Model Mathematics

Component: environment

addbuffer=Par_97 pHstat=Par_98 pH_cy=pH_calciftime1time>1addbuffer=0pHstatotherwise

Component: global_parameters

T=Par_94 I=Par_90

Component: parameters

Par_1=1.95 e -2 Par_2=0.002 Par_3=1.7 e -3 Par_4=4 e -3 Par_5=2 e -3 Par_6=4.7 e -3 Par_7=1.5 e -4 Par_8=2.7 e -3 Par_9=1.01 e -2 Par_10=2 e -4 Par_11=4.6 e -3 Par_12=1.5 e -2 Par_13=1.5 e -3 Par_14=7.4 e -3 Par_15=4.4 e -3 Par_16=0.00266054976219 Par_17=2 e -2 Par_18=1.7505240494613 Par_19=1.94.8 e -1 Par_20=6.3 e -5 Par_21=3 e -5 Par_22=1.98.8 e -1 Par_23=4.8 e -4 Par_24=1.19 e -4 Par_25=1.95.6 e -2 Par_26=1.8 e -4 Par_27=2 e -2 Par_28=8 e -5 Par_29=2.5 e -4 Par_30=4.02 e -3 Par_31=4.02 e -3 Par_32=2.7 e -3 Par_33=2.7 e -3 Par_34=8.7 e -4 Par_35=6 e -5 Par_36=1 e -2 Par_37=1 e -2 Par_38=13 Par_39=1.90.01065914307349 Par_40=5 e -5 Par_41=2 e -3 Par_42=1 e -3 Par_43=1.912 Par_44=3.2 e -4 Par_45=6.1 e -4 Par_46=1.98.25 e -2 Par_47=1.8 e -4 Par_48=1.2 e -5 Par_49=2.2 e -4 Par_50=8 e -6 Par_51=1.91.265 e 0 Par_52=2.5 e -6 Par_53=9 e -5 Par_54=2.9 e -4 Par_55=8 e -7 Par_56=3.3 e -6 Par_57=1.91.12 e 0 Par_58=2 e -3 Par_59=8 e -6 Par_60=1.2 e -3 Par_61=3.5 e -4 Par_62=1.91.12 e 0 Par_63=2 e -4 Par_64=1.4 e -5 Par_65=1.91.92 e -1 Par_66=1 e -4 Par_67=3.7 e -4 Par_68=1.91.44 e 0 Par_69=8 e -5 Par_70=3 e -4 Par_71=7.05 e -3 Par_72=1.13 e -3 Par_73=1.91.92 e 0 Par_74=3.35 e -4 Par_75=2 e -6 Par_76=1.7 e -2 Par_77=8.49 e -4 Par_78=1.95 e -1 Par_79=1.11 e -3 Par_80=3.5 e -3 Par_81=1.35 e -4 Par_82=3.9 e -3 Par_83=3.8 e -3 Par_84=1.98.8 e -1 Par_85=3.2 e -4 Par_86=2.7 e -4 Par_87=3.5 e -4 Par_88=5 e -3 Par_89=1 e -4 Par_90=1 e -1 Par_91=1.5 e -2 Par_92=2.5 e -2 Par_93=1 e -2 Par_94=310.15 Par_95=0.005 Par_96=0.08 Par_97=1 Par_98=7.3 Par_99=0 Par_100=45

Component: equilibrium_constants

mgT=Par_95 k=Par_96 c0=1

Component: correction_factors

RT2dadT=1.4775 B=1.6 Icorr=RT2dadTI1+BI I1=0.1 alphadebye=1.17582 IcorrpKa=1alphadebyeI11+BI1-I1+BIln10 TcorrpKa=1T-1T1ln10R RTalpha=2.91482 IcorrdeltaGpof=RTalphaI1+BI pKak_Pi=0.5 deltaH1o_Pi=3 deltaHmgo_Pi=-2.9 deltaH1_Pi=deltaH1o_Pi+Icorr22+12-12 deltaHmg_Pi=deltaHmgo_Pi+Icorr22+22-02 pKa1_Pi=6.75+IcorrpKa122+12-12+TcorrpKadeltaH1_Pi pKamg_Pi=1.65+IcorrpKa122+12-12+TcorrpKadeltaHmg_Pi P_Pi=1+10-pH_cy+pKa1_Pi+mgc010pKamg_Pi+kc010pKak_Pi HPi2=1P_Pi H2Pi1=10-pH_cy+pKa1_PiHPi2 kPi=kc010pKak_PiHPi2 mgPi=mgc010pKamg_PiHPi2 Navg_Pi=1H2Pi1 dNavgPidH=10pKa1_PiP_Pi-10-pH_cy+pKa1_Pic0P_Pi2 dNavgPidmg=-10-pH_cyc010pKa1_Pi+pKamg_PiP_Pi2 dmgPidmg=P_Pi10pKamg_Pic0-mgc0102pKamg_Pic0P_Pi2 dmgPidpH=mgc010-pH_cy+pKa1_Pi+pKamg_Piln10P_Pi2 NH_HPi2=1 deltaGof_HPi2=-1096.1 deltaGpof_HPi2=deltaGof_HPi2+NH_HPi2ln10RTpH_cy-IcorrdeltaGpof4-NH_HPi2 deltaH1o_ATP=-5 deltaHmgo_ATP=-18 deltaHko_ATP=-1 deltaH1_ATP=deltaH1o_ATP+Icorr42+12-32 deltaHmg_ATP=deltaHmgo_ATP+Icorr42+22-22 deltaHk_ATP=deltaHko_ATP+Icorr42+12-32 pKa1_ATP=6.48+IcorrpKa142+12-32+TcorrpKadeltaH1_ATP pKamg_ATP=4.19+IcorrpKa142+22-22+TcorrpKadeltaHmg_ATP pKak_ATP=1.17+IcorrpKa142+12-32+TcorrpKadeltaHk_ATP P_ATP=1+10-pH_cy+pKa1_ATP+mgc010pKamg_ATP+kc010pKak_ATP ATP4=1P_ATP HATP3=10-pH_cy+pKa1_ATPATP4 mgATP2=mgc010pKamg_ATPATP4 kATP=kc010pKak_ATPATP4 Navg_ATP=0ATP4+1HATP3+0mgATP2+0kATP dNavgATPdH=10pKa1_ATPP_ATP-10-pH_cy+pKa1_ATPc0P_ATP2 dNavgATPdmg=-10-pH_cyc010pKa1_ATP+pKamg_ATPP_ATP2 dmgATP2dmg=P_ATP10pKamg_ATPc0-mgc0102pKamg_ATPc0P_ATP2 dmgATP2dpH=mgc010-pH_cy+pKa1_ATP+pKamg_ATPln10P_ATP2 NH_ATP4=12 deltaGof_ATP4=-2768.1 deltaGpof_ATP4=deltaGof_ATP4+NH_ATP4RTln10pH_cy-IcorrdeltaGpof16-NH_ATP4 pKak_ADP=1 deltaH1o_ADP=-3 deltaHmgo_ADP=-15 deltaH1_ADP=deltaH1o_ADP+Icorr32+12-22 deltaHmg_ADP=deltaHmgo_ADP+Icorr32+22-12 pKa1_ADP=6.38+IcorrpKa132+12-22+TcorrpKadeltaH1_ADP pKamg_ADP=3.25+IcorrpKa132+22-12+TcorrpKadeltaHmg_ADP P_ADP=1+10-pH_cy+pKa1_ADP+mgc010pKamg_ADP+kc010pKak_ADP ADP3=1P_ADP HADP2=10-pH_cy+pKa1_ADPADP3 mgADP=ADP3mgc010pKamg_ADP kADP=ADP3kc010pKak_ADP Navg_ADP=0ADP3+1HADP2+0mgADP+0kADP dNavgADPdH=10pKa1_ADPP_ADP-10-pH_cy+pKa1_ADPc0P_ADP2 dNavgADPdmg=-10-pH_cyc010pKa1_ADP+pKamg_ADPP_ADP2 dmgADPdmg=P_ADP10pKamg_ADPc0-mgc0102pKamg_ADPc0P_ADP2 dmgADPdpH=mgc010-pH_cy+pKa1_ADP+pKamg_ADPln10P_ADP2 NH_ADP3=12 deltaGof_ADP3=-1906.13 deltaGpof_ADP3=deltaGof_ADP3+NH_ADP3RTln10pH_cy-IcorrdeltaGpof9-NH_ADP3 deltaH1o_AMP=-3 deltaHmgo_AMP=-7.5 deltaH1_AMP=deltaH1o_AMP+Icorr22+12-12 deltaHmg_AMP=deltaHmgo_AMP+Icorr22+22-02 pKa1_AMP=6.29+IcorrpKa122+12-12+TcorrpKadeltaH1_AMP pKamg_AMP=1.92+IcorrpKa122+22-02+TcorrpKadeltaHmg_AMP P_AMP=1+10pKa1_AMP-pH_cy+mgc010pKamg_AMP AMP2=1P_AMP HAMP1=AMP210pKa1_AMP-pH_cy mgAMP=mgc010pKamg_AMPAMP2 Navg_AMP=0AMP2+HAMP1+0mgAMP dNavgAMPdH=10pKa1_AMPP_AMP-10-pH_cy+pKa1_AMPc0P_AMP2 dNavgAMPdmg=-10-pH_cyc010pKa1_AMP+pKamg_AMPP_AMP2 dmgAMPdmg=P_AMP10pKamg_AMPc0-mgc0102pKamg_AMPc0P_AMP2 dmgAMPdpH=mgc010-pH_cy+pKa1_AMP+pKamg_AMPln10P_AMP2 NH_AMP2=12 deltaGof_AMP2=-1040.45 deltaGpof_AMP2=deltaGof_AMP2+NH_AMP2ln10RTpH_cy-IcorrdeltaGpof4-NH_AMP2 pKak_PCR=0.31 deltaH1o_PCR=2.66 deltaHmgo_PCR=8.19 deltaH1_PCR=deltaH1o_PCR+Icorr22+12-12 deltaHmg_PCR=deltaHmgo_PCR+Icorr22+22-02 pKa1_PCR=4.5+IcorrpKa122+12-12+TcorrpKadeltaH1_PCR pKamg_PCR=1.6+IcorrpKa122+22-02+TcorrpKadeltaHmg_PCR P_PCR=1+10-pH_cy+pKa1_PCR+mgc010pKamg_PCR+kc010pKak_PCR HPCR=1P_PCR H2PCR=10-pH_cy+pKa1_PCRHPCR kPCR=kc010pKak_PCRHPCR mgPCR=mgc010pKamg_PCRHPCR Navg_PCR=H2PCR dNavgPCRdH=10pKa1_PCRP_PCR-10-pH_cy+pKa1_PCRc0P_PCR2 dNavgPCRdmg=-10-pH_cyc010pKa1_PCR+pKamg_PCRP_PCR2 dmgPCRdmg=P_PCR10pKamg_PCRc0-mgc0102pKamg_PCRc0P_PCR2 dmgPCRdpH=mgc010-pH_cy+pKa1_PCR+pKamg_PCRln10P_PCR2 NH_HPCR=8 pKa1_CR=2.3 P_CR=1+10-pH_cy+pKa1_CR HCR=1P_CR H2CR=HCR10-pH_cy+pKa1_CR Navg_CR=0HCR+1H2CR dNavgCRdH=10pKa1_CRP_CR-10-pH_cy+pKa1_CRc0P_CR2 dNavgCRdmg=0 NH_HCR=9 deltaH1o_G1P=-1.7 deltaHmgo_G1P=-12 deltaH1_G1P=deltaH1o_G1P+Icorr22+12-12 deltaHmg_G1P=deltaHmgo_G1P+Icorr22+22-02 pKa1_G1P=6.09+IcorrpKa122+12-12+TcorrpKadeltaH1_G1P pKamg_G1P=2.48+IcorrpKa122+22-02+TcorrpKadeltaHmg_G1P P_G1P=1+10-pH_cy10pKa1_G1P+mgc010pKamg_G1P UG1P=1P_G1P HG1P=UG1P10-pH_cy+pKa1_G1P mgG1P=UG1Pmgc010pKamg_G1P Navg_G1P=HG1P dNavgG1PdH=10pKa1_G1PP_G1P-10-pH_cy+pKa1_G1Pc0P_G1P2 dNavgG1Pdmg=-10-pH_cyc010pKa1_G1P+pKamg_G1PP_G1P2 dmgG1Pdmg=P_G1P10pKamg_G1Pc0-mgc0102pKamg_G1Pc0P_G1P2 dmgG1PdpH=mgc010-pH_cy+pKa1_G1P+pKamg_G1Pln10P_G1P2 NH_UG1P=11 deltaGof_UG1P=-1756.87 deltaGpof_UG1P=deltaGof_UG1P+NH_UG1Pln10RTpH_cy-IcorrdeltaGpof4-NH_UG1P pKa1_G6P=6.11 P_G6P=1+10-pH_cy+pKa1_G6P UG6P=1P_G6P HG6P=UG6P10-pH_cy+pKa1_G6P Navg_G6P=HG6P dNavgG6PdH=10pKa1_G6PP_G6P-10-pH_cy+pKa1_G6Pc0P_G6P2 dNavgG6Pdmg=0 NH_UG6P=11 deltaGof_UG6P=-1763.94 deltaGpof_UG6P=deltaGof_UG6P+NH_UG6Pln10RTpH_cy-IcorrdeltaGpof4-NH_UG6P pKa1_F6P=5.89 P_F6P=1+10-pH_cy+pKa1_F6P UF6P=1P_F6P HF6P=UF6P10-pH_cy+pKa1_F6P Navg_F6P=HF6P dNavgF6PdH=10pKa1_F6PP_F6P-10-pH_cy+pKa1_F6Pc0P_F6P2 dNavgF6Pdmg=0 NH_UF6P=11 deltaGof_UF6P=-1760.8 deltaGpof_UF6P=deltaGof_UF6P+NH_UF6Pln10RTpH_cy-IcorrdeltaGpof4-NH_UF6P pKa1_FDP=6.4 pKa2_FDP=5.92 pKamg_FDP=2.7 P_FDP=1+10-pH_cy+pKa1_FDP+10-2pH_cy+pKa1_FDP+pKa2_FDP+mgc010pKamg_FDP UFDP=1P_FDP HFDP=UFDP10-pH_cy+pKa1_FDP H2FDP=UFDP10-2pH_cy+pKa1_FDP+pKa2_FDP mgFDP=UFDPmgc010pKamg_FDP Navg_FDP=HFDP+2H2FDP dNavgFDPdH=P_FDP10pKa1_FDP+210-pH_cy+pKa1_FDP+pKa2_FDP-10-pH_cy+pKa1_FDP+210-2pH_cy+pKa1_FDP+pKa2_FDP10pKa1_FDP+210-pH_cy+pKa1_FDP+pKa2_FDPc0P_FDP2 dNavgFDPdmg=-10-pH_cy+pKa1_FDP+210-2pH_cy+pKa1_FDP+pKa2_FDP10pKamg_FDPc0P_FDP2 dmgFDPdmg=P_FDP10pKamg_FDPc0-mgc0102pKamg_FDPc0P_FDP2 dmgFDPdpH=mgc010pKamg_FDPP_FDP10-pH_cy+pKa1_FDPln10-10-2pH_cy+pKa1_FDP+pKa2_FDP2ln10P_FDP2 NH_UFDP=10 deltaGof_UFDP=-2601.4 deltaGpof_UFDP=deltaGof_UFDP+NH_UFDPln10RTpH_cy-IcorrdeltaGpof16-NH_UFDP pKa1_GAP=6.45 P_GAP=1+10-pH_cy+pKa1_GAP UGAP=1P_GAP HGAP=UGAP10-pH_cy+pKa1_GAP Navg_GAP=HGAP dNavgGAPdH=10pKa1_GAPP_GAP-10-pH_cy+pKa1_GAPc0P_GAP2 dNavgGAPdmg=0 NH_UGAP=5 deltaGof_UGAP=-1288.6 deltaGpof_UGAP=deltaGof_UGAP+NH_UGAPln10RTpH_cy-IcorrdeltaGpof4-NH_UGAP pKamg_G3P=1.63 deltaH1o_G3P=-3.1 deltaH1_G3P=deltaH1o_G3P+Icorr22+12-12 pKa1_G3P=6.22+IcorrpKa122+12-12+TcorrpKadeltaH1_G3P P_G3P=1+10-pH_cy+pKa1_G3P+mgc010pKamg_G3P UG3P=1P_G3P HG3P=UG3P10-pH_cy+pKa1_G3P mgG3P=UG3Pmgc010pKamg_G3P Navg_G3P=HG3P dNavgG3PdH=10pKa1_G3PP_G3P-10-pH_cy+pKa1_G3Pc0P_G3P2 dNavgG3Pdmg=-10-pH_cyc010pKa1_G3P+pKamg_G3PP_G3P2 dmgG3Pdmg=P_G3P10pKamg_G3Pc0-mgc0102pKamg_G3Pc0P_G3P2 dmgG3PdpH=mgc010-pH_cy+pKa1_G3P+pKamg_G3Pln10P_G3P2 NH_UG3P=7 deltaGof_UG3P=-1339.25 deltaGpof_UG3P=deltaGof_UG3P+NH_UG3Pln10RTpH_cy-IcorrdeltaGpof4-NH_UG3P pKa1_DHAP=5.9 pKamg_DHAP=1.57 P_DHAP=1+10-pH_cy+pKa1_DHAP+mgc010pKamg_DHAP UDHAP=1P_DHAP HDHAP=UDHAP10-pH_cy+pKa1_DHAP mgDHAP=UDHAPmgc010pKamg_DHAP Navg_DHAP=HDHAP dNavgDHAPdH=10pKa1_DHAPP_DHAP-10-pH_cy+pKa1_DHAPc0P_DHAP2 dNavgDHAPdmg=-10-pH_cyc010pKa1_DHAP+pKamg_DHAPP_DHAP2 dmgDHAPdmg=P_DHAP10pKamg_DHAPc0-mgc0102pKamg_DHAPc0P_DHAP2 dmgDHAPdpH=mgc010-pH_cy+pKa1_DHAP+pKamg_DHAPln10P_DHAP2 NH_UDHAP=5 deltaGof_UDHAP=-1296.26 deltaGpof_UDHAP=deltaGof_UDHAP+NH_UDHAPln10RTpH_cy-IcorrdeltaGpof4-NH_UDHAP pKa1_13DPG=7.5 P_13DPG=1+10-pH_cy+pKa1_13DPG U13DPG=1P_13DPG H13DPG=U13DPG10-pH_cy+pKa1_13DPG Navg_13DPG=H13DPG dNavg13DPGdH=10pKa1_13DPGP_13DPG-10-pH_cy+pKa1_13DPGc0P_13DPG2 dNavg13DPGdmg=0 NH_U13DPG=4 deltaGof_U13DPG=-2356.14 deltaGpof_U13DPG=deltaGof_U13DPG+NH_U13DPGln10RTpH_cy-IcorrdeltaGpof16-NH_U13DPG pKa1_3PG=6.21 P_3PG=1+10-pH_cy+6.21 U3PG=1P_3PG H3PG=U3PG10-pH_cy+6.21 Navg_3PG=H3PG dNavg3PGdH=10pKa1_3PGP_3PG-10-pH_cy+pKa1_3PGc0P_3PG2 dNavg3PGdmg=0 NH_U3PG=4 deltaGof_U3PG=-1502.54 deltaGpof_U3PG=deltaGof_U3PG+NH_U3PGln10RTpH_cy-IcorrdeltaGpof9-NH_U3PG pKa1_2PG=7 pKamg_2PG=2.45 pKak_2PG=1.18 P_2PG=1+10-pH_cy+pKa1_2PG+mgc010pKamg_2PG+kc010pKak_2PG U2PG=1P_2PG H2PG=U2PG10-pH_cy+pKa1_2PG mg2PG=U2PGmgc010pKamg_2PG k2PG=U2PGkc010pKak_2PG Navg_2PG=H2PG dNavg2PGdH=10pKa1_2PGP_2PG-10-pH_cy+pKa1_2PGc0P_2PG2 dNavg2PGdmg=-10-pH_cyc010pKa1_2PG+pKamg_2PGP_2PG2 dmg2PGdmg=P_2PG10pKamg_2PGc0-mgc0102pKamg_2PGc0P_2PG2 dmg2PGdpH=mgc010-pH_cy+pKa1_2PG+pKamg_2PGln10P_2PG2 NH_U2PG=4 deltaGof_U2PG=-1496.38 deltaGpof_U2PG=deltaGof_U2PG+NH_U2PGln10RTpH_cy-IcorrdeltaGpof9-NH_U2PG pKa1_PEP=6.35 pKamg_PEP=2.26 pKak_PEP=1.08 P_PEP=1+10pKa1_PEP-pH_cy+mgc010pKamg_PEP+kc010pKak_PEP UPEP=1P_PEP HPEP=UPEP10pKa1_PEP-pH_cy kPEP=UPEPkc010pKak_PEP mgPEP=UPEPmgc010pKamg_PEP Navg_PEP=HPEP dNavgPEPdH=10pKa1_PEPP_PEP-10-pH_cy+pKa1_PEPc0P_PEP2 dNavgPEPdmg=-10-pH_cyc010pKa1_PEP+pKamg_PEPP_PEP2 dmgPEPdmg=P_PEP10pKamg_PEPc0-mgc0102pKamg_PEPc0P_PEP2 dmgPEPdpH=mgc010-pH_cy+pKa1_PEP+pKamg_PEPln10P_PEP2 NH_UPEP=2 deltaGof_UPEP=-1263.65 deltaGpof_UPEP=deltaGof_UPEP+NH_UPEPln10RTpH_cy-IcorrdeltaGpof9-NH_UPEP pKa1_PYR=2.49 P_PYR=1+10-pH_cy+pKa1_PYR UPYR=1P_PYR HPYR=UPYR10-pH_cy+pKa1_PYR Navg_PYR=HPYR dNavgPYRdH=10pKa1_PYRP_PYR-10-pH_cy+pKa1_PYRc0P_PYR2 dNavgPYRdmg=0 NH_UPYR=3 deltaGof_UPYR=-472.27 deltaGpof_UPYR=deltaGof_UPYR+NH_UPYRln10RTpH_cy-IcorrdeltaGpof1-NH_UPYR pKamg_LAC=0.98 deltaH1o_LAC=-0.33 deltaH1_LAC=deltaH1o_LAC+Icorr12+12-02 pKa1_LAC=3.67+IcorrpKa112+12-02+TcorrpKadeltaH1_LAC P_LAC=1+10-pH_cy+pKa1_LAC+mgc010pKamg_LAC ULAC=1P_LAC HLAC=ULAC10-pH_cy+pKa1_LAC mgLAC=mgc010pKamg_LACULAC Navg_LAC=HLAC dNavgLACdH=10pKa1_LACP_LAC-10-pH_cy+pKa1_LACc0P_LAC2 dNavgLACdmg=-10-pH_cyc010pKa1_LAC+pKamg_LACP_LAC2 dmgLACdmg=P_LAC10pKamg_LACc0-mgc0102pKamg_LACc0P_LAC2 dmgLACdpH=mgc010-pH_cy+pKa1_LAC+pKamg_LACln10P_LAC2 NH_ULAC=5 deltaGof_ULAC=-516.72 deltaGpof_ULAC=deltaGof_ULAC+NH_ULACln10RTpH_cy-IcorrdeltaGpof1-NH_ULAC dNH_GLY=-10 deltaGpo_GLY=655.7+dNH_GLYln10RTpH_cy NH_NAD=26 deltaGof_NAD=0 deltaGpof_NAD=deltaGof_NAD+NH_NADln10RTpH_cy-IcorrdeltaGpof1-NH_NAD NH_NADH=27 deltaGof_NADH=22.65 deltaGpof_NADH=deltaGof_NADH+NH_NADHln10RTpH_cy-IcorrdeltaGpof4-NH_NADH NH_H2O=2 deltaGof_H2O=-237.19 deltaGpof_H2O=deltaGof_H2O+NH_H2Oln10RTpH_cy-IcorrdeltaGpof0-NH_H2O NH_H=1 deltaGof_H=0 deltaGpof_H=deltaGof_H+NH_Hln10RTpH_cy deltaH_CK=Navg_ATP+Navg_CR-Navg_PCR-Navg_ADP+NH_ATP4+NH_HCR-NH_HPCR-NH_ADP3 Kref_CK=2.58 e 8 deltaHo_CKo=-17.55 deltaH1_CK=deltaHo_CKo+Icorr22+32+12-42-02 Kref_CKI=lnKref_CK+alphadebyeI22+32+12-42-021+BI Kref_CKT=10log10Kref_CKI-TcorrpKadeltaH1_CK deltaGpo_CK=-RTlnKref_CKT Kapp_CK=-deltaGpo_CKRT10-pH_cyP_ATPP_CRP_PCRP_ADP deltaH_ADK=2Navg_ADP-Navg_ATP-Navg_AMP+2NH_ADP3-NH_ATP4-NH_AMP2 deltaGpo_ADK=2deltaGpof_ADP3-deltaGpof_ATP4-deltaGpof_AMP2 Kapp_ADK=-deltaGpo_ADKRTP_ADP2P_ATPP_AMP deltaH_GP=Navg_G1P-Navg_Pi+1-NH_HPi2 deltaGpo_GP=deltaGpo_GLY+deltaGpof_UG1P-deltaGpof_HPi2 Kapp_GP=-deltaGpo_GPRTP_G1PP_Pi deltaH_PGLM=Navg_G6P-Navg_G1P+NH_UG6P-NH_UG1P deltaGpo_PGLM=deltaGpof_UG6P-deltaGpof_UG1P Kapp_PGLM=-deltaGpo_PGLMRTP_G6PP_G1P deltaH_PGI=Navg_F6P-Navg_G6P+NH_UF6P-NH_UG6P deltaGpo_PGI=deltaGpof_UF6P-deltaGpof_UG6P Kapp_PGI=-deltaGpo_PGIRTP_F6PP_G6P deltaH_PFK=Navg_ADP+Navg_FDP-Navg_F6P-Navg_ATP+NH_ADP3+NH_UFDP-NH_UF6P-NH_ATP4 deltaGpo_PFK=deltaGpof_UFDP+deltaGpof_ADP3+deltaGpof_H-deltaGpof_UF6P-deltaGpof_ATP4 Kapp_PFK=-deltaGpo_PFKRTP_FDPP_ADPP_F6PP_ATP10-pH_cy deltaH_ALD=Navg_DHAP+Navg_GAP-Navg_FDP+NH_UDHAP+NH_UGAP-NH_UFDP deltaGpo_ALD=deltaGpof_UDHAP+deltaGpof_UGAP-deltaGpof_UFDP Kapp_ALD=1-deltaGpo_ALDRTP_GAPP_FDPP_DHAP deltaH_TPI=Navg_DHAP-Navg_GAP+NH_UDHAP-NH_UGAP deltaGpo_TPI=deltaGpof_UDHAP-deltaGpof_UGAP Kapp_TPI=-deltaGpo_TPIRTP_DHAPP_GAP deltaH_GAPDH=Navg_13DPG-Navg_GAP-Navg_Pi+NH_U13DPG+NH_NADH-NH_UGAP-NH_HPi2-NH_NAD deltaGpo_GAPDH=deltaGpof_U13DPG+deltaGpof_NADH+deltaGpof_H-deltaGpof_HPi2-deltaGpof_UGAP-deltaGpof_NAD Kapp_GAPDH=-deltaGpo_GAPDHRTP_13DPGP_PiP_GAP10-pH_cy1 deltaH_G3PDH=Navg_DHAP-Navg_G3P+NH_UDHAP+NH_NADH-NH_NAD-NH_UG3P deltaGpo_G3PDH=deltaGpof_H+deltaGpof_NADH+deltaGpof_UDHAP-deltaGpof_NAD-deltaGpof_UG3P Kapp_G3PDH=-deltaGpo_G3PDHRTP_DHAPP_G3P10-pH_cy deltaH_PGK=Navg_3PG+Navg_ATP-Navg_13DPG-Navg_ADP+NH_U3PG+NH_ATP4-NH_U13DPG-NH_ADP3 deltaGpo_PGK=deltaGpof_ATP4+deltaGpof_U3PG-deltaGpof_U13DPG-deltaGpof_ADP3 Kapp_PGK=-deltaGpo_PGKRTP_ATPP_3PGP_13DPGP_ADP deltaH_PGM=Navg_2PG-Navg_3PG+NH_U2PG-NH_U3PG deltaGpo_PGM=deltaGpof_U2PG-deltaGpof_U3PG Kapp_PGM=-deltaGpo_PGMRTP_2PGP_3PG deltaH_ENOL=Navg_PEP-Navg_2PG+NH_H2O+NH_UPEP-NH_U2PG deltaGpo_ENOL=deltaGpof_H2O+deltaGpof_UPEP-deltaGpof_U2PG Kapp_ENOL=-deltaGpo_ENOLRTP_PEPP_2PG deltaH_PK=Navg_PYR+Navg_ATP-Navg_PEP-Navg_ADP+NH_UPYR+NH_ATP4-NH_UPEP-NH_ADP3 deltaGpo_PK=deltaGpof_UPYR+deltaGpof_ATP4-deltaGpof_H-deltaGpof_UPEP-deltaGpof_ADP3 Kapp_PK=-deltaGpo_PKRTP_PYRP_ATP10-pH_cyP_PEPP_ADP deltaH_LDH=Navg_LAC-Navg_PYR+NH_ULAC+NH_NAD-NH_UPYR-NH_NADH deltaGpo_LDH=deltaGpof_ULAC+deltaGpof_NAD-deltaGpof_UPYR-deltaGpof_NADH-deltaGpof_H Kapp_LDH=-deltaGpo_LDHRTP_LAC10-pH_cyP_PYR deltaH_ATPase=Navg_ADP+Navg_Pi-Navg_ATP+NH_ADP3+NH_HPi2-NH_ATP4-NH_H2O deltaGpo_ATPase=deltaGpof_ADP3+deltaGpof_HPi2+deltaGpof_H-deltaGpof_H2O-deltaGpof_ATP4 Kapp_ATPase=-deltaGpo_ATPaseRTP_ADPP_PiP_ATP10-pH_cy

Component: glycogen_phosphorylase

Vfgly=Par_1 expno=Par_100 fracA=Par_2ifexpno450.001iftime<400.004iftime40time<800.01iftime80time<1000.04iftime100 KgpA_glyf=Par_3 KgpA_pi=Par_4 KgpA_igly=Par_5 KgpA_ipi=Par_6 KgpA_glyb=Par_7 KgpA_g1p=Par_8 KgpA_ig1p=Par_9 Dglya=1+GlyKgpA_glyf+PiKgpA_pi+GlyPiKgpA_glyfKgpA_ipi+GlyKgpA_glyb+G1PKgpA_g1p+GlyG1PKgpA_ig1pKgpA_glyb pa=1.4041+105.94-pH_cy+10pH_cy-7.29 VbglyA=paVfglyKgpA_glybKgpA_ig1pKgpA_iglyKgpA_piKapp_GP glyAF=paVfglyPiKgpA_iglyKgpA_piDglya glyAR=VbglyAGlyKgpA_glybKgpA_ig1pDglya flux_GPa=fracAGlyglyAF-G1PglyAR

Component: glycogen_phosphorylase_B

fracB=1-fracA KgpB_pi=Par_10 KgpB_ipi=Par_11 KgpB_iglyf=Par_12 KgpB_g1p=Par_13 KgpB_ig1p=Par_14 KgpB_iglyb=Par_15 Kgp_amp=Par_16 interactioncoeff=Par_17 nH=Par_18 M=AMPKgp_ampnHinteractioncoeff1+AMPKgp_ampnHinteractioncoeff Dglyb=1+GlyKgpB_iglyf+PiKgpB_ipi+GlyKgpB_iglyb+G1PKgpB_ig1p+GlyPiKgpB_iglyfKgpB_pi+GlyG1PKgpB_g1pKgpB_iglyb pb=1.751+106.12-pH_cy+10pH_cy-7.03 VbglyB=pbVfglyKgpB_g1pKgpB_iglybKgpB_iglyfKgpB_piKapp_GP glyBF=pbMVfglyPiKgpB_iglyfKgpB_piDglyb glyBR=MVbglyBGlyKgpB_g1pKgpB_iglybDglyb flux_GPb=fracBGlyglyBF-G1PglyBR

Component: PGLM

Vffpglm=Par_19 Kpglm_g1p=Par_20 Kpglm_g6p=Par_21 Vfpglm=Vffpglm1.3291+10-pH_cy+6.64+10pH_cy-8.36 Vbpglm=VfpglmKpglm_g6pKpglm_g1pKapp_PGLM v_PGLM=VfpglmG1PKpglm_g1p-VbpglmG6PKpglm_g6p1+G1PKpglm_g1p+G6PKpglm_g6p

Component: PGI

Vbbpgi=Par_22 Kpgi_g6p=Par_23 Kpgi_f6p=Par_24 Vbpgi=Vbbpgi1+10-pH_cy+6.94+10pH_cy-9.35 Vfpgi=VbpgiKpgi_g6pKpgi_f6pKapp_PGI v_PGI=VfpgiG6PKpgi_g6p-VbpgiF6PKpgi_f6p1+F6PKpgi_f6p+G6PKpgi_g6p

Component: PFK

Vffpfk=Par_25 Kpfk_f6p=Par_26 Kpfk_f6pT=Par_27 Kpfk_atp=Par_28 Kpfk_atpT=Par_29 Kpfk_fbp=Par_30 Kpfk_fbpT=Par_31 Kpfk_adp=Par_32 Kpfk_adpT=Par_33 Kpfki=Par_34 Kmpfk=Par_35 d=Par_36 e_=Par_37 Lo=Par_38 Vfpfk=Vffpfk1+pH_cy6.8-30 Vbpfk=VfpfkKpfk_fbpKpfk_adpKpfk_f6pKpfk_atpKapp_PFK L=Lo1+ATPKpfki1+dATPKpfki1+e_AMPKmpfk1+AMPKmpfk4 alpha=Kpfk_f6pKpfk_atpKpfk_f6pTKpfk_atpT Delta=1+F6PKpfk_f6p1+ATPKpfk_atp+FBPKpfk_fbp+ADPKpfk_adp1+FBPKpfk_fbp Deltap=1+F6PKpfk_f6pT1+ATPKpfk_atpT+FBPKpfk_fbpT+ADPKpfk_adpT1+FBPKpfk_fbpT v_PFK=VfpfkF6PATPKpfk_f6pKpfk_atpDelta-VbpfkADPFBPKpfk_adpKpfk_fbpDelta1+alphaLDeltapDelta31+LDeltapDelta4

Component: ALD

Vffald=Par_39 Kald_fbp=Par_40 Kald_dhap=Par_41 Kald_gap=Par_42 Vfald=Vffald1.0131+10-pH_cy+5.32+10pH_cy-9.15 Vbald=VfaldKald_gapKald_dhapKald_fbpKapp_ALD v_ALD=VfaldFBPKald_fbp-VbaldGAPDHAPKald_gapKald_dhap1+FBPKald_fbp+GAPKald_gap+DHAPKald_dhap

Component: TPI

Vfftpi=Par_43 Ktpi_gap=Par_44 Ktpi_dhap=Par_45 Vftpi=Vfftpi Vbtpi=VftpiKtpi_dhapKtpi_gapKapp_TPI v_TPI=VftpiGAPKtpi_gap-VbtpiDHAPKtpi_dhap1+GAPKtpi_gap+DHAPKtpi_dhap

Component: G3PDH

Vbbg3pdh=Par_46 Kg3pdh_g3p=Par_47 Kg3pdh_nad=Par_48 Kg3pdh_dhap=Par_49 Kg3pdh_nadh=Par_50 Dg3pdh=1+G3PKg3pdh_g3p+NADHKg3pdh_nadh1+DHAPKg3pdh_dhap+NADKg3pdh_nadh Vbg3pdh=Vbbg3pdh Vfg3pdh=Vbg3pdhKg3pdh_g3pKg3pdh_nadKapp_G3PDHKg3pdh_dhapKg3pdh_nadh v_G3PDH=Vfg3pdhG3PNADKg3pdh_g3pKg3pdh_nad-Vbg3pdhDHAPNADHKg3pdh_dhapKg3pdh_nadhDg3pdh

Component: GAPDH

Vffgad=Par_51 Kgapdh_gap=Par_52 Kgapdh_nad=Par_53 Kgapdh_pi=Par_54 Kgapdh_bpg=Par_55 Kgapdh_nadh=Par_56 Dgap=1+PiKgapdh_pi+GAPKgapdh_gap+NADKgapdh_nad+GAPNADKgapdh_gapKgapdh_nad+GAPNADPiKgapdh_gapKgapdh_nadKgapdh_pi+BPGKgapdh_bpg+NADHKgapdh_nadh+BPGNADHKgapdh_nadhKgapdh_bpg Vfgad=Vffgad0.0007pH_cy0.8979 Vbgad=VfgadKgapdh_bpgKgapdh_nadhKgapdh_gapKgapdh_piKgapdh_nadKapp_GAPDH v_GAPDH=VfgadGAPNADPiKgapdh_nadKgapdh_gapKgapdh_pi-VbgadBPGNADHKgapdh_bpgKgapdh_nadhDgap

Component: PGK

Vbbpgk=Par_57 Kpgk_bpg=Par_58 Kpgk_adp=Par_59 Kpgk_3pg=Par_60 Kpgk_atp=Par_61 Vbpgk=Vbbpgk Vfpgk=VbpgkKpgk_bpgKpgk_adpKpgk_3pgKpgk_atpKapp_PGK D_PGK=1+ADPKpgk_adp+BPGKpgk_bpg+BPGADPKpgk_bpgKpgk_adp+P3GKpgk_3pg+ATPKpgk_atp+P3GATPKpgk_3pgKpgk_atp v_PGK=VfpgkBPGADPKpgk_adpKpgk_bpg-VbpgkATPP3GKpgk_atpKpgk_3pgD_PGK

Component: PGM

Vffpgm=Par_62 Kpgm_3pg=Par_63 Kpgm_2pg=Par_64 Vfpgm=Vffpgm0.9891+10-pH_cy+5.62+10pH_cy-8.74 Vbpgm=VfpgmKpgm_2pgKpgm_3pgKapp_PGM v_PGM=VfpgmP3GKpgm_3pg-VbpgmP2GKpgm_2pg1+P3GKpgm_3pg+P2GKpgm_2pg

Component: ENOL

Vffen=Par_65 Ken_2pg=Par_66 Ken_pep=Par_67 Vfen=Vffen Vben=VfenKen_pepKen_2pgKapp_ENOL v_ENOL=VfenP2GKen_2pg-VbenPEPKen_pep1+PEPKen_pep+P2GKen_2pg

Component: PK

Vffpk=Par_68 Kpk_pep=Par_69 Kpk_adp=Par_70 Kpk_pyr=Par_71 Kpk_atp=Par_72 Vfpk=Vffpk1.051+10-pH_cy+5.58+10pH_cy-8.79 Vbpk=VfpkKpk_pyrKpk_atpKpk_pepKpk_adpKapp_PK v_PK=VfpkPEPADPKpk_pepKpk_adp-VbpkPYRATPKpk_pyrKpk_atp1+PEPKpk_pep+ADPKpk_adp+PEPADPKpk_pepKpk_adp+ATPKpk_atp+PYRKpk_pyr+PYRATPKpk_pyrKpk_atp

Component: LDH

Vffldh=Par_73 Kldh_pyr=Par_74 Kldh_nadh=Par_75 Kldh_lac=Par_76 Kldh_nad=Par_77 Vfldh=Vffldh-0.1134pH_cy+1.6069 Vbldh=VfldhKldh_lacKldh_nadKldh_pyrKldh_nadhKapp_LDH v_LDH=VfldhPYRNADHKldh_pyrKldh_nadh-VbldhLACNADKldh_lacKldh_nad1+PYRKldh_pyr+NADHKldh_nadh+PYRNADHKldh_pyrKldh_nadh+LACKldh_lac+NADKldh_nad+LACNADKldh_lacKldh_nad

Component: ATPase

VmaxATPase=Par_88ifexpno5expno45Par_88ifexpno5expno=45time110Par_88ifexpno=5time>300otherwise Katp_ATPase=Par_89 ATPase=VmaxATPaseATPKatp_ATPase+ATP

Component: creatine_kinase

VforCK=Par_78 Kck_pcr=Par_79 Kck_iatp=Par_80 Kck_iadp=Par_81 Kck_ipcr=Par_82 Kck_cr=Par_83 VrevCK=VforCKKapp_CKKck_iatpKck_crKck_iadpKck_pcr CK=VrevCKATPCrKck_iatpKck_cr-VforCKADPPCrKck_iadpKck_pcr1+ADPKck_iadp+PCrKck_ipcr+PCrADPKck_iadpKck_pcr+ATPKck_iatp+CrATPKck_crKck_iatp

Component: adenylate_kinase

Vfadk=Par_84 Kadk_amp=Par_85 Kadk_atp=Par_86 Kadk_adp=Par_87 Vbadk=VfadkKadk_adp2Kadk_ampKadk_atpKapp_ADK ADK=VfadkATPAMPKadk_atpKadk_amp-VbadkADPKadk_adp21+ATPKadk_atp+AMPKadk_amp+ATPAMPKadk_atpKadk_amp+2ADPKadk_adp+ADP2Kadk_adp2

Component: buffer_capacity

carnosine=Par_92 tris=Par_91 acetate=Par_93 bufcapfixed=ln10carnosine10-pH_cy-6.8710-pH_cy+10-6.872+ln10tris10-pH_cy-8.310-pH_cy+10-8.32+ln10acetate10-pH_cy-4.810-pH_cy+10-4.82 bufcapmetab=ln1010-pH_cyc01+dNavgPidHPi+dNavgATPdHATP+dNavgADPdHADP+dNavgAMPdHAMP+dNavgPCRdHPCr+dNavgCRdHCr+dNavgG1PdHG1P+dNavgG6PdHG6P+dNavgF6PdHF6P+dNavgFDPdHFBP+dNavgGAPdHGAP+dNavgDHAPdHDHAP+dNavgG3PdHG3P+dNavg13DPGdHBPG+dNavg3PGdHP3G+dNavg2PGdHP2G+dNavgPEPdHPEP+dNavgPYRdHPYR+dNavgLACdHLAC protons_consumed=deltaH_CK-CK+deltaH_ADKADK+deltaH_PGLMv_PGLM+deltaH_GPflux_GPa+flux_GPb+deltaH_PGIv_PGI+deltaH_PFKv_PFK+deltaH_ALDv_ALD+deltaH_TPIv_TPI+deltaH_GAPDHv_GAPDH+deltaH_PGKv_PGK+deltaH_PGMv_PGM+deltaH_ENOLv_ENOL+deltaH_PKv_PK+deltaH_LDHv_LDH+deltaH_G3PDHv_G3PDH CKprtflux=deltaH_CK-CK glycprtflux=deltaH_PGLMv_PGLM+deltaH_GPflux_GPa+flux_GPb+deltaH_PGIv_PGI+deltaH_PFKv_PFK+deltaH_ALDv_ALD+deltaH_TPIv_TPI+deltaH_GAPDHv_GAPDH+deltaH_PGKv_PGK+deltaH_PGMv_PGM+deltaH_ENOLv_ENOL+deltaH_PKv_PK+deltaH_LDHv_LDH+deltaH_G3PDHv_G3PDH pHODEterm1=protons_consumedbufcapfixed+bufcapmetab pHODEterm2=dNavgPidmgPi+dNavgATPdmgATP+dNavgADPdmgADP+dNavgAMPdmgAMP+dNavgPCRdmgPCr+dNavgCRdmgCr+dNavgG1PdmgG1P+dNavgG6PdmgG6P+dNavgF6PdmgF6P+dNavgFDPdmgFBP+dNavgGAPdmgGAP+dNavgDHAPdmgDHAP+dNavgG3PdmgG3P+dNavg13DPGdmgBPG+dNavg3PGdmgP3G+dNavg2PGdmgP2G+dNavgPEPdmgPEP+dNavgPYRdmgPYR+dNavgLACdmgLACbufcapfixed+bufcapmetab denom_mgODE=-1-dmgATP2dmgATP+dmgADPdmgADP+dmgAMPdmgAMP+dmgPidmgPi+dmgPCRdmgPCr+dmgG1PdmgG1P+dmgFDPdmgFBP+dmgG3PdmgG3P+dmgDHAPdmgDHAP+dmgPEPdmgPEP+dmg2PGdmgP2G+dmgLACdmgLAC RHSterm1_mgODE=dmgATP2dpHATP+dmgADPdpHADP+dmgAMPdpHAMP+dmgPidpHPi+dmgPCRdpHPCr+dmgG1PdpHG1P+dmgFDPdpHFBP+dmgG3PdpHG3P+dmgDHAPdpHDHAP+dmgPEPdpHPEP+dmg2PGdpHP2G+dmgLACdpHLACdenom_mgODE denomMgpHODE=1-RHSterm1_mgODEpHODEterm2

Component: differential_equations

ddtimePCr=dPCrdt dPCrdt=CK ddtimeCr=dCrdt dCrdt=-CK ddtimeNAD=dNADdt dNADdt=-v_GAPDH-v_G3PDH+v_LDH ddtimeNADH=dNADHdt dNADHdt=v_GAPDH+v_G3PDH-v_LDH ddtimeATP=dATPdt dATPdt=-CK-ADK-v_PFK+v_PGK+v_PK-ATPase ddtimeADP=dADPdt dADPdt=CK+2ADK+v_PFK-v_PGK-v_PK+ATPase ddtimeAMP=dAMPdt dAMPdt=-ADK ddtimePi=dPidt dPidt=-flux_GPa+flux_GPb-v_GAPDH+ATPase ddtimeGly=dGlydt dGlydt=-flux_GPa+flux_GPb ddtimeG1P=dG1Pdt dG1Pdt=flux_GPa+flux_GPb-v_PGLM ddtimeG6P=dG6Pdt dG6Pdt=v_PGLM-v_PGI ddtimeF6P=dF6Pdt dF6Pdt=v_PGI-v_PFK ddtimeFBP=dFBPdt dFBPdt=v_PFK-v_ALD ddtimeDHAP=dDHAPdt dDHAPdt=v_ALD+v_TPI+v_G3PDH ddtimeG3P=dG3Pdt dG3Pdt=-v_G3PDH ddtimeGAP=dGAPdt dGAPdt=v_ALD-v_TPI-v_GAPDH ddtimeBPG=dBGPdt dBGPdt=v_GAPDH-v_PGK ddtimeP3G=dP3Gdt dP3Gdt=v_PGK-v_PGM ddtimeP2G=dP2Gdt dP2Gdt=v_PGM-v_ENOL ddtimePEP=dPEPdt dPEPdt=v_ENOL-v_PK ddtimePYR=dPYRdt dPYRdt=v_PK-v_LDH ddtimeLAC=dLACdt dLACdt=v_LDH RHSterm2_mgODE=mgATP2dATPdt+mgADPdADPdt+mgAMPdAMPdt+mgPidPidt+mgPCRdPCrdt+mgG1PdG1Pdt+mgFDPdFBPdt+mgG3PdG3Pdt+mgDHAPdDHAPdt+mgPEPdPEPdt+mg2PGdP2Gdt+mgLACdLACdtdenom_mgODE fixmg=1 ddtimeMg=fixmgRHSterm2_mgODE+RHSterm1_mgODEpHODEterm11-RHSterm1_mgODEpHODEterm2iftime1fixmgRHSterm2_mgODEotherwise fixpH=Par_99 ddtimepH_calc=fixpHpHODEterm1+RHSterm2_mgODEpHODEterm21-RHSterm1_mgODEpHODEterm2 ddtimeprotonload=-protons_consumed