unknown
2007-06-19T16:01:50+12:00
8869126
This is the CellML description of Dokos et al's 1996 mathematical
model of the ion currents underlying sinoatrial node pacemaker
activity. Please note that equations for reversal potentials were not included in the original published model and have had to be added.
Also, a current called i_KACh was included in the equations for
external and internal potassium ion concentration calculation. This
current had not been previously mentioned in the paper, and as i_KACh
is usually referred to in ischemic tissue, and also the background
potassium current i_bK had not been included in the equation, I am
assuming that this was a typo. The model authors have been contacted
and we are awaiting their reply.
This model has been validated by Penny Noble of Oxford University and is known to run in COR and PCEnv. A PCEnv session file is also associated with this version.
The Bioengineering Institute
The University of Auckland
The University of Auckland, Bioengineering Institute
Catherine Lloyd
cardiac
electrophysiology
pacemaker
sinoatrial node
2007-12-19T14:19:43+13:00
Ion currents underlying sinoatrial node pacemaker activity: a new single cell mathematical model
245
272
181(3)
unknown
unknown
unknown
Noble
Penny
May
Catherine
Lloyd
cmeta:id's have been added to several variables to allow creation of a PCEnv session file.
Dokos
S
1996-08-01
Richard
Lawson
James
unknown
unknown
Units checked, curated.
2003-04-10T00:00:00+00:00
This model has been validated by Penny Noble
Penny
J
Noble
James
Richard
Lawson
2007-06-19T15:55:00+12:00
keyword
2007-12-19T14:19:12+13:00
unknown
Lovell
N
Sinoatrial Node
100000
0.1
2
James Lawson
added cmeta:id's for some variables to allow referencing by PCEnv
c.lloyd@auckland.ac.nz
Celler
B
Journal of Theroretical Biology
2006-01-01