/*
   There are a total of 9 entries in the algebraic variable array.
   There are a total of 2 entries in each of the rate and state variable arrays.
   There are a total of 13 entries in the constant variable array.
 */
/*
 * VOI is time in component environment (hour).
 * CONSTANTS[0] is Ado in component Ado (micromolar).
 * ALGEBRAIC[0] is Met in component Met (micromolar).
 * ALGEBRAIC[1] is Hcy in component Hcy (micromolar).
 * STATES[0] is AdoHcy in component AdoHcy (micromolar).
 * CONSTANTS[1] is K_AHC in component K_AHC (micromolar).
 * STATES[1] is AdoMet in component AdoMet (micromolar).
 * ALGEBRAIC[6] is V_MET in component V_MET (flux).
 * ALGEBRAIC[7] is V_GNMT in component V_GNMT (flux).
 * ALGEBRAIC[2] is V_MATI in component V_MATI (flux).
 * ALGEBRAIC[4] is V_MATIII in component V_MATIII (flux).
 * ALGEBRAIC[8] is V_D in component V_D (flux).
 * CONSTANTS[2] is V_MATImax in component V_MATI (flux).
 * CONSTANTS[3] is Km_MATI in component V_MATI (micromolar).
 * CONSTANTS[4] is Ki_MATI in component V_MATI (micromolar).
 * CONSTANTS[5] is V_MATIIImax in component V_MATIII (flux).
 * ALGEBRAIC[3] is Km1_MATIII in component V_MATIII (micromolar).
 * CONSTANTS[6] is Km2_MATIII in component V_MATIII (micromolar).
 * CONSTANTS[7] is V_METmax in component V_MET (flux).
 * ALGEBRAIC[5] is Km1_MET in component V_MET (micromolar).
 * CONSTANTS[8] is Km2_MET_A in component V_MET (dimensionless).
 * CONSTANTS[9] is V_GNMTmax in component V_GNMT (flux).
 * CONSTANTS[10] is Km_GNMT in component V_GNMT (micromolar).
 * CONSTANTS[11] is Ki_GNMT in component V_GNMT (micromolar).
 * CONSTANTS[12] is alpha_d in component V_D (first_order_rate_constant).
 * RATES[1] is d/dt AdoMet in component AdoMet (micromolar).
 * RATES[0] is d/dt AdoHcy in component AdoHcy (micromolar).
 */
void
initConsts(double* CONSTANTS, double* RATES, double *STATES)
{
CONSTANTS[0] = 1;
STATES[0] = 3;
CONSTANTS[1] = 0.1;
STATES[1] = 60;
CONSTANTS[2] = 561;
CONSTANTS[3] = 41;
CONSTANTS[4] = 50;
CONSTANTS[5] = 22870;
CONSTANTS[6] = 21.1;
CONSTANTS[7] = 4544;
CONSTANTS[8] = 10;
CONSTANTS[9] = 10600;
CONSTANTS[10] = 4500;
CONSTANTS[11] = 20;
CONSTANTS[12] = 1333;
}
void
computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[5] =  10.0000*(1.00000+STATES[0]/4.00000);
ALGEBRAIC[6] = CONSTANTS[7]/(1.00000+ALGEBRAIC[5]/STATES[1]+CONSTANTS[8]+( CONSTANTS[8]*ALGEBRAIC[5])/STATES[1]);
ALGEBRAIC[7] = ( (CONSTANTS[9]/(1.00000+pow(CONSTANTS[10]/STATES[1], 2.30000)))*1.00000)/(1.00000+STATES[0]/CONSTANTS[11]);
ALGEBRAIC[0] = (VOI>=0.00000&&VOI<5.00000 ? 45.0000 : VOI>=5.00000&&VOI<15.0000 ? 52.0000 : VOI>=15.0000&&VOI<60.0000 ? 55.0000 : VOI>=60.0000&&VOI<75.0000 ? 52.0000 : VOI>=75.0000 ? 45.0000 : 0.0/0.0);
ALGEBRAIC[2] = CONSTANTS[2]/(1.00000+ (CONSTANTS[3]/ALGEBRAIC[0])*(1.00000+STATES[1]/CONSTANTS[4]));
ALGEBRAIC[3] = 20000.0/(1.00000+ 5.70000*pow(STATES[1]/(STATES[1]+600.000), 2.00000));
ALGEBRAIC[4] = CONSTANTS[5]/(1.00000+( ALGEBRAIC[3]*CONSTANTS[6])/(pow(ALGEBRAIC[0], 2.00000)+ ALGEBRAIC[0]*CONSTANTS[6]));
RATES[1] = (ALGEBRAIC[2]+ALGEBRAIC[4]) - (ALGEBRAIC[6]+ALGEBRAIC[7]);
ALGEBRAIC[1] = ( STATES[0]*CONSTANTS[1])/CONSTANTS[0];
ALGEBRAIC[8] =  CONSTANTS[12]*ALGEBRAIC[1];
RATES[0] = ((ALGEBRAIC[6]+ALGEBRAIC[7]) - ALGEBRAIC[8])/(1.00000+CONSTANTS[1]/CONSTANTS[0]);
}
void
computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[5] =  10.0000*(1.00000+STATES[0]/4.00000);
ALGEBRAIC[6] = CONSTANTS[7]/(1.00000+ALGEBRAIC[5]/STATES[1]+CONSTANTS[8]+( CONSTANTS[8]*ALGEBRAIC[5])/STATES[1]);
ALGEBRAIC[7] = ( (CONSTANTS[9]/(1.00000+pow(CONSTANTS[10]/STATES[1], 2.30000)))*1.00000)/(1.00000+STATES[0]/CONSTANTS[11]);
ALGEBRAIC[0] = (VOI>=0.00000&&VOI<5.00000 ? 45.0000 : VOI>=5.00000&&VOI<15.0000 ? 52.0000 : VOI>=15.0000&&VOI<60.0000 ? 55.0000 : VOI>=60.0000&&VOI<75.0000 ? 52.0000 : VOI>=75.0000 ? 45.0000 : 0.0/0.0);
ALGEBRAIC[2] = CONSTANTS[2]/(1.00000+ (CONSTANTS[3]/ALGEBRAIC[0])*(1.00000+STATES[1]/CONSTANTS[4]));
ALGEBRAIC[3] = 20000.0/(1.00000+ 5.70000*pow(STATES[1]/(STATES[1]+600.000), 2.00000));
ALGEBRAIC[4] = CONSTANTS[5]/(1.00000+( ALGEBRAIC[3]*CONSTANTS[6])/(pow(ALGEBRAIC[0], 2.00000)+ ALGEBRAIC[0]*CONSTANTS[6]));
ALGEBRAIC[1] = ( STATES[0]*CONSTANTS[1])/CONSTANTS[0];
ALGEBRAIC[8] =  CONSTANTS[12]*ALGEBRAIC[1];
}