function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =6; end % There are a total of 2 entries in each of the rate and state variable arrays. % There are a total of 15 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (minute)'); LEGEND_STATES(:,1) = strpad('G in component G (mg_per_litre)'); LEGEND_ALGEBRAIC(:,1) = strpad('Gin in component G (mg_per_litre_minute)'); LEGEND_ALGEBRAIC(:,3) = strpad('f2_G in component f2_G (mg_per_minute)'); LEGEND_ALGEBRAIC(:,4) = strpad('f3_G in component f3_G (per_litre)'); LEGEND_ALGEBRAIC(:,5) = strpad('f4_I in component f4_I (mg_per_minute)'); LEGEND_ALGEBRAIC(:,6) = strpad('f5_I in component f5_I (mg_per_minute)'); LEGEND_STATES(:,2) = strpad('I in component I (mU_per_litre)'); LEGEND_ALGEBRAIC(:,2) = strpad('Iin in component I (mU_per_litre_minute)'); LEGEND_CONSTANTS(:,1) = strpad('di in component model_parameters (first_order_rate_constant)'); LEGEND_CONSTANTS(:,2) = strpad('C2 in component model_parameters (mg_per_litre)'); LEGEND_CONSTANTS(:,3) = strpad('Ub in component model_parameters (mg_per_minute)'); LEGEND_CONSTANTS(:,4) = strpad('Vg in component model_parameters (litre)'); LEGEND_CONSTANTS(:,5) = strpad('C3 in component model_parameters (mg_per_litre)'); LEGEND_CONSTANTS(:,6) = strpad('C4 in component model_parameters (mU_per_litre)'); LEGEND_CONSTANTS(:,7) = strpad('Vi in component model_parameters (litre)'); LEGEND_CONSTANTS(:,8) = strpad('U0 in component model_parameters (mg_per_minute)'); LEGEND_CONSTANTS(:,9) = strpad('Um in component model_parameters (mg_per_minute)'); LEGEND_CONSTANTS(:,10) = strpad('beta in component model_parameters (dimensionless)'); LEGEND_CONSTANTS(:,11) = strpad('ti in component model_parameters (minute)'); LEGEND_CONSTANTS(:,12) = strpad('Vp in component model_parameters (litre)'); LEGEND_CONSTANTS(:,13) = strpad('C5 in component model_parameters (mU_per_litre)'); LEGEND_CONSTANTS(:,14) = strpad('Rg in component model_parameters (mg_per_minute)'); LEGEND_CONSTANTS(:,15) = strpad('alpha in component model_parameters (litre_per_mU)'); LEGEND_RATES(:,1) = strpad('d/dt G in component G (mg_per_litre)'); LEGEND_RATES(:,2) = strpad('d/dt I in component I (mU_per_litre)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; STATES(:,1) = 150.0; STATES(:,2) = 5.0; CONSTANTS(:,1) = 0.0107; CONSTANTS(:,2) = 144; CONSTANTS(:,3) = 72.0; CONSTANTS(:,4) = 10.0; CONSTANTS(:,5) = 1000.0; CONSTANTS(:,6) = 80.0; CONSTANTS(:,7) = 11.0; CONSTANTS(:,8) = 40.0; CONSTANTS(:,9) = 940.0; CONSTANTS(:,10) = 1.77; CONSTANTS(:,11) = 100.0; CONSTANTS(:,12) = 3.0; CONSTANTS(:,13) = 26.0; CONSTANTS(:,14) = 180.0; CONSTANTS(:,15) = 0.29; if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,2) = piecewise({VOI<=30.0000&VOI>=0.00000, 0.250000 , VOI<120.000&VOI>=30.0000, 0.250000+ 1.00000.*(1.00000+(VOI - 120.000)./90.0000) , VOI<240.000&VOI>=120.000, 0.250000+ 1.00000.*(1.00000 - 0.500000.*((VOI - 120.000)./120.000)) , VOI<=480.000&VOI>=240.000, 0.250000+ 0.500000.*(1.00000 - (VOI - 240.000)./240.000) , VOI<530.000&VOI>480.000, 0.250000 , VOI<620.000&VOI>=530.000, 0.250000+ 1.00000.*(1.00000+(VOI - 620.000)./90.0000) , VOI<740.000&VOI>=620.000, 0.250000+ 1.00000.*(1.00000 - 0.500000.*((VOI - 620.000)./120.000)) , VOI<=980.000&VOI>=740.000, 0.250000+ 0.500000.*(1.00000 - (VOI - 740.000)./240.000) }, NaN); RATES(:,2) = ALGEBRAIC(:,2) - CONSTANTS(:,1).*STATES(:,2); ALGEBRAIC(:,1) = piecewise({VOI<15.0000&VOI>=0.00000, 0.0500000+ (5.00000./15.0000).*VOI , VOI<45.0000&VOI>=15.0000, 0.0500000+ 5.00000.*((45.0000 - VOI)./(45.0000 - 15.0000)) , VOI<=240.000&VOI>=45.0000, 0.0500000 , VOI>240.000&VOI<255.000, 0.0500000+ (5.00000./255.000).*VOI , VOI<285.000&VOI>=255.000, 0.0500000+ 5.00000.*((285.000 - VOI)./(285.000 - 255.000)) , VOI<=480.000&VOI>=285.000, 0.0500000 , VOI<495.000&VOI>480.000, 0.0500000+ (5.00000./495.000).*VOI , VOI<525.000&VOI>=495.000, 0.0500000+ 5.00000.*((525.000 - VOI)./(525.000 - 495.000)) , VOI<=720.000&VOI>=525.000, 0.0500000 , VOI>720.000&VOI<735.000, 0.0500000+ (5.00000./735.000).*VOI , VOI<765.000&VOI>=735.000, 0.0500000+ 5.00000.*((765.000 - VOI)./(765.000 - 735.000)) , VOI<=960.000&VOI>=765.000, 0.0500000 }, NaN); ALGEBRAIC(:,3) = CONSTANTS(:,3).*(1.00000 - exp( - STATES(:,1)./( CONSTANTS(:,2).*CONSTANTS(:,4).*1.00000))); ALGEBRAIC(:,4) = STATES(:,1)./( CONSTANTS(:,5).*CONSTANTS(:,4)); ALGEBRAIC(:,5) = CONSTANTS(:,8)+(CONSTANTS(:,9) - CONSTANTS(:,8))./(1.00000+exp( - CONSTANTS(:,10).*log(STATES(:,2)./( CONSTANTS(:,6).*(1.00000./CONSTANTS(:,7)+1.00000./( 0.200000.*CONSTANTS(:,11))))))); ALGEBRAIC(:,6) = CONSTANTS(:,14)./(1.00000+exp( CONSTANTS(:,15).*(STATES(:,2)./( 1.00000.*( 1.00000.*CONSTANTS(:,12) - CONSTANTS(:,13)))))); RATES(:,1) = (ALGEBRAIC(:,1)+ 1.00000.*ALGEBRAIC(:,6)) - ( 1.00000.*ALGEBRAIC(:,3)+ ALGEBRAIC(:,4).*ALGEBRAIC(:,5)); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,2) = piecewise({VOI<=30.0000&VOI>=0.00000, 0.250000 , VOI<120.000&VOI>=30.0000, 0.250000+ 1.00000.*(1.00000+(VOI - 120.000)./90.0000) , VOI<240.000&VOI>=120.000, 0.250000+ 1.00000.*(1.00000 - 0.500000.*((VOI - 120.000)./120.000)) , VOI<=480.000&VOI>=240.000, 0.250000+ 0.500000.*(1.00000 - (VOI - 240.000)./240.000) , VOI<530.000&VOI>480.000, 0.250000 , VOI<620.000&VOI>=530.000, 0.250000+ 1.00000.*(1.00000+(VOI - 620.000)./90.0000) , VOI<740.000&VOI>=620.000, 0.250000+ 1.00000.*(1.00000 - 0.500000.*((VOI - 620.000)./120.000)) , VOI<=980.000&VOI>=740.000, 0.250000+ 0.500000.*(1.00000 - (VOI - 740.000)./240.000) }, NaN); ALGEBRAIC(:,1) = piecewise({VOI<15.0000&VOI>=0.00000, 0.0500000+ (5.00000./15.0000).*VOI , VOI<45.0000&VOI>=15.0000, 0.0500000+ 5.00000.*((45.0000 - VOI)./(45.0000 - 15.0000)) , VOI<=240.000&VOI>=45.0000, 0.0500000 , VOI>240.000&VOI<255.000, 0.0500000+ (5.00000./255.000).*VOI , VOI<285.000&VOI>=255.000, 0.0500000+ 5.00000.*((285.000 - VOI)./(285.000 - 255.000)) , VOI<=480.000&VOI>=285.000, 0.0500000 , VOI<495.000&VOI>480.000, 0.0500000+ (5.00000./495.000).*VOI , VOI<525.000&VOI>=495.000, 0.0500000+ 5.00000.*((525.000 - VOI)./(525.000 - 495.000)) , VOI<=720.000&VOI>=525.000, 0.0500000 , VOI>720.000&VOI<735.000, 0.0500000+ (5.00000./735.000).*VOI , VOI<765.000&VOI>=735.000, 0.0500000+ 5.00000.*((765.000 - VOI)./(765.000 - 735.000)) , VOI<=960.000&VOI>=765.000, 0.0500000 }, NaN); ALGEBRAIC(:,3) = CONSTANTS(:,3).*(1.00000 - exp( - STATES(:,1)./( CONSTANTS(:,2).*CONSTANTS(:,4).*1.00000))); ALGEBRAIC(:,4) = STATES(:,1)./( CONSTANTS(:,5).*CONSTANTS(:,4)); ALGEBRAIC(:,5) = CONSTANTS(:,8)+(CONSTANTS(:,9) - CONSTANTS(:,8))./(1.00000+exp( - CONSTANTS(:,10).*log(STATES(:,2)./( CONSTANTS(:,6).*(1.00000./CONSTANTS(:,7)+1.00000./( 0.200000.*CONSTANTS(:,11))))))); ALGEBRAIC(:,6) = CONSTANTS(:,14)./(1.00000+exp( CONSTANTS(:,15).*(STATES(:,2)./( 1.00000.*( 1.00000.*CONSTANTS(:,12) - CONSTANTS(:,13)))))); end % Compute result of a piecewise function function x = piecewise(cases, default) set = [0]; for i = 1:2:length(cases) if (length(cases{i+1}) == 1) x(cases{i} & ~set,:) = cases{i+1}; else x(cases{i} & ~set,:) = cases{i+1}(cases{i} & ~set); end set = set | cases{i}; if(set), break, end end if (length(default) == 1) x(~set,:) = default; else x(~set,:) = default(~set); end end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end