C C There are a total of 9 entries in the algebraic variable array. C There are a total of 16 entries in each of the rate and state variable arrays. C There are a total of 14 entries in the constant variable array. C C C VOI is time in component environment (day). C STATES(1) is B0 in component B0 (cells_per_GC). C CONSTS(1) is pr in component kinetic_parameters (dimensionless). C CONSTS(2) is mu in component kinetic_parameters (first_order_rate_constant). C CONSTS(3) is rho in component kinetic_parameters (first_order_rate_constant). C CONSTS(4) is delta_B in component kinetic_parameters (first_order_rate_constant). C ALGBRC(1) is CT_star in component CT_star (cells_per_GC). C STATES(2) is B1 in component B1 (cells_per_GC). C ALGBRC(5) is alpha_B in component alpha_B (dimensionless). C STATES(3) is B2 in component B2 (cells_per_GC). C STATES(4) is B3 in component B3 (cells_per_GC). C STATES(5) is B4 in component B4 (cells_per_GC). C STATES(6) is B5 in component B5 (cells_per_GC). C STATES(7) is B6 in component B6 (cells_per_GC). C STATES(8) is B7 in component B7 (cells_per_GC). C STATES(9) is B8 in component B8 (cells_per_GC). C STATES(10) is B9 in component B9 (cells_per_GC). C STATES(11) is B10 in component B10 (cells_per_GC). C ALGBRC(2) is B_sum in component centroblasts_sum (cells_per_GC). C STATES(12) is C in component C (cells_per_GC). C CONSTS(5) is d in component C (first_order_rate_constant). C STATES(13) is C_star in component C_star (cells_per_GC). C ALGBRC(3) is CA in component CA (cells_per_GC). C ALGBRC(6) is C_starsum in component centrocytes_sum (cells_per_GC). C STATES(14) is M in component M (cells_per_GC). C STATES(15) is A in component A (cells_per_GC). C CONSTS(6) is z in component A (first_order_rate_constant). C CONSTS(7) is u in component A (dimensionless). C ALGBRC(4) is log_A in component A (dimensionless). C STATES(16) is T in component T (cells_per_GC). C CONSTS(8) is p in component T (first_order_rate_constant). C CONSTS(9) is sigma in component T (first_order_rate_constant). C CONSTS(10) is delta_T in component T (first_order_rate_constant). C ALGBRC(7) is alpha_T in component alpha_T (dimensionless). C CONSTS(11) is SA in component CA (dimensionless). C CONSTS(12) is ST in component CT_star (dimensionless). C CONSTS(13) is KB in component alpha_B (dimensionless). C CONSTS(14) is KT in component alpha_T (dimensionless). C ALGBRC(8) is total in component total (cells_per_GC). C ALGBRC(9) is log_total in component total (dimensionless). C RATES(1) is d/dt B0 in component B0 (cells_per_GC). C RATES(2) is d/dt B1 in component B1 (cells_per_GC). C RATES(3) is d/dt B2 in component B2 (cells_per_GC). C RATES(4) is d/dt B3 in component B3 (cells_per_GC). C RATES(5) is d/dt B4 in component B4 (cells_per_GC). C RATES(6) is d/dt B5 in component B5 (cells_per_GC). C RATES(7) is d/dt B6 in component B6 (cells_per_GC). C RATES(8) is d/dt B7 in component B7 (cells_per_GC). C RATES(9) is d/dt B8 in component B8 (cells_per_GC). C RATES(10) is d/dt B9 in component B9 (cells_per_GC). C RATES(11) is d/dt B10 in component B10 (cells_per_GC). C RATES(12) is d/dt C in component C (cells_per_GC). C RATES(13) is d/dt C_star in component C_star (cells_per_GC). C RATES(14) is d/dt M in component M (cells_per_GC). C RATES(15) is d/dt A in component A (cells_per_GC). C RATES(16) is d/dt T in component T (cells_per_GC). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 3 CONSTS(1) = 0.15 CONSTS(2) = 3 CONSTS(3) = 4 CONSTS(4) = 0.8 STATES(2) = 0 STATES(3) = 0 STATES(4) = 0 STATES(5) = 0 STATES(6) = 0 STATES(7) = 0 STATES(8) = 0 STATES(9) = 0 STATES(10) = 0 STATES(11) = 0 STATES(12) = 0 CONSTS(5) = 2 STATES(13) = 0 STATES(14) = 0 STATES(15) = 500 CONSTS(6) = 0.02 CONSTS(7) = 0.15 STATES(16) = 0 CONSTS(8) = 2 CONSTS(9) = 5 CONSTS(10) = 0.8 CONSTS(11) = 500 CONSTS(12) = 50 CONSTS(13) = 1e4 CONSTS(14) = 100 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(12) = CONSTS(5)*CONSTS(3)*STATES(11)*1.00000 - CONSTS(2)*STATES(12) ALGBRC(1) = ( STATES(13)*STATES(16))/( CONSTS(12)*1.00000+STATES(13)) RATES(1) = CONSTS(1)*CONSTS(2)*ALGBRC(1) - ( CONSTS(3)*STATES(1)+ CONSTS(4)*STATES(1)) ALGBRC(3) = ( STATES(12)*STATES(15))/( CONSTS(11)*1.00000+STATES(15)) RATES(13) = CONSTS(2)*ALGBRC(3) - CONSTS(2)*STATES(13) RATES(14) = (1.00000 - CONSTS(1))*CONSTS(2)*ALGBRC(1) RATES(15) = - CONSTS(6)*STATES(15) - CONSTS(7)*ALGBRC(3)*1.00000 ALGBRC(2) = STATES(2)+STATES(2)+STATES(4)+STATES(5)+STATES(6)+STATES(7)+STATES(7)+STATES(8)+STATES(9)+STATES(10)+STATES(11) ALGBRC(5) = CONSTS(13)/(CONSTS(13)+ALGBRC(2)/1.00000) RATES(2) = CONSTS(3)*(1.00000+ALGBRC(5))*STATES(1) - ( CONSTS(3)*STATES(2)+ CONSTS(4)*STATES(2)) RATES(3) = CONSTS(3)*(1.00000+ALGBRC(5))*STATES(2) - ( CONSTS(3)*STATES(3)+ CONSTS(4)*STATES(3)) RATES(4) = CONSTS(3)*(1.00000+ALGBRC(5))*STATES(3) - ( CONSTS(3)*STATES(4)+ CONSTS(4)*STATES(4)) RATES(5) = CONSTS(3)*(1.00000+ALGBRC(5))*STATES(4) - ( CONSTS(3)*STATES(5)+ CONSTS(4)*STATES(5)) RATES(6) = CONSTS(3)*(1.00000+ALGBRC(5))*STATES(5) - ( CONSTS(3)*STATES(6)+ CONSTS(4)*STATES(6)) RATES(7) = CONSTS(3)*(1.00000+ALGBRC(5))*STATES(6) - ( CONSTS(3)*STATES(7)+ CONSTS(4)*STATES(7)) RATES(8) = CONSTS(3)*(1.00000+ALGBRC(5))*STATES(7) - ( CONSTS(3)*STATES(8)+ CONSTS(4)*STATES(8)) RATES(9) = CONSTS(3)*(1.00000+ALGBRC(5))*STATES(8) - ( CONSTS(3)*STATES(9)+ CONSTS(4)*STATES(9)) RATES(10) = CONSTS(3)*(1.00000+ALGBRC(5))*STATES(9) - ( CONSTS(3)*STATES(10)+ CONSTS(4)*STATES(10)) RATES(11) = CONSTS(3)*(1.00000+ALGBRC(5))*STATES(10) - ( CONSTS(3)*STATES(11)+ CONSTS(4)*STATES(11)) ALGBRC(7) = CONSTS(14)/(CONSTS(14)+STATES(16)/1.00000) RATES(16) = ( CONSTS(9)*1.00000+ CONSTS(8)*ALGBRC(7)*ALGBRC(1)) - CONSTS(10)*STATES(16) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = ( STATES(13)*STATES(16))/( CONSTS(12)*1.00000+STATES(13)) ALGBRC(3) = ( STATES(12)*STATES(15))/( CONSTS(11)*1.00000+STATES(15)) ALGBRC(2) = STATES(2)+STATES(2)+STATES(4)+STATES(5)+STATES(6)+STATES(7)+STATES(7)+STATES(8)+STATES(9)+STATES(10)+STATES(11) ALGBRC(5) = CONSTS(13)/(CONSTS(13)+ALGBRC(2)/1.00000) ALGBRC(7) = CONSTS(14)/(CONSTS(14)+STATES(16)/1.00000) ALGBRC(4) = arbitrary_log(STATES(15)/1.00000, 10) ALGBRC(6) = STATES(12)+STATES(13) ALGBRC(8) = ALGBRC(2)+ALGBRC(6) ALGBRC(9) = arbitrary_log(ALGBRC(8)/1.00000+1.00000e-12, 10) RETURN END