/* There are a total of 10 entries in the algebraic variable array. There are a total of 4 entries in each of the rate and state variable arrays. There are a total of 24 entries in the constant variable array. */ /* * VOI is time in component environment (millisecond). * STATES[0] is V in component membrane (millivolt). * CONSTANTS[0] is Cm in component membrane (femtofarad). * ALGEBRAIC[4] is Ica in component Ica (femtoampere). * ALGEBRAIC[6] is Is1 in component Is1 (femtoampere). * ALGEBRAIC[9] is Is2 in component Is2 (femtoampere). * ALGEBRAIC[8] is Il in component Il (femtoampere). * ALGEBRAIC[7] is Ik in component Ik (femtoampere). * CONSTANTS[1] is gCa in component Ica (picosiemens). * CONSTANTS[2] is VCa in component Ica (millivolt). * ALGEBRAIC[0] is m_infinity in component m (dimensionless). * CONSTANTS[3] is vm in component m (millivolt). * CONSTANTS[4] is sm in component m (millivolt). * CONSTANTS[5] is gs1 in component Is1 (picosiemens). * CONSTANTS[6] is VK in component Ik (millivolt). * STATES[1] is s1 in component s1 (dimensionless). * ALGEBRAIC[1] is s1_infinity in component s1 (dimensionless). * CONSTANTS[7] is autos1 in component s1 (dimensionless). * CONSTANTS[8] is s1knot in component s1 (dimensionless). * CONSTANTS[9] is tau_s1 in component s1 (millisecond). * CONSTANTS[10] is vs1 in component s1 (millivolt). * CONSTANTS[11] is ss1 in component s1 (millivolt). * CONSTANTS[12] is gK in component Ik (picosiemens). * STATES[2] is n in component n (dimensionless). * ALGEBRAIC[2] is n_infinity in component n (dimensionless). * CONSTANTS[13] is tau_n_bar in component n (millisecond). * ALGEBRAIC[5] is tau_n in component n (millisecond). * CONSTANTS[14] is vn in component n (millivolt). * CONSTANTS[15] is sn in component n (millivolt). * CONSTANTS[16] is gl in component Il (picosiemens). * CONSTANTS[17] is Vl in component Il (millivolt). * CONSTANTS[18] is gs2 in component Is2 (picosiemens). * STATES[3] is s2 in component s2 (dimensionless). * ALGEBRAIC[3] is s2_infinity in component s2 (dimensionless). * CONSTANTS[19] is autos2 in component s2 (dimensionless). * CONSTANTS[20] is s2knot in component s2 (dimensionless). * CONSTANTS[21] is tau_s2 in component s2 (millisecond). * CONSTANTS[22] is vs2 in component s2 (millivolt). * CONSTANTS[23] is ss2 in component s2 (millivolt). * RATES[0] is d/dt V in component membrane (millivolt). * RATES[1] is d/dt s1 in component s1 (dimensionless). * RATES[2] is d/dt n in component n (dimensionless). * RATES[3] is d/dt s2 in component s2 (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = -40.0; CONSTANTS[0] = 4525.0; CONSTANTS[1] = 280.0; CONSTANTS[2] = 100.0; CONSTANTS[3] = -22.0; CONSTANTS[4] = 7.5; CONSTANTS[5] = 20.0; CONSTANTS[6] = -80.0; STATES[1] = 0.9; CONSTANTS[7] = 1; CONSTANTS[8] = 1; CONSTANTS[9] = 1000.0; CONSTANTS[10] = -50.0; CONSTANTS[11] = 5; CONSTANTS[12] = 1300.0; STATES[2] = 0.0; CONSTANTS[13] = 8.25; CONSTANTS[14] = -9.0; CONSTANTS[15] = 10.0; CONSTANTS[16] = 25.0; CONSTANTS[17] = -40.0; CONSTANTS[18] = 16; STATES[3] = 0.5; CONSTANTS[19] = 1; CONSTANTS[20] = 0.49; CONSTANTS[21] = 30000.0; CONSTANTS[22] = -40.0; CONSTANTS[23] = 15; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = 1.00000/(1.00000+exp((CONSTANTS[10] - STATES[0])/CONSTANTS[11])); RATES[1] = CONSTANTS[7]*((ALGEBRAIC[1] - STATES[1])/CONSTANTS[9])+ (1.00000 - CONSTANTS[7])*(CONSTANTS[8] - STATES[1]); ALGEBRAIC[3] = 1.00000/(1.00000+exp((CONSTANTS[22] - STATES[0])/CONSTANTS[23])); RATES[3] = CONSTANTS[19]*((ALGEBRAIC[3] - STATES[3])/CONSTANTS[21])+ (1.00000 - CONSTANTS[19])*(CONSTANTS[20] - STATES[3]); ALGEBRAIC[2] = 1.00000/(1.00000+exp((CONSTANTS[14] - STATES[0])/CONSTANTS[15])); ALGEBRAIC[5] = CONSTANTS[13]/(1.00000+exp((STATES[0] - CONSTANTS[14])/CONSTANTS[15])); RATES[2] = (ALGEBRAIC[2] - STATES[2])/ALGEBRAIC[5]; ALGEBRAIC[0] = 1.00000/(1.00000+exp((CONSTANTS[3] - STATES[0])/CONSTANTS[4])); ALGEBRAIC[4] = CONSTANTS[1]*ALGEBRAIC[0]*(STATES[0] - CONSTANTS[2]); ALGEBRAIC[6] = CONSTANTS[5]*STATES[1]*(STATES[0] - CONSTANTS[6]); ALGEBRAIC[9] = CONSTANTS[18]*STATES[3]*(STATES[0] - CONSTANTS[6]); ALGEBRAIC[8] = CONSTANTS[16]*(STATES[0] - CONSTANTS[17]); ALGEBRAIC[7] = CONSTANTS[12]*STATES[2]*(STATES[0] - CONSTANTS[6]); RATES[0] = - (ALGEBRAIC[4]+ALGEBRAIC[6]+ALGEBRAIC[9]+ALGEBRAIC[8]+ALGEBRAIC[7])/CONSTANTS[0]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = 1.00000/(1.00000+exp((CONSTANTS[10] - STATES[0])/CONSTANTS[11])); ALGEBRAIC[3] = 1.00000/(1.00000+exp((CONSTANTS[22] - STATES[0])/CONSTANTS[23])); ALGEBRAIC[2] = 1.00000/(1.00000+exp((CONSTANTS[14] - STATES[0])/CONSTANTS[15])); ALGEBRAIC[5] = CONSTANTS[13]/(1.00000+exp((STATES[0] - CONSTANTS[14])/CONSTANTS[15])); ALGEBRAIC[0] = 1.00000/(1.00000+exp((CONSTANTS[3] - STATES[0])/CONSTANTS[4])); ALGEBRAIC[4] = CONSTANTS[1]*ALGEBRAIC[0]*(STATES[0] - CONSTANTS[2]); ALGEBRAIC[6] = CONSTANTS[5]*STATES[1]*(STATES[0] - CONSTANTS[6]); ALGEBRAIC[9] = CONSTANTS[18]*STATES[3]*(STATES[0] - CONSTANTS[6]); ALGEBRAIC[8] = CONSTANTS[16]*(STATES[0] - CONSTANTS[17]); ALGEBRAIC[7] = CONSTANTS[12]*STATES[2]*(STATES[0] - CONSTANTS[6]); }