Description of Guyton electrolytes module
2008-00-00 00:00
Extracellular and intracellular fluid electrolytes and volumes.
EL12:
Calculation of the total potassium inside all the cells of the body (KI) by
subtracting the potassium in the extracellular fluids (KE) from the total potassium
in the body (KTOT).
EL13:
Calculation of the concentration of potassium inside the cells of the body (CKI)
by dividing the total potassium inside all the cells (KI) by the volume of fluid
inside all the cells (VIC).
Electrolytes
Description of Guyton electrolytes module
electrolytes
Guyton
physiology
cardiovascular circulation
organ systems
organ systems
physiology
Guyton
electrolytes
cardiovascular circulation
2008-00-00 00:00
keyword
Encapsulation grouping component containing all the components in the Electrolytes Model. The inputs and
outputs of the Electrolytes Model must be passed by this component.
EL13:
Calculation of the concentration of potassium inside the cells of the body (CKI)
by dividing the total potassium inside all the cells (KI) by the volume of fluid
inside all the cells (VIC).
This is the CellML 1.1 "parent" file to test the Electrolytes Model.
Electrolytes
Guyton
Guyton
E L 6 :
T h e r a t e o f c h a n g e o f t h e t o t a l q u a n t i t y o f p o t a s s i u m i n a l l o f t h e b o d y f l u i d s ( K T O T D )
i s e q u a l t o t h e r a t e o f i n t a k e o f p o t a s s i u m ( K I D ) m i n u s t h e r a t e o f e x c r e t i o n o f
p o t a s s i u m i n t h e u r i n e ( K O D ) .
E L 7 :
T h e t o t a l q u a n t i t y o f p o t a s s i u m i n a l l t h e b o d y f l u i d s a t a n y g i v e n t i m e ( K T O T )
i s c a l c u l a t e d b y i n t e g r a t i n g w i t h r e s p e c t t o t i m e t h e r a t e o f c h a n g e o f t h e p o t a s s i u m
i n a l l o f t h e b o d y f l u i d s ( K T O T D ) .
E L 7 A :
C a l c u l a t i o n o f t h e f r e e l y m o b i l e p o t a s s i u m i n t h e b o d y ( a p p r o x i m a t e l y 6 1 6 ) b y
s u b t r a c t i n g t h e r e l a t i v e l y f i x e d p o t a s s i u m i n a l l t h e c e l l s o f t h e b o d y
( a p p r o x i m a t e l y 3 0 0 0 ) f r o m t h e t o t a l p o t a s s i u m o f t h e b o d y ( K T O T ) .
E L 7 B :
C a l c u l a t i o n o f t h e t o t a l p o t a s s i u m i n t h e e x t r a c e l l u l a r f l u i d o f t h e b o d y ( K E ) b y
d i v i d i n g t h e t o t a l f r e e l y m o b i l e c a l c i u m f r o m B l o c k E L 7 A b y a c o n s t a n t f a c t o r o f
9 . 3 3 3 3 ( w h i c h i s a d i s t r i b u t i o n r e l a t i o n s h i p o f t h e f r e e l y m o b i l e p o t a s s i u m b e t w e e n
t h e i n t r a c e l l u l a r a n d e x t r a c e l l u l a r f l u i d ) , a n d d i v i d e d b y a f a c t o r f r o m B l o c k E L 1 1
t h a t d e t e r m i n e s t h e a c t i v i t y o f a l d o s t e r o n e o n t h e d i s t r i b u t i o n r e l a t i o n s h i p o f
p o t a s s i u m a c r o s s t h e c e l l m e m b r a n e s .
E L 8 :
T h e c o n c e n t r a t i o n o f p o t a s s i u m i n t h e e x t r a c e l l u l a r f l u i d ( C K E ) i s e q u a l t o t h e
q u a n t i t y o f p o t a s s i u m i n t h e e x t r a c e l l u l a r f l u i d ( K E ) d i v i d e d b y t h e v o l u m e o f
e x t r a c e l l u l a r f l u i d ( V E C ) .
EL14 and EL15:
Calculation of the rate of change of volume inside all the cells of the body (VID)
caused in Block EL14 by differences in osmotic effect of sodium concentration (CNA)
outside the cells and potassium concentration (CKI) inside the cells. The rate of
transfer of this fluid (VID) is determined by a proportionality factor (VIDML).
EL16:
Calculation of the changing level of intracellular fluid volume in the entire body (VIC)
by integrating the rate of change of this fluid volume (VID).
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EL14 and EL15:
Calculation of the rate of change of volume inside all the cells of the body (VID)
caused in Block EL14 by differences in osmotic effect of sodium concentration (CNA)
outside the cells and potassium concentration (CKI) inside the cells. The rate of
transfer of this fluid (VID) is determined by a proportionality factor (VIDML).
EL16:
Calculation of the changing level of intracellular fluid volume in the entire body (VIC)
by integrating the rate of change of this fluid volume (VID).
EL14 and EL15:
Calculation of the rate of change of volume inside all the cells of the body (VID)
caused in Block EL14 by differences in osmotic effect of sodium concentration (CNA)
outside the cells and potassium concentration (CKI) inside the cells. The rate of
transfer of this fluid (VID) is determined by a proportionality factor (VIDML).
EL8:
The concentration of potassium in the extracellular fluid (CKE) is equal to the
quantity of potassium in the extracellular fluid (KE) divided by the volume of
extracellular fluid (VEC).
EL17:
The rate of change of total volume of water in the body (DVTW) is equal to the
rate of intake of water (TVD) minus the rate of output of water in the urine (VUD).
EL18:
The total volume of water in the body at any given instant (VTW) is determined
by integrating with respect times the rate of change of total water volume (DVTW).
EL7:
The total quantity of potassium in all the body fluids at any given time (KTOT)
is calculated by integrating with respect to time the rate of change of the potassium
in all of the body fluids (KTOTD).
EL5:
The concentration of sodium in the extracellular fluid (CNA) is equal to the quantity
of sodium in the extracellular fluid (NAE) divided by the extracellular fluid volume (VEC).
EL1, EL2, and EL3:
The rate of intake of sodium (NAINT) is equal to the normal rate of sodium intake (NID)
times a salt appetite multiplier factor (STH). The rate of change of sodium in the
extracellular fluid (NED) is equal to the rate of intake of sodium (NAINT), minus the
rate of excretion of sodium in the urine (NOD), plus sodium entering the body in
transfused plasma (TRPL).
EL19:
The extracellular fluid volume (VEC) is equal to the total volume of water in the
body (VTW) minus the total volume of water inside all of the cells of the body (VIC).
EL6:
The rate of change of the total quantity of potassium in all of the body fluids (KTOTD)
is equal to the rate of intake of potassium (KID) minus the rate of excretion of
potassium in the urine (KOD).
EL7A:
Calculation of the freely mobile potassium in the body (approximately 616) by
subtracting the relatively fixed potassium in all the cells of the body
(approximately 3000) from the total potassium of the body (KTOT).
EL7B:
Calculation of the total potassium in the extracellular fluid of the body (KE) by
dividing the total freely mobile calcium from Block EL7A by a constant factor of
9.3333 (which is a distribution relationship of the freely mobile potassium between
the intracellular and extracellular fluid), and divided by a factor from Block EL11
that determines the activity of aldosterone on the distribution relationship of
potassium across the cell membranes.
EL1, EL2, and EL3:
The rate of intake of sodium (NAINT) is equal to the normal rate of sodium intake (NID)
times a salt appetite multiplier factor (STH). The rate of change of sodium in the
extracellular fluid (NED) is equal to the rate of intake of sodium (NAINT), minus the
rate of excretion of sodium in the urine (NOD), plus sodium entering the body in
transfused plasma (TRPL).
EL4:
The instantaneous quantity of sodium in the extracellular fluid (NAE) is calculated
by integrating with respect to time the rate of change of sodium in the
extracellular fluid (NED).
EL5:
The concentration of sodium in the extracellular fluid (CNA) is equal to the quantity
of sodium in the extracellular fluid (NAE) divided by the extracellular fluid volume (VEC).
Component to set all input values to 1.0 or a prescribed value.
EL4:
The instantaneous quantity of sodium in the extracellular fluid (NAE) is calculated
by integrating with respect to time the rate of change of sodium in the
extracellular fluid (NED).
EL17:
The rate of change of total volume of water in the body (DVTW) is equal to the
rate of intake of water (TVD) minus the rate of output of water in the urine (VUD).
EL18:
The total volume of water in the body at any given instant (VTW) is determined
by integrating with respect times the rate of change of total water volume (DVTW).
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EL19:
The extracellular fluid volume (VEC) is equal to the total volume of water in the
body (VTW) minus the total volume of water inside all of the cells of the body (VIC).
EL9, EL10, and EL11:
Calculation of an aldosterone multiplier factor for the effect of aldosterone (AMK)
on the distribution of potassium across the cell membranes. The variable (ALCLK) is
a sensitivity control for adjusting the effect of the aldosterone on the cellular
membrane distribution relationship of potassium on the two sides of the cell membranes.
EL12:
Calculation of the total potassium inside all the cells of the body (KI) by
subtracting the potassium in the extracellular fluids (KE) from the total potassium
in the body (KTOT).
EL9, EL10, and EL11:
Calculation of an aldosterone multiplier factor for the effect of aldosterone (AMK)
on the distribution of potassium across the cell membranes. The variable (ALCLK) is
a sensitivity control for adjusting the effect of the aldosterone on the cellular
membrane distribution relationship of potassium on the two sides of the cell membranes.