/* There are a total of 24 entries in the algebraic variable array. There are a total of 33 entries in each of the rate and state variable arrays. There are a total of 97 entries in the constant variable array. */ /* * VOI is time in component environment (hour). * STATES[0] is ATbl in component ATbl (nanomole). * CONSTANTS[0] is k2T in component ATbl (nmol_hr). * ALGEBRAIC[17] is Qb in component model_parameters (l_hr). * ALGEBRAIC[15] is Qp in component Qp (l_hr). * CONSTANTS[1] is Ql in component model_parameters (l_hr). * CONSTANTS[2] is Qt in component model_parameters (l_hr). * CONSTANTS[94] is CTbf in component model_parameters (nM). * ALGEBRAIC[0] is CTblf in component CTblf (nM). * ALGEBRAIC[10] is CTpf in component CTpf (nM). * CONSTANTS[3] is CTbl in component model_parameters (nM). * CONSTANTS[90] is CTlf in component CTlf (nM). * CONSTANTS[93] is CTtv in component CTtv (nM). * CONSTANTS[4] is ts in component model_parameters (dimensionless). * STATES[1] is ADbl in component ADbl (nanomole). * ALGEBRAIC[18] is Qbt in component model_parameters (l_hr). * CONSTANTS[95] is CDbf in component model_parameters (nM). * ALGEBRAIC[4] is CDblf in component CDblf (nM). * ALGEBRAIC[12] is CDpf in component CDpf (nM). * CONSTANTS[92] is CDlf in component CDlf (nM). * CONSTANTS[5] is CDbl in component model_parameters (nM). * STATES[2] is CT_A in component CT_A (nM). * CONSTANTS[6] is kTA_on in component CT_A (second_order_rate_constant). * CONSTANTS[7] is kTA_off in component CT_A (first_order_rate_constant). * ALGEBRAIC[8] is CAf in component CAf (nM). * STATES[3] is CD_A in component CD_A (nM). * CONSTANTS[8] is kDA_on in component CD_A (second_order_rate_constant). * CONSTANTS[9] is kDA_off in component CD_A (first_order_rate_constant). * CONSTANTS[10] is CA in component model_parameters (nM). * STATES[4] is ATl in component ATl (nanomole). * CONSTANTS[11] is k1T in component model_parameters (first_order_rate_constant). * CONSTANTS[12] is km5alpha in component model_parameters (nM). * CONSTANTS[13] is Vmax1 in component model_parameters (nmol_hr). * CONSTANTS[14] is PTl in component model_parameters (dimensionless). * STATES[5] is ADl in component ADl (nanomole). * CONSTANTS[15] is k1D in component model_parameters (first_order_rate_constant). * CONSTANTS[16] is PDl in component model_parameters (dimensionless). * CONSTANTS[17] is CTl in component model_parameters (nM). * CONSTANTS[18] is CDl in component model_parameters (nM). * STATES[6] is ATif in component ATif (nanomole). * CONSTANTS[19] is mu in component model_parameters (l_hr). * CONSTANTS[20] is PTif in component model_parameters (dimensionless). * CONSTANTS[21] is CTif in component model_parameters (nM). * CONSTANTS[22] is CTst in component model_parameters (nM). * CONSTANTS[23] is CLH in component model_parameters (nanomole). * CONSTANTS[24] is PTst in component model_parameters (dimensionless). * STATES[7] is ATst in component ATst (nanomole). * STATES[8] is ATp in component ATp (nanomole). * CONSTANTS[25] is Vmax0 in component model_parameters (nmol_hr). * STATES[9] is ADp in component ADp (nanomole). * STATES[10] is CT_R in component CT_R (nM). * CONSTANTS[26] is kTR_on in component CT_R (second_order_rate_constant). * CONSTANTS[27] is kTR_off in component CT_R (first_order_rate_constant). * ALGEBRAIC[23] is CRf in component CRf (nM). * STATES[11] is CD_R in component CD_R (nM). * CONSTANTS[28] is kDR_on in component CD_R (second_order_rate_constant). * CONSTANTS[29] is kDR_off in component CD_R (first_order_rate_constant). * STATES[12] is CDT in component CDT (nM). * CONSTANTS[30] is kDT_on in component CDT (second_order_rate_constant). * CONSTANTS[31] is kDT_off in component CDT (first_order_rate_constant). * STATES[13] is CDD in component CDD (nM). * CONSTANTS[32] is kDD_on in component CDD (second_order_rate_constant). * CONSTANTS[33] is kDD_off in component CDD (first_order_rate_constant). * STATES[14] is CTT in component CTT (nM). * CONSTANTS[34] is kTT_on in component CTT (second_order_rate_constant). * CONSTANTS[35] is kTT_off in component CTT (first_order_rate_constant). * STATES[15] is CDD5a in component CDD5a (nM). * CONSTANTS[36] is kDNA_onDD5a in component CDD5a (second_order_rate_constant). * CONSTANTS[37] is kDNA_offDD5a in component CDD5a (first_order_rate_constant). * ALGEBRAIC[19] is CDNA5af in component CDNA5af (nM). * STATES[16] is CDDcd in component CDDcd (nM). * CONSTANTS[38] is kDNA_onDDcd in component CDDcd (second_order_rate_constant). * CONSTANTS[39] is kDNA_offDDcd in component CDDcd (first_order_rate_constant). * ALGEBRAIC[14] is CDNAcdf in component CDNAcdf (nM). * STATES[17] is CDDsec in component CDDsec (nM). * CONSTANTS[40] is kDNA_onDDsec in component CDDsec (second_order_rate_constant). * CONSTANTS[41] is kDNA_offDDsec in component CDDsec (first_order_rate_constant). * ALGEBRAIC[16] is CDNAsecf in component CDNAsecf (nM). * STATES[18] is CDDcp in component CDDcp (nM). * CONSTANTS[42] is kDNA_onDDcp in component CDDcp (second_order_rate_constant). * CONSTANTS[43] is kDNA_offDDcp in component CDDcp (first_order_rate_constant). * ALGEBRAIC[20] is CDNAcpf in component CDNAcpf (nM). * STATES[19] is CDT5a in component CDT5a (nM). * CONSTANTS[44] is kDNA_onDT5a in component CDT5a (second_order_rate_constant). * CONSTANTS[45] is kDNA_offDT5a in component CDT5a (first_order_rate_constant). * STATES[20] is CDTcd in component CDTcd (nM). * CONSTANTS[46] is kDNA_onDTcd in component CDTcd (second_order_rate_constant). * CONSTANTS[47] is kDNA_offDTcd in component CDTcd (first_order_rate_constant). * STATES[21] is CDTsec in component CDTsec (nM). * CONSTANTS[48] is kDNA_onDTsec in component CDTsec (second_order_rate_constant). * CONSTANTS[49] is kDNA_offDTsec in component CDTsec (first_order_rate_constant). * STATES[22] is CDTcp in component CDTcp (nM). * CONSTANTS[50] is kDNA_onDTcp in component CDTcp (second_order_rate_constant). * CONSTANTS[51] is kDNA_offDTcp in component CDTcp (first_order_rate_constant). * STATES[23] is CTT5a in component CTT5a (nM). * CONSTANTS[52] is kDNA_onTT5a in component CTT5a (second_order_rate_constant). * CONSTANTS[53] is kDNA_offTT5a in component CTT5a (first_order_rate_constant). * STATES[24] is CTTcd in component CTTcd (nM). * CONSTANTS[54] is kDNA_onTTcd in component CTTcd (second_order_rate_constant). * CONSTANTS[55] is kDNA_offTTcd in component CTTcd (first_order_rate_constant). * STATES[25] is CTTsec in component CTTsec (nM). * CONSTANTS[56] is kDNA_onTTsec in component CTTsec (second_order_rate_constant). * CONSTANTS[57] is kDNA_offTTsec in component CTTsec (first_order_rate_constant). * STATES[26] is CTTcp in component CTTcp (nM). * CONSTANTS[58] is kDNA_onTTcp in component CTTcp (second_order_rate_constant). * CONSTANTS[59] is kDNA_offTTcp in component CTTcp (first_order_rate_constant). * ALGEBRAIC[7] is T in component CTpf (nM). * CONSTANTS[60] is NTp in component CTpf (dimensionless). * CONSTANTS[61] is CTp in component model_parameters (nM). * ALGEBRAIC[11] is D in component CDpf (nM). * CONSTANTS[62] is NDp in component CDpf (dimensionless). * CONSTANTS[63] is CDp in component model_parameters (nM). * ALGEBRAIC[22] is CR in component CR (nM). * CONSTANTS[64] is CDNAcd in component model_parameters (nM). * CONSTANTS[65] is CDNAsec in component model_parameters (nM). * CONSTANTS[66] is CDNA5a in component model_parameters (nM). * CONSTANTS[67] is CDNAcp in component model_parameters (nM). * ALGEBRAIC[1] is DNAocp in component DNAocp (dimensionless). * ALGEBRAIC[2] is DNAosec in component DNAosec (dimensionless). * ALGEBRAIC[5] is DNAocd in component DNAocd (dimensionless). * ALGEBRAIC[3] is DNAo5a in component DNAo5a (dimensionless). * STATES[27] is ATb in component ATb (nanomole). * CONSTANTS[68] is CTb in component model_parameters (nM). * CONSTANTS[69] is PTb in component model_parameters (dimensionless). * STATES[28] is ADb in component ADb (nanomole). * CONSTANTS[70] is CDb in component model_parameters (nM). * CONSTANTS[71] is PDb in component model_parameters (dimensionless). * STATES[29] is ALH in component ALH (nanomole). * CONSTANTS[72] is kLH1 in component ALH (l_hr). * CONSTANTS[73] is kLH2 in component ALH (nmol_hr). * CONSTANTS[74] is kLH3 in component ALH (nmol_hr). * CONSTANTS[75] is kLH4 in component ALH (first_order_rate_constant). * CONSTANTS[76] is alpha_T in component ALH (dimensionless). * CONSTANTS[77] is alpha_D in component ALH (dimensionless). * ALGEBRAIC[9] is A in component ALH (nmol_hr). * CONSTANTS[91] is B in component ALH (nmol_hr). * STATES[30] is AR in component AR (nanomole). * CONSTANTS[78] is k1R in component AR (nmol_hr). * CONSTANTS[79] is keR in component AR (l_hr). * ALGEBRAIC[21] is Vp in component Vp (litre). * CONSTANTS[80] is kQp in component Qp (first_order_rate_constant). * ALGEBRAIC[13] is Vpc in component Qp (litre). * STATES[31] is VPC1 in component VPC1 (litre). * CONSTANTS[81] is VPC2 in component model_parameters (litre). * ALGEBRAIC[6] is Vmax in component Vmax (nmol_hr). * CONSTANTS[82] is k5a in component Vmax (nmol_hr). * CONSTANTS[83] is kcpl in component VPC1 (kg_hr). * CONSTANTS[84] is kcd1 in component VPC1 (first_order_rate_constant). * CONSTANTS[85] is VPC1b in component model_parameters (kg). * STATES[32] is VPL1 in component VPL1 (litre). * CONSTANTS[86] is ksec in component VPL1 (kg_hr). * CONSTANTS[87] is kflo in component VPL1 (first_order_rate_constant). * CONSTANTS[88] is VPL2 in component model_parameters (litre). * CONSTANTS[89] is Qc in component model_parameters (l_hr). * RATES[0] is d/dt ATbl in component ATbl (nanomole). * RATES[1] is d/dt ADbl in component ADbl (nanomole). * RATES[2] is d/dt CT_A in component CT_A (nM). * RATES[3] is d/dt CD_A in component CD_A (nM). * RATES[4] is d/dt ATl in component ATl (nanomole). * RATES[5] is d/dt ADl in component ADl (nanomole). * RATES[6] is d/dt ATif in component ATif (nanomole). * RATES[7] is d/dt ATst in component ATst (nanomole). * RATES[8] is d/dt ATp in component ATp (nanomole). * RATES[9] is d/dt ADp in component ADp (nanomole). * RATES[10] is d/dt CT_R in component CT_R (nM). * RATES[11] is d/dt CD_R in component CD_R (nM). * RATES[12] is d/dt CDT in component CDT (nM). * RATES[13] is d/dt CDD in component CDD (nM). * RATES[14] is d/dt CTT in component CTT (nM). * RATES[15] is d/dt CDD5a in component CDD5a (nM). * RATES[16] is d/dt CDDcd in component CDDcd (nM). * RATES[17] is d/dt CDDsec in component CDDsec (nM). * RATES[18] is d/dt CDDcp in component CDDcp (nM). * RATES[19] is d/dt CDT5a in component CDT5a (nM). * RATES[20] is d/dt CDTcd in component CDTcd (nM). * RATES[21] is d/dt CDTsec in component CDTsec (nM). * RATES[22] is d/dt CDTcp in component CDTcp (nM). * RATES[23] is d/dt CTT5a in component CTT5a (nM). * RATES[24] is d/dt CTTcd in component CTTcd (nM). * RATES[25] is d/dt CTTsec in component CTTsec (nM). * RATES[26] is d/dt CTTcp in component CTTcp (nM). * RATES[27] is d/dt ATb in component ATb (nanomole). * RATES[28] is d/dt ADb in component ADb (nanomole). * RATES[29] is d/dt ALH in component ALH (nanomole). * RATES[30] is d/dt AR in component AR (nanomole). * RATES[31] is d/dt VPC1 in component VPC1 (litre). * RATES[32] is d/dt VPL1 in component VPL1 (litre). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 0.0; CONSTANTS[0] = 0.17; CONSTANTS[1] = 1.06; CONSTANTS[2] = 0.061; CONSTANTS[3] = 7.60; CONSTANTS[4] = 0.56; STATES[1] = 0.0; CONSTANTS[5] = 0.59; STATES[2] = 0.0; CONSTANTS[6] = 0.18; CONSTANTS[7] = 8131.0; STATES[3] = 0.0; CONSTANTS[8] = 0.15; CONSTANTS[9] = 5407.0; CONSTANTS[10] = 5.00E5; STATES[4] = 0.0; CONSTANTS[11] = 87.93; CONSTANTS[12] = 40.00; CONSTANTS[13] = 3.65; CONSTANTS[14] = 2.75; STATES[5] = 0.0; CONSTANTS[15] = 77.20; CONSTANTS[16] = 2.00; CONSTANTS[17] = 9.92; CONSTANTS[18] = 0.92; STATES[6] = 0.0; CONSTANTS[19] = 1000.0; CONSTANTS[20] = 1.96; CONSTANTS[21] = 307.29; CONSTANTS[22] = 307.29; CONSTANTS[23] = 0.104; CONSTANTS[24] = 1.00; STATES[7] = 0.0; STATES[8] = 0.0; CONSTANTS[25] = 2.89; STATES[9] = 0.0; STATES[10] = 0.0; CONSTANTS[26] = 0.14; CONSTANTS[27] = 0.069; STATES[11] = 0.0; CONSTANTS[28] = 0.053; CONSTANTS[29] = 0.018; STATES[12] = 0.0; CONSTANTS[30] = 0.14; CONSTANTS[31] = 3.13; STATES[13] = 0.0; CONSTANTS[32] = 0.14; CONSTANTS[33] = 3.13; STATES[14] = 0.0; CONSTANTS[34] = 0.14; CONSTANTS[35] = 3.13; STATES[15] = 0.0; CONSTANTS[36] = 0.14; CONSTANTS[37] = 0.07; STATES[16] = 0.0; CONSTANTS[38] = 0.14; CONSTANTS[39] = 0.1; STATES[17] = 0.0; CONSTANTS[40] = 0.14; CONSTANTS[41] = 0.2; STATES[18] = 0.0; CONSTANTS[42] = 0.14; CONSTANTS[43] = 0.7; STATES[19] = 0.0; CONSTANTS[44] = 0.14; CONSTANTS[45] = 0.56; STATES[20] = 0.0; CONSTANTS[46] = 0.14; CONSTANTS[47] = 0.8; STATES[21] = 0.0; CONSTANTS[48] = 0.14; CONSTANTS[49] = 1.6; STATES[22] = 0.0; CONSTANTS[50] = 0.14; CONSTANTS[51] = 5.6; STATES[23] = 0.0; CONSTANTS[52] = 0.14; CONSTANTS[53] = 0.84; STATES[24] = 0.0; CONSTANTS[54] = 0.14; CONSTANTS[55] = 1.2; STATES[25] = 0.0; CONSTANTS[56] = 0.14; CONSTANTS[57] = 2.4; STATES[26] = 0.0; CONSTANTS[58] = 0.14; CONSTANTS[59] = 8.4; CONSTANTS[60] = 0.79; CONSTANTS[61] = 11.38; CONSTANTS[62] = 1.00; CONSTANTS[63] = 52.46; CONSTANTS[64] = 0.075; CONSTANTS[65] = 0.075; CONSTANTS[66] = 0.075; CONSTANTS[67] = 0.075; STATES[27] = 0.0; CONSTANTS[68] = 0.6275; CONSTANTS[69] = 1.00; STATES[28] = 0.0; CONSTANTS[70] = 0.019884; CONSTANTS[71] = 0.62; STATES[29] = 0.0; CONSTANTS[72] = 0.13; CONSTANTS[73] = 0.026; CONSTANTS[74] = 1.68E-4; CONSTANTS[75] = 0.80; CONSTANTS[76] = 0.25; CONSTANTS[77] = 0.75; STATES[30] = 0.0; CONSTANTS[78] = 68.15; CONSTANTS[79] = 71.90; CONSTANTS[80] = 73.84; STATES[31] = 0.0; CONSTANTS[81] = 5.08E-5; CONSTANTS[82] = 3.02; CONSTANTS[83] = 1.17E-7; CONSTANTS[84] = 0.014; CONSTANTS[85] = 1E-4; STATES[32] = 0.0; CONSTANTS[86] = 8.44E-6; CONSTANTS[87] = 0.043; CONSTANTS[88] = 3.08E-6; CONSTANTS[89] = 6.08; CONSTANTS[90] = CONSTANTS[17]/CONSTANTS[14]; CONSTANTS[91] = CONSTANTS[74]; CONSTANTS[96] = CONSTANTS[19]*(CONSTANTS[21] - CONSTANTS[22]/CONSTANTS[24]); CONSTANTS[92] = CONSTANTS[18]/CONSTANTS[16]; CONSTANTS[93] = CONSTANTS[21]/CONSTANTS[20]; CONSTANTS[94] = CONSTANTS[68]/CONSTANTS[69]; CONSTANTS[95] = CONSTANTS[70]/CONSTANTS[71]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { RATES[7] = CONSTANTS[96]; RATES[4] = CONSTANTS[1]*(CONSTANTS[3] - CONSTANTS[90]) - (( CONSTANTS[13]*CONSTANTS[90])/(CONSTANTS[12]+CONSTANTS[90])+ CONSTANTS[11]*(STATES[4]/CONSTANTS[14])); RATES[5] = CONSTANTS[1]*(CONSTANTS[5] - CONSTANTS[92]) - (( CONSTANTS[13]*CONSTANTS[90])/(CONSTANTS[12]+CONSTANTS[90])+ CONSTANTS[15]*(STATES[5]/CONSTANTS[16])); RATES[12] = CONSTANTS[30]*STATES[11]*STATES[10] - CONSTANTS[31]*STATES[12]; RATES[13] = CONSTANTS[32]*pow(STATES[11], 2.00000) - CONSTANTS[33]*STATES[13]; RATES[14] = CONSTANTS[34]*pow(STATES[10], 2.00000) - CONSTANTS[35]*STATES[14]; ALGEBRAIC[0] = CONSTANTS[3] - STATES[2]; RATES[6] = CONSTANTS[2]*(1.00000 - CONSTANTS[4])*(ALGEBRAIC[0] - CONSTANTS[21]/CONSTANTS[20])+ CONSTANTS[19]*(CONSTANTS[22]/CONSTANTS[24] - CONSTANTS[21])+ CONSTANTS[11]*CONSTANTS[23]; ALGEBRAIC[2] = (STATES[25]+STATES[17]+STATES[21])/CONSTANTS[65]; RATES[32] = (STATES[31]/CONSTANTS[85])*CONSTANTS[86]*ALGEBRAIC[2] - CONSTANTS[87]*STATES[32]; ALGEBRAIC[1] = (STATES[26]+STATES[18]+STATES[22])/CONSTANTS[67]; ALGEBRAIC[5] = (STATES[24]+STATES[16]+STATES[20])/CONSTANTS[64]; RATES[31] = (STATES[31]/CONSTANTS[85])*CONSTANTS[83]*ALGEBRAIC[1] - CONSTANTS[84]*(1.00000 - ALGEBRAIC[5])*STATES[31]; ALGEBRAIC[8] = CONSTANTS[10] - (STATES[2]+STATES[3]); RATES[2] = CONSTANTS[6]*ALGEBRAIC[0]*ALGEBRAIC[8] - CONSTANTS[7]*STATES[2]; ALGEBRAIC[4] = CONSTANTS[5] - STATES[3]; RATES[3] = CONSTANTS[8]*ALGEBRAIC[4]*ALGEBRAIC[8] - CONSTANTS[9]*STATES[3]; ALGEBRAIC[9] = - CONSTANTS[72]*( CONSTANTS[76]*ALGEBRAIC[0]+ CONSTANTS[77]*ALGEBRAIC[4])+CONSTANTS[73]; RATES[29] = (ALGEBRAIC[9]>CONSTANTS[91] ? ALGEBRAIC[9] - CONSTANTS[75]*STATES[29] : CONSTANTS[91] - CONSTANTS[75]*STATES[29]); ALGEBRAIC[14] = CONSTANTS[64] - (STATES[24]+STATES[16]+STATES[20]); RATES[16] = CONSTANTS[38]*STATES[13]*ALGEBRAIC[14] - CONSTANTS[39]*STATES[16]; RATES[20] = CONSTANTS[46]*STATES[12]*ALGEBRAIC[14] - CONSTANTS[47]*STATES[20]; RATES[24] = CONSTANTS[54]*STATES[14]*ALGEBRAIC[14] - CONSTANTS[55]*STATES[24]; ALGEBRAIC[13] = STATES[31]+CONSTANTS[81]; ALGEBRAIC[15] = CONSTANTS[80]*ALGEBRAIC[13]; ALGEBRAIC[7] = STATES[25]+STATES[21]+STATES[23]+STATES[19]+STATES[24]+STATES[20]+STATES[26]+STATES[22]; ALGEBRAIC[10] = (CONSTANTS[61] - (STATES[10]+ 2.00000*STATES[14]+STATES[12]+ALGEBRAIC[7]))/(1.00000+CONSTANTS[60]); RATES[8] = ALGEBRAIC[15]*(CONSTANTS[3] - ALGEBRAIC[10]) - ( CONSTANTS[25]*ALGEBRAIC[10])/(CONSTANTS[12]+ALGEBRAIC[10]); ALGEBRAIC[11] = STATES[17]+STATES[21]+STATES[15]+STATES[19]+STATES[16]+STATES[20]+STATES[18]+STATES[22]; ALGEBRAIC[12] = (CONSTANTS[63] - (STATES[11]+ 2.00000*STATES[13]+STATES[12]+ALGEBRAIC[11]))/(1.00000+CONSTANTS[62]); RATES[9] = ALGEBRAIC[15]*(CONSTANTS[5] - ALGEBRAIC[12]) - ( CONSTANTS[25]*ALGEBRAIC[10])/(CONSTANTS[12]+ALGEBRAIC[10]); ALGEBRAIC[16] = CONSTANTS[65] - (STATES[25]+STATES[17]+STATES[21]); RATES[17] = CONSTANTS[40]*STATES[13]*ALGEBRAIC[16] - CONSTANTS[41]*STATES[17]; RATES[21] = CONSTANTS[48]*STATES[12]*ALGEBRAIC[16] - CONSTANTS[49]*STATES[21]; RATES[25] = CONSTANTS[56]*STATES[14]*ALGEBRAIC[16] - CONSTANTS[57]*STATES[25]; ALGEBRAIC[17] = CONSTANTS[89] - (ALGEBRAIC[15]+CONSTANTS[2]+CONSTANTS[1]); RATES[0] = ALGEBRAIC[17]*(CONSTANTS[94] - ALGEBRAIC[0])+ ALGEBRAIC[15]*(ALGEBRAIC[10] - CONSTANTS[3])+ CONSTANTS[1]*(CONSTANTS[90] - CONSTANTS[3])+ CONSTANTS[2]*(1.00000 - CONSTANTS[4])*(CONSTANTS[93] - ALGEBRAIC[0])+CONSTANTS[0]; ALGEBRAIC[18] = CONSTANTS[89] - (ALGEBRAIC[15]+CONSTANTS[1]); RATES[1] = ALGEBRAIC[18]*(CONSTANTS[95] - ALGEBRAIC[4])+ ALGEBRAIC[15]*(ALGEBRAIC[12] - ALGEBRAIC[4])+ CONSTANTS[1]*(CONSTANTS[92] - CONSTANTS[5]); ALGEBRAIC[19] = CONSTANTS[66] - (STATES[23]+STATES[15]+STATES[19]); RATES[15] = CONSTANTS[36]*STATES[13]*ALGEBRAIC[19] - CONSTANTS[37]*STATES[15]; RATES[19] = CONSTANTS[44]*STATES[12]*ALGEBRAIC[19] - CONSTANTS[45]*STATES[19]; RATES[23] = CONSTANTS[52]*STATES[14]*ALGEBRAIC[19] - CONSTANTS[53]*STATES[23]; RATES[27] = ALGEBRAIC[17]*(ALGEBRAIC[0] - CONSTANTS[68]/CONSTANTS[69]); RATES[28] = ALGEBRAIC[18]*(ALGEBRAIC[4] - CONSTANTS[70]/CONSTANTS[71]); ALGEBRAIC[20] = CONSTANTS[67] - (STATES[26]+STATES[18]+STATES[22]); RATES[18] = CONSTANTS[42]*STATES[13]*ALGEBRAIC[20] - CONSTANTS[43]*STATES[18]; RATES[22] = CONSTANTS[50]*STATES[12]*ALGEBRAIC[20] - CONSTANTS[51]*STATES[22]; RATES[26] = CONSTANTS[58]*STATES[14]*ALGEBRAIC[20] - CONSTANTS[59]*STATES[26]; ALGEBRAIC[21] = STATES[31]+CONSTANTS[81]+STATES[32]+CONSTANTS[88]; ALGEBRAIC[22] = STATES[30]/ALGEBRAIC[21]; ALGEBRAIC[23] = ALGEBRAIC[22] - (STATES[10]+STATES[11]+ 2.00000*(STATES[14]+STATES[13]+STATES[12])+ 2.00000*(ALGEBRAIC[14]+ALGEBRAIC[16]+ALGEBRAIC[20]+ALGEBRAIC[19])); RATES[10] = CONSTANTS[26]*ALGEBRAIC[10]*ALGEBRAIC[23] - CONSTANTS[27]*STATES[10]; RATES[11] = CONSTANTS[28]*ALGEBRAIC[12]*ALGEBRAIC[23] - CONSTANTS[29]*STATES[11]; RATES[30] = CONSTANTS[78] - CONSTANTS[79]*ALGEBRAIC[23]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[3] - STATES[2]; ALGEBRAIC[2] = (STATES[25]+STATES[17]+STATES[21])/CONSTANTS[65]; ALGEBRAIC[1] = (STATES[26]+STATES[18]+STATES[22])/CONSTANTS[67]; ALGEBRAIC[5] = (STATES[24]+STATES[16]+STATES[20])/CONSTANTS[64]; ALGEBRAIC[8] = CONSTANTS[10] - (STATES[2]+STATES[3]); ALGEBRAIC[4] = CONSTANTS[5] - STATES[3]; ALGEBRAIC[9] = - CONSTANTS[72]*( CONSTANTS[76]*ALGEBRAIC[0]+ CONSTANTS[77]*ALGEBRAIC[4])+CONSTANTS[73]; ALGEBRAIC[14] = CONSTANTS[64] - (STATES[24]+STATES[16]+STATES[20]); ALGEBRAIC[13] = STATES[31]+CONSTANTS[81]; ALGEBRAIC[15] = CONSTANTS[80]*ALGEBRAIC[13]; ALGEBRAIC[7] = STATES[25]+STATES[21]+STATES[23]+STATES[19]+STATES[24]+STATES[20]+STATES[26]+STATES[22]; ALGEBRAIC[10] = (CONSTANTS[61] - (STATES[10]+ 2.00000*STATES[14]+STATES[12]+ALGEBRAIC[7]))/(1.00000+CONSTANTS[60]); ALGEBRAIC[11] = STATES[17]+STATES[21]+STATES[15]+STATES[19]+STATES[16]+STATES[20]+STATES[18]+STATES[22]; ALGEBRAIC[12] = (CONSTANTS[63] - (STATES[11]+ 2.00000*STATES[13]+STATES[12]+ALGEBRAIC[11]))/(1.00000+CONSTANTS[62]); ALGEBRAIC[16] = CONSTANTS[65] - (STATES[25]+STATES[17]+STATES[21]); ALGEBRAIC[17] = CONSTANTS[89] - (ALGEBRAIC[15]+CONSTANTS[2]+CONSTANTS[1]); ALGEBRAIC[18] = CONSTANTS[89] - (ALGEBRAIC[15]+CONSTANTS[1]); ALGEBRAIC[19] = CONSTANTS[66] - (STATES[23]+STATES[15]+STATES[19]); ALGEBRAIC[20] = CONSTANTS[67] - (STATES[26]+STATES[18]+STATES[22]); ALGEBRAIC[21] = STATES[31]+CONSTANTS[81]+STATES[32]+CONSTANTS[88]; ALGEBRAIC[22] = STATES[30]/ALGEBRAIC[21]; ALGEBRAIC[23] = ALGEBRAIC[22] - (STATES[10]+STATES[11]+ 2.00000*(STATES[14]+STATES[13]+STATES[12])+ 2.00000*(ALGEBRAIC[14]+ALGEBRAIC[16]+ALGEBRAIC[20]+ALGEBRAIC[19])); ALGEBRAIC[3] = (STATES[23]+STATES[15]+STATES[19])/CONSTANTS[66]; ALGEBRAIC[6] = CONSTANTS[82]*ALGEBRAIC[3]; }