C C There are a total of 52 entries in the algebraic variable array. C There are a total of 15 entries in each of the rate and state variable arrays. C There are a total of 71 entries in the constant variable array. C C C VOI is time in component environment (second). C CONSTS(1) is dCell in component membrane (dimensionless). C CONSTS(50) is FCell in component membrane (dimensionless). C STATES(1) is V in component membrane (millivolt). C CONSTS(2) is R in component membrane (millijoule_per_mole_kelvin). C CONSTS(3) is T in component membrane (kelvin). C CONSTS(4) is F in component membrane (coulomb_per_mole). C CONSTS(55) is Cm in component membrane (microF). C CONSTS(5) is CmCentre in component membrane (microF). C CONSTS(6) is CmPeriphery in component membrane (microF). C ALGBRC(28) is i_Na in component sodium_current (nanoA). C ALGBRC(35) is i_Ca_L in component L_type_Ca_channel (nanoA). C ALGBRC(40) is i_Ca_T in component T_type_Ca_channel (nanoA). C ALGBRC(41) is i_to in component four_AP_sensitive_currents (nanoA). C ALGBRC(42) is i_sus in component four_AP_sensitive_currents (nanoA). C ALGBRC(44) is i_K_r in component rapid_delayed_rectifying_potassium_current (nanoA). C ALGBRC(45) is i_K_s in component slow_delayed_rectifying_potassium_current (nanoA). C ALGBRC(46) is i_f_Na in component hyperpolarisation_activated_current (nanoA). C ALGBRC(47) is i_f_K in component hyperpolarisation_activated_current (nanoA). C ALGBRC(48) is i_b_Na in component sodium_background_current (nanoA). C ALGBRC(50) is i_b_Ca in component calcium_background_current (nanoA). C ALGBRC(49) is i_b_K in component potassium_background_current (nanoA). C ALGBRC(51) is i_NaCa in component sodium_calcium_exchanger (nanoA). C ALGBRC(52) is i_p in component sodium_potassium_pump (nanoA). C CONSTS(71) is i_Ca_p in component persistent_calcium_current (nanoA). C CONSTS(56) is g_Na in component sodium_current (microlitre_per_second). C CONSTS(7) is g_Na_Centre in component sodium_current (microlitre_per_second). C CONSTS(8) is g_Na_Periphery in component sodium_current (microlitre_per_second). C CONSTS(51) is E_Na in component reversal_and_equilibrium_potentials (millivolt). C CONSTS(9) is Na_o in component ionic_concentrations (millimolar). C STATES(2) is m in component sodium_current_m_gate (dimensionless). C ALGBRC(14) is h in component sodium_current_h_gate (dimensionless). C ALGBRC(2) is m_infinity in component sodium_current_m_gate (dimensionless). C ALGBRC(15) is tau_m in component sodium_current_m_gate (second). C ALGBRC(1) is F_Na in component sodium_current_h_gate (dimensionless). C STATES(3) is h1 in component sodium_current_h_gate (dimensionless). C STATES(4) is h2 in component sodium_current_h_gate (dimensionless). C ALGBRC(3) is h1_infinity in component sodium_current_h_gate (dimensionless). C ALGBRC(16) is h2_infinity in component sodium_current_h_gate (dimensionless). C ALGBRC(17) is tau_h1 in component sodium_current_h_gate (second). C ALGBRC(29) is tau_h2 in component sodium_current_h_gate (second). C CONSTS(10) is g_Ca_L_Centre in component L_type_Ca_channel (microS). C CONSTS(11) is g_Ca_L_Periphery in component L_type_Ca_channel (microS). C CONSTS(57) is g_Ca_L in component L_type_Ca_channel (microS). C CONSTS(12) is E_Ca_L in component L_type_Ca_channel (millivolt). C STATES(5) is d_L in component L_type_Ca_channel_d_gate (dimensionless). C STATES(6) is f_L in component L_type_Ca_channel_f_gate (dimensionless). C ALGBRC(4) is alpha_d_L in component L_type_Ca_channel_d_gate (per_second). C ALGBRC(18) is beta_d_L in component L_type_Ca_channel_d_gate (per_second). C ALGBRC(36) is d_L_infinity in component L_type_Ca_channel_d_gate (dimensionless). C ALGBRC(30) is tau_d_L in component L_type_Ca_channel_d_gate (second). C ALGBRC(5) is alpha_f_L in component L_type_Ca_channel_f_gate (per_second). C ALGBRC(19) is beta_f_L in component L_type_Ca_channel_f_gate (per_second). C ALGBRC(37) is f_L_infinity in component L_type_Ca_channel_f_gate (dimensionless). C ALGBRC(31) is tau_f_L in component L_type_Ca_channel_f_gate (second). C CONSTS(13) is g_Ca_T_Centre in component T_type_Ca_channel (microS). C CONSTS(14) is g_Ca_T_Periphery in component T_type_Ca_channel (microS). C CONSTS(58) is g_Ca_T in component T_type_Ca_channel (microS). C CONSTS(15) is E_Ca_T in component T_type_Ca_channel (millivolt). C STATES(7) is d_T in component T_type_Ca_channel_d_gate (dimensionless). C STATES(8) is f_T in component T_type_Ca_channel_f_gate (dimensionless). C ALGBRC(6) is alpha_d_T in component T_type_Ca_channel_d_gate (per_second). C ALGBRC(20) is beta_d_T in component T_type_Ca_channel_d_gate (per_second). C ALGBRC(38) is d_T_infinity in component T_type_Ca_channel_d_gate (dimensionless). C ALGBRC(32) is tau_d_T in component T_type_Ca_channel_d_gate (second). C ALGBRC(7) is alpha_f_T in component T_type_Ca_channel_f_gate (per_second). C ALGBRC(21) is beta_f_T in component T_type_Ca_channel_f_gate (per_second). C ALGBRC(39) is f_T_infinity in component T_type_Ca_channel_f_gate (dimensionless). C ALGBRC(33) is tau_f_T in component T_type_Ca_channel_f_gate (second). C CONSTS(16) is g_to_Centre in component four_AP_sensitive_currents (microS). C CONSTS(17) is g_to_Periphery in component four_AP_sensitive_currents (microS). C CONSTS(59) is g_to in component four_AP_sensitive_currents (microS). C CONSTS(18) is g_sus_Centre in component four_AP_sensitive_currents (microS). C CONSTS(19) is g_sus_Periphery in component four_AP_sensitive_currents (microS). C CONSTS(60) is g_sus in component four_AP_sensitive_currents (microS). C CONSTS(52) is E_K in component reversal_and_equilibrium_potentials (millivolt). C STATES(9) is q in component four_AP_sensitive_currents_q_gate (dimensionless). C STATES(10) is r in component four_AP_sensitive_currents_r_gate (dimensionless). C ALGBRC(8) is q_infinity in component four_AP_sensitive_currents_q_gate (dimensionless). C ALGBRC(22) is tau_q in component four_AP_sensitive_currents_q_gate (second). C ALGBRC(9) is r_infinity in component four_AP_sensitive_currents_r_gate (dimensionless). C ALGBRC(23) is tau_r in component four_AP_sensitive_currents_r_gate (second). C CONSTS(20) is g_K_r_Centre in component rapid_delayed_rectifying_potassium_current (microS). C CONSTS(21) is g_K_r_Periphery in component rapid_delayed_rectifying_potassium_current (microS). C CONSTS(61) is g_K_r in component rapid_delayed_rectifying_potassium_current (microS). C ALGBRC(43) is P_a in component rapid_delayed_rectifying_potassium_current (dimensionless). C STATES(11) is P_af in component rapid_delayed_rectifying_potassium_current_P_af_gate (dimensionless). C STATES(12) is P_as in component rapid_delayed_rectifying_potassium_current_P_as_gate (dimensionless). C STATES(13) is P_i in component rapid_delayed_rectifying_potassium_current_P_i_gate (dimensionless). C ALGBRC(10) is P_af_infinity in component rapid_delayed_rectifying_potassium_current_P_af_gate (dimensionless). C ALGBRC(24) is tau_P_af in component rapid_delayed_rectifying_potassium_current_P_af_gate (second). C ALGBRC(25) is P_as_infinity in component rapid_delayed_rectifying_potassium_current_P_as_gate (dimensionless). C ALGBRC(34) is tau_P_as in component rapid_delayed_rectifying_potassium_current_P_as_gate (second). C ALGBRC(11) is P_i_infinity in component rapid_delayed_rectifying_potassium_current_P_i_gate (dimensionless). C CONSTS(22) is tau_P_i in component rapid_delayed_rectifying_potassium_current_P_i_gate (second). C CONSTS(23) is g_K_s_Centre in component slow_delayed_rectifying_potassium_current (microS). C CONSTS(24) is g_K_s_Periphery in component slow_delayed_rectifying_potassium_current (microS). C CONSTS(62) is g_K_s in component slow_delayed_rectifying_potassium_current (microS). C CONSTS(53) is E_K_s in component reversal_and_equilibrium_potentials (millivolt). C STATES(14) is xs in component slow_delayed_rectifying_potassium_current_xs_gate (dimensionless). C ALGBRC(12) is alpha_xs in component slow_delayed_rectifying_potassium_current_xs_gate (per_second). C ALGBRC(26) is beta_xs in component slow_delayed_rectifying_potassium_current_xs_gate (per_second). C CONSTS(25) is g_f_Na_Centre in component hyperpolarisation_activated_current (microS). C CONSTS(26) is g_f_Na_Periphery in component hyperpolarisation_activated_current (microS). C CONSTS(63) is g_f_Na in component hyperpolarisation_activated_current (microS). C CONSTS(27) is g_f_K_Centre in component hyperpolarisation_activated_current (microS). C CONSTS(28) is g_f_K_Periphery in component hyperpolarisation_activated_current (microS). C CONSTS(64) is g_f_K in component hyperpolarisation_activated_current (microS). C STATES(15) is y in component hyperpolarisation_activated_current_y_gate (dimensionless). C ALGBRC(13) is alpha_y in component hyperpolarisation_activated_current_y_gate (per_second). C ALGBRC(27) is beta_y in component hyperpolarisation_activated_current_y_gate (per_second). C CONSTS(29) is g_b_Na_Centre in component sodium_background_current (microS). C CONSTS(30) is g_b_Na_Periphery in component sodium_background_current (microS). C CONSTS(65) is g_b_Na in component sodium_background_current (microS). C CONSTS(31) is g_b_K_Centre in component potassium_background_current (microS). C CONSTS(32) is g_b_K_Periphery in component potassium_background_current (microS). C CONSTS(66) is g_b_K in component potassium_background_current (microS). C CONSTS(33) is g_b_Ca_Centre in component calcium_background_current (microS). C CONSTS(34) is g_b_Ca_Periphery in component calcium_background_current (microS). C CONSTS(67) is g_b_Ca in component calcium_background_current (microS). C CONSTS(54) is E_Ca in component reversal_and_equilibrium_potentials (millivolt). C CONSTS(35) is k_NaCa_Centre in component sodium_calcium_exchanger (nanoA). C CONSTS(36) is k_NaCa_Periphery in component sodium_calcium_exchanger (nanoA). C CONSTS(68) is k_NaCa in component sodium_calcium_exchanger (nanoA). C CONSTS(37) is d_NaCa in component sodium_calcium_exchanger (dimensionless). C CONSTS(38) is gamma_NaCa in component sodium_calcium_exchanger (dimensionless). C CONSTS(39) is Na_i in component ionic_concentrations (millimolar). C CONSTS(40) is Ca_i in component ionic_concentrations (millimolar). C CONSTS(41) is Ca_o in component ionic_concentrations (millimolar). C CONSTS(42) is K_m_Na in component sodium_potassium_pump (millimolar). C CONSTS(43) is K_m_K in component sodium_potassium_pump (millimolar). C CONSTS(44) is i_p_max_Centre in component sodium_potassium_pump (nanoA). C CONSTS(45) is i_p_max_Periphery in component sodium_potassium_pump (nanoA). C CONSTS(69) is i_p_max in component sodium_potassium_pump (nanoA). C CONSTS(46) is K_o in component ionic_concentrations (millimolar). C CONSTS(47) is i_Ca_p_max_Centre in component persistent_calcium_current (nanoA). C CONSTS(48) is i_Ca_p_max_Periphery in component persistent_calcium_current (nanoA). C CONSTS(70) is i_Ca_p_max in component persistent_calcium_current (nanoA). C CONSTS(49) is K_i in component ionic_concentrations (millimolar). C RATES(1) is d/dt V in component membrane (millivolt). C RATES(2) is d/dt m in component sodium_current_m_gate (dimensionless). C RATES(3) is d/dt h1 in component sodium_current_h_gate (dimensionless). C RATES(4) is d/dt h2 in component sodium_current_h_gate (dimensionless). C RATES(5) is d/dt d_L in component L_type_Ca_channel_d_gate (dimensionless). C RATES(6) is d/dt f_L in component L_type_Ca_channel_f_gate (dimensionless). C RATES(7) is d/dt d_T in component T_type_Ca_channel_d_gate (dimensionless). C RATES(8) is d/dt f_T in component T_type_Ca_channel_f_gate (dimensionless). C RATES(9) is d/dt q in component four_AP_sensitive_currents_q_gate (dimensionless). C RATES(10) is d/dt r in component four_AP_sensitive_currents_r_gate (dimensionless). C RATES(11) is d/dt P_af in component rapid_delayed_rectifying_potassium_current_P_af_gate (dimensionless). C RATES(12) is d/dt P_as in component rapid_delayed_rectifying_potassium_current_P_as_gate (dimensionless). C RATES(13) is d/dt P_i in component rapid_delayed_rectifying_potassium_current_P_i_gate (dimensionless). C RATES(14) is d/dt xs in component slow_delayed_rectifying_potassium_current_xs_gate (dimensionless). C RATES(15) is d/dt y in component hyperpolarisation_activated_current_y_gate (dimensionless). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 0 STATES(1) = -39.013558536 CONSTS(2) = 8314 CONSTS(3) = 310 CONSTS(4) = 96845 CONSTS(5) = 2e-5 CONSTS(6) = 6.5e-5 CONSTS(7) = 0 CONSTS(8) = 1.2e-6 CONSTS(9) = 140 STATES(2) = 0.092361701692 STATES(3) = 0.015905380261 STATES(4) = 0.01445216109 CONSTS(10) = 0.0058 CONSTS(11) = 0.0659 CONSTS(12) = 46.4 STATES(5) = 0.04804900895 STATES(6) = 0.48779845203 CONSTS(13) = 0.0043 CONSTS(14) = 0.0139 CONSTS(15) = 45 STATES(7) = 0.42074047435 STATES(8) = 0.038968420558 CONSTS(16) = 0.00491 CONSTS(17) = 0.03649 CONSTS(18) = 6.65e-5 CONSTS(19) = 0.0114 STATES(9) = 0.29760539675 STATES(10) = 0.064402950262 CONSTS(20) = 0.000797 CONSTS(21) = 0.016 STATES(11) = 0.13034201158 STATES(12) = 0.46960956028 STATES(13) = 0.87993375273 CONSTS(22) = 0.002 CONSTS(23) = 0.000518 CONSTS(24) = 0.0104 STATES(14) = 0.082293827208 CONSTS(25) = 0.000548 CONSTS(26) = 0.0069 CONSTS(27) = 0.000548 CONSTS(28) = 0.0069 STATES(15) = 0.03889291759 CONSTS(29) = 5.8e-5 CONSTS(30) = 0.000189 CONSTS(31) = 2.52e-5 CONSTS(32) = 8.19e-5 CONSTS(33) = 1.32e-5 CONSTS(34) = 4.3e-5 CONSTS(35) = 2.7e-6 CONSTS(36) = 8.8e-6 CONSTS(37) = 0.0001 CONSTS(38) = 0.5 CONSTS(39) = 8 CONSTS(40) = 0.0001 CONSTS(41) = 2 CONSTS(42) = 5.64 CONSTS(43) = 0.621 CONSTS(44) = 0.0478 CONSTS(45) = 0.16 CONSTS(46) = 5.4 CONSTS(47) = 0 CONSTS(48) = 0 CONSTS(49) = 140 CONSTS(50) = ( 1.07000*( 3.00000*CONSTS(1) - 0.100000))/( 3.00000*(1.00000+ 0.774500*EXP(- ( 3.00000*CONSTS(1) - 2.05000)/0.295000))) CONSTS(51) = (( CONSTS(2)*CONSTS(3))/CONSTS(4))*log(CONSTS(9)/CONSTS(39)) CONSTS(52) = (( CONSTS(2)*CONSTS(3))/CONSTS(4))*log(CONSTS(46)/CONSTS(49)) CONSTS(53) = (( CONSTS(2)*CONSTS(3))/CONSTS(4))*log((CONSTS(46)+ 0.120000*CONSTS(9))/(CONSTS(49)+ 0.120000*CONSTS(39))) CONSTS(54) = (( CONSTS(2)*CONSTS(3))/( 2.00000*CONSTS(4)))*log(CONSTS(41)/CONSTS(40)) CONSTS(55) = CONSTS(5)+ CONSTS(50)*(CONSTS(6) - CONSTS(5)) CONSTS(56) = CONSTS(7)+ CONSTS(50)*(CONSTS(8) - CONSTS(7)) CONSTS(57) = CONSTS(10)+ CONSTS(50)*(CONSTS(11) - CONSTS(10)) CONSTS(58) = CONSTS(13)+ CONSTS(50)*(CONSTS(14) - CONSTS(13)) CONSTS(59) = CONSTS(16)+ CONSTS(50)*(CONSTS(17) - CONSTS(16)) CONSTS(60) = CONSTS(18)+ CONSTS(50)*(CONSTS(19) - CONSTS(18)) CONSTS(61) = CONSTS(20)+ CONSTS(50)*(CONSTS(21) - CONSTS(20)) CONSTS(62) = CONSTS(23)+ CONSTS(50)*(CONSTS(24) - CONSTS(23)) CONSTS(63) = CONSTS(25)+ CONSTS(50)*(CONSTS(26) - CONSTS(25)) CONSTS(64) = CONSTS(27)+ CONSTS(50)*(CONSTS(28) - CONSTS(27)) CONSTS(65) = CONSTS(29)+ CONSTS(50)*(CONSTS(30) - CONSTS(29)) CONSTS(66) = CONSTS(31)+ CONSTS(50)*(CONSTS(32) - CONSTS(31)) CONSTS(67) = CONSTS(33)+ CONSTS(50)*(CONSTS(34) - CONSTS(33)) CONSTS(68) = CONSTS(35)+ CONSTS(50)*(CONSTS(36) - CONSTS(35)) CONSTS(69) = CONSTS(44)+ CONSTS(50)*(CONSTS(45) - CONSTS(44)) CONSTS(70) = CONSTS(47)+ CONSTS(50)*(CONSTS(48) - CONSTS(47)) CONSTS(71) = ( CONSTS(70)*CONSTS(40))/(CONSTS(40)+0.000400000) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(11) = 1.00000/(1.00000+EXP((STATES(1)+18.6000)/10.1000)) RATES(13) = (ALGBRC(11) - STATES(13))/CONSTS(22) ALGBRC(2) = 1.00000/(1.00000+EXP(- STATES(1)/5.46000)) ** 1.00000/3.00000 ALGBRC(15) = 0.000624700/( 0.832000*EXP( - 0.335000*(STATES(1)+56.7000))+ 0.627000*EXP( 0.0820000*(STATES(1)+65.0100)))+4.00000e-05 RATES(2) = (ALGBRC(2) - STATES(2))/ALGBRC(15) ALGBRC(3) = 1.00000/(1.00000+EXP((STATES(1)+66.1000)/6.40000)) ALGBRC(17) = ( 3.71700e-06*EXP( - 0.281500*(STATES(1)+17.1100)))/(1.00000+ 0.00373200*EXP( - 0.342600*(STATES(1)+37.7600)))+0.000597700 RATES(3) = (ALGBRC(3) - STATES(3))/ALGBRC(17) ALGBRC(8) = 1.00000/(1.00000+EXP((STATES(1)+59.3700)/13.1000)) ALGBRC(22) = 0.0101000+0.0651700/( 0.570000*EXP( - 0.0800000*(STATES(1)+49.0000)))+ 2.40000e-05*EXP( 0.100000*(STATES(1)+50.9300)) RATES(9) = (ALGBRC(8) - STATES(9))/ALGBRC(22) ALGBRC(9) = 1.00000/(1.00000+EXP(- (STATES(1) - 10.9300)/19.7000)) ALGBRC(23) = 0.00100000*(2.98000+15.5900/( 1.03700*EXP( 0.0900000*(STATES(1)+30.6100))+ 0.369000*EXP( - 0.120000*(STATES(1)+23.8400)))) RATES(10) = (ALGBRC(9) - STATES(10))/ALGBRC(23) ALGBRC(10) = 1.00000/(1.00000+EXP(- (STATES(1)+14.2000)/10.6000)) ALGBRC(24) = 1.00000/( 37.2000*EXP((STATES(1) - 9.00000)/15.9000)+ 0.960000*EXP(- (STATES(1) - 9.00000)/22.5000)) RATES(11) = (ALGBRC(10) - STATES(11))/ALGBRC(24) ALGBRC(12) = 14.0000/(1.00000+EXP(- (STATES(1) - 40.0000)/9.00000)) ALGBRC(26) = 1.00000*EXP(- STATES(1)/45.0000) RATES(14) = ALGBRC(12)*(1.00000 - STATES(14)) - ALGBRC(26)*STATES(14) ALGBRC(13) = 1.00000*EXP(- (STATES(1)+78.9100)/26.6200) ALGBRC(27) = 1.00000*EXP((STATES(1)+75.1300)/21.2500) RATES(15) = ALGBRC(13)*(1.00000 - STATES(15)) - ALGBRC(27)*STATES(15) ALGBRC(16) = ALGBRC(3) ALGBRC(29) = ( 3.18600e-08*EXP( - 0.621900*(STATES(1)+18.8000)))/(1.00000+ 7.18900e-05*EXP( - 0.668300*(STATES(1)+34.0700)))+0.00355600 RATES(4) = (ALGBRC(16) - STATES(4))/ALGBRC(29) ALGBRC(25) = ALGBRC(10) ALGBRC(34) = 1.00000/( 4.20000*EXP((STATES(1) - 9.00000)/17.0000)+ 0.150000*EXP(- (STATES(1) - 9.00000)/21.6000)) RATES(12) = (ALGBRC(25) - STATES(12))/ALGBRC(34) ALGBRC(36) = 1.00000/(1.00000+EXP(- (STATES(1)+23.1000)/6.00000)) ALGBRC(4) = ( - 28.3800*(STATES(1)+35.0000))/(EXP(- (STATES(1)+35.0000)/2.50000) - 1.00000) - ( 84.9000*STATES(1))/(EXP( - 0.208000*STATES(1)) - 1.00000) ALGBRC(18) = ( 11.4200*(STATES(1) - 5.00000))/(EXP( 0.400000*(STATES(1) - 5.00000)) - 1.00000) ALGBRC(30) = 2.00000/(ALGBRC(4)+ALGBRC(18)) RATES(5) = (ALGBRC(36) - STATES(5))/ALGBRC(30) ALGBRC(37) = 1.00000/(1.00000+EXP((STATES(1)+45.0000)/5.00000)) ALGBRC(5) = ( 3.12000*(STATES(1)+28.0000))/(EXP((STATES(1)+28.0000)/4.00000) - 1.00000) ALGBRC(19) = 25.0000/(1.00000+EXP(- (STATES(1)+28.0000)/4.00000)) ALGBRC(31) = 1.00000/(ALGBRC(5)+ALGBRC(19)) RATES(6) = (ALGBRC(37) - STATES(6))/ALGBRC(31) ALGBRC(38) = 1.00000/(1.00000+EXP(- (STATES(1)+37.0000)/6.80000)) ALGBRC(6) = 1068.00*EXP((STATES(1)+26.3000)/30.0000) ALGBRC(20) = 1068.00*EXP(- (STATES(1)+26.3000)/30.0000) ALGBRC(32) = 1.00000/(ALGBRC(6)+ALGBRC(20)) RATES(7) = (ALGBRC(38) - STATES(7))/ALGBRC(32) ALGBRC(39) = 1.00000/(1.00000+EXP((STATES(1)+71.0000)/9.00000)) ALGBRC(7) = 15.3000*EXP(- (STATES(1)+71.7000)/83.3000) ALGBRC(21) = 15.0000*EXP((STATES(1)+71.7000)/15.3800) ALGBRC(33) = 1.00000/(ALGBRC(7)+ALGBRC(21)) RATES(8) = (ALGBRC(39) - STATES(8))/ALGBRC(33) ALGBRC(1) = ( 0.0952000*EXP( - 0.0630000*(STATES(1)+34.4000)))/(1.00000+ 1.66000*EXP( - 0.225000*(STATES(1)+63.7000)))+0.0869000 ALGBRC(14) = (1.00000 - ALGBRC(1))*STATES(3)+ ALGBRC(1)*STATES(4) ALGBRC(28) = (( (( CONSTS(56)*STATES(2) ** 3.00000*ALGBRC(14)*CONSTS(9)*CONSTS(4) ** 2.00000)/( CONSTS(2)*CONSTS(3)))*(EXP(( (STATES(1) - CONSTS(51))*CONSTS(4))/( CONSTS(2)*CONSTS(3))) - 1.00000))/(EXP(( STATES(1)*CONSTS(4))/( CONSTS(2)*CONSTS(3))) - 1.00000))*STATES(1) ALGBRC(35) = CONSTS(57)*( STATES(6)*STATES(5)+0.00600000/(1.00000+EXP(- (STATES(1)+14.1000)/6.00000)))*(STATES(1) - CONSTS(12)) ALGBRC(40) = CONSTS(58)*STATES(7)*STATES(8)*(STATES(1) - CONSTS(15)) ALGBRC(41) = CONSTS(59)*STATES(9)*STATES(10)*(STATES(1) - CONSTS(52)) ALGBRC(42) = CONSTS(60)*STATES(10)*(STATES(1) - CONSTS(52)) ALGBRC(43) = 0.600000*STATES(11)+ 0.400000*STATES(12) ALGBRC(44) = CONSTS(61)*ALGBRC(43)*STATES(13)*(STATES(1) - CONSTS(52)) ALGBRC(45) = CONSTS(62)*STATES(14) ** 2.00000*(STATES(1) - CONSTS(53)) ALGBRC(46) = CONSTS(63)*STATES(15)*(STATES(1) - CONSTS(51)) ALGBRC(47) = CONSTS(64)*STATES(15)*(STATES(1) - CONSTS(52)) ALGBRC(48) = CONSTS(65)*(STATES(1) - CONSTS(51)) ALGBRC(50) = CONSTS(67)*(STATES(1) - CONSTS(54)) ALGBRC(49) = CONSTS(66)*(STATES(1) - CONSTS(52)) ALGBRC(51) = ( CONSTS(68)*( CONSTS(39) ** 3.00000*CONSTS(41)*EXP( 0.0374300*STATES(1)*CONSTS(38)) - CONSTS(9) ** 3.00000*CONSTS(40)*EXP( 0.0374000*STATES(1)*(CONSTS(38) - 1.00000))))/(1.00000+ CONSTS(37)*( CONSTS(40)*CONSTS(9) ** 3.00000+ CONSTS(41)*CONSTS(39) ** 3.00000)) ALGBRC(52) = ( CONSTS(69)*CONSTS(39)/(CONSTS(42)+CONSTS(39)) ** 3.00000*CONSTS(46)/(CONSTS(43)+CONSTS(46)) ** 2.00000*1.60000)/(1.50000+EXP(- (STATES(1)+60.0000)/40.0000)) RATES(1) = (- 1.00000/CONSTS(55))*(ALGBRC(28)+ALGBRC(35)+ALGBRC(40)+ALGBRC(41)+ALGBRC(42)+ALGBRC(44)+ALGBRC(45)+ALGBRC(46)+ALGBRC(47)+ALGBRC(48)+ALGBRC(50)+ALGBRC(49)+ALGBRC(51)+ALGBRC(52)+CONSTS(71)) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(11) = 1.00000/(1.00000+EXP((STATES(1)+18.6000)/10.1000)) ALGBRC(2) = 1.00000/(1.00000+EXP(- STATES(1)/5.46000)) ** 1.00000/3.00000 ALGBRC(15) = 0.000624700/( 0.832000*EXP( - 0.335000*(STATES(1)+56.7000))+ 0.627000*EXP( 0.0820000*(STATES(1)+65.0100)))+4.00000e-05 ALGBRC(3) = 1.00000/(1.00000+EXP((STATES(1)+66.1000)/6.40000)) ALGBRC(17) = ( 3.71700e-06*EXP( - 0.281500*(STATES(1)+17.1100)))/(1.00000+ 0.00373200*EXP( - 0.342600*(STATES(1)+37.7600)))+0.000597700 ALGBRC(8) = 1.00000/(1.00000+EXP((STATES(1)+59.3700)/13.1000)) ALGBRC(22) = 0.0101000+0.0651700/( 0.570000*EXP( - 0.0800000*(STATES(1)+49.0000)))+ 2.40000e-05*EXP( 0.100000*(STATES(1)+50.9300)) ALGBRC(9) = 1.00000/(1.00000+EXP(- (STATES(1) - 10.9300)/19.7000)) ALGBRC(23) = 0.00100000*(2.98000+15.5900/( 1.03700*EXP( 0.0900000*(STATES(1)+30.6100))+ 0.369000*EXP( - 0.120000*(STATES(1)+23.8400)))) ALGBRC(10) = 1.00000/(1.00000+EXP(- (STATES(1)+14.2000)/10.6000)) ALGBRC(24) = 1.00000/( 37.2000*EXP((STATES(1) - 9.00000)/15.9000)+ 0.960000*EXP(- (STATES(1) - 9.00000)/22.5000)) ALGBRC(12) = 14.0000/(1.00000+EXP(- (STATES(1) - 40.0000)/9.00000)) ALGBRC(26) = 1.00000*EXP(- STATES(1)/45.0000) ALGBRC(13) = 1.00000*EXP(- (STATES(1)+78.9100)/26.6200) ALGBRC(27) = 1.00000*EXP((STATES(1)+75.1300)/21.2500) ALGBRC(16) = ALGBRC(3) ALGBRC(29) = ( 3.18600e-08*EXP( - 0.621900*(STATES(1)+18.8000)))/(1.00000+ 7.18900e-05*EXP( - 0.668300*(STATES(1)+34.0700)))+0.00355600 ALGBRC(25) = ALGBRC(10) ALGBRC(34) = 1.00000/( 4.20000*EXP((STATES(1) - 9.00000)/17.0000)+ 0.150000*EXP(- (STATES(1) - 9.00000)/21.6000)) ALGBRC(36) = 1.00000/(1.00000+EXP(- (STATES(1)+23.1000)/6.00000)) ALGBRC(4) = ( - 28.3800*(STATES(1)+35.0000))/(EXP(- (STATES(1)+35.0000)/2.50000) - 1.00000) - ( 84.9000*STATES(1))/(EXP( - 0.208000*STATES(1)) - 1.00000) ALGBRC(18) = ( 11.4200*(STATES(1) - 5.00000))/(EXP( 0.400000*(STATES(1) - 5.00000)) - 1.00000) ALGBRC(30) = 2.00000/(ALGBRC(4)+ALGBRC(18)) ALGBRC(37) = 1.00000/(1.00000+EXP((STATES(1)+45.0000)/5.00000)) ALGBRC(5) = ( 3.12000*(STATES(1)+28.0000))/(EXP((STATES(1)+28.0000)/4.00000) - 1.00000) ALGBRC(19) = 25.0000/(1.00000+EXP(- (STATES(1)+28.0000)/4.00000)) ALGBRC(31) = 1.00000/(ALGBRC(5)+ALGBRC(19)) ALGBRC(38) = 1.00000/(1.00000+EXP(- (STATES(1)+37.0000)/6.80000)) ALGBRC(6) = 1068.00*EXP((STATES(1)+26.3000)/30.0000) ALGBRC(20) = 1068.00*EXP(- (STATES(1)+26.3000)/30.0000) ALGBRC(32) = 1.00000/(ALGBRC(6)+ALGBRC(20)) ALGBRC(39) = 1.00000/(1.00000+EXP((STATES(1)+71.0000)/9.00000)) ALGBRC(7) = 15.3000*EXP(- (STATES(1)+71.7000)/83.3000) ALGBRC(21) = 15.0000*EXP((STATES(1)+71.7000)/15.3800) ALGBRC(33) = 1.00000/(ALGBRC(7)+ALGBRC(21)) ALGBRC(1) = ( 0.0952000*EXP( - 0.0630000*(STATES(1)+34.4000)))/(1.00000+ 1.66000*EXP( - 0.225000*(STATES(1)+63.7000)))+0.0869000 ALGBRC(14) = (1.00000 - ALGBRC(1))*STATES(3)+ ALGBRC(1)*STATES(4) ALGBRC(28) = (( (( CONSTS(56)*STATES(2) ** 3.00000*ALGBRC(14)*CONSTS(9)*CONSTS(4) ** 2.00000)/( CONSTS(2)*CONSTS(3)))*(EXP(( (STATES(1) - CONSTS(51))*CONSTS(4))/( CONSTS(2)*CONSTS(3))) - 1.00000))/(EXP(( STATES(1)*CONSTS(4))/( CONSTS(2)*CONSTS(3))) - 1.00000))*STATES(1) ALGBRC(35) = CONSTS(57)*( STATES(6)*STATES(5)+0.00600000/(1.00000+EXP(- (STATES(1)+14.1000)/6.00000)))*(STATES(1) - CONSTS(12)) ALGBRC(40) = CONSTS(58)*STATES(7)*STATES(8)*(STATES(1) - CONSTS(15)) ALGBRC(41) = CONSTS(59)*STATES(9)*STATES(10)*(STATES(1) - CONSTS(52)) ALGBRC(42) = CONSTS(60)*STATES(10)*(STATES(1) - CONSTS(52)) ALGBRC(43) = 0.600000*STATES(11)+ 0.400000*STATES(12) ALGBRC(44) = CONSTS(61)*ALGBRC(43)*STATES(13)*(STATES(1) - CONSTS(52)) ALGBRC(45) = CONSTS(62)*STATES(14) ** 2.00000*(STATES(1) - CONSTS(53)) ALGBRC(46) = CONSTS(63)*STATES(15)*(STATES(1) - CONSTS(51)) ALGBRC(47) = CONSTS(64)*STATES(15)*(STATES(1) - CONSTS(52)) ALGBRC(48) = CONSTS(65)*(STATES(1) - CONSTS(51)) ALGBRC(50) = CONSTS(67)*(STATES(1) - CONSTS(54)) ALGBRC(49) = CONSTS(66)*(STATES(1) - CONSTS(52)) ALGBRC(51) = ( CONSTS(68)*( CONSTS(39) ** 3.00000*CONSTS(41)*EXP( 0.0374300*STATES(1)*CONSTS(38)) - CONSTS(9) ** 3.00000*CONSTS(40)*EXP( 0.0374000*STATES(1)*(CONSTS(38) - 1.00000))))/(1.00000+ CONSTS(37)*( CONSTS(40)*CONSTS(9) ** 3.00000+ CONSTS(41)*CONSTS(39) ** 3.00000)) ALGBRC(52) = ( CONSTS(69)*CONSTS(39)/(CONSTS(42)+CONSTS(39)) ** 3.00000*CONSTS(46)/(CONSTS(43)+CONSTS(46)) ** 2.00000*1.60000)/(1.50000+EXP(- (STATES(1)+60.0000)/40.0000)) RETURN END