/* There are a total of 9 entries in the algebraic variable array. There are a total of 3 entries in each of the rate and state variable arrays. There are a total of 8 entries in the constant variable array. */ /* * VOI is time in component model (minute). * STATES[0] is NFATP_cyt in component model (molecule). * STATES[1] is NFAT_cyt in component model (molecule). * STATES[2] is NFAT_nuc in component model (molecule). * ALGEBRAIC[5] is NFAT_tot in component model (molecule). * CONSTANTS[0] is k1_unstim in component model (per_minute). * CONSTANTS[1] is k1_stim in component model (per_minute). * ALGEBRAIC[1] is k1 in component model (per_minute). * CONSTANTS[2] is k2 in component model (per_minute). * CONSTANTS[3] is k3 in component model (per_minute). * CONSTANTS[4] is k4 in component model (per_minute). * CONSTANTS[5] is stim_wavelength in component model (minute). * CONSTANTS[6] is stim_duration in component model (minute). * ALGEBRAIC[0] is stim_on in component model (dimensionless). * CONSTANTS[7] is time_before_stim in component model (minute). * ALGEBRAIC[2] is Jdephosphorylation in component model (molecules_per_minute). * ALGEBRAIC[3] is Jtranslocate in component model (molecules_per_minute). * ALGEBRAIC[4] is Jexport in component model (molecules_per_minute). * ALGEBRAIC[6] is percentage_NFAT_cyt in component model (dimensionless). * ALGEBRAIC[7] is percentage_NFATP_cyt in component model (dimensionless). * ALGEBRAIC[8] is percentage_NFAT_nuc in component model (dimensionless). * RATES[0] is d/dt NFATP_cyt in component model (molecule). * RATES[1] is d/dt NFAT_cyt in component model (molecule). * RATES[2] is d/dt NFAT_nuc in component model (molecule). * There are a total of 2 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 5000; STATES[1] = 0; STATES[2] = 0; CONSTANTS[0] = 0; CONSTANTS[1] = 0.359; CONSTANTS[2] = 0.147; CONSTANTS[3] = 0.06; CONSTANTS[4] = 0.035; CONSTANTS[5] = 3; CONSTANTS[6] = 0.5; CONSTANTS[7] = 1; RATES[0] = 0.1001; RATES[1] = 0.1001; RATES[2] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[0] - ALGEBRAIC[4] - ALGEBRAIC[2]; resid[1] = RATES[1] - ALGEBRAIC[2] - ALGEBRAIC[3]; resid[2] = RATES[2] - ALGEBRAIC[3] - ALGEBRAIC[4]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[5] = STATES[0]+STATES[1]+STATES[2]; ALGEBRAIC[6] = ( STATES[1]*100.000)/ALGEBRAIC[5]; ALGEBRAIC[7] = ( STATES[0]*100.000)/ALGEBRAIC[5]; ALGEBRAIC[8] = ( STATES[2]*100.000)/ALGEBRAIC[5]; } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = (CONDVAR[0]>=0.00000&&CONDVAR[1]<=0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[1] = (ALGEBRAIC[0]==1.00000 ? CONSTANTS[1] : CONSTANTS[0]); ALGEBRAIC[2] = ALGEBRAIC[1]*STATES[0] - CONSTANTS[2]*STATES[1]; ALGEBRAIC[3] = CONSTANTS[3]*STATES[1]; ALGEBRAIC[4] = CONSTANTS[4]*STATES[2]; } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { CONDVAR[0] = VOI - CONSTANTS[7]; CONDVAR[1] = (int)(VOI - CONSTANTS[7]) % (int)(CONSTANTS[5]) - CONSTANTS[6]; }