c.lloyd@auckland.ac.nz
S
Demir
Semahat
Added more metadata.
Rabbit
Sinoatrial Node Cell
Demir et al's 1999 mathematical model of a rabbit sinoatrial node cell
John
Clark
W
1999-06-01
May
Lloyd
Catherine
276
H2244
H2221
Parasympathetic modulation of sinoatrial node pacemaker activity in rabbit heart: a unifying model
added cmeta:id's for some variables to allow referencing by PCEnv session
signal transduction
sinoatrial node
electrophysiology
cardiac
Catherine
Lloyd
May
May
Lloyd
Catherine
The Bioengineering Institute
The University of Auckland
American Journal of Physiology
May
Lloyd
Catherine
R
Wayne
Giles
The effects of ACh and Iso on i_Ca_L and i_K are produced indirectly via the cAMP-dependent modulation of L-type Ca2+ and K+ channel
conductance (g_Ca_L and g_K) respectively.
The University of Auckland, Bioengineering Institute
A
Autumn
Cuellar
Peter
J
Villiger
2002-07-18
May
Catherine
Lloyd
Richard
James
Lawson
Below is a CellML description of Demir et al's 1999 mathematical model of parasympathetic modulation of sinoatrial node (SAN) pacemaker activity in a rabbit heart. Based on experimental data, this model is a development of their earlier model of the single rabbit SAN cell (1994). Modifications have been made enabling it to mimic the important effects of the second-messenger cAMP and to simulate the response of SAN cells to the neurotransmitter acetylcholine (ACh) and isoprenaline (Iso).
keyword
2002-07-18
The effects of Iso on i_NaK may be species dependent as it has been observed that Iso directly stimulates Na+-K+-ATPase activity in rabbit ventricular myocytes (Desilets and Baumgarten, 1986), but indirectly stimulates i_NaK in guinea pig ventricular myocytes via a PKA phosphorylation step (Gao et al. 1992, 1994). In the absence of any quantitative evidence, in this model Demir et al. have assumed that cAMP directly stimulates i_NaK in the rabbit SAN cell and that this cAMP dependency may be modelled by the equations below.
2007-06-19T15:32:11+12:00
This model has been validated by Penny Noble of Oxford University and is known to run in COR and PCEnv. A PCEnv session file is also associated with this version. Model curated by Penny Noble using Demir 1994 Oxsoft Heart model code and Demir 1999 paper.
Changed the model name so the model loads in the database easier.
Changed equivalent to eq in apply id line.
2002-02-28
Corrected some units.
This model has been validated by Penny Noble of Oxford University.
James Lawson
10362707
Changed sign of i_rel in dCai-dt equation. Changed the name of sodium-calcium pump to an exchanger. Changed U_calculation from an equals sign to an equivalent sign.
Noble
J
Penny
Corrected several equations.
2007-12-19T13:48:43+13:00
The T-type calcium channel has two gates, an activation gate d_T and an inactivation gate f_T.
2
100000
0.1
2002-02-06T00:00:00+00:00
2002-02-25
2005-04-25
i_f is modulated via a direct effect of cAMP on the
voltage-dependence of its steady-state activation variable y.
2003-04-05
Catherine Lloyd
ACh has a direct stimulatory affect on the ACh-sensitive potassium
channel. The G-protein-mediated, direct affect of ACh on i_K_ACh
occurs via the extrajunctional M2/K_ACh muscarinic receptor. This
channel has a single gating variable a.