C C There are a total of 13 entries in the algebraic variable array. C There are a total of 8 entries in each of the rate and state variable arrays. C There are a total of 17 entries in the constant variable array. C C C VOI is time in component environment (second). C CONSTS(1) is vol in component environment (pL). C STATES(1) is q_A in component environment (fmol). C STATES(2) is q_M in component environment (fmol). C STATES(3) is q_Mp in component environment (fmol). C STATES(4) is q_AM in component environment (fmol). C STATES(5) is q_AMp in component environment (fmol). C STATES(6) is q_Pi in component environment (fmol). C STATES(7) is q_Ca_i in component environment (fmol). C STATES(8) is q_cGMP in component environment (fmol). C ALGBRC(10) is v_R_12 in component HaiMurphy (fmol_per_sec). C ALGBRC(11) is v_R_34 in component HaiMurphy (fmol_per_sec). C ALGBRC(12) is v_R_56 in component HaiMurphy (fmol_per_sec). C ALGBRC(13) is v_R_78 in component HaiMurphy (fmol_per_sec). C CONSTS(2) is n_Cai_SM in component environment (dimensionless). C ALGBRC(2) is stress in component environment (dimensionless). C CONSTS(3) is kappa_R_12 in component HaiMurphy_parameters (fmol_per_sec). C CONSTS(4) is kappa_R_34 in component HaiMurphy_parameters (fmol_per_sec). C CONSTS(5) is kappa_R_56 in component HaiMurphy_parameters (fmol_per_sec). C CONSTS(6) is kappa_R_78 in component HaiMurphy_parameters (fmol_per_sec). C CONSTS(7) is K_A in component HaiMurphy_parameters (per_fmol). C CONSTS(8) is K_M in component HaiMurphy_parameters (per_fmol). C CONSTS(9) is K_Mp in component HaiMurphy_parameters (per_fmol). C CONSTS(10) is K_AM in component HaiMurphy_parameters (per_fmol). C CONSTS(11) is K_AMp in component HaiMurphy_parameters (per_fmol). C CONSTS(12) is K_Pi in component HaiMurphy_parameters (per_fmol). C CONSTS(13) is K_Ca_i in component HaiMurphy_parameters (per_fmol). C CONSTS(14) is K_cGMP in component HaiMurphy_parameters (per_fmol). C CONSTS(15) is R in component constants (J_per_K_per_mol). C CONSTS(16) is T in component constants (kelvin). C ALGBRC(1) is mu_A in component HaiMurphy (J_per_mol). C ALGBRC(3) is mu_M in component HaiMurphy (J_per_mol). C ALGBRC(4) is mu_Mp in component HaiMurphy (J_per_mol). C ALGBRC(5) is mu_AM in component HaiMurphy (J_per_mol). C ALGBRC(6) is mu_AMp in component HaiMurphy (J_per_mol). C ALGBRC(7) is mu_Pi in component HaiMurphy (J_per_mol). C ALGBRC(8) is mu_Ca_i in component HaiMurphy (J_per_mol). C ALGBRC(9) is mu_cGMP in component HaiMurphy (J_per_mol). C CONSTS(17) is F in component constants (C_per_mol). C RATES(1) is d/dt q_A in component environment (fmol). C RATES(2) is d/dt q_M in component environment (fmol). C RATES(3) is d/dt q_Mp in component environment (fmol). C RATES(4) is d/dt q_AM in component environment (fmol). C RATES(5) is d/dt q_AMp in component environment (fmol). C RATES(6) is d/dt q_Pi in component environment (fmol). C RATES(7) is d/dt q_Ca_i in component environment (fmol). C RATES(8) is d/dt q_cGMP in component environment (fmol). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 1 STATES(1) = 1e-6 STATES(2) = 1e-6 STATES(3) = 0 STATES(4) = 0 STATES(5) = 0 STATES(6) = 15 STATES(7) = 1e-3 STATES(8) = 1e-6 CONSTS(2) = 1.66 CONSTS(3) = 0.117606 CONSTS(4) = 6.98167 CONSTS(5) = 2.11691 CONSTS(6) = 0.0270688 CONSTS(7) = 0.532601 CONSTS(8) = 4.08193 CONSTS(9) = 0.0351692 CONSTS(10) = 0.448094 CONSTS(11) = 0.0038607 CONSTS(12) = 250.692 CONSTS(13) = 0.145785 CONSTS(14) = 0.0971738 CONSTS(15) = 8.31 CONSTS(16) = 310 CONSTS(17) = 96485 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(3) = CONSTS(15)*CONSTS(16)*log( CONSTS(8)*STATES(2)) ALGBRC(4) = CONSTS(15)*CONSTS(16)*log( CONSTS(9)*STATES(3)) ALGBRC(7) = CONSTS(15)*CONSTS(16)*log( CONSTS(12)*STATES(6)) ALGBRC(8) = CONSTS(15)*CONSTS(16)*log( CONSTS(13)*STATES(7)) ALGBRC(9) = CONSTS(15)*CONSTS(16)*log( CONSTS(14)*STATES(8)) ALGBRC(10) = CONSTS(3)*(EXP((ALGBRC(3)+ALGBRC(7)+ CONSTS(2)*ALGBRC(8))/( CONSTS(15)*CONSTS(16))) - EXP((ALGBRC(4)+ALGBRC(9))/( CONSTS(15)*CONSTS(16)))) ALGBRC(1) = CONSTS(15)*CONSTS(16)*log( CONSTS(7)*STATES(1)) ALGBRC(6) = CONSTS(15)*CONSTS(16)*log( CONSTS(11)*STATES(5)) ALGBRC(11) = CONSTS(4)*(EXP((ALGBRC(1)+ALGBRC(4))/( CONSTS(15)*CONSTS(16))) - EXP(ALGBRC(6)/( CONSTS(15)*CONSTS(16)))) RATES(3) = ALGBRC(10) - ALGBRC(11) ALGBRC(5) = CONSTS(15)*CONSTS(16)*log( CONSTS(10)*STATES(4)) ALGBRC(12) = CONSTS(5)*(EXP((ALGBRC(6)+ CONSTS(2)*ALGBRC(8))/( CONSTS(15)*CONSTS(16))) - EXP((ALGBRC(5)+ALGBRC(7)+ALGBRC(9))/( CONSTS(15)*CONSTS(16)))) RATES(5) = ALGBRC(11) - ALGBRC(12) RATES(6) = - ALGBRC(10)+ALGBRC(12) RATES(7) = CONSTS(2)*(- ALGBRC(10) - ALGBRC(12)) RATES(8) = ALGBRC(10)+ALGBRC(12) ALGBRC(13) = CONSTS(6)*(EXP(ALGBRC(5)/( CONSTS(15)*CONSTS(16))) - EXP((ALGBRC(1)+ALGBRC(3))/( CONSTS(15)*CONSTS(16)))) RATES(1) = - ALGBRC(11)+ALGBRC(13) RATES(2) = - ALGBRC(10)+ALGBRC(13) RATES(4) = ALGBRC(12) - ALGBRC(13) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(3) = CONSTS(15)*CONSTS(16)*log( CONSTS(8)*STATES(2)) ALGBRC(4) = CONSTS(15)*CONSTS(16)*log( CONSTS(9)*STATES(3)) ALGBRC(7) = CONSTS(15)*CONSTS(16)*log( CONSTS(12)*STATES(6)) ALGBRC(8) = CONSTS(15)*CONSTS(16)*log( CONSTS(13)*STATES(7)) ALGBRC(9) = CONSTS(15)*CONSTS(16)*log( CONSTS(14)*STATES(8)) ALGBRC(10) = CONSTS(3)*(EXP((ALGBRC(3)+ALGBRC(7)+ CONSTS(2)*ALGBRC(8))/( CONSTS(15)*CONSTS(16))) - EXP((ALGBRC(4)+ALGBRC(9))/( CONSTS(15)*CONSTS(16)))) ALGBRC(1) = CONSTS(15)*CONSTS(16)*log( CONSTS(7)*STATES(1)) ALGBRC(6) = CONSTS(15)*CONSTS(16)*log( CONSTS(11)*STATES(5)) ALGBRC(11) = CONSTS(4)*(EXP((ALGBRC(1)+ALGBRC(4))/( CONSTS(15)*CONSTS(16))) - EXP(ALGBRC(6)/( CONSTS(15)*CONSTS(16)))) ALGBRC(5) = CONSTS(15)*CONSTS(16)*log( CONSTS(10)*STATES(4)) ALGBRC(12) = CONSTS(5)*(EXP((ALGBRC(6)+ CONSTS(2)*ALGBRC(8))/( CONSTS(15)*CONSTS(16))) - EXP((ALGBRC(5)+ALGBRC(7)+ALGBRC(9))/( CONSTS(15)*CONSTS(16)))) ALGBRC(13) = CONSTS(6)*(EXP(ALGBRC(5)/( CONSTS(15)*CONSTS(16))) - EXP((ALGBRC(1)+ALGBRC(3))/( CONSTS(15)*CONSTS(16)))) ALGBRC(2) = (STATES(4)+STATES(5))/1.00000 RETURN END