/* There are a total of 13 entries in the algebraic variable array. There are a total of 8 entries in each of the rate and state variable arrays. There are a total of 17 entries in the constant variable array. */ /* * VOI is time in component environment (second). * CONSTANTS[0] is vol in component environment (pL). * STATES[0] is q_A in component environment (fmol). * STATES[1] is q_M in component environment (fmol). * STATES[2] is q_Mp in component environment (fmol). * STATES[3] is q_AM in component environment (fmol). * STATES[4] is q_AMp in component environment (fmol). * STATES[5] is q_Pi in component environment (fmol). * STATES[6] is q_Ca_i in component environment (fmol). * STATES[7] is q_cGMP in component environment (fmol). * ALGEBRAIC[9] is v_R_12 in component HaiMurphy (fmol_per_sec). * ALGEBRAIC[10] is v_R_34 in component HaiMurphy (fmol_per_sec). * ALGEBRAIC[11] is v_R_56 in component HaiMurphy (fmol_per_sec). * ALGEBRAIC[12] is v_R_78 in component HaiMurphy (fmol_per_sec). * CONSTANTS[1] is n_Cai_SM in component environment (dimensionless). * ALGEBRAIC[1] is stress in component environment (dimensionless). * CONSTANTS[2] is kappa_R_12 in component HaiMurphy_parameters (fmol_per_sec). * CONSTANTS[3] is kappa_R_34 in component HaiMurphy_parameters (fmol_per_sec). * CONSTANTS[4] is kappa_R_56 in component HaiMurphy_parameters (fmol_per_sec). * CONSTANTS[5] is kappa_R_78 in component HaiMurphy_parameters (fmol_per_sec). * CONSTANTS[6] is K_A in component HaiMurphy_parameters (per_fmol). * CONSTANTS[7] is K_M in component HaiMurphy_parameters (per_fmol). * CONSTANTS[8] is K_Mp in component HaiMurphy_parameters (per_fmol). * CONSTANTS[9] is K_AM in component HaiMurphy_parameters (per_fmol). * CONSTANTS[10] is K_AMp in component HaiMurphy_parameters (per_fmol). * CONSTANTS[11] is K_Pi in component HaiMurphy_parameters (per_fmol). * CONSTANTS[12] is K_Ca_i in component HaiMurphy_parameters (per_fmol). * CONSTANTS[13] is K_cGMP in component HaiMurphy_parameters (per_fmol). * CONSTANTS[14] is R in component constants (J_per_K_per_mol). * CONSTANTS[15] is T in component constants (kelvin). * ALGEBRAIC[0] is mu_A in component HaiMurphy (J_per_mol). * ALGEBRAIC[2] is mu_M in component HaiMurphy (J_per_mol). * ALGEBRAIC[3] is mu_Mp in component HaiMurphy (J_per_mol). * ALGEBRAIC[4] is mu_AM in component HaiMurphy (J_per_mol). * ALGEBRAIC[5] is mu_AMp in component HaiMurphy (J_per_mol). * ALGEBRAIC[6] is mu_Pi in component HaiMurphy (J_per_mol). * ALGEBRAIC[7] is mu_Ca_i in component HaiMurphy (J_per_mol). * ALGEBRAIC[8] is mu_cGMP in component HaiMurphy (J_per_mol). * CONSTANTS[16] is F in component constants (C_per_mol). * RATES[0] is d/dt q_A in component environment (fmol). * RATES[1] is d/dt q_M in component environment (fmol). * RATES[2] is d/dt q_Mp in component environment (fmol). * RATES[3] is d/dt q_AM in component environment (fmol). * RATES[4] is d/dt q_AMp in component environment (fmol). * RATES[5] is d/dt q_Pi in component environment (fmol). * RATES[6] is d/dt q_Ca_i in component environment (fmol). * RATES[7] is d/dt q_cGMP in component environment (fmol). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 1; STATES[0] = 1e-6; STATES[1] = 1e-6; STATES[2] = 0; STATES[3] = 0; STATES[4] = 0; STATES[5] = 15; STATES[6] = 1e-3; STATES[7] = 1e-6; CONSTANTS[1] = 1.66; CONSTANTS[2] = 0.117606; CONSTANTS[3] = 6.98167; CONSTANTS[4] = 2.11691; CONSTANTS[5] = 0.0270688; CONSTANTS[6] = 0.532601; CONSTANTS[7] = 4.08193; CONSTANTS[8] = 0.0351692; CONSTANTS[9] = 0.448094; CONSTANTS[10] = 0.0038607; CONSTANTS[11] = 250.692; CONSTANTS[12] = 0.145785; CONSTANTS[13] = 0.0971738; CONSTANTS[14] = 8.31; CONSTANTS[15] = 310; CONSTANTS[16] = 96485; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[2] = CONSTANTS[14]*CONSTANTS[15]*log( CONSTANTS[7]*STATES[1]); ALGEBRAIC[3] = CONSTANTS[14]*CONSTANTS[15]*log( CONSTANTS[8]*STATES[2]); ALGEBRAIC[6] = CONSTANTS[14]*CONSTANTS[15]*log( CONSTANTS[11]*STATES[5]); ALGEBRAIC[7] = CONSTANTS[14]*CONSTANTS[15]*log( CONSTANTS[12]*STATES[6]); ALGEBRAIC[8] = CONSTANTS[14]*CONSTANTS[15]*log( CONSTANTS[13]*STATES[7]); ALGEBRAIC[9] = CONSTANTS[2]*(exp((ALGEBRAIC[2]+ALGEBRAIC[6]+ CONSTANTS[1]*ALGEBRAIC[7])/( CONSTANTS[14]*CONSTANTS[15])) - exp((ALGEBRAIC[3]+ALGEBRAIC[8])/( CONSTANTS[14]*CONSTANTS[15]))); ALGEBRAIC[0] = CONSTANTS[14]*CONSTANTS[15]*log( CONSTANTS[6]*STATES[0]); ALGEBRAIC[5] = CONSTANTS[14]*CONSTANTS[15]*log( CONSTANTS[10]*STATES[4]); ALGEBRAIC[10] = CONSTANTS[3]*(exp((ALGEBRAIC[0]+ALGEBRAIC[3])/( CONSTANTS[14]*CONSTANTS[15])) - exp(ALGEBRAIC[5]/( CONSTANTS[14]*CONSTANTS[15]))); RATES[2] = ALGEBRAIC[9] - ALGEBRAIC[10]; ALGEBRAIC[4] = CONSTANTS[14]*CONSTANTS[15]*log( CONSTANTS[9]*STATES[3]); ALGEBRAIC[11] = CONSTANTS[4]*(exp((ALGEBRAIC[5]+ CONSTANTS[1]*ALGEBRAIC[7])/( CONSTANTS[14]*CONSTANTS[15])) - exp((ALGEBRAIC[4]+ALGEBRAIC[6]+ALGEBRAIC[8])/( CONSTANTS[14]*CONSTANTS[15]))); RATES[4] = ALGEBRAIC[10] - ALGEBRAIC[11]; RATES[5] = - ALGEBRAIC[9]+ALGEBRAIC[11]; RATES[6] = CONSTANTS[1]*(- ALGEBRAIC[9] - ALGEBRAIC[11]); RATES[7] = ALGEBRAIC[9]+ALGEBRAIC[11]; ALGEBRAIC[12] = CONSTANTS[5]*(exp(ALGEBRAIC[4]/( CONSTANTS[14]*CONSTANTS[15])) - exp((ALGEBRAIC[0]+ALGEBRAIC[2])/( CONSTANTS[14]*CONSTANTS[15]))); RATES[0] = - ALGEBRAIC[10]+ALGEBRAIC[12]; RATES[1] = - ALGEBRAIC[9]+ALGEBRAIC[12]; RATES[3] = ALGEBRAIC[11] - ALGEBRAIC[12]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[2] = CONSTANTS[14]*CONSTANTS[15]*log( CONSTANTS[7]*STATES[1]); ALGEBRAIC[3] = CONSTANTS[14]*CONSTANTS[15]*log( CONSTANTS[8]*STATES[2]); ALGEBRAIC[6] = CONSTANTS[14]*CONSTANTS[15]*log( CONSTANTS[11]*STATES[5]); ALGEBRAIC[7] = CONSTANTS[14]*CONSTANTS[15]*log( CONSTANTS[12]*STATES[6]); ALGEBRAIC[8] = CONSTANTS[14]*CONSTANTS[15]*log( CONSTANTS[13]*STATES[7]); ALGEBRAIC[9] = CONSTANTS[2]*(exp((ALGEBRAIC[2]+ALGEBRAIC[6]+ CONSTANTS[1]*ALGEBRAIC[7])/( CONSTANTS[14]*CONSTANTS[15])) - exp((ALGEBRAIC[3]+ALGEBRAIC[8])/( CONSTANTS[14]*CONSTANTS[15]))); ALGEBRAIC[0] = CONSTANTS[14]*CONSTANTS[15]*log( CONSTANTS[6]*STATES[0]); ALGEBRAIC[5] = CONSTANTS[14]*CONSTANTS[15]*log( CONSTANTS[10]*STATES[4]); ALGEBRAIC[10] = CONSTANTS[3]*(exp((ALGEBRAIC[0]+ALGEBRAIC[3])/( CONSTANTS[14]*CONSTANTS[15])) - exp(ALGEBRAIC[5]/( CONSTANTS[14]*CONSTANTS[15]))); ALGEBRAIC[4] = CONSTANTS[14]*CONSTANTS[15]*log( CONSTANTS[9]*STATES[3]); ALGEBRAIC[11] = CONSTANTS[4]*(exp((ALGEBRAIC[5]+ CONSTANTS[1]*ALGEBRAIC[7])/( CONSTANTS[14]*CONSTANTS[15])) - exp((ALGEBRAIC[4]+ALGEBRAIC[6]+ALGEBRAIC[8])/( CONSTANTS[14]*CONSTANTS[15]))); ALGEBRAIC[12] = CONSTANTS[5]*(exp(ALGEBRAIC[4]/( CONSTANTS[14]*CONSTANTS[15])) - exp((ALGEBRAIC[0]+ALGEBRAIC[2])/( CONSTANTS[14]*CONSTANTS[15]))); ALGEBRAIC[1] = (STATES[3]+STATES[4])/1.00000; }