Wang, Huang, Huang, 2006

Model Status

This CellML model is the model which was used to produce the original results in the paper. The units have been checked and are consistent and this model is known to be valid CellML.

Model Structure

ABSTRACT: A quantitative kinetic model is proposed to simulate the ATP-induced intracellular Ca(2+) oscillations. The quantitative effect of ATP concentration upon the oscillations was successfully simulated. Our simulation results support previous experimental explanations that the Ca(2+) oscillations are mainly due to interaction of Ca(2+) release from the endoplasmic reticulum (ER) and the ATP-dependent Ca(2+) pump back into the ER, and the oscillations are prolonged by extracellular Ca(2+) entry that maintains the constant Ca(2+) supplies to its intracellular stores. The model is also able to simulate the sudden disappearance phenomenon of the Ca(2+) oscillations observed in some cell types by taking into account of the biphasic characteristic of the Ca(2+) release from the endoplasmic reticulum (ER). Moreover, the model simulation results for the Ca(2+) oscillations characteristics such as duration, peak [Ca(2+)](cyt), and average interval, etc., lead to prediction of some possible factors responsible for the variations of Ca(2+) oscillations in different types of cells.

The original paper is cited below:

A quantitative kinetic model for ATP-induced intracellular Ca2+ oscillations. J. Wang, X. Huang and W. Huang, 2006, Journal of Theoretical Biology, 245, 510-519. PubMed ID: 17188305

A schematic diagram of the pathway described by the mathematical model.