/* There are a total of 9 entries in the algebraic variable array. There are a total of 2 entries in each of the rate and state variable arrays. There are a total of 13 entries in the constant variable array. */ /* * VOI is time in component environment (hour). * CONSTANTS[0] is Ado in component Ado (micromolar). * ALGEBRAIC[0] is Met in component Met (micromolar). * ALGEBRAIC[1] is Hcy in component Hcy (micromolar). * STATES[0] is AdoHcy in component AdoHcy (micromolar). * CONSTANTS[1] is K_AHC in component K_AHC (micromolar). * STATES[1] is AdoMet in component AdoMet (micromolar). * ALGEBRAIC[8] is V_MET in component V_MET (flux). * ALGEBRAIC[5] is V_GNMT in component V_GNMT (flux). * ALGEBRAIC[2] is V_MATI in component V_MATI (flux). * ALGEBRAIC[7] is V_MATIII in component V_MATIII (flux). * ALGEBRAIC[6] is V_D in component V_D (flux). * CONSTANTS[2] is V_MATImax in component V_MATI (flux). * CONSTANTS[3] is Km_MATI in component V_MATI (micromolar). * CONSTANTS[4] is Ki_MATI in component V_MATI (micromolar). * CONSTANTS[5] is V_MATIIImax in component V_MATIII (flux). * ALGEBRAIC[3] is Km1_MATIII in component V_MATIII (micromolar). * CONSTANTS[6] is Km2_MATIII in component V_MATIII (micromolar). * CONSTANTS[7] is V_METmax in component V_MET (flux). * ALGEBRAIC[4] is Km1_MET in component V_MET (micromolar). * CONSTANTS[8] is Km2_MET_A in component V_MET (dimensionless). * CONSTANTS[9] is V_GNMTmax in component V_GNMT (flux). * CONSTANTS[10] is Km_GNMT in component V_GNMT (micromolar). * CONSTANTS[11] is Ki_GNMT in component V_GNMT (micromolar). * CONSTANTS[12] is alpha_d in component V_D (first_order_rate_constant). * RATES[1] is d/dt AdoMet in component AdoMet (micromolar). * RATES[0] is d/dt AdoHcy in component AdoHcy (micromolar). * There are a total of 9 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 1; STATES[0] = 3; CONSTANTS[1] = 0.1; STATES[1] = 60; CONSTANTS[2] = 561; CONSTANTS[3] = 41; CONSTANTS[4] = 50; CONSTANTS[5] = 22870; CONSTANTS[6] = 21.1; CONSTANTS[7] = 4544; CONSTANTS[8] = 10; CONSTANTS[9] = 10600; CONSTANTS[10] = 4500; CONSTANTS[11] = 20; CONSTANTS[12] = 1333; RATES[1] = 0.1001; RATES[0] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[1] - (ALGEBRAIC[2]+ALGEBRAIC[7]) - (ALGEBRAIC[8]+ALGEBRAIC[5]); resid[1] = RATES[0] - ((ALGEBRAIC[8]+ALGEBRAIC[5]) - ALGEBRAIC[6])/(1.00000+CONSTANTS[1]/CONSTANTS[0]); } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = (CONDVAR[0]>=0.00000&&CONDVAR[1]<0.00000 ? 45.0000 : CONDVAR[2]>=0.00000&&CONDVAR[3]<0.00000 ? 52.0000 : CONDVAR[4]>=0.00000&&CONDVAR[5]<0.00000 ? 55.0000 : CONDVAR[6]>=0.00000&&CONDVAR[7]<0.00000 ? 52.0000 : CONDVAR[8]>=0.00000 ? 45.0000 : 0.0/0.0); ALGEBRAIC[2] = CONSTANTS[2]/(1.00000+ (CONSTANTS[3]/ALGEBRAIC[0])*(1.00000+STATES[1]/CONSTANTS[4])); ALGEBRAIC[5] = ( (CONSTANTS[9]/(1.00000+pow(CONSTANTS[10]/STATES[1], 2.30000)))*1.00000)/(1.00000+STATES[0]/CONSTANTS[11]); ALGEBRAIC[1] = ( STATES[0]*CONSTANTS[1])/CONSTANTS[0]; ALGEBRAIC[6] = CONSTANTS[12]*ALGEBRAIC[1]; ALGEBRAIC[3] = 20000.0/(1.00000+ 5.70000*pow(STATES[1]/(STATES[1]+600.000), 2.00000)); ALGEBRAIC[7] = CONSTANTS[5]/(1.00000+( ALGEBRAIC[3]*CONSTANTS[6])/(pow(ALGEBRAIC[0], 2.00000)+ ALGEBRAIC[0]*CONSTANTS[6])); ALGEBRAIC[4] = 10.0000*(1.00000+STATES[0]/4.00000); ALGEBRAIC[8] = CONSTANTS[7]/(1.00000+ALGEBRAIC[4]/STATES[1]+CONSTANTS[8]+( CONSTANTS[8]*ALGEBRAIC[4])/STATES[1]); } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { CONDVAR[0] = VOI - 0.00000; CONDVAR[1] = VOI - 5.00000; CONDVAR[2] = VOI - 5.00000; CONDVAR[3] = VOI - 15.0000; CONDVAR[4] = VOI - 15.0000; CONDVAR[5] = VOI - 60.0000; CONDVAR[6] = VOI - 60.0000; CONDVAR[7] = VOI - 75.0000; CONDVAR[8] = VOI - 75.0000; }