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C C There are a total of 13 entries in the algebraic variable array. C There are a total of 8 entries in each of the rate and state variable arrays. C There are a total of 55 entries in the constant variable array. C C C ALGBRC(1) is time in component environment (second). C STATES(1) is p in component p (dimensionless). C CONSTS(31) is v1 in component v1 (dimensionless). C ALGBRC(2) is v2 in component v2 (dimensionless). C ALGBRC(7) is v7 in component v7 (dimensionless). C VOI is tau in component normalised_constants (dimensionless). C STATES(2) is a in component a (dimensionless). C ALGBRC(3) is v3 in component v3 (dimensionless). C CONSTS(49) is epsilon1 in component normalised_constants (dimensionless). C STATES(3) is c in component c (dimensionless). C ALGBRC(4) is v4 in component v4 (dimensionless). C CONSTS(50) is epsilon2 in component normalised_constants (dimensionless). C STATES(4) is k in component k (dimensionless). C ALGBRC(5) is v5 in component v5 (dimensionless). C ALGBRC(6) is v6 in component v6 (dimensionless). C CONSTS(51) is epsilon3 in component normalised_constants (dimensionless). C STATES(5) is o in component o (dimensionless). C ALGBRC(8) is v8 in component v8 (dimensionless). C CONSTS(52) is epsilon4 in component normalised_constants (dimensionless). C STATES(6) is n in component n (dimensionless). C ALGBRC(11) is vresp in component vresp (dimensionless). C CONSTS(53) is epsilon5 in component normalised_constants (dimensionless). C STATES(7) is en in component en (dimensionless). C ALGBRC(13) is vATP in component vATP (dimensionless). C ALGBRC(9) is vANT in component vANT (dimensionless). C CONSTS(54) is epsilon6 in component normalised_constants (dimensionless). C STATES(8) is s in component s (dimensionless). C ALGBRC(10) is vleak in component vleak (dimensionless). C CONSTS(55) is epsilon7 in component normalised_constants (dimensionless). C CONSTS(32) is beta2 in component normalised_constants (dimensionless). C CONSTS(33) is beta3 in component normalised_constants (dimensionless). C CONSTS(34) is beta4 in component normalised_constants (dimensionless). C CONSTS(35) is beta5 in component normalised_constants (dimensionless). C CONSTS(36) is delta_6 in component normalised_constants (dimensionless). C CONSTS(37) is beta6 in component normalised_constants (dimensionless). C CONSTS(38) is beta7 in component normalised_constants (dimensionless). C CONSTS(39) is beta8 in component normalised_constants (dimensionless). C CONSTS(40) is beta_ANT in component normalised_constants (dimensionless). C CONSTS(41) is beta_leak in component normalised_constants (dimensionless). C CONSTS(42) is beta_resp in component normalised_constants (dimensionless). C CONSTS(43) is delta_r1 in component normalised_constants (dimensionless). C CONSTS(44) is delta_r2 in component normalised_constants (dimensionless). C CONSTS(45) is beta_ATP in component normalised_constants (dimensionless). C CONSTS(46) is delta_atp in component normalised_constants (dimensionless). C ALGBRC(12) is en_crit in component en_crit (dimensionless). C CONSTS(47) is Kapp_dash in component normalised_constants (dimensionless). C CONSTS(48) is delta_crit in component normalised_constants (dimensionless). C CONSTS(1) is At in component normalised_constants (millimolar). C CONSTS(2) is Nt in component normalised_constants (millimolar). C CONSTS(3) is Pyr_bar in component normalised_constants (dimensionless). C CONSTS(4) is Cit_bar in component normalised_constants (dimensionless). C CONSTS(5) is AcCoA_bar in component normalised_constants (dimensionless). C CONSTS(6) is KG_bar in component normalised_constants (dimensionless). C CONSTS(7) is OAA_bar in component normalised_constants (dimensionless). C CONSTS(8) is k1 in component normalised_constants (micromolar_per_second). C CONSTS(9) is k2 in component normalised_constants (second_order_rate_constant). C CONSTS(10) is k3 in component normalised_constants (second_order_rate_constant). C CONSTS(11) is k4 in component normalised_constants (second_order_rate_constant). C CONSTS(12) is k5 in component normalised_constants (third_order_rate_constant). C CONSTS(13) is k6 in component normalised_constants (first_order_rate_constant). C CONSTS(14) is k7 in component normalised_constants (second_order_rate_constant). C CONSTS(15) is k8 in component normalised_constants (first_order_rate_constant). C CONSTS(16) is kresp in component normalised_constants (millimolar_per_second). C CONSTS(17) is kATP in component normalised_constants (millimolar_per_second). C CONSTS(18) is kANT in component normalised_constants (dimensionless). C CONSTS(19) is kleak in component normalised_constants (molar_per_millivolt_per_second). C CONSTS(20) is Keq in component normalised_constants (dimensionless). C CONSTS(21) is K in component normalised_constants (millimolar). C CONSTS(22) is alpha in component normalised_constants (per_millivolt). C CONSTS(23) is b in component normalised_constants (per_millimolar). C CONSTS(24) is delta_psi_m in component normalised_constants (millivolt). C CONSTS(25) is R in component normalised_constants (joule_per_mole_kelvin). C CONSTS(26) is T in component normalised_constants (kelvin). C CONSTS(27) is F in component normalised_constants (coulomb_per_mole). C CONSTS(28) is C in component normalised_constants (millimolar_per_millivolt). C CONSTS(29) is Kapp in component normalised_constants (per_millimolar). C CONSTS(30) is Pi in component normalised_constants (millimolar). C RATES(1) is d/dt p in component p (dimensionless). C RATES(2) is d/dt a in component a (dimensionless). C RATES(3) is d/dt c in component c (dimensionless). C RATES(4) is d/dt k in component k (dimensionless). C RATES(5) is d/dt o in component o (dimensionless). C RATES(6) is d/dt n in component n (dimensionless). C RATES(7) is d/dt en in component en (dimensionless). C RATES(8) is d/dt s in component s (dimensionless). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 0.154 STATES(2) = 0.063 STATES(3) = 0.44 STATES(4) = 0.225 STATES(5) = 0.005 STATES(6) = 0.856 STATES(7) = 3.536 STATES(8) = 150.0 CONSTS(1) = 4.160 CONSTS(2) = 1.070 CONSTS(3) = 0.161 CONSTS(4) = 0.460 CONSTS(5) = 0.105 CONSTS(6) = 0.146 CONSTS(7) = 0.004 CONSTS(8) = 38 CONSTS(9) = 152 CONSTS(10) = 57142 CONSTS(11) = 53 CONSTS(12) = 40 CONSTS(13) = 82361 CONSTS(14) = 3.2e-3 CONSTS(15) = 3.6 CONSTS(16) = 2.5 CONSTS(17) = 131.9 CONSTS(18) = 0.1 CONSTS(19) = 0.426 CONSTS(20) = 0.3975 CONSTS(21) = 2 CONSTS(22) = 0.100 CONSTS(23) = 0.004 CONSTS(24) = 150.0 CONSTS(25) = 8.314 CONSTS(26) = 298 CONSTS(27) = 96485 CONSTS(28) = 6.75e-06 CONSTS(29) = 4.4e-6 CONSTS(30) = 2.440 CONSTS(31) = 1.00000 CONSTS(32) = (CONSTS(9)/CONSTS(8))*CONSTS(2)*CONSTS(3) CONSTS(33) = (CONSTS(10)/CONSTS(8))*CONSTS(7)*CONSTS(5) CONSTS(34) = (CONSTS(11)/CONSTS(8))*CONSTS(2)*CONSTS(4) CONSTS(35) = (CONSTS(12)/CONSTS(8))*CONSTS(2)*CONSTS(1)*CONSTS(6) CONSTS(36) = CONSTS(6)/( CONSTS(7)*CONSTS(20)) CONSTS(37) = (CONSTS(13)/CONSTS(8))*CONSTS(7) CONSTS(38) = (CONSTS(14)/CONSTS(8))*CONSTS(1)*CONSTS(3) CONSTS(39) = (CONSTS(15)/CONSTS(8))*CONSTS(7) CONSTS(40) = (CONSTS(18)/CONSTS(8))*CONSTS(1) CONSTS(41) = (CONSTS(19)/CONSTS(8))*CONSTS(24) CONSTS(42) = CONSTS(16)/CONSTS(8) CONSTS(43) = CONSTS(21)/CONSTS(2) CONSTS(44) = CONSTS(22)*CONSTS(24) CONSTS(45) = CONSTS(17)/CONSTS(8) CONSTS(46) = CONSTS(23)*CONSTS(1) CONSTS(47) = CONSTS(29)*CONSTS(30) CONSTS(48) = 3.00000*(( 1.20000*CONSTS(27)*CONSTS(24))/( CONSTS(25)*CONSTS(26))) CONSTS(49) = CONSTS(5)/CONSTS(3) CONSTS(50) = CONSTS(4)/CONSTS(3) CONSTS(51) = CONSTS(6)/CONSTS(3) CONSTS(52) = CONSTS(7)/CONSTS(3) CONSTS(53) = CONSTS(2)/CONSTS(3) CONSTS(54) = CONSTS(1)/CONSTS(3) CONSTS(55) = (CONSTS(24)/CONSTS(3))*CONSTS(28) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = CONSTS(32)*STATES(1)*STATES(6) ALGBRC(3) = CONSTS(33)*STATES(5)*STATES(2) RATES(2) = (ALGBRC(2) - ALGBRC(3))/CONSTS(49) ALGBRC(4) = CONSTS(34)*STATES(3)*STATES(6) RATES(3) = (ALGBRC(3) - ALGBRC(4))/CONSTS(50) ALGBRC(5) = CONSTS(35)*STATES(4)*STATES(6)*(1.00000 - STATES(7)) ALGBRC(6) = CONSTS(37)*(STATES(5) - CONSTS(36)*STATES(4)) RATES(4) = ((ALGBRC(4)+ALGBRC(6)) - ALGBRC(5))/CONSTS(51) ALGBRC(7) = CONSTS(38)*STATES(1)*STATES(7) RATES(1) = CONSTS(31) - (ALGBRC(2)+ALGBRC(7)) ALGBRC(8) = CONSTS(39)*STATES(5) RATES(5) = ((ALGBRC(5)+ALGBRC(7)) - (ALGBRC(3)+ALGBRC(8)+ALGBRC(6)))/CONSTS(52) ALGBRC(11) = CONSTS(42)*((1.00000 - STATES(6))/((CONSTS(43)+1.00000) - STATES(6)))*(1.00000/(1.00000+EXP( CONSTS(44)*(STATES(8) - 1.00000)))) RATES(6) = (ALGBRC(11) - (ALGBRC(2)+ALGBRC(4)+ 2.00000*ALGBRC(5)))/CONSTS(53) ALGBRC(12) = CONSTS(47)/(CONSTS(47)+EXP( -1.00000*CONSTS(48)*STATES(8))) ALGBRC(13) = CONSTS(45)*(2.00000/(1.00000+EXP( CONSTS(46)*(STATES(7) - ALGBRC(12)*STATES(8)))) - 1.00000) ALGBRC(9) = CONSTS(40)*STATES(7) RATES(7) = ((ALGBRC(13)+ALGBRC(5)) - (ALGBRC(9)+ALGBRC(7)))/CONSTS(54) ALGBRC(10) = CONSTS(41)*STATES(8) RATES(8) = ( 10.0000*ALGBRC(11) - ( 3.00000*ALGBRC(13)+ALGBRC(10)+ALGBRC(9)))/CONSTS(55) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = CONSTS(32)*STATES(1)*STATES(6) ALGBRC(3) = CONSTS(33)*STATES(5)*STATES(2) ALGBRC(4) = CONSTS(34)*STATES(3)*STATES(6) ALGBRC(5) = CONSTS(35)*STATES(4)*STATES(6)*(1.00000 - STATES(7)) ALGBRC(6) = CONSTS(37)*(STATES(5) - CONSTS(36)*STATES(4)) ALGBRC(7) = CONSTS(38)*STATES(1)*STATES(7) ALGBRC(8) = CONSTS(39)*STATES(5) ALGBRC(11) = CONSTS(42)*((1.00000 - STATES(6))/((CONSTS(43)+1.00000) - STATES(6)))*(1.00000/(1.00000+EXP( CONSTS(44)*(STATES(8) - 1.00000)))) ALGBRC(12) = CONSTS(47)/(CONSTS(47)+EXP( -1.00000*CONSTS(48)*STATES(8))) ALGBRC(13) = CONSTS(45)*(2.00000/(1.00000+EXP( CONSTS(46)*(STATES(7) - ALGBRC(12)*STATES(8)))) - 1.00000) ALGBRC(9) = CONSTS(40)*STATES(7) ALGBRC(10) = CONSTS(41)*STATES(8) CALL minimize(minfunc_0, CONSTS, VARIABLES, ALGBRC(1)) RETURN END REAL FUNCTION minfunc_0(CONSTS, VARIABLES) REAL CONSTS(*), VARIABLES(*) minfunc_0 = abs(VOI - (CONSTS(8)/CONSTS(3))*ALGBRC(1)) RETURN END