c67
(EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GDP
Raf-Ras-GTPi
c70
(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP-Prot
c89
c7
(EGF-EGFR*)2-GAP-Grb20-Prot
c100
(EGF-EGFRi*)2-GAP-Grb2-Sos-deg
c92
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Prot
MEK-PP-phosphatase2
c52
c28
Ras-GTP
c33
(EGF-EGFR*)2-GAP-SHC*
Joe
Cursons
Raf*
c45
ERKi-PP-phosphatase3
c84
c18
(EGF-EGFRi*)2-GAP-Grb2
c3
EGF-EGFR complex
EGF-EGFR
ERKi-P
c81
MAPK signalling
MAPK
signal transduction
kinetic model
ERKi-MEKi-PP
c80
Frank
J
Bruggeman
c58
ERK-P-MEK-PP
ERK-PP-phosphatase3
c61
c97
(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-ERK-PP
c8
(EGF-EGFRi*)2
(EGF-EGFRi*)2-GAP
c17
(EGF-EGFRi*)2-GAP-SHC
c63
Prot
c12
This is the CellML description of Hornberg et al.'s 2005 mathematical model of the MAPK signal transduction cascade.
c78
MEKi-PP-phosphatase2
ERKi-P-phosphatase3
c85
c68
(EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GTP
Hans
V
Westerhoff
c26
Ras-GDP
c11
(EGF-EGFRi)2
EGFi
c16
EGFR
c2
epidermal growth factor receptor
c19
(EGF-EGFRi*)2-GAP-Grb2-Sos
Hornberg et al.'s 2005 mathematical model of the MAPK signal transduction cascade.
c31
Shc
Proti
c9
Sos
c24
c13
EGFideg
c59
ERK-PP
ERK-MEK-PP
c56
(EGF-EGFR*)2-GAP-Grb2-Sos-deg
c99
c23
(EGF-EGFR*)2-GAP-Grb2
MEK-P-Rafi*
c76
(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTP
c21
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GDP
c36
c49
MEK-P
(EGF-EGFR*)2-GAP
c15
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GDP-Prot
c93
Sos-ERK-PP
c101
c66
(EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos
The University of Auckland, Auckland Bioengineering Institute
May
Catherine
Lloyd
(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-ERKi-PP
c98
keyword
c6
EGFRi
c88
(EGF-EGFR*)2-GAP-Grb2-Sos-Prot
EGF-EGFR complex dimer
(EGF-EGFR)2
c4
5533
24
Control of MAPK signalling: from complexity to what really matters
5542
Bernd
Binder
Oncogene
phosphatase3
c60
c102
Sos-ERKi-PP
MEKi-PP
c77
c.lloyd@auckland.ac.nz
(EGF-EGFRi*)2deg
c87
c65
(EGF-EGFRi*)2-GAP-SHC*-Grb2
J
Jorrit
Hornberg
c22
Grb2
EGFRideg
c86
c64
(EGF-EGFRi*)2-GAP-SHC*
Shc*-Grb2
c39
(EGF-EGFRi*)2-GAP-Grb2-Sos-ERKi-PP
c96
c25
(EGF-EGFR*)2-GAP-Grb2-Sos
phosphatase2
c53
This CellML model runs in both PCENv and COR to recreate the published results. Thank you to the model author Jorrit Hornberg for providing us with the original mathematica code, and also to Joe Cursons for the hours he has spent debugging the CellMl model.
c20
(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP
c35
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos
Catherine Lloyd
16007170
ERK-P-phosphatase3
c62
c1
epidermal growth factor
EGF
c27
(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GTP
c37
(EGF-EGFR*)2-GAP-SHC*-Grb2
c34
c43
Ras-GTP*
c72
Rafi*
Auckland Bioengineering Institute
The University of Auckland
MEK-PP
c51
(EGF-EGFR*)2-GAP-SHC
c32
Phosphatase1
c44
c75
MEKi-P
Birgit
Schoeberl
2007-10-15T00:00:00+00:00
c71
Ras-GTPi*
Raf
c41
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GTP-Prot
c94
6000
MEK-Raf*
c48
MEK-Rafi*
c74
Shc*
c40
ERK
c55
c42
Ras-Raf-GTP
Raf*-phosphatase1
c46
(EGF-EGFR*)2-GAP-Grb2-Sos-ERK-PP
c95
(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP
c29
EGF-EGFRi
c10
c50
MEK-P-Raf*
(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP-Prot
c90
c69
Ras-GTPi
MEK-P-phosphatase2
c54
c30
Grb2-Sos
MEKi-P-phosphatase2
c79
MEK
c47
c73
Rafi*-phosphatase1
2005-08-25
c91
(EGF-EGFR*)2-GAP-SHC*-Grb2-Prot
c103
Sosi
Heinrich
Reinhart
2008-04-14T09:22:00+12:00
(EGF-EGFR*)2
phosphorylated EGF-EGFR complex dimer
c5
Shc*-Grb2-Sos
c38
GAP
c14
ERKi-PP
c83
De-bugged the CellML code using the model author's original Mathematica files. The changes are listed in a PDF document associated with the model blurb.
c82
ERKi-P-MEKi-PP
c57
ERK-P
Catherine Lloyd