K ATP protein knowledge page
About
Landing page for the ATP-sensitive potassium channel (K-ATP).
This channel transports potassium ions across the plasma membrane according to the concentration gradient, and is activated by internal ATP. K-ATP is part of the inward rectifying (K-ir) family
Some isoforms are also G-protein regulated.
Pictures
Fig. 1. Visualisation of the KIR2.2 channel. Image from the RCSB PDB (RCSB.org) of PDB ID 1BNA (H.R. Drew, R.M. Wing, T. Takano, C. Broka, S. Tanaka, K. Itakura, R.E.Dickerson, Structure of a B-DNA dodecamer: conformation and dynamics (1981) Proc.Natl.Acad.Sci.USA 78: 2179-2183)
Subfamilies
The following list contains the known isoforms of K-ATP.
| Channel name | x | Alias | Gene | Structure | Interacts with |
|---|---|---|---|---|---|
| KCNJx | 1 | ROMK1 | Uniprot 1 | SMR 1 | |
| 5 | Kir3.4 | Uniprot 5 | SMR 5 | G protein | |
| 6 | Kir3.2 | Uniprot 6 | SMR 6 | G protein | |
| 8 | Kir6.1 | Uniprot 8 | SMR 8 | ||
| 10 | Kir4.1/1.2 | Uniprot 10 | SMR 10 | ||
| 11 | Kir6.2 | Uniprot 11 | PDB 11 | ABCC9 | |
| 12 | Kir2.2 | Uniprot 12 | SMR 12 | ||
| 14 | kir2.4 | Uniprot 14 | SMR 14 | ||
| 15 | Kir4.2/Kir1.3 | Uniprot 15 | SMR 15 | ||
| 18 | kir2.6 | Uniprot 18 | SMR 18 | ||
| ABCC8 | NA | SUR1 | Uniprot SUR1 | PDB SUR1 | KCNJ11 |
| ABCC9 | NA | SUR2 | Uniprot SUR2 | SMR SUR2 | KCNJ11 |
The KCNJx protein forms the pore of the channel. Column 'Interacts with' contains the experimentally-proven interactions this protein makes with other proteins, which generally help in regulating the activity of KCNJx.
Literature
| Title | Author |
|---|---|
| Potassium channels in the heart: structure, function and regulation | Grandi et al. |
Existing models
| Title | Author |
|---|---|
| BG_K_ATP | S Fong |
| Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study*^ | Faber and Rudy |
Models denoted by [*] are not in bond graph form. Models denoted by [^] are part of a whole cell model.