c.lloyd@auckland.ac.nz
hypothalamus
MacGregor and Leng's 2005 mathematical model of hypothalamic control of growth hormone secretion.
The University of Auckland
Auckland Bioengineering Institute
Catherine Lloyd
J
MacGregor
D
The University of Auckland, Auckland Bioengineering Institute
Modelling the hypothalamic control of growth hormone secretion: the full pituitary + hypothalamic model
The model now runs in PCEnv to replicate the published results (as shown in figure 12). The only difference is my stimulus was hand written by a piecewise equation where as the model authors used some sort of a random pulse generator... I probably need to make the piecewise equation carry on for longer to get this result.
J
MacGregor
D
exogenous somatostatin
se
s
endogenous somatostatin
GHRH
growth hormone releasing hormone
r
hh
human growth hormone
803
Modelling the hypothalamic control of growth hormone secretion.
17
788
endocrine
hypothalamus
growth hormone
growth hormone releasing hormone
somatostatin
Modelling the hypothalamic control of growth hormone secretion.
788
803
17
MacGregor and Leng's 2005 mathematical model of hypothalamic control of growth hormone secretion.
hypothalamus
I've checked the model in COR and have corrected all the units. I've also added some piecewise equations to stimulate the model (as set out in the figure legends of the paper).
Journal of Neuroendocrinology
Modelling the hypothalamic control of growth hormone secretion: pituitary model only
The University of Auckland, Auckland Bioengineering Institute
16280026
This is the CellML description of MacGregor and Leng's 2005 mathematical model of hypothalamic control of growth hormone secretion.
The model runs in PCEnv to replicate the results in the published paper. In particular the initial conditions have been set to the same as those which generate the results for figure 3B in the published paper.
16280026
endocrine
somatostatin
growth hormone releasing hormone
hypothalamus
growth hormone
keyword
Checked the model in COR and made all the units consistent. I also reduced the model back to its foundation form (the pituitary part only), and added two complex piecewise equations to simulate the injection of the hormones.
Lloyd
May
Catherine
GH
h
growth hormone
Leng
G
May
Catherine
Lloyd
2007-09-04T15:52:40+12:00
keyword
density of free GHRH receptors
f
2007-05-28T00:00:00+00:00
Catherine Lloyd
f
density of free GHRH receptors
GHRH
growth hormone releasing hormone
r
G
Leng
c.lloyd@auckland.ac.nz
releasable store of somatostatin
g
Catherine
Lloyd
May
Catherine Lloyd
2005-00-00 00:00
s
endogenous somatostatin
Journal of Neuroendocrinology
h
growth hormone
GH
Catherine
Lloyd
May
Auckland Bioengineering Institute
The University of Auckland
Catherine Lloyd
2005-00-00 00:00
2007-05-28T00:00:00+00:00
This is the CellML description of MacGregor and Leng's 2005 mathematical model of hypothalamic control of growth hormone secretion.
2007-09-04T15:13:18+12:00