C C There are a total of 8 entries in the algebraic variable array. C There are a total of 4 entries in each of the rate and state variable arrays. C There are a total of 17 entries in the constant variable array. C C C VOI is time in component environment (minute). C STATES(1) is Ca_cyt in component Ca_cyt (micromolar). C ALGBRC(1) is J_ERch in component J_ERch (micromolar). C ALGBRC(4) is J_ERpump in component J_ERpump (micromolar). C ALGBRC(7) is J_in in component J_in (micromolar). C ALGBRC(8) is J_out in component J_out (micromolar). C STATES(2) is Ca_ER in component Ca_ER (micromolar). C STATES(3) is PLC in component PLC (micromolar). C ALGBRC(2) is J_PLCact in component J_PLCact (micromolar). C ALGBRC(5) is J_PLCinact in component J_PLCinact (micromolar). C STATES(4) is G_alpha in component G_alpha (micromolar). C ALGBRC(3) is J_actG_alpha in component J_actG_alpha (micromolar). C ALGBRC(6) is J_inactG_alpha in component J_inactG_alpha (micromolar). C CONSTS(1) is k_10 in component J_ERch (dimensionless). C CONSTS(2) is K_11 in component J_ERch (dimensionless). C CONSTS(3) is K_17 in component J_ERpump (dimensionless). C CONSTS(4) is k_16 in component J_ERpump (dimensionless). C CONSTS(5) is K_12 in component J_in (dimensionless). C CONSTS(6) is k_13 in component J_in (dimensionless). C CONSTS(7) is k_14 in component J_out (dimensionless). C CONSTS(8) is K_15 in component J_out (dimensionless). C CONSTS(9) is k_7 in component J_PLCact (dimensionless). C CONSTS(10) is k_8 in component J_PLCinact (dimensionless). C CONSTS(11) is K_9 in component J_PLCinact (dimensionless). C CONSTS(12) is k_1 in component J_actG_alpha (dimensionless). C CONSTS(13) is k_2 in component J_actG_alpha (dimensionless). C CONSTS(14) is k_3 in component J_inactG_alpha (dimensionless). C CONSTS(15) is K_4 in component J_inactG_alpha (dimensionless). C CONSTS(16) is k_5 in component J_inactG_alpha (dimensionless). C CONSTS(17) is K_6 in component J_inactG_alpha (dimensionless). C RATES(1) is d/dt Ca_cyt in component Ca_cyt (micromolar). C RATES(2) is d/dt Ca_ER in component Ca_ER (micromolar). C RATES(3) is d/dt PLC in component PLC (micromolar). C RATES(4) is d/dt G_alpha in component G_alpha (micromolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 0.01 STATES(2) = 20 STATES(3) = 0.01 STATES(4) = 0.01 CONSTS(1) = 5 CONSTS(2) = 3 CONSTS(3) = 0.05 CONSTS(4) = 5.37 CONSTS(5) = 2.8 CONSTS(6) = 13.4 CONSTS(7) = 153 CONSTS(8) = 0.16 CONSTS(9) = 2.08 CONSTS(10) = 32.24 CONSTS(11) = 29.09 CONSTS(12) = 0.01 CONSTS(13) = 0.1 CONSTS(14) = 0.64 CONSTS(15) = 0.09 CONSTS(16) = 4.88 CONSTS(17) = 1.18 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(1)*STATES(1)*STATES(3)*(STATES(2)/(CONSTS(2)+STATES(2))) ALGBRC(4) = CONSTS(4)*(STATES(1)/(CONSTS(3)+STATES(2))) RATES(2) = (ALGBRC(4) - ALGBRC(1))*1.00000 ALGBRC(2) = CONSTS(9)*STATES(4) ALGBRC(5) = CONSTS(10)*(STATES(3)/(CONSTS(11)+STATES(3))) RATES(3) = (ALGBRC(2) - ALGBRC(5))*1.00000 ALGBRC(3) = CONSTS(12)+ CONSTS(13)*STATES(4) ALGBRC(6) = CONSTS(14)*STATES(3)*(STATES(4)/(CONSTS(15)+STATES(4)))+ CONSTS(16)*STATES(1)*(STATES(4)/(CONSTS(17)+STATES(4))) RATES(4) = (ALGBRC(3) - ALGBRC(6))*1.00000 ALGBRC(7) = CONSTS(5)*STATES(3)+ CONSTS(6)*STATES(4) ALGBRC(8) = CONSTS(7)*(STATES(1)/(CONSTS(8)+STATES(1))) RATES(1) = (((ALGBRC(1) - ALGBRC(4))+ALGBRC(7)) - ALGBRC(8))*1.00000 RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(1)*STATES(1)*STATES(3)*(STATES(2)/(CONSTS(2)+STATES(2))) ALGBRC(4) = CONSTS(4)*(STATES(1)/(CONSTS(3)+STATES(2))) ALGBRC(2) = CONSTS(9)*STATES(4) ALGBRC(5) = CONSTS(10)*(STATES(3)/(CONSTS(11)+STATES(3))) ALGBRC(3) = CONSTS(12)+ CONSTS(13)*STATES(4) ALGBRC(6) = CONSTS(14)*STATES(3)*(STATES(4)/(CONSTS(15)+STATES(4)))+ CONSTS(16)*STATES(1)*(STATES(4)/(CONSTS(17)+STATES(4))) ALGBRC(7) = CONSTS(5)*STATES(3)+ CONSTS(6)*STATES(4) ALGBRC(8) = CONSTS(7)*(STATES(1)/(CONSTS(8)+STATES(1))) RETURN END