This is the CellML description of Sarkar and Lauffenburger's 2003 computational model of GCSF endocytic trafficking dynamics. The pharmacokinetic and pharmacodynamic part of the model is now included in version 03.
intracellular ligand
Li
j.lawson@auckland.ac.nz
intracellular complex
Ci
Ld
degraded ligand
Cs
cell surface complex
Douglas
Lauffenburger
A
signal transduction
gpcr
gscf
pharmacology
neutrophil
pharmacokinetics
Catherine Lloyd
Sarkar
A
Casim
Casim
Sarkar
A
Sarkar and Lauffenburger's 2003 computational model of GCSF endocytic
trafficking dynamics.
neutrophil
Lawson
James
R.
keyword
Ri
intracellular receptor
University of Auckland
Bioengineering Institute
63
Cell-Level Pharmacokinetic Model of Granulocyte Colony-Stimulating Factor: Implications for Ligand Lifetime and Potency in Vivo
158
147
2007-05-01
Rs
cell surface receptor
Molecular Pharmacology
100000
0.001
10
A
Douglas
Lauffenburger
The University of Auckland, Bioengineering Institute
extracellular ligand
L
2003-01-01
12488547