Cursons
Joe
Hornberg et al.'s 2005 mathematical model of the MAPK signal transduction cascade.
6000
Control of MAPK signalling: from complexity to what really matters
5533
24
5542
Reinhart
Heinrich
Raf-Ras-GTPi
c70
c2
epidermal growth factor receptor
EGFR
c45
Raf*
(EGF-EGFR*)2-GAP-Grb20-Prot
c7
(EGF-EGFRi*)2deg
c87
c93
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GDP-Prot
Bernd
Binder
phosphorylated EGF-EGFR complex dimer
c5
(EGF-EGFR*)2
MEK-P
c49
ERK-MEK-PP
c56
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Prot
c92
EGFi
c16
J
Jorrit
Hornberg
(EGF-EGFR*)2-GAP-Grb2
c23
(EGF-EGFRi*)2-GAP-Grb2-Sos-deg
c100
Catherine Lloyd
ERK-P
c57
signal transduction
MAPK signalling
MAPK
kinetic model
ERKi-P
c81
EGFRideg
c86
This CellML model runs in both PCENv and COR to recreate the published results. Thank you to the model author Jorrit Hornberg for providing us with the original mathematica code, and also to Joe Cursons for the hours he has spent debugging the CellMl model.
MEK-PP
c51
(EGF-EGFRi*)2-GAP
c17
The University of Auckland, Auckland Bioengineering Institute
(EGF-EGFRi*)2-GAP-Grb2-Sos
c19
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GDP
c36
c44
Phosphatase1
c58
ERK-P-MEK-PP
c98
(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-ERKi-PP
Ras-GDP
c26
c27
(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP
c99
(EGF-EGFR*)2-GAP-Grb2-Sos-deg
ERK-PP-phosphatase3
c61
c13
EGFideg
Raf*-phosphatase1
c46
c4
(EGF-EGFR)2
EGF-EGFR complex dimer
c67
(EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GDP
c20
(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP
MEK-Raf*
c48
c33
(EGF-EGFR*)2-GAP-SHC*
c80
ERKi-MEKi-PP
Catherine
Lloyd
May
keyword
Sos-ERK-PP
c101
c14
GAP
(EGF-EGFR*)2-GAP-Grb2-Sos-Prot
c88
c52
MEK-PP-phosphatase2
De-bugged the CellML code using the model author's original Mathematica files. The changes are listed in a PDF document associated with the model blurb.
Ras-GTPi
c69
(EGF-EGFR*)2-GAP-SHC
c32
2007-10-15T00:00:00+00:00
c8
(EGF-EGFRi*)2
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos
c35
MEK-Rafi*
c74
c78
MEKi-PP-phosphatase2
Sosi
c103
(EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GTP
c68
c83
ERKi-PP
c76
MEK-P-Rafi*
EGFRi
c6
2005-08-25
c.lloyd@auckland.ac.nz
c42
Ras-Raf-GTP
c89
(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP-Prot
c22
Grb2
c28
Ras-GTP
c75
MEKi-P
c10
EGF-EGFRi
(EGF-EGFRi*)2-GAP-SHC
c63
c102
Sos-ERKi-PP
ERKi-PP-phosphatase3
c84
c21
(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTP
Rafi*-phosphatase1
c73
MEK
c47
c1
epidermal growth factor
EGF
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GTP-Prot
c94
16007170
c85
ERKi-P-phosphatase3
c95
(EGF-EGFR*)2-GAP-Grb2-Sos-ERK-PP
c71
Ras-GTPi*
EGF-EGFR complex
c3
EGF-EGFR
phosphatase3
c60
Auckland Bioengineering Institute
The University of Auckland
Hans
Westerhoff
V
c34
(EGF-EGFR*)2-GAP-SHC*-Grb2
c53
phosphatase2
Frank
J
Bruggeman
Oncogene
(EGF-EGFRi)2
c11
c40
Shc*
c66
(EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos
c9
Proti
Grb2-Sos
c30
c90
(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP-Prot
c24
Sos
c18
(EGF-EGFRi*)2-GAP-Grb2
2008-04-14T09:22:00+12:00
(EGF-EGFR*)2-GAP-SHC*-Grb2-Prot
c91
c43
Ras-GTP*
MEKi-PP
c77
Schoeberl
Birgit
c41
Raf
c59
ERK-PP
MEK-P-Raf*
c50
(EGF-EGFRi*)2-GAP-SHC*-Grb2
c65
Shc*-Grb2
c39
(EGF-EGFR*)2-GAP
c15
Catherine Lloyd
ERKi-P-MEKi-PP
c82
c55
ERK
c12
Prot
c37
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GTP
Shc*-Grb2-Sos
c38
c54
MEK-P-phosphatase2
c62
ERK-P-phosphatase3
(EGF-EGFRi*)2-GAP-Grb2-Sos-ERKi-PP
c96
c25
(EGF-EGFR*)2-GAP-Grb2-Sos
Shc
c31
(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-ERK-PP
c97
This is the CellML description of Hornberg et al.'s 2005 mathematical model of the MAPK signal transduction cascade.
c72
Rafi*
c64
(EGF-EGFRi*)2-GAP-SHC*
MEKi-P-phosphatase2
c79
c29
(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP