
<units name="faradays_constant_units">
<unit prefix="nano" units="coulomb"/>
<unit exponent="-1" prefix="nano" units="mole"/>
</units>
<units name="micrometer">
<unit prefix="micro" units="metre"/>
</units>
<units name="N_per_mm2">
<unit units="newton"/>
<unit exponent="-2" prefix="milli" units="metre"/>
</units>
<component name="environment">
<variable name="time" public_interface="out" units="ms"/>
<variable initial_value="1" name="lambda" public_interface="out" units="dimensionless"/>
<variable initial_value="0" name="dlambdadt" public_interface="out" units="per_ms"/>
</component>
<component cmeta:id="id_00001" name="membrane">
<variable initial_value="-84.1638" name="V" public_interface="out" units="mV"/>
<variable initial_value="8.3145e3" name="R" public_interface="out" units="gas_constant_units"/>
<variable initial_value="310" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="9.6845e4" name="F" public_interface="out" units="faradays_constant_units"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="i_Na" public_interface="in" units="uA_per_mm2"/>
<variable name="i_Ca_L_Ca" public_interface="in" units="uA_per_mm2"/>
<variable name="i_Ca_L_K" public_interface="in" units="uA_per_mm2"/>
<variable name="i_K" public_interface="in" units="uA_per_mm2"/>
<variable name="i_K1" public_interface="in" units="uA_per_mm2"/>
<variable name="i_NaCa" public_interface="in" units="uA_per_mm2"/>
<variable name="i_Kp" public_interface="in" units="uA_per_mm2"/>
<variable name="i_p_Ca" public_interface="in" units="uA_per_mm2"/>
<variable name="i_Na_b" public_interface="in" units="uA_per_mm2"/>
<variable name="i_Ca_b" public_interface="in" units="uA_per_mm2"/>
<variable name="i_NaK" public_interface="in" units="uA_per_mm2"/>
<variable name="i_ns_Ca" public_interface="in" units="uA_per_mm2"/>
<variable initial_value="0.01" name="Cm" units="uF_per_mm2"/>
<variable name="I_stim" units="uA_per_mm2"/>
<variable initial_value="100" name="stim_start" units="ms"/>
<variable initial_value="9000" name="stim_end" units="ms"/>
<variable initial_value="750" name="stim_period" units="ms"/>
<variable initial_value="1" name="stim_duration" units="ms"/>
<variable initial_value="-100" name="stim_amplitude" units="uA_per_mm2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_Ca_L_Ca</ci>
<ci>i_Ca_L_K</ci>
<ci>i_K</ci>
<ci>i_NaCa</ci>
<ci>i_K1</ci>
<ci>i_Kp</ci>
<ci>i_p_Ca</ci>
<ci>i_Na_b</ci>
<ci>i_Ca_b</ci>
<ci>i_NaK</ci>
<ci>i_ns_Ca</ci>
<ci>I_stim</ci>
</apply>
<ci>Cm</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_stim</ci>
<piecewise>
<piece>
<ci>stim_amplitude</ci>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<leq/>
<ci>time</ci>
<ci>stim_end</ci>
</apply>
<apply>
<leq/>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
<apply>
<minus/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_duration</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="uA_per_mm2">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component cmeta:id="id_00002" name="fast_sodium_current">
<variable name="i_Na" public_interface="out" units="uA_per_mm2"/>
<variable name="E_Na" public_interface="out" units="mV"/>
<variable initial_value="0.128" name="g_Na" units="mS_per_mm2"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="m" private_interface="in" units="dimensionless"/>
<variable name="h" private_interface="in" units="dimensionless"/>
<variable name="j" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Na</ci>
<apply>
<times/>
<ci>g_Na</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>h</ci>
<ci>j</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00003" name="fast_sodium_current_m_gate">
<variable initial_value="0.0328302" name="m" public_interface="out" units="dimensionless"/>
<variable name="alpha_m" units="per_ms"/>
<variable name="beta_m" units="per_ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_m</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_mV_ms">0.32</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">47.13</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">47.13</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_m</ci>
<apply>
<times/>
<cn cellml:units="per_ms">0.08</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="mV">11</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_m</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>m</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_m</ci>
<ci>m</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00004" name="fast_sodium_current_h_gate">
<variable initial_value="0.988354" name="h" public_interface="out" units="dimensionless"/>
<variable name="alpha_h" units="per_ms"/>
<variable name="beta_h" units="per_ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_h</ci>
<piecewise>
<piece>
<apply>
<times/>
<cn cellml:units="per_ms">0.135</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<cn cellml:units="mV">80</cn>
<ci>V</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">6.8</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="mV">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="per_ms">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_h</ci>
<piecewise>
<piece>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_ms">3.56</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.079</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_ms">310000</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.35</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="mV">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="ms">0.13</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">10.66</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">11.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_h</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>h</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_h</ci>
<ci>h</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00005" name="fast_sodium_current_j_gate">
<variable initial_value="0.99254" name="j" public_interface="out" units="dimensionless"/>
<variable name="alpha_j" units="per_ms"/>
<variable name="beta_j" units="per_ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_j</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV_ms">127140</cn>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.2444</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_mV_ms">0.00003474</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.04391</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">37.78</cn>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.311</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">79.23</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="mV">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="per_ms">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_j</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_ms">0.1212</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.01052</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.1378</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">40.14</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="mV">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_ms">0.3</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.0000002535</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">32</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>j</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_j</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>j</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_j</ci>
<ci>j</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00014" name="L_type_Ca_channel">
<variable name="i_Ca_L_Ca" public_interface="out" units="uA_per_mm2"/>
<variable name="i_Ca_L_K" public_interface="out" units="uA_per_mm2"/>
<variable initial_value="33.75e-6" name="P_Ca" units="mm_per_ms"/>
<variable initial_value="1e-9" name="P_K" units="mm_per_ms"/>
<variable name="p_k" units="mm_per_ms"/>
<variable initial_value="-4.58e-3" name="i_Ca_L_Ca_half" units="uA_per_mm2"/>
<variable name="i_Ca_L_Ca_max" units="uA_per_mm2"/>
<variable initial_value="9.84546e-21" name="O" units="dimensionless"/>
<variable initial_value="0" name="O_Ca" units="dimensionless"/>
<variable name="alpha" units="per_ms"/>
<variable name="beta" units="per_ms"/>
<variable name="gamma" units="per_ms"/>
<variable name="alpha_a" units="per_ms"/>
<variable name="beta_b" units="per_ms"/>
<variable initial_value="2" name="a" units="dimensionless"/>
<variable initial_value="2" name="b" units="dimensionless"/>
<variable initial_value="2" name="g" units="per_ms"/>
<variable initial_value="0.3" name="f" units="per_ms"/>
<variable initial_value="0" name="g_" units="per_ms"/>
<variable initial_value="0" name="f_" units="per_ms"/>
<variable initial_value="0.01" name="omega" units="per_ms"/>
<variable initial_value="0.997208" name="C0" units="dimensionless"/>
<variable initial_value="6.38897e-5" name="C1" units="dimensionless"/>
<variable initial_value="1.535e-9" name="C2" units="dimensionless"/>
<variable initial_value="1.63909e-14" name="C3" units="dimensionless"/>
<variable initial_value="6.56337e-20" name="C4" units="dimensionless"/>
<variable initial_value="2.72826e-3" name="C_Ca0" units="dimensionless"/>
<variable initial_value="6.99215e-7" name="C_Ca1" units="dimensionless"/>
<variable initial_value="6.71989e-11" name="C_Ca2" units="dimensionless"/>
<variable initial_value="2.87031e-15" name="C_Ca3" units="dimensionless"/>
<variable initial_value="4.59752e-20" name="C_Ca4" units="dimensionless"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="Ca_SS" public_interface="in" units="mM"/>
<variable name="Cao" public_interface="in" units="mM"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="y" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ca_L_Ca</ci>
<apply>
<times/>
<ci>i_Ca_L_Ca_max</ci>
<ci>y</ci>
<apply>
<plus/>
<ci>O</ci>
<ci>O_Ca</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_L_K</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>p_k</ci>
<ci>y</ci>
<apply>
<plus/>
<ci>O</ci>
<ci>O_Ca</ci>
</apply>
<ci>V</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Ki</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<ci>Ko</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_k</ci>
<apply>
<divide/>
<ci>P_K</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>i_Ca_L_Ca_max</ci>
<ci>i_Ca_L_Ca_half</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_L_Ca_max</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_Ca</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>V</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="mM">0.001</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.341</cn>
<ci>Cao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha</ci>
<apply>
<times/>
<cn cellml:units="per_ms">0.4</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">12</cn>
</apply>
<cn cellml:units="mV">10</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta</ci>
<apply>
<times/>
<cn cellml:units="per_ms">0.05</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">12</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">13</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_a</ci>
<apply>
<times/>
<ci>alpha</ci>
<ci>a</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_b</ci>
<apply>
<divide/>
<ci>beta</ci>
<ci>b</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_ms">0.1875</cn>
<ci>Ca_SS</ci>
</apply>
<cn cellml:units="mM">1</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C0</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>beta</ci>
<ci>C1</ci>
</apply>
<apply>
<times/>
<ci>omega</ci>
<ci>C_Ca0</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha</ci>
</apply>
<ci>gamma</ci>
</apply>
<ci>C0</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha</ci>
<ci>C0</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta</ci>
<ci>C2</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>omega</ci>
<ci>b</ci>
</apply>
<ci>C_Ca1</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>beta</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<ci>a</ci>
</apply>
</apply>
<ci>C1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
<ci>C1</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta</ci>
<ci>C3</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<ci>C_Ca2</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>beta</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<ci>C2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
<ci>C2</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
<ci>C4</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<ci>C_Ca3</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>beta</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>alpha</ci>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<ci>C3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C4</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha</ci>
<ci>C3</ci>
</apply>
<apply>
<times/>
<ci>g</ci>
<ci>O</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
<ci>C_Ca4</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>beta</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
<ci>f</ci>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
</apply>
<ci>C4</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>f</ci>
<ci>C4</ci>
</apply>
<apply>
<times/>
<ci>g</ci>
<ci>O</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C_Ca0</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_b</ci>
<ci>C_Ca1</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<ci>C0</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha_a</ci>
</apply>
<ci>omega</ci>
</apply>
<ci>C_Ca0</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C_Ca1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha_a</ci>
<ci>C_Ca0</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta_b</ci>
<ci>C_Ca2</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<ci>a</ci>
<ci>C1</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>beta_b</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha_a</ci>
</apply>
<apply>
<divide/>
<ci>omega</ci>
<ci>b</ci>
</apply>
</apply>
<ci>C_Ca1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C_Ca2</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha_a</ci>
<ci>C_Ca1</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta_b</ci>
<ci>C_Ca3</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>C2</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_b</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha_a</ci>
</apply>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<ci>C_Ca2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C_Ca3</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha_a</ci>
<ci>C_Ca2</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta_b</ci>
<ci>C_Ca4</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>C3</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_b</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>alpha_a</ci>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<ci>C_Ca3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C_Ca4</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_a</ci>
<ci>C_Ca3</ci>
</apply>
<apply>
<times/>
<ci>g_</ci>
<ci>O_Ca</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
<ci>C4</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_b</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
<ci>f_</ci>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
</apply>
<ci>C_Ca4</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O_Ca</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>f_</ci>
<ci>C_Ca4</ci>
</apply>
<apply>
<times/>
<ci>g_</ci>
<ci>O_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00015" name="L_type_Ca_channel_y_gate">
<variable initial_value="0.998983" name="y" public_interface="out" units="dimensionless"/>
<variable name="y_infinity" units="dimensionless"/>
<variable name="tau_y" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_infinity</ci>
<ci>y</ci>
</apply>
<ci>tau_y</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>y_infinity</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">55</cn>
</apply>
<cn cellml:units="mV">7.5</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="mV">21</cn>
</apply>
<cn cellml:units="mV">6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_y</ci>
<apply>
<plus/>
<cn cellml:units="ms">20</cn>
<apply>
<divide/>
<cn cellml:units="ms">600</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">30</cn>
</apply>
<cn cellml:units="mV">9.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00025" name="time_dependent_potassium_current">
<variable name="i_K" public_interface="out" units="uA_per_mm2"/>
<variable name="g_K" units="mS_per_mm2"/>
<variable initial_value="0.001128" name="g_K_max" units="mS_per_mm2"/>
<variable name="E_K" units="mV"/>
<variable initial_value="0.01833" name="P_NaK" units="dimensionless"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="X" private_interface="in" units="dimensionless"/>
<variable name="Xi" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_K</ci>
<apply>
<times/>
<ci>g_K_max</ci>
<apply>
<root/>
<apply>
<divide/>
<ci>Ko</ci>
<cn cellml:units="mM">5.4</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ko</ci>
<apply>
<times/>
<ci>P_NaK</ci>
<ci>Nao</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>Ki</ci>
<apply>
<times/>
<ci>P_NaK</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_K</ci>
<apply>
<times/>
<ci>g_K</ci>
<ci>Xi</ci>
<apply>
<power/>
<ci>X</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00026" name="time_dependent_potassium_current_X_gate">
<variable initial_value="0.000928836" name="X" public_interface="out" units="dimensionless"/>
<variable name="alpha_X" units="per_ms"/>
<variable name="beta_X" units="per_ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_X</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_mV_ms">0.0000719</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">30</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.148</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">30</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_X</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_mV_ms">0.000131</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">30</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.0687</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">30</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>X</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_X</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>X</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_X</ci>
<ci>X</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00027" name="time_dependent_potassium_current_Xi_gate">
<variable name="Xi" public_interface="out" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Xi</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">56.26</cn>
</apply>
<cn cellml:units="mV">32.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00028" name="time_independent_potassium_current">
<variable name="i_K1" public_interface="out" units="uA_per_mm2"/>
<variable name="E_K1" private_interface="out" public_interface="out" units="mV"/>
<variable name="g_K1" units="mS_per_mm2"/>
<variable initial_value="7.5e-3" name="g_K1_max" units="mS_per_mm2"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="K1_infinity" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_K1</ci>
<apply>
<times/>
<ci>g_K1_max</ci>
<apply>
<root/>
<apply>
<divide/>
<ci>Ko</ci>
<cn cellml:units="mM">5.4</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K1</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<times/>
<ci>g_K1</ci>
<ci>K1_infinity</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00029" name="time_independent_potassium_current_K1_gate">
<variable name="K1_infinity" public_interface="out" units="dimensionless"/>
<variable name="alpha_K1" units="per_ms"/>
<variable name="beta_K1" units="per_ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="E_K1" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_K1</ci>
<apply>
<divide/>
<cn cellml:units="per_ms">1.02</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.2385</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K1</ci>
</apply>
<cn cellml:units="mV">59.215</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_K1</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_ms">0.49124</cn>
<apply>
<plus/>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.08032</cn>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">5.476</cn>
</apply>
<ci>E_K1</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.06175</cn>
<apply>
<minus/>
<ci>V</ci>
<apply>
<plus/>
<ci>E_K1</ci>
<cn cellml:units="mV">594.31</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.5143</cn>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K1</ci>
</apply>
<cn cellml:units="mV">4.753</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K1_infinity</ci>
<apply>
<divide/>
<ci>alpha_K1</ci>
<apply>
<plus/>
<ci>alpha_K1</ci>
<ci>beta_K1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00030" name="plateau_potassium_current">
<variable name="i_Kp" public_interface="out" units="uA_per_mm2"/>
<variable name="E_Kp" units="mV"/>
<variable initial_value="8.28e-5" name="g_Kp" units="mS_per_mm2"/>
<variable name="Kp" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="E_K1" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Kp</ci>
<ci>E_K1</ci>
</apply>
<apply>
<eq/>
<ci>Kp</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="mV">7.488</cn>
<ci>V</ci>
</apply>
<cn cellml:units="mV">5.98</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Kp</ci>
<apply>
<times/>
<ci>g_Kp</ci>
<ci>Kp</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Kp</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00041" name="Na_Ca_exchanger">
<variable name="i_NaCa" public_interface="out" units="uA_per_mm2"/>
<variable initial_value="50" name="k_NaCa" units="uA_per_mm2"/>
<variable initial_value="87.5" name="K_mNa" units="mM"/>
<variable initial_value="1.38" name="K_mCa" units="mM"/>
<variable initial_value="0.1" name="k_sat" units="dimensionless"/>
<variable initial_value="0.35" name="eta" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="Cao" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>k_NaCa</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>K_mNa</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<ci>K_mCa</ci>
<ci>Cao</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>k_sat</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>eta</ci>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cao</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00043" name="sarcolemmal_calcium_pump">
<variable name="i_p_Ca" public_interface="out" units="uA_per_mm2"/>
<variable initial_value="0.5e-3" name="K_mpCa" units="mM"/>
<variable initial_value="1.15e-2" name="I_pCa" units="uA_per_mm2"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="Cai" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_p_Ca</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>I_pCa</ci>
<ci>Cai</ci>
</apply>
<apply>
<plus/>
<ci>K_mpCa</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00044" name="sodium_background_current">
<variable name="i_Na_b" public_interface="out" units="uA_per_mm2"/>
<variable initial_value="1.41e-5" name="g_Nab" units="mS_per_mm2"/>
<variable name="E_NaN" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="E_Na" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_NaN</ci>
<ci>E_Na</ci>
</apply>
<apply>
<eq/>
<ci>i_Na_b</ci>
<apply>
<times/>
<ci>g_Nab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_NaN</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00016" name="calcium_background_current">
<variable name="i_Ca_b" public_interface="out" units="uA_per_mm2"/>
<variable initial_value="6.032e-5" name="g_Cab" units="mS_per_mm2"/>
<variable name="E_CaN" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="Cao" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_CaN</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_b</ci>
<apply>
<times/>
<ci>g_Cab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_CaN</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00046" name="sodium_potassium_pump">
<variable name="i_NaK" public_interface="out" units="uA_per_mm2"/>
<variable initial_value="0.013" name="I_NaK" units="uA_per_mm2"/>
<variable name="f_NaK" units="dimensionless"/>
<variable initial_value="10" name="K_mNai" units="mM"/>
<variable initial_value="1.5" name="K_mKo" units="mM"/>
<variable name="sigma" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Ko" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_NaK</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">7</cn>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Nao</ci>
<cn cellml:units="mM">67.3</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>I_NaK</ci>
<ci>f_NaK</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>K_mNai</ci>
<ci>Nai</ci>
</apply>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
<ci>Ko</ci>
</apply>
<apply>
<plus/>
<ci>Ko</ci>
<ci>K_mKo</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00047" name="non_specific_calcium_activated_current">
<variable name="i_ns_Ca" public_interface="out" units="uA_per_mm2"/>
<variable name="i_ns_Na" public_interface="out" units="uA_per_mm2"/>
<variable name="i_ns_K" public_interface="out" units="uA_per_mm2"/>
<variable name="I_ns_Na" units="uA_per_mm2"/>
<variable name="I_ns_K" units="uA_per_mm2"/>
<variable initial_value="1.2e-3" name="K_m_ns_Ca" units="mM"/>
<variable initial_value="1.75e-9" name="P_ns_Ca" units="mm_per_ms"/>
<variable name="EnsCa" units="mV"/>
<variable name="VnsCa" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Ki" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>EnsCa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ko</ci>
<ci>Nao</ci>
</apply>
<apply>
<plus/>
<ci>Ki</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>VnsCa</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>EnsCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_ns_Na</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>I_ns_Na</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>K_m_ns_Ca</ci>
<ci>Cai</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_ns_K</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>I_ns_K</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>K_m_ns_Ca</ci>
<ci>Cai</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_ns_Ca</ci>
<apply>
<plus/>
<ci>i_ns_Na</ci>
<ci>i_ns_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_ns_Na</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_ns_Ca</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>VnsCa</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.75</cn>
<ci>Nai</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>VnsCa</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.75</cn>
<ci>Nao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>VnsCa</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_ns_K</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_ns_Ca</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>VnsCa</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.75</cn>
<ci>Ki</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>VnsCa</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.75</cn>
<ci>Ko</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>VnsCa</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00017" name="calcium_subsystem">
<variable initial_value="9.94893e-11" name="Cai" public_interface="out" units="mM"/>
<variable initial_value="1.36058e-4" name="Ca_SS" public_interface="out" units="mM"/>
<variable initial_value="546.69" name="Am" public_interface="out" units="per_mm"/>
<variable initial_value="0.92" name="V_myo" public_interface="out" units="dimensionless"/>
<variable name="RyR_open" units="dimensionless"/>
<variable initial_value="1.19168e-3" name="P_O1" units="dimensionless"/>
<variable initial_value="6.30613e-9" name="P_O2" units="dimensionless"/>
<variable initial_value="0.762527" name="P_C1" units="dimensionless"/>
<variable initial_value="0.236283" name="P_C2" units="dimensionless"/>
<variable initial_value="1.8" name="v1" units="per_ms"/>
<variable initial_value="0.58e-4" name="v2" units="per_ms"/>
<variable initial_value="1.8e-3" name="v3" units="mM_per_ms"/>
<variable initial_value="4" name="nCa" units="dimensionless"/>
<variable initial_value="3" name="mCa" units="dimensionless"/>
<variable initial_value="1.215e10" name="k_a_plus" units="per_mM4_per_ms"/>
<variable initial_value="0.1425" name="k_a_minus" units="per_ms"/>
<variable initial_value="4.05e7" name="k_b_plus" units="per_mM3_per_ms"/>
<variable initial_value="1.93" name="k_b_minus" units="per_ms"/>
<variable initial_value="0.018" name="k_c_plus" units="per_ms"/>
<variable initial_value="0.0008" name="k_c_minus" units="per_ms"/>
<variable initial_value="20" name="k_htrpn_plus" units="per_mM_per_ms"/>
<variable initial_value="0.066e-3" name="k_htrpn_minus" units="per_ms"/>
<variable initial_value="40" name="k_ltrpn_plus" units="per_mM_per_ms"/>
<variable initial_value="0.04" name="k_ltrpn_minus" units="per_ms"/>
<variable initial_value="34.48" name="tau_tr" units="ms"/>
<variable initial_value="1.17504" name="Ca_JSR" units="mM"/>
<variable initial_value="1.243891" name="Ca_NSR" units="mM"/>
<variable name="V_JSR" units="dimensionless"/>
<variable name="V_NSR" units="dimensionless"/>
<variable name="V_SS" units="dimensionless"/>
<variable initial_value="0.5e-3" name="K_mup" units="mM"/>
<variable initial_value="2.38e-3" name="K_mCMDN" units="mM"/>
<variable initial_value="0.8" name="K_mCSQN" units="mM"/>
<variable initial_value="3.125" name="tau_xfer" units="ms"/>
<variable initial_value="0.14" name="HTRPN_tot" units="mM"/>
<variable initial_value="0.07" name="LTRPN_tot" units="mM"/>
<variable initial_value="0.13598" name="HTRPNCa" units="mM"/>
<variable initial_value="0.00635" name="LTRPNCa" units="mM"/>
<variable initial_value="15" name="CSQN_tot" units="mM"/>
<variable initial_value="0.05" name="CMDN_tot" units="mM"/>
<variable name="Bi" units="dimensionless"/>
<variable name="B_SS" units="dimensionless"/>
<variable name="B_JSR" units="dimensionless"/>
<variable name="J_rel" units="mM_per_ms"/>
<variable name="J_leak" units="mM_per_ms"/>
<variable name="J_up" units="mM_per_ms"/>
<variable name="J_tr" units="mM_per_ms"/>
<variable name="J_xfer" units="mM_per_ms"/>
<variable name="J_trpn" units="mM_per_ms"/>
<variable name="J_htrpn" units="mM_per_ms"/>
<variable name="J_ltrpn" units="mM_per_ms"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="i_Ca_b" public_interface="in" units="uA_per_mm2"/>
<variable name="i_Ca_L_Ca" public_interface="in" units="uA_per_mm2"/>
<variable name="i_NaCa" public_interface="in" units="uA_per_mm2"/>
<variable name="i_p_Ca" public_interface="in" units="uA_per_mm2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_SS</ci>
<apply>
<times/>
<cn cellml:units="dimensionless" type="e-notation">5.828<sep/>-5</cn>
<ci>V_myo</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_NSR</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.081</cn>
<ci>V_myo</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_JSR</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.00464</cn>
<ci>V_myo</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_rel</ci>
<apply>
<times/>
<ci>v1</ci>
<ci>RyR_open</ci>
<apply>
<minus/>
<ci>Ca_JSR</ci>
<ci>Ca_SS</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>RyR_open</ci>
<apply>
<plus/>
<ci>P_O1</ci>
<ci>P_O2</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_C1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>k_a_plus</ci>
</apply>
<apply>
<power/>
<ci>Ca_SS</ci>
<ci>nCa</ci>
</apply>
<ci>P_C1</ci>
</apply>
<apply>
<times/>
<ci>k_a_minus</ci>
<ci>P_O1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_O1</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>k_a_plus</ci>
<apply>
<power/>
<ci>Ca_SS</ci>
<ci>nCa</ci>
</apply>
<ci>P_C1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>k_a_minus</ci>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_b_plus</ci>
<apply>
<power/>
<ci>Ca_SS</ci>
<ci>mCa</ci>
</apply>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_c_plus</ci>
<ci>P_O1</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>k_b_minus</ci>
<ci>P_O2</ci>
</apply>
<apply>
<times/>
<ci>k_c_minus</ci>
<ci>P_C2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_O2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_b_plus</ci>
<apply>
<power/>
<ci>Ca_SS</ci>
<ci>mCa</ci>
</apply>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_b_minus</ci>
<ci>P_O2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_C2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_c_plus</ci>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_c_minus</ci>
<ci>P_C2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_leak</ci>
<apply>
<times/>
<ci>v2</ci>
<apply>
<minus/>
<ci>Ca_NSR</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_up</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>v3</ci>
<apply>
<power/>
<ci>Cai</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>K_mup</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>Cai</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_tr</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_NSR</ci>
<ci>Ca_JSR</ci>
</apply>
<ci>tau_tr</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_xfer</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_SS</ci>
<ci>Cai</ci>
</apply>
<ci>tau_xfer</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_htrpn</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>k_htrpn_plus</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>HTRPN_tot</ci>
<ci>HTRPNCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_htrpn_minus</ci>
<ci>HTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_ltrpn</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>k_ltrpn_plus</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>LTRPN_tot</ci>
<ci>LTRPNCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_ltrpn_minus</ci>
<ci>LTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_trpn</ci>
<apply>
<plus/>
<ci>J_htrpn</ci>
<ci>J_ltrpn</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>HTRPNCa</ci>
</apply>
<ci>J_htrpn</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>LTRPNCa</ci>
</apply>
<ci>J_ltrpn</ci>
</apply>
<apply>
<eq/>
<ci>Bi</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDN_tot</ci>
<ci>K_mCMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>K_mCMDN</ci>
<ci>Cai</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>B_SS</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDN_tot</ci>
<ci>K_mCMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>K_mCMDN</ci>
<ci>Ca_SS</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>B_JSR</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CSQN_tot</ci>
<ci>K_mCSQN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>K_mCSQN</ci>
<ci>Ca_JSR</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai</ci>
</apply>
<apply>
<times/>
<ci>Bi</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>J_leak</ci>
<ci>J_xfer</ci>
</apply>
<apply>
<plus/>
<ci>J_up</ci>
<ci>J_trpn</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<minus/>
<ci>i_Ca_b</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaCa</ci>
</apply>
</apply>
<ci>i_p_Ca</ci>
</apply>
<ci>Am</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SS</ci>
</apply>
<apply>
<times/>
<ci>B_SS</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>J_rel</ci>
<ci>V_JSR</ci>
</apply>
<ci>V_SS</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>J_xfer</ci>
<ci>V_myo</ci>
</apply>
<ci>V_SS</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>i_Ca_L_Ca</ci>
<ci>Am</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V_SS</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_JSR</ci>
</apply>
<apply>
<times/>
<ci>B_JSR</ci>
<apply>
<minus/>
<ci>J_tr</ci>
<ci>J_rel</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_NSR</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>J_up</ci>
<ci>J_leak</ci>
</apply>
<ci>V_myo</ci>
</apply>
<ci>V_NSR</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>J_tr</ci>
<ci>V_JSR</ci>
</apply>
<ci>V_NSR</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ionic_concentrations">
<variable initial_value="10.2042" name="Nai" public_interface="out" units="mM"/>
<variable initial_value="140" name="Nao" public_interface="out" units="mM"/>
<variable initial_value="143.727" name="Ki" public_interface="out" units="mM"/>
<variable initial_value="5.4" name="Ko" public_interface="out" units="mM"/>
<variable initial_value="1.8" name="Cao" public_interface="out" units="mM"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="i_Na" public_interface="in" units="uA_per_mm2"/>
<variable name="i_Na_b" public_interface="in" units="uA_per_mm2"/>
<variable name="i_ns_Na" public_interface="in" units="uA_per_mm2"/>
<variable name="i_NaCa" public_interface="in" units="uA_per_mm2"/>
<variable name="i_NaK" public_interface="in" units="uA_per_mm2"/>
<variable name="i_Ca_L_K" public_interface="in" units="uA_per_mm2"/>
<variable name="i_K" public_interface="in" units="uA_per_mm2"/>
<variable name="i_K1" public_interface="in" units="uA_per_mm2"/>
<variable name="i_Kp" public_interface="in" units="uA_per_mm2"/>
<variable name="i_ns_K" public_interface="in" units="uA_per_mm2"/>
<variable name="Am" public_interface="in" units="per_mm"/>
<variable name="V_myo" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_Na_b</ci>
<ci>i_ns_Na</ci>
<apply>
<times/>
<ci>i_NaCa</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<times/>
<ci>i_NaK</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<ci>Am</ci>
</apply>
<apply>
<times/>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ki</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Ca_L_K</ci>
<ci>i_K</ci>
<ci>i_K1</ci>
<ci>i_Kp</ci>
<ci>i_ns_K</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>i_NaK</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<ci>Am</ci>
</apply>
<apply>
<times/>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ko</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>i_Ca_L_K</ci>
<ci>i_K</ci>
<ci>i_K1</ci>
<ci>i_Kp</ci>
<ci>i_ns_K</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>i_NaK</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<ci>Am</ci>
</apply>
<apply>
<times/>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00048" name="Myofilaments">
<variable name="time" public_interface="in" units="ms"/>
<variable name="lambda" public_interface="in" units="dimensionless"/>
<variable name="dlambdadt" public_interface="in" units="per_ms"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable initial_value="56.2" name="Tref" units="N_per_mm2"/>
<variable initial_value="4.9" name="beta0" units="dimensionless"/>
<variable initial_value="0.35" name="a" units="dimensionless"/>
<variable initial_value="0" name="Q1" units="dimensionless"/>
<variable initial_value="0" name="Q2" units="dimensionless"/>
<variable initial_value="0" name="Q3" units="dimensionless"/>
<variable initial_value="-29" name="A1" units="dimensionless"/>
<variable initial_value="138" name="A2" units="dimensionless"/>
<variable initial_value="129" name="A3" units="dimensionless"/>
<variable initial_value="0.03" name="alpha1" units="dimensionless"/>
<variable initial_value="0.13" name="alpha2" units="dimensionless"/>
<variable initial_value="0.625" name="alpha3" units="dimensionless"/>
<variable initial_value="1.05e-3" name="Ca50ref" units="mM"/>
<variable initial_value="0.85" name="zp" units="dimensionless"/>
<variable initial_value="-4" name="beta1" units="dimensionless"/>
<variable initial_value="8e-3" name="alpha0" units="per_ms"/>
<variable initial_value="2e-3" name="alphar1" units="per_ms"/>
<variable initial_value="1.75e-3" name="alphar2" units="per_ms"/>
<variable initial_value="3" name="nRel" units="dimensionless"/>
<variable initial_value="0.15" name="Kz" units="dimensionless"/>
<variable initial_value="3" name="nHill" units="dimensionless"/>
<variable initial_value="100" name="kon" units="per_mM_per_ms"/>
<variable initial_value="0.2" name="koff" units="per_ms"/>
<variable initial_value="2" name="gamma_trpn" units="dimensionless"/>
<variable initial_value="0.07" name="TRPN_tot" units="mM"/>
<variable name="T0" units="N_per_mm2"/>
<variable name="T0max" units="N_per_mm2"/>
<variable initial_value="0" name="z" units="dimensionless"/>
<variable name="z_max" units="dimensionless"/>
<variable name="Q" units="dimensionless"/>
<variable initial_value="0" name="Cab" units="mM"/>
<variable name="Ca50" units="mM"/>
<variable name="CaTRPN50" units="mM"/>
<variable name="K_2" units="dimensionless"/>
<variable name="K_1" units="dimensionless"/>
<variable name="Tension" units="N_per_mm2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cab</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kon</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>TRPN_tot</ci>
<ci>Cab</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Tension</ci>
<apply>
<times/>
<ci>gamma_trpn</ci>
<ci>Tref</ci>
</apply>
</apply>
</apply>
<ci>Cab</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_2</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="ms">1</cn>
<ci>alphar2</ci>
<apply>
<power/>
<ci>zp</ci>
<ci>nRel</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>zp</ci>
<ci>nRel</ci>
</apply>
<apply>
<power/>
<ci>Kz</ci>
<ci>nRel</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>nRel</ci>
<apply>
<power/>
<ci>Kz</ci>
<ci>nRel</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>zp</ci>
<ci>nRel</ci>
</apply>
<apply>
<power/>
<ci>Kz</ci>
<ci>nRel</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_1</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="ms">1</cn>
<ci>alphar2</ci>
<apply>
<power/>
<ci>zp</ci>
<apply>
<minus/>
<ci>nRel</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<ci>nRel</ci>
<apply>
<power/>
<ci>Kz</ci>
<ci>nRel</ci>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<apply>
<power/>
<ci>zp</ci>
<ci>nRel</ci>
</apply>
<apply>
<power/>
<ci>Kz</ci>
<ci>nRel</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>z_max</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha0</ci>
<cn cellml:units="ms">1</cn>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci>CaTRPN50</ci>
<ci>TRPN_tot</ci>
</apply>
<ci>nHill</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_2</ci>
<cn cellml:units="per_ms">1</cn>
</apply>
<apply>
<plus/>
<ci>alphar1</ci>
<apply>
<times/>
<ci>K_1</ci>
<cn cellml:units="per_ms">1</cn>
</apply>
<apply>
<divide/>
<ci>alpha0</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>CaTRPN50</ci>
<ci>TRPN_tot</ci>
</apply>
<ci>nHill</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ca50</ci>
<apply>
<times/>
<ci>Ca50ref</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>beta1</ci>
<apply>
<minus/>
<ci>lambda</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>CaTRPN50</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Ca50</ci>
<ci>TRPN_tot</ci>
</apply>
<apply>
<plus/>
<ci>Ca50</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>koff</ci>
<ci>kon</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>beta0</ci>
<apply>
<minus/>
<ci>lambda</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">0.5</cn>
</apply>
<ci>gamma_trpn</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>z</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha0</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Cab</ci>
<ci>CaTRPN50</ci>
</apply>
<ci>nHill</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>z</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<ci>z</ci>
</apply>
<ci>alphar1</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>alphar2</ci>
</apply>
<apply>
<power/>
<ci>z</ci>
<ci>nRel</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>z</ci>
<ci>nRel</ci>
</apply>
<apply>
<power/>
<ci>Kz</ci>
<ci>nRel</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>T0max</ci>
<apply>
<times/>
<ci>Tref</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>beta0</ci>
<apply>
<minus/>
<ci>lambda</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>T0</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>T0max</ci>
<ci>z</ci>
</apply>
<ci>z_max</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Tension</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<ci>T0</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>a</ci>
<ci>Q</ci>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>Q</ci>
</apply>
</apply>
<apply>
<lt/>
<ci>Q</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<ci>T0</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<plus/>
<ci>a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Q</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>Q</ci>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Q1</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>A1</ci>
<ci>dlambdadt</ci>
</apply>
<apply>
<times/>
<cn cellml:units="per_ms">1</cn>
<ci>alpha1</ci>
<ci>Q1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Q2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>A2</ci>
<ci>dlambdadt</ci>
</apply>
<apply>
<times/>
<cn cellml:units="per_ms">1</cn>
<ci>alpha2</ci>
<ci>Q2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Q3</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>A3</ci>
<ci>dlambdadt</ci>
</apply>
<apply>
<times/>
<cn cellml:units="per_ms">1</cn>
<ci>alpha3</ci>
<ci>Q3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Q</ci>
<apply>
<plus/>
<ci>Q1</ci>
<ci>Q2</ci>
<ci>Q3</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="containment"/>
<component_ref cmeta:id="id_00052" component="membrane">
<component_ref cmeta:id="id_00006" component="fast_sodium_current">
<component_ref cmeta:id="id_00007" component="fast_sodium_current_m_gate"/>
<component_ref cmeta:id="id_00008" component="fast_sodium_current_h_gate"/>
<component_ref cmeta:id="id_00009" component="fast_sodium_current_j_gate"/>
</component_ref>
<component_ref cmeta:id="id_00018" component="L_type_Ca_channel">
<component_ref cmeta:id="id_00019" component="L_type_Ca_channel_y_gate"/>
</component_ref>
<component_ref cmeta:id="id_00036" component="time_dependent_potassium_current">
<component_ref cmeta:id="id_00037" component="time_dependent_potassium_current_X_gate"/>
<component_ref cmeta:id="id_00038" component="time_dependent_potassium_current_Xi_gate"/>
</component_ref>
<component_ref cmeta:id="id_00042" component="Na_Ca_exchanger"/>
<component_ref cmeta:id="id_00035" component="time_independent_potassium_current">
<component_ref cmeta:id="id_00049" component="time_independent_potassium_current_K1_gate"/>
</component_ref>
<component_ref cmeta:id="id_00034" component="plateau_potassium_current"/>
<component_ref cmeta:id="id_00020" component="sarcolemmal_calcium_pump"/>
<component_ref cmeta:id="id_00045" component="sodium_background_current"/>
<component_ref cmeta:id="id_00021" component="calcium_background_current"/>
<component_ref cmeta:id="id_00050" component="sodium_potassium_pump"/>
<component_ref cmeta:id="id_00051" component="non_specific_calcium_activated_current"/>
<component_ref cmeta:id="id_00022" component="calcium_subsystem"/>
<component_ref component="ionic_concentrations"/>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref cmeta:id="id_00010" component="fast_sodium_current">
<component_ref cmeta:id="id_00011" component="fast_sodium_current_m_gate"/>
<component_ref cmeta:id="id_00012" component="fast_sodium_current_h_gate"/>
<component_ref cmeta:id="id_00013" component="fast_sodium_current_j_gate"/>
</component_ref>
<component_ref cmeta:id="id_00023" component="L_type_Ca_channel">
<component_ref cmeta:id="id_00024" component="L_type_Ca_channel_y_gate"/>
</component_ref>
<component_ref cmeta:id="id_00031" component="time_dependent_potassium_current">
<component_ref cmeta:id="id_00032" component="time_dependent_potassium_current_X_gate"/>
<component_ref cmeta:id="id_00033" component="time_dependent_potassium_current_Xi_gate"/>
</component_ref>
<component_ref cmeta:id="id_00039" component="time_independent_potassium_current">
<component_ref cmeta:id="id_00040" component="time_independent_potassium_current_K1_gate"/>
</component_ref>
</group>
<connection>
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="time_dependent_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="plateau_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sarcolemmal_calcium_pump" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_background_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium_background_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="non_specific_calcium_activated_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium_subsystem" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ionic_concentrations" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Myofilaments" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="lambda" variable_2="lambda"/>
<map_variables variable_1="dlambdadt" variable_2="dlambdadt"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="fast_sodium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="calcium_subsystem" component_2="Myofilaments"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="L_type_Ca_channel"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ca_L_Ca" variable_2="i_Ca_L_Ca"/>
<map_variables variable_1="i_Ca_L_K" variable_2="i_Ca_L_K"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="time_dependent_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_K" variable_2="i_K"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="Na_Ca_exchanger"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="time_independent_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="plateau_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kp" variable_2="i_Kp"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sarcolemmal_calcium_pump"/>
<map_variables variable_1="i_p_Ca" variable_2="i_p_Ca"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_background_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Na_b" variable_2="i_Na_b"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_background_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ca_b" variable_2="i_Ca_b"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_pump"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="non_specific_calcium_activated_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_ns_Ca" variable_2="i_ns_Ca"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_subsystem"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="ionic_concentrations"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="ionic_concentrations"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="sodium_background_current"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="calcium_subsystem"/>
<map_variables variable_1="Ca_SS" variable_2="Ca_SS"/>
<map_variables variable_1="i_Ca_L_Ca" variable_2="i_Ca_L_Ca"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="ionic_concentrations"/>
<map_variables variable_1="i_Ca_L_K" variable_2="i_Ca_L_K"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection>
<map_components component_1="time_dependent_potassium_current" component_2="ionic_concentrations"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_K" variable_2="i_K"/>
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger" component_2="ionic_concentrations"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger" component_2="calcium_subsystem"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="ionic_concentrations"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
</connection>
<connection>
<map_components component_1="plateau_potassium_current" component_2="time_independent_potassium_current"/>
<map_variables variable_1="E_K1" variable_2="E_K1"/>
</connection>
<connection>
<map_components component_1="plateau_potassium_current" component_2="ionic_concentrations"/>
<map_variables variable_1="i_Kp" variable_2="i_Kp"/>
</connection>
<connection>
<map_components component_1="sodium_background_current" component_2="ionic_concentrations"/>
<map_variables variable_1="i_Na_b" variable_2="i_Na_b"/>
</connection>
<connection>
<map_components component_1="sarcolemmal_calcium_pump" component_2="calcium_subsystem"/>
<map_variables variable_1="i_p_Ca" variable_2="i_p_Ca"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="calcium_background_current" component_2="calcium_subsystem"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_Ca_b" variable_2="i_Ca_b"/>
</connection>
<connection>
<map_components component_1="calcium_background_current" component_2="ionic_concentrations"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="ionic_concentrations"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="non_specific_calcium_activated_current" component_2="ionic_concentrations"/>
<map_variables variable_1="i_ns_Na" variable_2="i_ns_Na"/>
<map_variables variable_1="i_ns_K" variable_2="i_ns_K"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection>
<map_components component_1="non_specific_calcium_activated_current" component_2="calcium_subsystem"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="ionic_concentrations" component_2="calcium_subsystem"/>
<map_variables variable_1="Am" variable_2="Am"/>
<map_variables variable_1="V_myo" variable_2="V_myo"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_j_gate"/>
<map_variables variable_1="j" variable_2="j"/>
<map_variables variable_1="time" variable_2="time"/>
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<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_y_gate"/>
<map_variables variable_1="y" variable_2="y"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
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<connection>
<map_components component_1="time_dependent_potassium_current" component_2="time_dependent_potassium_current_X_gate"/>
<map_variables variable_1="X" variable_2="X"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
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<connection>
<map_components component_1="time_dependent_potassium_current" component_2="time_dependent_potassium_current_Xi_gate"/>
<map_variables variable_1="Xi" variable_2="Xi"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="time_independent_potassium_current_K1_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="E_K1" variable_2="E_K1"/>
<map_variables variable_1="K1_infinity" variable_2="K1_infinity"/>
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<article xmlns="http://cellml.org/tmp-documentation">
<articleinfo xmlns="http://cellml.org/tmp-documentation">
<title xmlns="http://cellml.org/tmp-documentation">Jafri-Rice-Winslow Ventricular Model 1998</title>
<author xmlns="http://cellml.org/tmp-documentation">
<firstname xmlns="http://cellml.org/tmp-documentation">Catherine</firstname>
<surname xmlns="http://cellml.org/tmp-documentation">Lloyd</surname>
<affiliation xmlns="http://cellml.org/tmp-documentation">
<shortaffil xmlns="http://cellml.org/tmp-documentation">Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
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<section xmlns="http://cellml.org/tmp-documentation" id="sec_status">
<title xmlns="http://cellml.org/tmp-documentation">Model Status</title>
<para xmlns="http://cellml.org/tmp-documentation">
This model is known to run in both PCEnv and COR, and has been curated by Penny Noble of Oxford University. This variant also contains an embedded CellML description of Niederer, Hunter and Smith's quantitative model of cardiac myocyte regulation. The reference for this paper is given below.
</para>
</section>
<sect1 xmlns="http://cellml.org/tmp-documentation" id="sec_structure">
<title xmlns="http://cellml.org/tmp-documentation">Model Structure</title>
<para xmlns="http://cellml.org/tmp-documentation">
ABSTRACT: We construct a detailed mathematical model for Ca2+ regulation in the ventricular myocyte that includes novel descriptions of subcellular mechanisms based on recent experimental findings: 1) the Keizer-Levine model for the ryanodine receptor (RyR), which displays adaptation at elevated Ca2+; 2) a model for the L-type Ca2+ channel that inactivates by mode switching; and 3) a restricted subspace into which the RyRs and L-type Ca2+ channels empty and interact via Ca2+. We add membrane currents from the Luo-Rudy Phase II ventricular cell model to our description of Ca2+ handling to formulate a new model for ventricular action potentials and Ca2+ regulation. The model can simulate Ca2+ transients during an action potential similar to those seen experimentally. The subspace [Ca2+] rises more rapidly and reaches a higher level (10-30 microM) than the bulk myoplasmic Ca2+ (peak [Ca2+]i approximately 1 microM). Termination of sarcoplasmic reticulum (SR) Ca2+ release is predominately due to emptying of the SR, but is influenced by RyR adaptation. Because force generation is roughly proportional to peak myoplasmic Ca2+, we use [Ca2+]i in the model to explore the effects of pacing rate on force generation. The model reproduces transitions seen in force generation due to changes in pacing that cannot be simulated by previous models. Simulation of such complex phenomena requires an interplay of both RyR adaptation and the degree of SR Ca2+ loading. This model, therefore, shows improved behavior over existing models that lack detailed descriptions of subcellular Ca2+ regulatory mechanisms.
</para>
<para xmlns="http://cellml.org/tmp-documentation">
The original paper reference is cited below:
</para>
<para xmlns="http://cellml.org/tmp-documentation">
Cardiac Calcium Dynamics: The Roles of Ryanodine Receptor Adaptation and Sarcoplasmic Reticulum Load, M. Saleet Jafri, J. Jeremy Rice and Raimond L. Winslow, 1998,
<emphasis xmlns="http://cellml.org/tmp-documentation">Biophysical Journal</emphasis>, 74, 1149-1168. <ulink xmlns="http://cellml.org/tmp-documentation" url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9512016&dopt=Abstract">PubMed ID: 9512016</ulink>
</para>
<para xmlns="http://cellml.org/tmp-documentation">
The reference for the embedded Niederer Hunter Smith model of cardiac myocyte relaxation is: "A Quantitative Analysis of Cardiac Myocyte Relaxation: A Simulation Study" Niederer, S.A., Hunter, P.J., Smith, N.P, Biophysical Journal, Volume 90, March 2006, pp. 1697-1722.
</para>
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<objectinfo xmlns="http://cellml.org/tmp-documentation">
<title xmlns="http://cellml.org/tmp-documentation">cell diagram of the Jafri-Rice-Winslow model showing ionic currents, pumps and exchangers within the sarcolemma and the sarcoplasmic reticulum</title>
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<caption xmlns="http://cellml.org/tmp-documentation">A schematic diagram describing the current flows across the cell membrane that are captured in the Jafri-Rice-Winslow model.</caption>
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</article>
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<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Jafri</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Saleet</vCard:Other>
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<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#author2VcardN">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">John</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Rice</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Jeremy</vCard:Other>
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<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#author3VcardN">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Raimond</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Winslow</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">L</vCard:Other>
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<rdf:type xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
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<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#dbe501ef-01c1-4bcb-bd8d-e51013ca0dd1"/>
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<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#62efef11-6d63-4ae6-ae94-5caa43b3e590">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">M</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Jafri</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Saleet</vCard:Other>
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<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">John</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Rice</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Jeremy</vCard:Other>
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<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Raimond</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Winslow</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">L</vCard:Other>
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<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#381202dd-b46a-4f25-a29b-f5fb8775c135"/>
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<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#381202dd-b46a-4f25-a29b-f5fb8775c135">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The voltage-dependent inactivation gate for the L-type calcium
channel - the y gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#1f01afbb-c1b6-438f-97d0-c3969915c018">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Rate constants for state changes in mode normal.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#dcbb6aa9-ae72-4aa1-abe4-441cfc3eb735">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The voltage- and time-dependent activation gate for the
time-dependent potassium current - the X gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#9c262e7e-ab38-4fd7-bd1a-dc1038ecfde3">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The potassium permeability of the channel, which depends on the
calcium current component.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#beta_h_calculation_eq">
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<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#f482e965-99de-48a1-9852-4c2d7ed54695"/>
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<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#f482e965-99de-48a1-9852-4c2d7ed54695">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The closing rate of the h gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#219f5ab0-c1bc-4800-99db-37938c290bd3">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calculate the uptake flux into the NSR from the myoplasm.</rdf:value>
</rdf:Description>
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</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#1b23ea30-5d66-4460-91b7-248fa4a6231b">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The channel's reversal potential.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#12722d36-293a-4b83-8b20-06f18b5826ea">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The time-independent inactivation gate for the time-dependent
potassium channel.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#903f5c62-f8f7-4436-9a15-9a235803802d">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calculate the translocation flux between the uptake (NSR) and
release (JSR) stores.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#2eeac2c4-b1fd-4c67-9abc-062101ce6d2b">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calculation of the background sodium current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#jafri_rice_winslow_1998_version02">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#b1179327-5f99-4cfe-a215-e645b1a9f16f"/>
</cmeta:comment>
<cmeta:bio_entity xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Ventricular Myocyte</cmeta:bio_entity>
<ns7:simulation xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#$9jbrV3"/>
</ns7:simulation>
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The Jafri-Rice-Winslow Model for Calcium Regulation in the Ventricular
Myocyte, 1997</dc:title>
<cmeta:species xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Mammalia</cmeta:species>
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#4587df3a-08b0-46ae-99bc-67d5a2bdd139"/>
</bqs:reference>
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:nodeID="n1"/>
</bqs:reference>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#b1179327-5f99-4cfe-a215-e645b1a9f16f">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">This is the CellML description of Jafri, Rice and Winslow's mathematical model for calcium regulation in the ventricular myocyte. It is based on an accurate model of the membrane currents and adds a more sophisticated model of calcium handling. The JRW model is based on the LR-II model for ventricular action potentials, with several modifications.</rdf:value>
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#e1d81e5c-d287-4425-8b52-0aafe161881b"/>
</dc:creator>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#$9jbrV3">
<ns7:boundIntervals xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#$ajbrV3"/>
</ns7:boundIntervals>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#4587df3a-08b0-46ae-99bc-67d5a2bdd139">
<bqs:Pubmed_id xmlns:bqs="http://www.cellml.org/bqs/1.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">9512016</bqs:Pubmed_id>
<bqs:JournalArticle xmlns:bqs="http://www.cellml.org/bqs/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#66e14b47-9a73-4697-bc55-a241e8496dd9"/>
</bqs:JournalArticle>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#e1d81e5c-d287-4425-8b52-0aafe161881b">
<vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Catherine Lloyd</vCard:FN>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#$ajbrV3">
<rdf:first xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#$bjbrV3"/>
</rdf:first>
<rdf:rest xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
</rdf:rest>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#66e14b47-9a73-4697-bc55-a241e8496dd9">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Cardiac Ca2+ Dynamics: The Roles of Ryanodine Receptor Adaptation and Sarcoplasmic Reticulum Load</dc:title>
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#c1eac369-66b1-4be0-8a0a-568845c120bb"/>
</dc:creator>
<bqs:volume xmlns:bqs="http://www.cellml.org/bqs/1.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">74</bqs:volume>
<bqs:first_page xmlns:bqs="http://www.cellml.org/bqs/1.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">1149</bqs:first_page>
<bqs:Journal xmlns:bqs="http://www.cellml.org/bqs/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#19de6dea-e3a4-4725-9338-7f60e692e850"/>
</bqs:Journal>
<dcterms:issued xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#41088e5c-001c-4930-87f3-41113ce0a73c"/>
</dcterms:issued>
<bqs:last_page xmlns:bqs="http://www.cellml.org/bqs/1.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">1168</bqs:last_page>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#$bjbrV3">
<ns7:endingValue xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">3000</ns7:endingValue>
<pointDensity xmlns="http://www.cellml.org/metadata/simulation/1.0#nonstandard-" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">100000</pointDensity>
<ns7:maximumStepSize xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">0.1</ns7:maximumStepSize>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#19de6dea-e3a4-4725-9338-7f60e692e850">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Biophysical Journal</dc:title>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#41088e5c-001c-4930-87f3-41113ce0a73c">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">1998-03-01</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#da6198e9-5668-4bee-a76e-6da5db8c80ec">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The plateau potassium current component contains the equations which
describe the contribution of a time independent [K]o-insensitive
channel at plateau potentials.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#ionic_concentrations">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#b0fbc344-49e1-43f6-95a7-a2851c375fa8"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#b0fbc344-49e1-43f6-95a7-a2851c375fa8">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The descriptions of the rate of change of [Na]i and [K]i are the
same as the LR-II model.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#4c24f963-b2b3-4b4c-a1b7-3bac71e76097">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calculate the current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#i_K1_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#4c24f963-b2b3-4b4c-a1b7-3bac71e76097"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#alpha_h_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#0886d6e7-b4ed-4a05-877b-655f07f13c23"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#0886d6e7-b4ed-4a05-877b-655f07f13c23">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The opening rate of the h gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#C0_diff_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#6c2141e9-882d-4886-962f-5a9b8afc349e"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#6c2141e9-882d-4886-962f-5a9b8afc349e">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The kinetics of the state transitions in mode normal.
In the normal mode, the calcium channel is able to make the
transition to the open, conducting state (O) from the closed state
(C) at a normal rate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#i_ns_Na_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#7cbd6926-4079-4627-aeb4-980877d15eca"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#7cbd6926-4079-4627-aeb4-980877d15eca">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The sodium component of the channel's current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#e50a5ea4-de41-4321-8f12-1ae320cbcff5">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The fast sodium current component contains the differential
equations governing the influx of sodium ions through the cell
surface membrane into the cell.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#fast_sodium_current">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#e50a5ea4-de41-4321-8f12-1ae320cbcff5"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#bf72189f-a875-4906-8eb1-514525848cbb">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The kinetics of the h gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#K1_infinity_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#6cb2ccac-6d26-4142-bfea-c5f71bec19a7"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#6cb2ccac-6d26-4142-bfea-c5f71bec19a7">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The steady-state approximation for the K1 gating kinetics.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#398816f5-c23b-4cf8-bac4-0528e4302905">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The kinetics of calcium binding to the myoplasm buffer troponin -
both high and low affinity binding sites.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#282e1a65-80d4-4c22-9ea4-7fa13d1b885b">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The closing rate of the j gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#J_leak_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#c490f6a1-536d-45b9-b576-97e01c51d188"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#c490f6a1-536d-45b9-b576-97e01c51d188">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calculate the leakage flux from the NSR into the myoplasm.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#8fef7c77-6810-4289-97d0-2d35d54914cc">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The rate of change of intracellular sodium ion concentration.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#J_tr_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#903f5c62-f8f7-4436-9a15-9a235803802d"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#J_rel_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#373a86d2-0230-4aa9-bb3d-d655c58c8c0f"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#373a86d2-0230-4aa9-bb3d-d655c58c8c0f">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The calcium release flux from the JSR into the restricted subspace
is governed by the fraction of RyR channels in an open state.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#g_K1_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#482f5aa5-751c-4f08-a861-f0012b5a46b6"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#482f5aa5-751c-4f08-a861-f0012b5a46b6">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calculation of the maximal channel conductance, dependent on
extracellular potassium concentration.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#E_CaN_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#390c1948-87ea-4ad5-b84b-e66a3e842826"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#390c1948-87ea-4ad5-b84b-e66a3e842826">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The reversal potential for the background calcium current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#i_Na_b_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#2eeac2c4-b1fd-4c67-9abc-062101ce6d2b"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5321b474-ca6b-4aa0-81d4-0490640fefa8">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The reversal potential for the background sodium channel.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#membrane_voltage_diff_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5503cefb-15ec-4084-9f59-a87f88601ce3"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5503cefb-15ec-4084-9f59-a87f88601ce3">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The kinetics of the transmembrane potential, defined as the sum of
all the sarcolemmal currents and an applied stimulus current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#d4ed6796-21bc-4d5a-84d7-7d0f669c1d5e">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The time constants for the K1 gate are small enough that the gating
variable can be approximated with it's steady-state value.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#RyR_open_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#3d74ad55-3a32-4a31-a3ef-1da4d0955353"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#3d74ad55-3a32-4a31-a3ef-1da4d0955353">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The "open" RyR's are those P_O1 and P_O2 states.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#0369ac4e-eed4-49da-ae19-79542aa70493">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The following equation calculates the reversal potential of the
time-independent potassium current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5845a0e2-5166-485a-8890-5f5ed5d38b27">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The total nonspecific calcium activated current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#HTRPNCa_diff_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#9c32c531-ccd3-45f2-92aa-931008c32918"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#9c32c531-ccd3-45f2-92aa-931008c32918">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Keep track of the concentration of calcium ions bound to high and
low affinity troponin binding sites.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#plateau_potassium_current">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#da6198e9-5668-4bee-a76e-6da5db8c80ec"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#calcium_subsystem">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#b19917af-867f-44ba-ab12-31486eab52de"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#b19917af-867f-44ba-ab12-31486eab52de">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">In the JRW model, subcellular calcium regulatory mechanisms are
described in detail. There are six calcium fluxes to consider;
J_rel, J_leak, J_up, J_tr, J_xfer and J_trpn. In addition, three
membrane current fluxes are also necessary for the formulation of
calcium regulation; i_p_Ca, i_Ca_L_Ca and i_NaCa.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#aee41d98-40e6-4b37-843c-d37f7b7132d9">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The opening rate of the K1 gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#Na_Ca_exchanger">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#3a228af7-a587-44ff-a2f8-3fb836f3ddbe"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#3a228af7-a587-44ff-a2f8-3fb836f3ddbe">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The Na/Ca exchanger component describes how a protein molecule in
the cell surface membrane transports Na ions into the cytosol and
exports Ca ions into the extracellular volume, in a ratio of 3:1
respectively.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#f_NaK_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#f690db2d-eb3d-4974-a518-dc77ff82de98"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#f690db2d-eb3d-4974-a518-dc77ff82de98">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calculation of the Na/K pump current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#fast_sodium_current_h_gate">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#7bc72e28-d28c-4160-b5c3-f9aa39b2c081"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#7bc72e28-d28c-4160-b5c3-f9aa39b2c081">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The voltage-dependent inactivation gate for the fast sodium current
- the h gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#J_xfer_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#9fc3abe3-2c03-4489-8e83-726c4a8131e6"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#9fc3abe3-2c03-4489-8e83-726c4a8131e6">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calculate the calcium flux from the diffusion of calcium out of the
restricted subspace into the myoplasm.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#1647eb04-92c1-4804-aab6-6fcfb410ad2c">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The time-independent potassium current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#alpha_X_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#bd9fdeb3-53d0-4e83-aef8-0442dd315536"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#bd9fdeb3-53d0-4e83-aef8-0442dd315536">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The opening rate of the X gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#6ef85e73-a236-458b-a884-b9048c08a25c">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The time-dependent potassium current has an X^2 dependence on it's
activation gate, and an Xi inactivation gate. This channel is also
assumed permeable to sodium ions.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#68023ec0-d242-4459-80e7-845fb91c4dca">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The voltage-dependent slow inactivation gate for the fast sodium
current - the j gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#alpha_j_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#09bc439b-1d42-4289-bad1-ada2102458ca"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#09bc439b-1d42-4289-bad1-ada2102458ca">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The opening rate of the j gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#calcium_internal_diff_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#dd0f94a1-be17-4d3c-bf38-7db4369c0bb7"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#dd0f94a1-be17-4d3c-bf38-7db4369c0bb7">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The kinetics of the calcium ion concentration changes in the various
compartments of the model.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#683e3709-a3fe-4eb9-95e4-bb3566e9f6f1">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The kinetics of the state transitions in mode Ca.
Calcium binding to the Ca channel induces a conformational change
from normal mode to mode Ca. This effectively inhibits the
conduction of calcium ions because in mode Ca, the calcium channel
makes the transition to the open, conducting state (O) extremely
slowly.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#E_Na_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#f996f632-013a-44f4-b739-8b14712ebdf3"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#f996f632-013a-44f4-b739-8b14712ebdf3">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The sodium reversal potential.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#VnsCa_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#99ea7d04-14f7-4f8f-a325-9b54ef8b2075"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#99ea7d04-14f7-4f8f-a325-9b54ef8b2075">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The potential offset for the channel.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#IStim_for_cmiss_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#86d5770b-672b-4dd4-a4c6-73015fb1641e"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#86d5770b-672b-4dd4-a4c6-73015fb1641e">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">This is a dummy equation that we simply use to make grabbing the
value in CMISS much easier.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#i_p_Ca_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#7ddfbcc9-9bcb-4fe4-ad8e-71f0f6cac2b0"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#7ddfbcc9-9bcb-4fe4-ad8e-71f0f6cac2b0">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The calcium pump current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#E_K1_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#0369ac4e-eed4-49da-ae19-79542aa70493"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#0f1ed0e4-6d3c-4b56-98fd-fc7c0d93e2e4">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The closing rate of the m gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#i_Ca_L_Ca_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#53293fee-69c3-4129-8cee-9ee80381c4f8"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#53293fee-69c3-4129-8cee-9ee80381c4f8">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calculation of the calcium current component of the total channel
current, given as the maximal current multiplied by the
voltage-dependent inactivation gate and the open probability of the
channel based on the mode-switching model.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#fast_sodium_current_m_gate">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#3e450836-34ec-4a41-bc56-d275ff567a6d"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#3e450836-34ec-4a41-bc56-d275ff567a6d">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The voltage-dependent activation gate for the fast sodium current -
the m gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#b2d117d3-c431-4efc-956c-62608568025c">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The rate of change of intracellular potassium ion concentration.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#e10d779d-5ea9-4866-a2a8-42119c7918e5">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The sodium background current is a time-independent diffusion of
Na ions down their electrochemical gradient, through the cell
surface membrane into the cytosol.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#dm_dt_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#0a2d9210-8282-4cb8-ba81-57ba73f665c4"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#0a2d9210-8282-4cb8-ba81-57ba73f665c4">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The kinetics of the m gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#J_up_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#219f5ab0-c1bc-4800-99db-37938c290bd3"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#alpha_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#1f01afbb-c1b6-438f-97d0-c3969915c018"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#19e507f5-2e34-4938-ba36-ab0660d9a60f">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The rate of change of extracellular potassium ion concentration.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#033e0120-32a3-460a-b3ed-e608fc10acb9">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calculation of the time-dependent potassium current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5fefa518-4317-4642-9cb0-70a5c95a481e">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The maximal potassium component current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#L_type_Ca_channel">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5eb96e50-3a06-4319-a449-e041479a023f"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5eb96e50-3a06-4319-a449-e041479a023f">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The JWR model creates a new mathematical model to describe the
L-type calcium channel that is based on the experimentally observed
mode-switching behaviour of the channel. Inactivation occurs as
calcium ion binding induces the channel to switch (from mode normal)
to a mode in which transitions to open states are extremely slow
(mode Ca). The channel has one voltage inactivation gate, y. As well
as Ca, the channel is assumed permeable to K ions also.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#sodium_diff_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#8fef7c77-6810-4289-97d0-2d35d54914cc"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#potassium_internal_diff_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#b2d117d3-c431-4efc-956c-62608568025c"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#beta_K1_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#283ef951-972e-447c-a607-28aa80255764"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#283ef951-972e-447c-a607-28aa80255764">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The closing rate of the K1 gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#p_K_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#9c262e7e-ab38-4fd7-bd1a-dc1038ecfde3"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#4b84685c-44dc-44c7-b908-38e08c75f7af">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calculation of the plateau potassium current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#time_dependent_potassium_current_Xi_gate">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#12722d36-293a-4b83-8b20-06f18b5826ea"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#835c7777-1095-4391-89ed-42f400cea57d">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The maximal sodium component current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#4e609ca2-bc3f-4ed6-9eb3-4bf9e2cdc962">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calculation of the Na/Ca exchanger current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5367cdd4-0e34-41d4-82c4-8e8d261ed246">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The main component of the model which defines the action potential.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#i_K_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#033e0120-32a3-460a-b3ed-e608fc10acb9"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#dj_dt_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#eb0ea281-b5e1-4386-9d7a-ebeaa4ea9477"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#eb0ea281-b5e1-4386-9d7a-ebeaa4ea9477">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The kinetics of the j gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#y_diff_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5210dece-3135-4c13-9a3e-b75a3d82ea67"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5210dece-3135-4c13-9a3e-b75a3d82ea67">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The kinetics of the y gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#e24c338d-ca40-48a7-b588-19037f4fc73a">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calculation of the fast sodium current using the three
Hodkin-Huxley type voltage-dependent gating variables m, h, and j.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#2a82804c-14ac-4488-96b4-897538ff88fd">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The sarcolemmal calcium pump is an additional mechanism for removing
Ca ions from the myoplasm to help maintain a low intracellular
calcium concentration when at rest.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#potassium_external_diff_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#19e507f5-2e34-4938-ba36-ab0660d9a60f"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#243419e0-6d85-4733-9b4c-f8546f83b7a4">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calculation of the potassium current component of the total channel
current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#membrane">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5367cdd4-0e34-41d4-82c4-8e8d261ed246"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#alpha_K1_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#aee41d98-40e6-4b37-843c-d37f7b7132d9"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#C_Ca0_diff_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#683e3709-a3fe-4eb9-95e4-bb3566e9f6f1"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#ff4606f2-8637-46ad-b862-69e0b88de05e">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The closing rate of the X gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#V_SS_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#76fd3acd-1b94-4d41-b8cc-72eac01422bc"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#76fd3acd-1b94-4d41-b8cc-72eac01422bc">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calculate some volume fractions as proportions of the total
myoplasmic volume.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#calcium_background_current">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#381df5ee-2bac-4704-83f3-032825cce1ea"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#381df5ee-2bac-4704-83f3-032825cce1ea">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The calcium background current describes a time-independent
diffusion of Ca ions down their electrochemical gradient through the
cell surface membrane into the cytosol. However, calcium is not
allowed to accumulate to high intracellular concentrations. This
influx is balanced by the Ca ion extrusion through the Na-Ca
exchanger and the sarcolemmal Ca pump.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#g_K_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#8d17d79c-9e87-4ff1-877c-cf4000b524fc"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#8d17d79c-9e87-4ff1-877c-cf4000b524fc">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calculation of the maximal channel conductance, dependent on
extracellular potassium concentration.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#1775b7a7-7ada-46ea-a2ba-390a0ee912be">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The nonspecific calcium activated current describes a channel which
is activated by calcium ions, but is permeable to only sodium and
potassium ions.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#77d0a8bd-bbdb-48de-81e8-c3711fe2cf16">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Rate constant for switching between mode normal and mode Ca.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#Bi_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#13a28452-e692-483c-9aa7-02e6c73e7464"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#13a28452-e692-483c-9aa7-02e6c73e7464">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calcium is buffered by calmodulin (CMDN) in the subspace and
myoplasm, and by calsequestrin (CSQN) in the JSR. These are fast
buffers and their effect is modelled using the rapid buffering
approximation.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#i_ns_K_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#4883548f-e381-4a8d-bdfe-2e6add011c43"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#4883548f-e381-4a8d-bdfe-2e6add011c43">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The potassium component of the channel's current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#02790508-bb45-42b1-b6da-39202a32797c">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Calculation of the background calcium current.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#P_C1_diff_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#11c8815a-fed4-4f76-8be7-2df9b3cddac5"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#11c8815a-fed4-4f76-8be7-2df9b3cddac5">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The kinetic equations governing the transitions between the four
states used to model the RyR's.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#sodium_potassium_pump">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#8845e476-c0c5-4d31-a07d-501ec259885e"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#8845e476-c0c5-4d31-a07d-501ec259885e">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The sodium potassium pump is an active protein in the cell membrane
which couples the free energy released by the hydrolysis of ATP to
the movement of Na and K ions against their electrochemical
gradients through the cell membrane.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5580b920-d04c-4598-bfc0-4503e68356d0">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The kinetics of the X gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#dX_dt_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5580b920-d04c-4598-bfc0-4503e68356d0"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#0d6f844f-69d8-4d90-b8d7-ad63b27dd018">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The opening rate of the m gate.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#E_NaN_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5321b474-ca6b-4aa0-81d4-0490640fefa8"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#time_dependent_potassium_current_X_gate">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#dcbb6aa9-ae72-4aa1-abe4-441cfc3eb735"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#alpha_a_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#1814fb0f-f79f-4e7c-8d1f-2449b1fb8720"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#1814fb0f-f79f-4e7c-8d1f-2449b1fb8720">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Rate constants for state changes in mode Ca (corresponding to
alpha-prime and beta-prime in the JRW paper).</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#I_ns_K_max_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5fefa518-4317-4642-9cb0-70a5c95a481e"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#i_Ca_L_K_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#243419e0-6d85-4733-9b4c-f8546f83b7a4"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#I_ns_Na_max_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#835c7777-1095-4391-89ed-42f400cea57d"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#time_dependent_potassium_current">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#6ef85e73-a236-458b-a884-b9048c08a25c"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#beta_j_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#282e1a65-80d4-4c22-9ea4-7fa13d1b885b"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#13ebb9eb-5ba8-4942-99b3-cbe891cb9d52">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Xi is the inward rectification parameter and is given by the
following equation.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#time_independent_potassium_current">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#1647eb04-92c1-4804-aab6-6fcfb410ad2c"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#alpha_m_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#0d6f844f-69d8-4d90-b8d7-ad63b27dd018"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5d6c233b-69dc-4344-922f-95ad5138ca76">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The maximal calcium current through the channel.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#fast_sodium_current_j_gate">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#68023ec0-d242-4459-80e7-845fb91c4dca"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#i_Na_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#e24c338d-ca40-48a7-b588-19037f4fc73a"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#sarcolemmal_calcium_pump">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#2a82804c-14ac-4488-96b4-897538ff88fd"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#dh_dt_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#bf72189f-a875-4906-8eb1-514525848cbb"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#E_K_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#c1809e54-6320-4eae-9d42-372675b76ca5"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#c1809e54-6320-4eae-9d42-372675b76ca5">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The reversal potential of the channel.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#i_Ca_L_Ca_max_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5d6c233b-69dc-4344-922f-95ad5138ca76"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#beta_X_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#ff4606f2-8637-46ad-b862-69e0b88de05e"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#beta_m_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#0f1ed0e4-6d3c-4b56-98fd-fc7c0d93e2e4"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#60792332-37ac-45fd-aa50-b8c1a538327d">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The reversal potential of the channel.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#time_independent_potassium_current_K1_gate">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#d4ed6796-21bc-4d5a-84d7-7d0f669c1d5e"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#J_htrpn_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#398816f5-c23b-4cf8-bac4-0528e4302905"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#i_Ca_b_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#02790508-bb45-42b1-b6da-39202a32797c"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#gamma_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#77d0a8bd-bbdb-48de-81e8-c3711fe2cf16"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#sodium_background_current">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#e10d779d-5ea9-4866-a2a8-42119c7918e5"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#Na_Ca_exchanger_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#4e609ca2-bc3f-4ed6-9eb3-4bf9e2cdc962"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#i_Kp_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#4b84685c-44dc-44c7-b908-38e08c75f7af"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#Kp_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#d8bc8fb4-700e-4586-9204-f6044de0ab3e"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#d8bc8fb4-700e-4586-9204-f6044de0ab3e">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The activation variable.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#EnsCa_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#60792332-37ac-45fd-aa50-b8c1a538327d"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#non_specific_calcium_activated_current">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#1775b7a7-7ada-46ea-a2ba-390a0ee912be"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#Xi_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#13ebb9eb-5ba8-4942-99b3-cbe891cb9d52"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#i_ns_Ca_calculation_eq">
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5845a0e2-5166-485a-8890-5f5ed5d38b27"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#id_00001">
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0060075"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0030322"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0042391"/>
</isVersionOf>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#id_00002">
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0001518"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0005248"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0005272"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0034706"/>
</isVersionOf>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#id_00003">
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0001518"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0005248"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0005272"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0034706"/>
</isVersionOf>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#id_00004">
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0001518"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0005248"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0005272"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0034706"/>
</isVersionOf>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#id_00005">
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0001518"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0005248"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0005272"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0034706"/>
</isVersionOf>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#id_00006">
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0001518"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0005248"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0005272"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0034706"/>
</isVersionOf>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#id_00007">
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0001518"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0005248"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0005272"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0034706"/>
</isVersionOf>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#id_00008">
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0001518"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://identifiers.org/go/GO:0005248"/>
</isVersionOf>
<isVersionOf xmlns="http://biomodels.net/biology-qualifiers/">
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