/* There are a total of 2 entries in the algebraic variable array. There are a total of 9 entries in each of the rate and state variable arrays. There are a total of 30 entries in the constant variable array. */ /* * VOI is time in component environment (hour). * CONSTANTS[29] is F_c_dopa in component gastrointestinal_compartment_L_dopa (dimensionless). * STATES[0] is A_dopa_c in component gastrointestinal_compartment_L_dopa (umole). * CONSTANTS[0] is ka_c_dopa in component gastrointestinal_compartment_L_dopa (per_hour). * CONSTANTS[21] is F_G in component gastrointestinal_compartment_L_dopa (dimensionless). * CONSTANTS[28] is F_H in component gastrointestinal_compartment_L_dopa (dimensionless). * CONSTANTS[25] is CL_H in component gastrointestinal_compartment_L_dopa (liter_per_hour). * CONSTANTS[1] is Q in component gastrointestinal_compartment_L_dopa (liter_per_hour). * CONSTANTS[2] is f_H in component gastrointestinal_compartment_L_dopa (dimensionless). * CONSTANTS[3] is CL_dopa_0 in component L_dopa_clearance (liter_per_hour). * STATES[1] is C_dopa_c in component body_compartment_L_dopa (uM). * CONSTANTS[4] is V_dopa in component body_compartment_L_dopa (liter). * ALGEBRAIC[1] is CL_dopa in component L_dopa_clearance (liter_per_hour). * STATES[2] is C_OMD_c in component body_compartment_3_OMD (uM). * CONSTANTS[5] is CL_OMD_c in component body_compartment_3_OMD (liter_per_hour). * CONSTANTS[6] is V_OMD_c in component body_compartment_3_OMD (liter). * CONSTANTS[22] is CL_COMT in component L_dopa_clearance (liter_per_hour). * ALGEBRAIC[0] is CL_AADC in component L_dopa_clearance (liter_per_hour). * CONSTANTS[23] is CL_AADC0 in component L_dopa_clearance (liter_per_hour). * STATES[3] is C_Ro_central in component central_compartment_Ro (uM). * CONSTANTS[26] is CL_REST in component L_dopa_clearance (liter_per_hour). * CONSTANTS[7] is ki in component L_dopa_clearance (uM). * STATES[4] is A_bens in component gastrointestinal_compartment_benserazide (umole). * CONSTANTS[8] is ka_B in component gastrointestinal_compartment_benserazide (per_hour). * CONSTANTS[9] is F_B in component gastrointestinal_compartment_benserazide (dimensionless). * STATES[5] is C_bens_central in component central_compartment_benserazide (uM). * CONSTANTS[10] is V1_B in component central_compartment_benserazide (liter). * CONSTANTS[11] is CLd_B in component central_compartment_benserazide (liter_per_hour). * STATES[6] is C_bens_peripheral in component peripheral_compartment_benserazide (uM). * CONSTANTS[24] is CL_bens_total in component benserazide_clearance (liter_per_hour). * CONSTANTS[12] is V2_B in component peripheral_compartment_benserazide (liter). * CONSTANTS[27] is CL_Ro in component benserazide_clearance (liter_per_hour). * CONSTANTS[13] is CL_B in component benserazide_clearance (liter_per_hour). * CONSTANTS[14] is fm in component benserazide_clearance (dimensionless). * STATES[7] is A_Ro in component gastrointestinal_compartment_Ro (umole). * CONSTANTS[15] is ka_M in component gastrointestinal_compartment_Ro (per_hour). * CONSTANTS[16] is F_Ro in component gastrointestinal_compartment_Ro (dimensionless). * CONSTANTS[17] is V1_M in component central_compartment_Ro (liter). * CONSTANTS[18] is CLd_M in component central_compartment_Ro (liter_per_hour). * CONSTANTS[19] is CL_M in component central_compartment_Ro (liter_per_hour). * STATES[8] is C_Ro_peripheral in component peripheral_compartment_Ro (uM). * CONSTANTS[20] is V2_M in component peripheral_compartment_Ro (liter). * RATES[0] is d/dt A_dopa_c in component gastrointestinal_compartment_L_dopa (umole). * RATES[1] is d/dt C_dopa_c in component body_compartment_L_dopa (uM). * RATES[2] is d/dt C_OMD_c in component body_compartment_3_OMD (uM). * RATES[4] is d/dt A_bens in component gastrointestinal_compartment_benserazide (umole). * RATES[5] is d/dt C_bens_central in component central_compartment_benserazide (uM). * RATES[6] is d/dt C_bens_peripheral in component peripheral_compartment_benserazide (uM). * RATES[7] is d/dt A_Ro in component gastrointestinal_compartment_Ro (umole). * RATES[3] is d/dt C_Ro_central in component central_compartment_Ro (uM). * RATES[8] is d/dt C_Ro_peripheral in component peripheral_compartment_Ro (uM). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 101; CONSTANTS[0] = 1.29; CONSTANTS[1] = 0.828; CONSTANTS[2] = 0.13; CONSTANTS[3] = 0.823; STATES[1] = 0; CONSTANTS[4] = 0.496; STATES[2] = 0; CONSTANTS[5] = 0.00895; CONSTANTS[6] = 0.128; STATES[3] = 0; CONSTANTS[7] = 0.00246; STATES[4] = 19.51; CONSTANTS[8] = 0.94; CONSTANTS[9] = 0.022; STATES[5] = 0; CONSTANTS[10] = 0.202; CONSTANTS[11] = 0.072; STATES[6] = 0; CONSTANTS[12] = 0.127; CONSTANTS[13] = 1.67; CONSTANTS[14] = 0.15; STATES[7] = 1.3658; CONSTANTS[15] = 2.47; CONSTANTS[16] = 1; CONSTANTS[17] = 0.0691; CONSTANTS[18] = 1.06; CONSTANTS[19] = 4.29; STATES[8] = 0; CONSTANTS[20] = 3.2; CONSTANTS[21] = 1.00000; CONSTANTS[22] = CONSTANTS[3]*0.100000; CONSTANTS[23] = CONSTANTS[3]*0.690000; CONSTANTS[24] = CONSTANTS[13]/(1.00000 - CONSTANTS[14]); CONSTANTS[25] = CONSTANTS[2]*CONSTANTS[3]; CONSTANTS[26] = CONSTANTS[3]*0.210000; CONSTANTS[27] = CONSTANTS[24]*CONSTANTS[14]; CONSTANTS[28] = 1.00000 - CONSTANTS[25]/CONSTANTS[1]; CONSTANTS[29] = CONSTANTS[28]*CONSTANTS[21]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { RATES[0] = - CONSTANTS[0]*STATES[0]; RATES[2] = (1.00000/CONSTANTS[6])*( CONSTANTS[22]*STATES[1] - CONSTANTS[5]*STATES[2]); RATES[4] = - CONSTANTS[8]*STATES[4]; RATES[5] = (1.00000/CONSTANTS[10])*(( CONSTANTS[8]*STATES[4]*CONSTANTS[9] - CONSTANTS[24]*STATES[5])+ CONSTANTS[11]*(STATES[6] - STATES[5])); RATES[6] = (1.00000/CONSTANTS[12])*CONSTANTS[11]*(STATES[5] - STATES[6]); RATES[7] = - CONSTANTS[15]*STATES[7]; RATES[3] = (1.00000/CONSTANTS[17])*(( CONSTANTS[15]*STATES[7]*CONSTANTS[16] - CONSTANTS[19]*STATES[3])+ CONSTANTS[27]*STATES[5]+ CONSTANTS[18]*(STATES[8] - STATES[3])); RATES[8] = (1.00000/CONSTANTS[20])*CONSTANTS[18]*(STATES[3] - STATES[8]); ALGEBRAIC[0] = CONSTANTS[23]/(1.00000+STATES[3]/CONSTANTS[7]); ALGEBRAIC[1] = ALGEBRAIC[0]+CONSTANTS[22]+CONSTANTS[26]; RATES[1] = (1.00000/CONSTANTS[4])*( CONSTANTS[0]*STATES[0]*CONSTANTS[29] - ALGEBRAIC[1]*STATES[1]); } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[23]/(1.00000+STATES[3]/CONSTANTS[7]); ALGEBRAIC[1] = ALGEBRAIC[0]+CONSTANTS[22]+CONSTANTS[26]; }