function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =10; end % There are a total of 7 entries in each of the rate and state variable arrays. % There are a total of 13 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (second)'); LEGEND_STATES(:,1) = strpad('q_L in component environment (fmol)'); LEGEND_STATES(:,2) = strpad('q_K1 in component environment (fmol)'); LEGEND_STATES(:,3) = strpad('q_K2 in component environment (fmol)'); LEGEND_STATES(:,4) = strpad('q_LK1 in component environment (fmol)'); LEGEND_STATES(:,5) = strpad('q_K2P in component environment (fmol)'); LEGEND_STATES(:,6) = strpad('q_P in component environment (fmol)'); LEGEND_STATES(:,7) = strpad('q_LK1K2 in component environment (fmol)'); LEGEND_ALGEBRAIC(:,8) = strpad('v_Re1 in component RTK (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,9) = strpad('v_Re2 in component RTK (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,10) = strpad('v_Re3 in component RTK (fmol_per_sec)'); LEGEND_CONSTANTS(:,1) = strpad('kappa_Re1 in component RTK_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,2) = strpad('kappa_Re2 in component RTK_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,3) = strpad('kappa_Re3 in component RTK_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,4) = strpad('K_L in component RTK_parameters (per_fmol)'); LEGEND_CONSTANTS(:,5) = strpad('K_K1 in component RTK_parameters (per_fmol)'); LEGEND_CONSTANTS(:,6) = strpad('K_K2 in component RTK_parameters (per_fmol)'); LEGEND_CONSTANTS(:,7) = strpad('K_LK1 in component RTK_parameters (per_fmol)'); LEGEND_CONSTANTS(:,8) = strpad('K_K2P in component RTK_parameters (per_fmol)'); LEGEND_CONSTANTS(:,9) = strpad('K_P in component RTK_parameters (per_fmol)'); LEGEND_CONSTANTS(:,10) = strpad('K_LK1K2 in component RTK_parameters (per_fmol)'); LEGEND_CONSTANTS(:,11) = strpad('R in component constants (J_per_K_per_mol)'); LEGEND_CONSTANTS(:,12) = strpad('T in component constants (kelvin)'); LEGEND_ALGEBRAIC(:,1) = strpad('mu_L in component RTK (J_per_mol)'); LEGEND_ALGEBRAIC(:,2) = strpad('mu_K1 in component RTK (J_per_mol)'); LEGEND_ALGEBRAIC(:,3) = strpad('mu_K2 in component RTK (J_per_mol)'); LEGEND_ALGEBRAIC(:,4) = strpad('mu_LK1 in component RTK (J_per_mol)'); LEGEND_ALGEBRAIC(:,5) = strpad('mu_K2P in component RTK (J_per_mol)'); LEGEND_ALGEBRAIC(:,6) = strpad('mu_P in component RTK (J_per_mol)'); LEGEND_ALGEBRAIC(:,7) = strpad('mu_LK1K2 in component RTK (J_per_mol)'); LEGEND_CONSTANTS(:,13) = strpad('F in component constants (C_per_mol)'); LEGEND_RATES(:,1) = strpad('d/dt q_L in component environment (fmol)'); LEGEND_RATES(:,2) = strpad('d/dt q_K1 in component environment (fmol)'); LEGEND_RATES(:,3) = strpad('d/dt q_K2 in component environment (fmol)'); LEGEND_RATES(:,4) = strpad('d/dt q_LK1 in component environment (fmol)'); LEGEND_RATES(:,5) = strpad('d/dt q_K2P in component environment (fmol)'); LEGEND_RATES(:,6) = strpad('d/dt q_P in component environment (fmol)'); LEGEND_RATES(:,7) = strpad('d/dt q_LK1K2 in component environment (fmol)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; STATES(:,1) = 1; STATES(:,2) = 1e-3; STATES(:,3) = 1e-3; STATES(:,4) = 1e-6; STATES(:,5) = 1e-9; STATES(:,6) = 1; STATES(:,7) = 1e-9; CONSTANTS(:,1) = 0.000186898; CONSTANTS(:,2) = 0.0125535; CONSTANTS(:,3) = 132.879; CONSTANTS(:,4) = 197.162; CONSTANTS(:,5) = 197.162; CONSTANTS(:,6) = 4.01297e+09; CONSTANTS(:,7) = 0.00144219; CONSTANTS(:,8) = 3.79118e-07; CONSTANTS(:,9) = 2.54645e+07; CONSTANTS(:,10) = 2.14714e-05; CONSTANTS(:,11) = 8.31; CONSTANTS(:,12) = 310; CONSTANTS(:,13) = 96485; if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,1) = CONSTANTS(:,11).*CONSTANTS(:,12).*log( CONSTANTS(:,4).*STATES(:,1)); ALGEBRAIC(:,2) = CONSTANTS(:,11).*CONSTANTS(:,12).*log( CONSTANTS(:,5).*STATES(:,2)); ALGEBRAIC(:,4) = CONSTANTS(:,11).*CONSTANTS(:,12).*log( CONSTANTS(:,7).*STATES(:,4)); ALGEBRAIC(:,8) = CONSTANTS(:,1).*(exp((ALGEBRAIC(:,1)+ALGEBRAIC(:,2))./( CONSTANTS(:,11).*CONSTANTS(:,12))) - exp(ALGEBRAIC(:,4)./( CONSTANTS(:,11).*CONSTANTS(:,12)))); RATES(:,1) = - ALGEBRAIC(:,8); RATES(:,2) = - ALGEBRAIC(:,8); ALGEBRAIC(:,3) = CONSTANTS(:,11).*CONSTANTS(:,12).*log( CONSTANTS(:,6).*STATES(:,3)); ALGEBRAIC(:,7) = CONSTANTS(:,11).*CONSTANTS(:,12).*log( CONSTANTS(:,10).*STATES(:,7)); ALGEBRAIC(:,9) = CONSTANTS(:,2).*(exp((ALGEBRAIC(:,4)+ALGEBRAIC(:,3))./( CONSTANTS(:,11).*CONSTANTS(:,12))) - exp(ALGEBRAIC(:,7)./( CONSTANTS(:,11).*CONSTANTS(:,12)))); RATES(:,3) = - ALGEBRAIC(:,9); ALGEBRAIC(:,5) = CONSTANTS(:,11).*CONSTANTS(:,12).*log( CONSTANTS(:,8).*STATES(:,5)); ALGEBRAIC(:,6) = CONSTANTS(:,11).*CONSTANTS(:,12).*log( CONSTANTS(:,9).*STATES(:,6)); ALGEBRAIC(:,10) = CONSTANTS(:,3).*(exp((ALGEBRAIC(:,6)+ALGEBRAIC(:,7))./( CONSTANTS(:,11).*CONSTANTS(:,12))) - exp((ALGEBRAIC(:,4)+ALGEBRAIC(:,5))./( CONSTANTS(:,11).*CONSTANTS(:,12)))); RATES(:,4) = (ALGEBRAIC(:,8) - ALGEBRAIC(:,9))+ALGEBRAIC(:,10); RATES(:,5) = ALGEBRAIC(:,10); RATES(:,6) = - ALGEBRAIC(:,10); RATES(:,7) = ALGEBRAIC(:,9) - ALGEBRAIC(:,10); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,1) = CONSTANTS(:,11).*CONSTANTS(:,12).*log( CONSTANTS(:,4).*STATES(:,1)); ALGEBRAIC(:,2) = CONSTANTS(:,11).*CONSTANTS(:,12).*log( CONSTANTS(:,5).*STATES(:,2)); ALGEBRAIC(:,4) = CONSTANTS(:,11).*CONSTANTS(:,12).*log( CONSTANTS(:,7).*STATES(:,4)); ALGEBRAIC(:,8) = CONSTANTS(:,1).*(exp((ALGEBRAIC(:,1)+ALGEBRAIC(:,2))./( CONSTANTS(:,11).*CONSTANTS(:,12))) - exp(ALGEBRAIC(:,4)./( CONSTANTS(:,11).*CONSTANTS(:,12)))); ALGEBRAIC(:,3) = CONSTANTS(:,11).*CONSTANTS(:,12).*log( CONSTANTS(:,6).*STATES(:,3)); ALGEBRAIC(:,7) = CONSTANTS(:,11).*CONSTANTS(:,12).*log( CONSTANTS(:,10).*STATES(:,7)); ALGEBRAIC(:,9) = CONSTANTS(:,2).*(exp((ALGEBRAIC(:,4)+ALGEBRAIC(:,3))./( CONSTANTS(:,11).*CONSTANTS(:,12))) - exp(ALGEBRAIC(:,7)./( CONSTANTS(:,11).*CONSTANTS(:,12)))); ALGEBRAIC(:,5) = CONSTANTS(:,11).*CONSTANTS(:,12).*log( CONSTANTS(:,8).*STATES(:,5)); ALGEBRAIC(:,6) = CONSTANTS(:,11).*CONSTANTS(:,12).*log( CONSTANTS(:,9).*STATES(:,6)); ALGEBRAIC(:,10) = CONSTANTS(:,3).*(exp((ALGEBRAIC(:,6)+ALGEBRAIC(:,7))./( CONSTANTS(:,11).*CONSTANTS(:,12))) - exp((ALGEBRAIC(:,4)+ALGEBRAIC(:,5))./( CONSTANTS(:,11).*CONSTANTS(:,12)))); end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end