Generated Code
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C
C There are a total of 22 entries in the algebraic variable array.
C There are a total of 11 entries in each of the rate and state variable arrays.
C There are a total of 25 entries in the constant variable array.
C
C
C CONSTS(1) is kappa_R_1a_cGMP in component BG_parameters (fmol_per_sec).
C CONSTS(2) is kappa_R_1b_cGMP in component BG_parameters (fmol_per_sec).
C CONSTS(3) is kappa_R_2a_cGMP in component BG_parameters (fmol_per_sec).
C CONSTS(4) is kappa_R_2b_cGMP in component BG_parameters (fmol_per_sec).
C CONSTS(5) is kappa_R_1_sGC in component BG_parameters (fmol_per_sec).
C CONSTS(6) is kappa_R_2_sGC in component BG_parameters (fmol_per_sec).
C CONSTS(7) is kappa_R_3_sGC in component BG_parameters (fmol_per_sec).
C CONSTS(8) is kappa_R_4_sGC in component BG_parameters (fmol_per_sec).
C CONSTS(9) is kappa_R_DNO_sGC in component BG_parameters (fmol_per_sec).
C CONSTS(10) is K_GTP in component BG_parameters (per_fmol).
C CONSTS(11) is K_E5c in component BG_parameters (per_fmol).
C CONSTS(12) is K_cGMP in component BG_parameters (per_fmol).
C CONSTS(13) is K_PDE in component BG_parameters (per_fmol).
C CONSTS(14) is K_GTP_E5c in component BG_parameters (per_fmol).
C CONSTS(15) is K_cGMP_PDE in component BG_parameters (per_fmol).
C CONSTS(16) is K_GMP in component BG_parameters (per_fmol).
C CONSTS(17) is K_Eb in component BG_parameters (per_fmol).
C CONSTS(18) is K_NO in component BG_parameters (per_fmol).
C CONSTS(19) is K_E6c in component BG_parameters (per_fmol).
C CONSTS(20) is K_NO_product in component BG_parameters (per_fmol).
C VOI is t in component environment (second).
C CONSTS(21) is vol_myo in component environment (pL).
C STATES(1) is q_cGMP in component environment (fmol).
C STATES(2) is q_GTP in component environment (fmol).
C STATES(3) is q_E5c in component environment (fmol).
C STATES(4) is q_PDE in component environment (fmol).
C STATES(5) is q_GTP_E5c in component environment (fmol).
C STATES(6) is q_cGMP_PDE in component environment (fmol).
C STATES(7) is q_GMP in component environment (fmol).
C STATES(8) is q_Eb in component environment (fmol).
C STATES(9) is q_NO in component environment (fmol).
C STATES(10) is q_E6c in component environment (fmol).
C STATES(11) is q_NO_product in component environment (fmol).
C ALGBRC(8) is v_R_1a_cGMP in component cGMP (fmol_per_sec).
C ALGBRC(9) is v_R_1b_cGMP in component cGMP (fmol_per_sec).
C ALGBRC(10) is v_R_2a_cGMP in component cGMP (fmol_per_sec).
C ALGBRC(11) is v_R_2b_cGMP in component cGMP (fmol_per_sec).
C ALGBRC(18) is v_R_1_sGC in component sGC (fmol_per_sec).
C ALGBRC(19) is v_R_2_sGC in component sGC (fmol_per_sec).
C ALGBRC(20) is v_R_3_sGC in component sGC (fmol_per_sec).
C ALGBRC(21) is v_R_4_sGC in component sGC (fmol_per_sec).
C ALGBRC(22) is v_R_DNO_sGC in component sGC (fmol_per_sec).
C CONSTS(22) is v_NO_generation in component environment (fmol_per_sec).
C CONSTS(23) is R in component constants (J_per_K_per_mol).
C CONSTS(24) is T in component constants (kelvin).
C CONSTS(25) is F in component constants (C_per_mol).
C ALGBRC(1) is mu_GTP in component cGMP (J_per_mol).
C ALGBRC(2) is mu_E5c in component cGMP (J_per_mol).
C ALGBRC(3) is mu_cGMP in component cGMP (J_per_mol).
C ALGBRC(4) is mu_PDE in component cGMP (J_per_mol).
C ALGBRC(5) is mu_GTP_E5c in component cGMP (J_per_mol).
C ALGBRC(6) is mu_cGMP_PDE in component cGMP (J_per_mol).
C ALGBRC(7) is mu_GMP in component cGMP (J_per_mol).
C ALGBRC(12) is mu_Eb in component sGC (J_per_mol).
C ALGBRC(13) is mu_NO in component sGC (J_per_mol).
C ALGBRC(14) is mu_E6c in component sGC (J_per_mol).
C ALGBRC(15) is mu_E5c in component sGC (J_per_mol).
C ALGBRC(16) is mu_cGMP in component sGC (J_per_mol).
C ALGBRC(17) is mu_NO_product in component sGC (J_per_mol).
C RATES(1) is d/dt q_cGMP in component environment (fmol).
C RATES(2) is d/dt q_GTP in component environment (fmol).
C RATES(3) is d/dt q_E5c in component environment (fmol).
C RATES(4) is d/dt q_PDE in component environment (fmol).
C RATES(5) is d/dt q_GTP_E5c in component environment (fmol).
C RATES(6) is d/dt q_cGMP_PDE in component environment (fmol).
C RATES(7) is d/dt q_GMP in component environment (fmol).
C RATES(8) is d/dt q_Eb in component environment (fmol).
C RATES(9) is d/dt q_NO in component environment (fmol).
C RATES(10) is d/dt q_E6c in component environment (fmol).
C RATES(11) is d/dt q_NO_product in component environment (fmol).
C
SUBROUTINE initConsts(CONSTS, RATES, STATES)
REAL CONSTS(*), RATES(*), STATES(*)
CONSTS(1) = 192.663
CONSTS(2) = 0.00328297
CONSTS(3) = 56591.2
CONSTS(4) = 0.0110353
CONSTS(5) = 3.61127e+06
CONSTS(6) = 0.00328297
CONSTS(7) = 4.92446
CONSTS(8) = 0.0361127
CONSTS(9) = 0.01
CONSTS(10) = 17040
CONSTS(11) = 0.304602
CONSTS(12) = 1
CONSTS(13) = 17.6706
CONSTS(14) = 5190.42
CONSTS(15) = 35.3412
CONSTS(16) = 0.0051282
CONSTS(17) = 0.0276911
CONSTS(18) = 1
CONSTS(19) = 30.4602
CONSTS(20) = 0.1
CONSTS(21) = 1
STATES(1) = 1e-6
STATES(2) = 0.0005
STATES(3) = 1e-16
STATES(4) = 1e-10
STATES(5) = 1e-16
STATES(6) = 1e-16
STATES(7) = 1e-16
STATES(8) = 1e-6
STATES(9) = 0.00836
STATES(10) = 1e-16
STATES(11) = 1e-16
CONSTS(22) = 0.000114
CONSTS(23) = 8.31
CONSTS(24) = 310
CONSTS(25) = 96485
RETURN
END
SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC)
REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*)
ALGBRC(1) = CONSTS(23)*CONSTS(24)*log( CONSTS(10)*STATES(2))
ALGBRC(2) = CONSTS(23)*CONSTS(24)*log( CONSTS(11)*STATES(3))
ALGBRC(5) = CONSTS(23)*CONSTS(24)*log( CONSTS(14)*STATES(5))
ALGBRC(8) = CONSTS(1)*(EXP((ALGBRC(1)+ALGBRC(2))/( CONSTS(23)*CONSTS(24))) - EXP(ALGBRC(5)/( CONSTS(23)*CONSTS(24))))
RATES(2) = - ALGBRC(8)
ALGBRC(3) = CONSTS(23)*CONSTS(24)*log( CONSTS(12)*STATES(1))
ALGBRC(9) = CONSTS(2)*(EXP(ALGBRC(5)/( CONSTS(23)*CONSTS(24))) - EXP((ALGBRC(3)+ALGBRC(2))/( CONSTS(23)*CONSTS(24))))
RATES(5) = ALGBRC(8) - ALGBRC(9)
ALGBRC(4) = CONSTS(23)*CONSTS(24)*log( CONSTS(13)*STATES(4))
ALGBRC(6) = CONSTS(23)*CONSTS(24)*log( CONSTS(15)*STATES(6))
ALGBRC(10) = CONSTS(3)*(EXP((ALGBRC(3)+ALGBRC(4))/( CONSTS(23)*CONSTS(24))) - EXP(ALGBRC(6)/( CONSTS(23)*CONSTS(24))))
ALGBRC(7) = CONSTS(23)*CONSTS(24)*log( CONSTS(16)*STATES(7))
ALGBRC(11) = CONSTS(4)*(EXP((ALGBRC(6)+ALGBRC(3))/( CONSTS(23)*CONSTS(24))) - EXP((ALGBRC(7)+ALGBRC(4))/( CONSTS(23)*CONSTS(24))))
RATES(4) = - ALGBRC(10)+ALGBRC(11)
RATES(6) = ALGBRC(10) - ALGBRC(11)
RATES(7) = ALGBRC(11)
ALGBRC(12) = CONSTS(23)*CONSTS(24)*log( CONSTS(17)*STATES(8))
ALGBRC(13) = CONSTS(23)*CONSTS(24)*log( CONSTS(18)*STATES(9))
ALGBRC(14) = CONSTS(23)*CONSTS(24)*log( CONSTS(19)*STATES(10))
ALGBRC(18) = CONSTS(5)*(EXP((ALGBRC(12)+ALGBRC(13))/( CONSTS(23)*CONSTS(24))) - EXP(ALGBRC(14)/( CONSTS(23)*CONSTS(24))))
ALGBRC(15) = CONSTS(23)*CONSTS(24)*log( CONSTS(11)*STATES(3))
ALGBRC(19) = CONSTS(6)*(EXP(ALGBRC(14)/( CONSTS(23)*CONSTS(24))) - EXP(ALGBRC(15)/( CONSTS(23)*CONSTS(24))))
ALGBRC(20) = CONSTS(7)*(EXP((ALGBRC(14)+ALGBRC(13))/( CONSTS(23)*CONSTS(24))) - EXP((ALGBRC(15)+ALGBRC(13))/( CONSTS(23)*CONSTS(24))))
RATES(10) = (ALGBRC(18) - ALGBRC(19)) - ALGBRC(20)
ALGBRC(16) = CONSTS(23)*CONSTS(24)*log( CONSTS(12)*STATES(1))
ALGBRC(21) = CONSTS(8)*(EXP((ALGBRC(15)+ ALGBRC(16)*2.00000)/( CONSTS(23)*CONSTS(24))) - EXP((ALGBRC(12)+ALGBRC(13))/( CONSTS(23)*CONSTS(24))))
RATES(1) = ((ALGBRC(9) - ALGBRC(10)) - ALGBRC(11)) - 2.00000*ALGBRC(21)
RATES(3) = (- ALGBRC(8)+ALGBRC(9)+ALGBRC(19)+ALGBRC(20)) - ALGBRC(21)
RATES(8) = - ALGBRC(18)+ALGBRC(21)
ALGBRC(17) = CONSTS(23)*CONSTS(24)*log( CONSTS(20)*STATES(11))
ALGBRC(22) = CONSTS(9)*(EXP(ALGBRC(13)/( CONSTS(23)*CONSTS(24))) - EXP(ALGBRC(17)/( CONSTS(23)*CONSTS(24))))
RATES(9) = ((- ALGBRC(18)+ALGBRC(21)) - ALGBRC(22))+CONSTS(22)
RATES(11) = ALGBRC(22)
RETURN
END
SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC)
REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*)
ALGBRC(1) = CONSTS(23)*CONSTS(24)*log( CONSTS(10)*STATES(2))
ALGBRC(2) = CONSTS(23)*CONSTS(24)*log( CONSTS(11)*STATES(3))
ALGBRC(5) = CONSTS(23)*CONSTS(24)*log( CONSTS(14)*STATES(5))
ALGBRC(8) = CONSTS(1)*(EXP((ALGBRC(1)+ALGBRC(2))/( CONSTS(23)*CONSTS(24))) - EXP(ALGBRC(5)/( CONSTS(23)*CONSTS(24))))
ALGBRC(3) = CONSTS(23)*CONSTS(24)*log( CONSTS(12)*STATES(1))
ALGBRC(9) = CONSTS(2)*(EXP(ALGBRC(5)/( CONSTS(23)*CONSTS(24))) - EXP((ALGBRC(3)+ALGBRC(2))/( CONSTS(23)*CONSTS(24))))
ALGBRC(4) = CONSTS(23)*CONSTS(24)*log( CONSTS(13)*STATES(4))
ALGBRC(6) = CONSTS(23)*CONSTS(24)*log( CONSTS(15)*STATES(6))
ALGBRC(10) = CONSTS(3)*(EXP((ALGBRC(3)+ALGBRC(4))/( CONSTS(23)*CONSTS(24))) - EXP(ALGBRC(6)/( CONSTS(23)*CONSTS(24))))
ALGBRC(7) = CONSTS(23)*CONSTS(24)*log( CONSTS(16)*STATES(7))
ALGBRC(11) = CONSTS(4)*(EXP((ALGBRC(6)+ALGBRC(3))/( CONSTS(23)*CONSTS(24))) - EXP((ALGBRC(7)+ALGBRC(4))/( CONSTS(23)*CONSTS(24))))
ALGBRC(12) = CONSTS(23)*CONSTS(24)*log( CONSTS(17)*STATES(8))
ALGBRC(13) = CONSTS(23)*CONSTS(24)*log( CONSTS(18)*STATES(9))
ALGBRC(14) = CONSTS(23)*CONSTS(24)*log( CONSTS(19)*STATES(10))
ALGBRC(18) = CONSTS(5)*(EXP((ALGBRC(12)+ALGBRC(13))/( CONSTS(23)*CONSTS(24))) - EXP(ALGBRC(14)/( CONSTS(23)*CONSTS(24))))
ALGBRC(15) = CONSTS(23)*CONSTS(24)*log( CONSTS(11)*STATES(3))
ALGBRC(19) = CONSTS(6)*(EXP(ALGBRC(14)/( CONSTS(23)*CONSTS(24))) - EXP(ALGBRC(15)/( CONSTS(23)*CONSTS(24))))
ALGBRC(20) = CONSTS(7)*(EXP((ALGBRC(14)+ALGBRC(13))/( CONSTS(23)*CONSTS(24))) - EXP((ALGBRC(15)+ALGBRC(13))/( CONSTS(23)*CONSTS(24))))
ALGBRC(16) = CONSTS(23)*CONSTS(24)*log( CONSTS(12)*STATES(1))
ALGBRC(21) = CONSTS(8)*(EXP((ALGBRC(15)+ ALGBRC(16)*2.00000)/( CONSTS(23)*CONSTS(24))) - EXP((ALGBRC(12)+ALGBRC(13))/( CONSTS(23)*CONSTS(24))))
ALGBRC(17) = CONSTS(23)*CONSTS(24)*log( CONSTS(20)*STATES(11))
ALGBRC(22) = CONSTS(9)*(EXP(ALGBRC(13)/( CONSTS(23)*CONSTS(24))) - EXP(ALGBRC(17)/( CONSTS(23)*CONSTS(24))))
RETURN
END