/* There are a total of 42 entries in the algebraic variable array. There are a total of 10 entries in each of the rate and state variable arrays. There are a total of 47 entries in the constant variable array. */ /* * VOI is time in component environment (millisecond). * STATES[0] is Gi in component Gi (millimolar). * ALGEBRAIC[4] is Jglut in component Jglut (millimolar_per_millisecond). * ALGEBRAIC[6] is Jgk in component Jgk (millimolar_per_millisecond). * STATES[1] is Ge in component Ge (millimolar). * ALGEBRAIC[1] is G_infinity in component Ge (millimolar). * CONSTANTS[0] is tau_G in component Ge (millisecond). * CONSTANTS[1] is Gmax in component Ge (millimolar). * CONSTANTS[2] is Gmin in component Ge (millimolar). * CONSTANTS[3] is SG in component Ge (dimensionless). * CONSTANTS[4] is I_ in component Ge (dimensionless). * STATES[2] is I in component I (dimensionless). * STATES[3] is G6P in component G6P (millimolar). * CONSTANTS[5] is kappa in component model_parameters (dimensionless). * ALGEBRAIC[41] is JPFK in component JPFK (micromolar_per_millisecond). * STATES[4] is FBP in component FBP (micromolar). * ALGEBRAIC[7] is JGPDH in component JGPDH (micromolar_per_millisecond). * ALGEBRAIC[0] is F6P in component F6P (millimolar). * CONSTANTS[6] is Kglut in component Jglut (millimolar). * CONSTANTS[7] is Vglut in component Jglut (millimolar_per_millisecond). * CONSTANTS[8] is Kgk in component Jgk (millimolar). * CONSTANTS[9] is Vgk in component Jgk (millimolar_per_millisecond). * CONSTANTS[10] is ngk in component Jgk (dimensionless). * CONSTANTS[11] is lambda in component JPFK (dimensionless). * CONSTANTS[12] is Vmax in component JPFK (micromolar_per_millisecond). * CONSTANTS[46] is w0000 in component w (dimensionless). * ALGEBRAIC[25] is w1000 in component w (dimensionless). * ALGEBRAIC[8] is w0100 in component w (dimensionless). * ALGEBRAIC[9] is w0010 in component w (dimensionless). * ALGEBRAIC[27] is w0001 in component w (dimensionless). * ALGEBRAIC[29] is w1100 in component w (dimensionless). * ALGEBRAIC[31] is w1010 in component w (dimensionless). * ALGEBRAIC[33] is w1001 in component w (dimensionless). * ALGEBRAIC[34] is w0101 in component w (dimensionless). * ALGEBRAIC[35] is w0011 in component w (dimensionless). * ALGEBRAIC[10] is w0110 in component w (dimensionless). * ALGEBRAIC[36] is w1110 in component w (dimensionless). * ALGEBRAIC[37] is w0111 in component w (dimensionless). * ALGEBRAIC[38] is w1011 in component w (dimensionless). * ALGEBRAIC[39] is w1101 in component w (dimensionless). * ALGEBRAIC[40] is w1111 in component w (dimensionless). * CONSTANTS[13] is f13 in component w (dimensionless). * CONSTANTS[14] is f23 in component w (dimensionless). * CONSTANTS[15] is f41 in component w (dimensionless). * CONSTANTS[16] is f42 in component w (dimensionless). * CONSTANTS[17] is f43 in component w (dimensionless). * CONSTANTS[18] is K1 in component w (micromolar). * CONSTANTS[19] is K2 in component w (micromolar). * CONSTANTS[20] is K3 in component w (micromolar). * CONSTANTS[21] is K4 in component w (micromolar). * ALGEBRAIC[23] is AMP in component AMP (micromolar). * ALGEBRAIC[24] is ATP in component ATP (micromolar). * CONSTANTS[22] is Atot in component ATP (micromolar). * STATES[5] is ADP in component ADP (micromolar). * CONSTANTS[23] is tau_a in component ADP (millisecond). * CONSTANTS[24] is r in component ADP (dimensionless). * CONSTANTS[25] is r1 in component ADP (micromolar). * ALGEBRAIC[11] is gamma in component gamma (dimensionless). * STATES[6] is Ca in component Ca (micromolar). * CONSTANTS[26] is v_gamma in component gamma (dimensionless). * CONSTANTS[27] is k_gamma in component gamma (micromolar_per_millisecond). * STATES[7] is v in component membrane (millivolt). * CONSTANTS[28] is cm in component membrane (femtofarad). * ALGEBRAIC[14] is I_Ca in component I_Ca (picoampere). * ALGEBRAIC[12] is I_K in component I_K (picoampere). * ALGEBRAIC[17] is I_K_Ca in component I_K_Ca (picoampere). * ALGEBRAIC[32] is I_K_ATP in component I_K_ATP (picoampere). * CONSTANTS[29] is gK_ in component I_K (picosiemens). * CONSTANTS[30] is vK in component model_parameters (millivolt). * STATES[8] is n in component n (dimensionless). * ALGEBRAIC[5] is n_infinity in component n (dimensionless). * ALGEBRAIC[2] is tau_n in component n (millisecond). * CONSTANTS[31] is gCa_ in component I_Ca (picosiemens). * CONSTANTS[32] is vCa in component model_parameters (millivolt). * ALGEBRAIC[13] is m_infinity in component m (dimensionless). * CONSTANTS[33] is gkCa_ in component I_K_Ca (picosiemens). * ALGEBRAIC[15] is gkCa in component I_K_Ca (picosiemens). * CONSTANTS[34] is KD in component I_K_Ca (micromolar). * CONSTANTS[35] is gkATP_ in component I_K_ATP (picosiemens). * ALGEBRAIC[30] is gkATP in component I_K_ATP (picosiemens). * ALGEBRAIC[28] is o_infinity in component I_K_ATP (dimensionless). * ALGEBRAIC[19] is MgADP in component I_K_ATP (micromolar). * ALGEBRAIC[21] is ADP3_ in component I_K_ATP (micromolar). * ALGEBRAIC[26] is ATP4_ in component I_K_ATP (micromolar). * CONSTANTS[36] is fcyt in component Ca (dimensionless). * ALGEBRAIC[16] is Jmem in component Jmem (micromolar_per_millisecond). * ALGEBRAIC[22] is Jer in component Jer (micromolar_per_millisecond). * STATES[9] is Caer in component Caer (micromolar). * CONSTANTS[37] is fer in component Caer (dimensionless). * CONSTANTS[38] is Vcyt_Ver in component Caer (dimensionless). * CONSTANTS[39] is kPMCA in component Jmem (first_order_rate_constant). * CONSTANTS[40] is alpha in component Jmem (micromolar_per_millisecond). * ALGEBRAIC[20] is Jleak in component Jleak (micromolar_per_millisecond). * ALGEBRAIC[18] is JSERCA in component JSERCA (micromolar_per_millisecond). * CONSTANTS[41] is kSERCA in component JSERCA (first_order_rate_constant). * CONSTANTS[42] is pleak in component Jleak (first_order_rate_constant). * ALGEBRAIC[3] is I_infinity in component I (dimensionless). * CONSTANTS[43] is tau_I in component I (millisecond). * CONSTANTS[44] is I_slope in component I (per_micromolar). * CONSTANTS[45] is Canull in component I (micromolar). * RATES[0] is d/dt Gi in component Gi (millimolar). * RATES[1] is d/dt Ge in component Ge (millimolar). * RATES[3] is d/dt G6P in component G6P (millimolar). * RATES[4] is d/dt FBP in component FBP (micromolar). * RATES[5] is d/dt ADP in component ADP (micromolar). * RATES[7] is d/dt v in component membrane (millivolt). * RATES[8] is d/dt n in component n (dimensionless). * RATES[6] is d/dt Ca in component Ca (micromolar). * RATES[9] is d/dt Caer in component Caer (micromolar). * RATES[2] is d/dt I in component I (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 0; STATES[1] = 7; CONSTANTS[0] = 450000; CONSTANTS[1] = 15; CONSTANTS[2] = 1; CONSTANTS[3] = 1; CONSTANTS[4] = 5; STATES[2] = 0; STATES[3] = 200; CONSTANTS[5] = 0.005; STATES[4] = 40; CONSTANTS[6] = 7; CONSTANTS[7] = 8; CONSTANTS[8] = 7; CONSTANTS[9] = 0.8; CONSTANTS[10] = 4; CONSTANTS[11] = 0.06; CONSTANTS[12] = 2; CONSTANTS[13] = 0.02; CONSTANTS[14] = 0.2; CONSTANTS[15] = 20; CONSTANTS[16] = 20; CONSTANTS[17] = 20; CONSTANTS[18] = 30; CONSTANTS[19] = 1; CONSTANTS[20] = 50000; CONSTANTS[21] = 1000; CONSTANTS[22] = 3000; STATES[5] = 780; CONSTANTS[23] = 300000; CONSTANTS[24] = 0.5; CONSTANTS[25] = 0.35; STATES[6] = 0.1; CONSTANTS[26] = 2.2; CONSTANTS[27] = 0.1; STATES[7] = -60; CONSTANTS[28] = 5300; CONSTANTS[29] = 2700; CONSTANTS[30] = -75; STATES[8] = 0; CONSTANTS[31] = 1000; CONSTANTS[32] = 25; CONSTANTS[33] = 400; CONSTANTS[34] = 0.5; CONSTANTS[35] = 40000; CONSTANTS[36] = 0.01; STATES[9] = 185; CONSTANTS[37] = 0.01; CONSTANTS[38] = 31; CONSTANTS[39] = 0.18; CONSTANTS[40] = 4.5e-6; CONSTANTS[41] = 0.4; CONSTANTS[42] = 0.0002; CONSTANTS[43] = 10000; CONSTANTS[44] = 210; CONSTANTS[45] = 0.055; CONSTANTS[46] = 1.00000; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = CONSTANTS[2]+(CONSTANTS[1] - CONSTANTS[2])/(1.00000+exp((STATES[2] - CONSTANTS[4])/CONSTANTS[3])); RATES[1] = (ALGEBRAIC[1] - STATES[1])/CONSTANTS[0]; ALGEBRAIC[3] = (STATES[6]>=CONSTANTS[45] ? CONSTANTS[44]*(STATES[6] - CONSTANTS[45]) : STATES[6]=CONSTANTS[45] ? CONSTANTS[44]*(STATES[6] - CONSTANTS[45]) : STATES[6]aVOI #define CONSTANTS rfi->aCONSTANTS #define RATES rfi->aRATES #define STATES rfi->aSTATES #define ALGEBRAIC rfi->aALGEBRAIC #define pret rfi->aPRET ALGEBRAIC[23] = p[0]; ALGEBRAIC[24] = p[1]; hx[0] = ALGEBRAIC[24] - (CONSTANTS[22] - (STATES[5]+ALGEBRAIC[23])); hx[1] = ALGEBRAIC[23] - pow(STATES[5], 2.00000)/ALGEBRAIC[24]; #undef VOI #undef CONSTANTS #undef RATES #undef STATES #undef ALGEBRAIC #undef pret } void rootfind_0(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC, int* pret) { static double p[2] = {0.1,0.1}; double bp[2], work[LM_DIF_WORKSZ(2, 2)]; struct rootfind_info rfi; rfi.aVOI = VOI; rfi.aCONSTANTS = CONSTANTS; rfi.aRATES = RATES; rfi.aSTATES = STATES; rfi.aALGEBRAIC = ALGEBRAIC; rfi.aPRET = pret; do_levmar(objfunc_0, p, bp, work, pret, 2, &rfi); ALGEBRAIC[23] = p[0]; ALGEBRAIC[24] = p[1]; }