/* There are a total of 2 entries in the algebraic variable array. There are a total of 34 entries in each of the rate and state variable arrays. There are a total of 55 entries in the constant variable array. */ /* * VOI is time in component environment (minute). * STATES[0] is v_c in component v_c (nanomolar). * ALGEBRAIC[0] is dv_c_dt in component dv_c_dt (flux). * CONSTANTS[0] is k_growth in component rate_constants (first_order_rate_constant). * STATES[1] is v_n in component v_n (nanomolar). * ALGEBRAIC[1] is k_volume in component k_volume (dimensionless). * STATES[2] is mcln2_c in component mcln2_c (nanomolar). * CONSTANTS[1] is k_50 in component rate_constants (first_order_rate_constant). * CONSTANTS[2] is k_10 in component rate_constants (first_order_rate_constant). * STATES[3] is mcln2_n in component mcln2_n (nanomolar). * STATES[4] is mclb5_c in component mclb5_c (nanomolar). * CONSTANTS[3] is k_51 in component rate_constants (first_order_rate_constant). * CONSTANTS[4] is k_11 in component rate_constants (first_order_rate_constant). * STATES[5] is mclb5_n in component mclb5_n (nanomolar). * CONSTANTS[5] is k_1 in component rate_constants (first_order_rate_constant). * STATES[6] is sbf_n in component sbf_n (nanomolar). * CONSTANTS[6] is k_2 in component rate_constants (first_order_rate_constant). * CONSTANTS[7] is k_39 in component rate_constants (first_order_rate_constant). * CONSTANTS[8] is k_34 in component rate_constants (second_order_rate_constant). * CONSTANTS[9] is k_35 in component rate_constants (first_order_rate_constant). * STATES[7] is sbfwhi5p_n in component sbfwhi5p_n (nanomolar). * STATES[8] is whi5_n in component whi5_n (nanomolar). * STATES[9] is sbfwhi5_n in component sbfwhi5_n (nanomolar). * STATES[10] is cln3_c in component cln3_c (nanomolar). * CONSTANTS[10] is k_6 in component rate_constants (flux). * CONSTANTS[11] is k_43 in component rate_constants (first_order_rate_constant). * CONSTANTS[12] is k_15 in component rate_constants (first_order_rate_constant). * STATES[11] is cln2_c in component cln2_c (nanomolar). * CONSTANTS[13] is k_3 in component rate_constants (first_order_rate_constant). * CONSTANTS[14] is k_26 in component rate_constants (second_order_rate_constant). * CONSTANTS[15] is k_27 in component rate_constants (first_order_rate_constant). * CONSTANTS[16] is k_12 in component rate_constants (first_order_rate_constant). * STATES[12] is cdk1_c in component cdk1_c (nanomolar). * STATES[13] is cdk1cln2_c in component cdk1cln2_c (nanomolar). * STATES[14] is clb5_c in component clb5_c (nanomolar). * CONSTANTS[17] is k_4 in component rate_constants (first_order_rate_constant). * CONSTANTS[18] is k_28 in component rate_constants (second_order_rate_constant). * CONSTANTS[19] is k_29 in component rate_constants (first_order_rate_constant). * CONSTANTS[20] is k_13 in component rate_constants (first_order_rate_constant). * STATES[15] is cdk1clb5_c in component cdk1clb5_c (nanomolar). * CONSTANTS[21] is k_7 in component rate_constants (flux). * CONSTANTS[22] is k_44 in component rate_constants (first_order_rate_constant). * CONSTANTS[23] is k_49 in component rate_constants (first_order_rate_constant). * CONSTANTS[24] is k_16 in component rate_constants (first_order_rate_constant). * STATES[16] is cdk1_n in component cdk1_n (nanomolar). * STATES[17] is cln3_n in component cln3_n (nanomolar). * CONSTANTS[25] is k_24 in component rate_constants (second_order_rate_constant). * CONSTANTS[26] is k_25 in component rate_constants (first_order_rate_constant). * CONSTANTS[27] is k_20 in component rate_constants (first_order_rate_constant). * STATES[18] is cdk1cln3_n in component cdk1cln3_n (nanomolar). * CONSTANTS[28] is k_21 in component rate_constants (first_order_rate_constant). * CONSTANTS[29] is k_46 in component rate_constants (first_order_rate_constant). * CONSTANTS[30] is k_53 in component rate_constants (first_order_rate_constant). * STATES[19] is cdk1cln2_n in component cdk1cln2_n (nanomolar). * CONSTANTS[31] is k_33 in component rate_constants (first_order_rate_constant). * CONSTANTS[32] is k_32 in component rate_constants (second_order_rate_constant). * CONSTANTS[33] is k_48 in component rate_constants (first_order_rate_constant). * STATES[20] is cdk1clb5sic1_c in component cdk1clb5sic1_c (nanomolar). * STATES[21] is sic1_c in component sic1_c (nanomolar). * STATES[22] is cdk1clb5_n in component cdk1clb5_n (nanomolar). * CONSTANTS[34] is k_41 in component rate_constants (first_order_rate_constant). * STATES[23] is cdk1clb5sic1p_n in component cdk1clb5sic1p_n (nanomolar). * CONSTANTS[35] is k_31 in component rate_constants (first_order_rate_constant). * CONSTANTS[36] is k_30 in component rate_constants (second_order_rate_constant). * CONSTANTS[37] is k_40 in component rate_constants (first_order_rate_constant). * STATES[24] is cdk1cln3far1_n in component cdk1cln3far1_n (nanomolar). * STATES[25] is far1_n in component far1_n (nanomolar). * STATES[26] is cdk1cln3far1p_n in component cdk1cln3far1p_n (nanomolar). * CONSTANTS[38] is k_36 in component rate_constants (second_order_rate_constant). * CONSTANTS[39] is k_37 in component rate_constants (second_order_rate_constant). * STATES[27] is cdk1clb5sic1_n in component cdk1clb5sic1_n (nanomolar). * CONSTANTS[40] is k_47 in component rate_constants (first_order_rate_constant). * CONSTANTS[41] is k_38 in component rate_constants (second_order_rate_constant). * CONSTANTS[42] is k_9 in component rate_constants (flux). * CONSTANTS[43] is k_18 in component rate_constants (first_order_rate_constant). * STATES[28] is whi5_c in component whi5_c (nanomolar). * CONSTANTS[44] is k_8 in component rate_constants (flux). * CONSTANTS[45] is k_45 in component rate_constants (first_order_rate_constant). * CONSTANTS[46] is k_17 in component rate_constants (first_order_rate_constant). * STATES[29] is far1_c in component far1_c (nanomolar). * CONSTANTS[47] is k_5 in component rate_constants (flux). * CONSTANTS[48] is k_42 in component rate_constants (first_order_rate_constant). * CONSTANTS[49] is k_14 in component rate_constants (first_order_rate_constant). * STATES[30] is whi5p_c in component whi5p_c (nanomolar). * CONSTANTS[50] is k_52 in component rate_constants (first_order_rate_constant). * STATES[31] is whi5p_n in component whi5p_n (nanomolar). * STATES[32] is sic1P_n in component sic1P_n (nanomolar). * STATES[33] is far1P_n in component far1P_n (nanomolar). * CONSTANTS[51] is k_22 in component rate_constants (first_order_rate_constant). * CONSTANTS[52] is k_19 in component rate_constants (first_order_rate_constant). * CONSTANTS[53] is k_23 in component rate_constants (first_order_rate_constant). * RATES[0] is d/dt v_c in component v_c (nanomolar). * RATES[1] is d/dt v_n in component v_n (nanomolar). * RATES[2] is d/dt mcln2_c in component mcln2_c (nanomolar). * RATES[4] is d/dt mclb5_c in component mclb5_c (nanomolar). * RATES[3] is d/dt mcln2_n in component mcln2_n (nanomolar). * RATES[5] is d/dt mclb5_n in component mclb5_n (nanomolar). * RATES[6] is d/dt sbf_n in component sbf_n (nanomolar). * RATES[10] is d/dt cln3_c in component cln3_c (nanomolar). * RATES[11] is d/dt cln2_c in component cln2_c (nanomolar). * RATES[14] is d/dt clb5_c in component clb5_c (nanomolar). * RATES[12] is d/dt cdk1_c in component cdk1_c (nanomolar). * RATES[17] is d/dt cln3_n in component cln3_n (nanomolar). * RATES[16] is d/dt cdk1_n in component cdk1_n (nanomolar). * RATES[13] is d/dt cdk1cln2_c in component cdk1cln2_c (nanomolar). * RATES[15] is d/dt cdk1clb5_c in component cdk1clb5_c (nanomolar). * RATES[19] is d/dt cdk1cln2_n in component cdk1cln2_n (nanomolar). * RATES[22] is d/dt cdk1clb5_n in component cdk1clb5_n (nanomolar). * RATES[18] is d/dt cdk1cln3_n in component cdk1cln3_n (nanomolar). * RATES[9] is d/dt sbfwhi5_n in component sbfwhi5_n (nanomolar). * RATES[7] is d/dt sbfwhi5p_n in component sbfwhi5p_n (nanomolar). * RATES[24] is d/dt cdk1cln3far1_n in component cdk1cln3far1_n (nanomolar). * RATES[27] is d/dt cdk1clb5sic1_n in component cdk1clb5sic1_n (nanomolar). * RATES[23] is d/dt cdk1clb5sic1p_n in component cdk1clb5sic1p_n (nanomolar). * RATES[26] is d/dt cdk1cln3far1p_n in component cdk1cln3far1p_n (nanomolar). * RATES[20] is d/dt cdk1clb5sic1_c in component cdk1clb5sic1_c (nanomolar). * RATES[21] is d/dt sic1_c in component sic1_c (nanomolar). * RATES[28] is d/dt whi5_c in component whi5_c (nanomolar). * RATES[29] is d/dt far1_c in component far1_c (nanomolar). * RATES[30] is d/dt whi5p_c in component whi5p_c (nanomolar). * RATES[32] is d/dt sic1P_n in component sic1P_n (nanomolar). * RATES[33] is d/dt far1P_n in component far1P_n (nanomolar). * RATES[8] is d/dt whi5_n in component whi5_n (nanomolar). * RATES[25] is d/dt far1_n in component far1_n (nanomolar). * RATES[31] is d/dt whi5p_n in component whi5p_n (nanomolar). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 0.5; CONSTANTS[0] = 0.0051; STATES[1] = 0.5; STATES[2] = 0; CONSTANTS[1] = 0.6; CONSTANTS[2] = 0.12; STATES[3] = 0; STATES[4] = 0; CONSTANTS[3] = 0.6; CONSTANTS[4] = 0.12; STATES[5] = 0; CONSTANTS[5] = 0.03523; STATES[6] = 0; CONSTANTS[6] = 0.03523; CONSTANTS[7] = 1; CONSTANTS[8] = 8.46; CONSTANTS[9] = 0.0005; STATES[7] = 0; STATES[8] = 0; STATES[9] = 0.025544; STATES[10] = 0.000485; CONSTANTS[10] = 0.00001; CONSTANTS[11] = 0.005; CONSTANTS[12] = 0.01; STATES[11] = 0; CONSTANTS[13] = 0.32; CONSTANTS[14] = 2.82; CONSTANTS[15] = 0.55; CONSTANTS[16] = 0.1; STATES[12] = 0.333333; STATES[13] = 0; STATES[14] = 0; CONSTANTS[17] = 0.32; CONSTANTS[18] = 2.82; CONSTANTS[19] = 0.55; CONSTANTS[20] = 0.35; STATES[15] = 0; CONSTANTS[21] = 0.01; CONSTANTS[22] = 0.005; CONSTANTS[23] = 0.001; CONSTANTS[24] = 0.03; STATES[16] = 0.0074127; STATES[17] = 0; CONSTANTS[25] = 2.82; CONSTANTS[26] = 0.55; CONSTANTS[27] = 0.01; STATES[18] = 0; CONSTANTS[28] = 0; CONSTANTS[29] = 0.1; CONSTANTS[30] = 0.001; STATES[19] = 0; CONSTANTS[31] = 0.55; CONSTANTS[32] = 84.6; CONSTANTS[33] = 0.012; STATES[20] = 0; STATES[21] = 0.039234; STATES[22] = 0; CONSTANTS[34] = 1; STATES[23] = 0; CONSTANTS[35] = 0.55; CONSTANTS[36] = 42300; CONSTANTS[37] = 1; STATES[24] = 0; STATES[25] = 0; STATES[26] = 0; CONSTANTS[38] = 4363.6; CONSTANTS[39] = 4363.6; STATES[27] = 0; CONSTANTS[40] = 1; CONSTANTS[41] = 4363.6; CONSTANTS[42] = 0.00005; CONSTANTS[43] = 0.0008; STATES[28] = 0.073564; CONSTANTS[44] = 0.00004; CONSTANTS[45] = 0.005; CONSTANTS[46] = 0.01; STATES[29] = 0.0037926; CONSTANTS[47] = 0.000042; CONSTANTS[48] = 0.005; CONSTANTS[49] = 0.01; STATES[30] = 0; CONSTANTS[50] = 0.005; STATES[31] = 0; STATES[32] = 0; STATES[33] = 0; CONSTANTS[51] = 0.01; CONSTANTS[52] = 0.01; CONSTANTS[53] = 0.01; CONSTANTS[54] = 0.00000; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { RATES[1] = CONSTANTS[54]; RATES[3] = CONSTANTS[5]*STATES[6] - CONSTANTS[1]*STATES[3]; RATES[5] = CONSTANTS[6]*STATES[6] - CONSTANTS[3]*STATES[5]; RATES[6] = ( CONSTANTS[7]*STATES[7] - CONSTANTS[8]*STATES[6]*STATES[8])+ CONSTANTS[9]*STATES[9]; RATES[18] = ((( CONSTANTS[25]*STATES[17]*STATES[16] - CONSTANTS[26]*STATES[18])+ CONSTANTS[35]*STATES[24]) - CONSTANTS[36]*STATES[25]*STATES[18])+ CONSTANTS[37]*STATES[26]; RATES[9] = ( CONSTANTS[8]*STATES[6]*STATES[8] - CONSTANTS[9]*STATES[9]) - CONSTANTS[38]*STATES[9]*STATES[18]; RATES[7] = CONSTANTS[38]*STATES[9]*STATES[18] - CONSTANTS[7]*STATES[7]; RATES[24] = ( CONSTANTS[36]*STATES[25]*STATES[18] - CONSTANTS[35]*STATES[24]) - CONSTANTS[39]*STATES[24]*STATES[19]; RATES[23] = CONSTANTS[41]*STATES[27]*STATES[19] - CONSTANTS[34]*STATES[23]; RATES[26] = CONSTANTS[39]*STATES[24]*STATES[19] - CONSTANTS[37]*STATES[26]; RATES[32] = CONSTANTS[34]*STATES[23]; RATES[33] = CONSTANTS[37]*STATES[26]; RATES[31] = ( CONSTANTS[7]*STATES[7] - CONSTANTS[50]*STATES[31]) - CONSTANTS[53]*STATES[31]; ALGEBRAIC[0] = CONSTANTS[0]*STATES[0]; RATES[0] = ALGEBRAIC[0]; RATES[10] = ((CONSTANTS[10] - CONSTANTS[11]*STATES[10]) - CONSTANTS[12]*STATES[10]) - (ALGEBRAIC[0]/STATES[0])*STATES[10]; RATES[11] = ((( CONSTANTS[13]*STATES[2] - CONSTANTS[14]*STATES[12]*STATES[11])+ CONSTANTS[15]*STATES[13]) - CONSTANTS[16]*STATES[11]) - (ALGEBRAIC[0]/STATES[0])*STATES[11]; RATES[14] = ((( CONSTANTS[17]*STATES[4] - CONSTANTS[18]*STATES[14]*STATES[12])+ CONSTANTS[19]*STATES[15]) - CONSTANTS[20]*STATES[14]) - (ALGEBRAIC[0]/STATES[0])*STATES[14]; RATES[12] = ((((((CONSTANTS[21] - CONSTANTS[22]*STATES[12])+ CONSTANTS[23]*STATES[16]+ CONSTANTS[15]*STATES[13]) - CONSTANTS[14]*STATES[12]*STATES[11]) - CONSTANTS[18]*STATES[12]*STATES[14])+ CONSTANTS[19]*STATES[15]) - CONSTANTS[24]*STATES[12]) - (ALGEBRAIC[0]/STATES[0])*STATES[12]; RATES[15] = (((( CONSTANTS[18]*STATES[12]*STATES[14] - CONSTANTS[19]*STATES[15])+ CONSTANTS[31]*STATES[20]) - CONSTANTS[32]*STATES[21]*STATES[15]) - CONSTANTS[33]*STATES[15]) - (ALGEBRAIC[0]/STATES[0])*STATES[15]; RATES[20] = (( CONSTANTS[32]*STATES[21]*STATES[15] - CONSTANTS[31]*STATES[20]) - CONSTANTS[40]*STATES[20]) - (ALGEBRAIC[0]/STATES[0])*STATES[20]; RATES[21] = (((CONSTANTS[42] - CONSTANTS[32]*STATES[21]*STATES[15])+ CONSTANTS[31]*STATES[20]) - CONSTANTS[43]*STATES[21]) - (ALGEBRAIC[0]/STATES[0])*STATES[21]; RATES[28] = ((CONSTANTS[44] - CONSTANTS[45]*STATES[28]) - CONSTANTS[46]*STATES[28]) - (ALGEBRAIC[0]/STATES[0])*STATES[28]; RATES[29] = ((CONSTANTS[47] - CONSTANTS[48]*STATES[29]) - CONSTANTS[49]*STATES[29]) - (ALGEBRAIC[0]/STATES[0])*STATES[29]; ALGEBRAIC[1] = STATES[1]/STATES[0]; RATES[2] = ( CONSTANTS[1]*STATES[3]*ALGEBRAIC[1] - CONSTANTS[2]*STATES[2]) - (ALGEBRAIC[0]/STATES[0])*STATES[2]; RATES[4] = ( CONSTANTS[3]*STATES[5]*ALGEBRAIC[1] - CONSTANTS[4]*STATES[4]) - (ALGEBRAIC[0]/STATES[0])*STATES[4]; RATES[17] = ((( CONSTANTS[11]*STATES[10])/ALGEBRAIC[1] - CONSTANTS[25]*STATES[17]*STATES[16])+ CONSTANTS[26]*STATES[18]) - CONSTANTS[27]*STATES[17]; RATES[16] = (((( CONSTANTS[22]*STATES[12])/ALGEBRAIC[1] - CONSTANTS[23]*STATES[16]) - CONSTANTS[25]*STATES[17]*STATES[16])+ CONSTANTS[26]*STATES[18]) - CONSTANTS[28]*STATES[16]; RATES[13] = ((( CONSTANTS[14]*STATES[12]*STATES[11] - CONSTANTS[15]*STATES[13]) - CONSTANTS[29]*STATES[13])+ CONSTANTS[30]*STATES[19]*ALGEBRAIC[1]) - (ALGEBRAIC[0]/STATES[0])*STATES[13]; RATES[19] = ( CONSTANTS[29]*STATES[13])/ALGEBRAIC[1] - CONSTANTS[30]*STATES[19]; RATES[22] = CONSTANTS[34]*STATES[23]+( CONSTANTS[33]*STATES[15])/ALGEBRAIC[1]; RATES[27] = ( CONSTANTS[40]*STATES[20])/ALGEBRAIC[1] - CONSTANTS[41]*STATES[27]*STATES[19]; RATES[30] = CONSTANTS[50]*STATES[31]*ALGEBRAIC[1]; RATES[8] = (( CONSTANTS[45]*STATES[28])/ALGEBRAIC[1] - CONSTANTS[8]*STATES[8]*STATES[6]) - CONSTANTS[51]*STATES[8]; RATES[25] = ((( CONSTANTS[48]*STATES[29])/ALGEBRAIC[1] - CONSTANTS[36]*STATES[25]*STATES[18])+ CONSTANTS[35]*STATES[24]) - CONSTANTS[52]*STATES[25]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[0]*STATES[0]; ALGEBRAIC[1] = STATES[1]/STATES[0]; }