C C There are a total of 7 entries in the algebraic variable array. C There are a total of 3 entries in each of the rate and state variable arrays. C There are a total of 17 entries in the constant variable array. C C C VOI is time in component environment (second). C ALGBRC(1) is Ca_Pr in component total_calcium (micromolar). C CONSTS(1) is Ca_tot in component total_calcium (micromolar). C CONSTS(2) is rho_ER in component ER_calcium (dimensionless). C CONSTS(3) is beta_ER in component ER_calcium (dimensionless). C CONSTS(4) is rho_m in component mitochondrial_calcium (dimensionless). C CONSTS(5) is beta_m in component mitochondrial_calcium (dimensionless). C STATES(1) is Ca_cyt in component cytosolic_calcium (micromolar). C STATES(2) is Ca_ER in component ER_calcium (micromolar). C STATES(3) is Ca_m in component mitochondrial_calcium (micromolar). C ALGBRC(2) is Pr in component total_protein (micromolar). C CONSTS(6) is Pr_tot in component total_protein (micromolar). C CONSTS(7) is k_plus in component cytosolic_calcium (second_order_rate_constant). C CONSTS(8) is k_minus in component cytosolic_calcium (first_order_rate_constant). C ALGBRC(4) is J_ch in component Ca_efflux_from_the_ER (flux). C ALGBRC(5) is J_leak in component Ca_leak_flux_from_the_ER (flux). C ALGBRC(3) is J_pump in component ATP_dependent_Ca_uptake_into_the_ER (flux). C ALGBRC(7) is J_out in component mitochondrial_Ca_release (flux). C ALGBRC(6) is J_in in component mitochondrial_Ca_uptake (flux). C CONSTS(9) is k_pump in component ATP_dependent_Ca_uptake_into_the_ER (first_order_rate_constant). C CONSTS(10) is k_ch in component Ca_efflux_from_the_ER (first_order_rate_constant). C CONSTS(11) is K1 in component Ca_efflux_from_the_ER (micromolar). C CONSTS(12) is k_leak in component Ca_leak_flux_from_the_ER (first_order_rate_constant). C CONSTS(13) is k_in in component mitochondrial_Ca_uptake (flux). C CONSTS(14) is K2 in component mitochondrial_Ca_uptake (micromolar). C CONSTS(15) is k_out in component mitochondrial_Ca_release (first_order_rate_constant). C CONSTS(16) is k_m in component mitochondrial_Ca_release (first_order_rate_constant). C CONSTS(17) is K3 in component mitochondrial_Ca_release (micromolar). C RATES(1) is d/dt Ca_cyt in component cytosolic_calcium (micromolar). C RATES(2) is d/dt Ca_ER in component ER_calcium (micromolar). C RATES(3) is d/dt Ca_m in component mitochondrial_calcium (micromolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 90.0 CONSTS(2) = 0.01 CONSTS(3) = 0.0025 CONSTS(4) = 0.01 CONSTS(5) = 0.0025 STATES(1) = 0.05 STATES(2) = 1.0 STATES(3) = 0.4 CONSTS(6) = 120.0 CONSTS(7) = 0.1 CONSTS(8) = 0.01 CONSTS(9) = 20.0 CONSTS(10) = 4100.0 CONSTS(11) = 5.0 CONSTS(12) = 0.05 CONSTS(13) = 300.0 CONSTS(14) = 0.8 CONSTS(15) = 125.0 CONSTS(16) = 0.00625 CONSTS(17) = 5.0 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(4) = CONSTS(10)*(STATES(1) ** 2.00000/(CONSTS(11) ** 2.00000+STATES(1) ** 2.00000))*(STATES(2) - STATES(1)) ALGBRC(5) = CONSTS(12)*(STATES(2) - STATES(1)) ALGBRC(3) = CONSTS(9)*STATES(1) RATES(2) = (CONSTS(3)/CONSTS(2))*(ALGBRC(3) - (ALGBRC(4)+ALGBRC(5))) ALGBRC(1) = CONSTS(1) - (STATES(1)+ (CONSTS(2)/CONSTS(3))*STATES(2)+ (CONSTS(4)/CONSTS(5))*STATES(3)) ALGBRC(2) = CONSTS(6) - ALGBRC(1) ALGBRC(7) = ( CONSTS(15)*(STATES(1) ** 2.00000/(CONSTS(17) ** 2.00000+STATES(1) ** 2.00000))+CONSTS(16))*STATES(3) ALGBRC(6) = CONSTS(13)*(STATES(1) ** 8.00000/(CONSTS(14) ** 8.00000+STATES(1) ** 8.00000)) RATES(1) = (ALGBRC(4)+ALGBRC(5)+ALGBRC(7)+ CONSTS(8)*ALGBRC(1)) - (ALGBRC(3)+ALGBRC(6)+ CONSTS(7)*STATES(1)*ALGBRC(2)) RATES(3) = (CONSTS(5)/CONSTS(4))*(ALGBRC(6) - ALGBRC(7)) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(4) = CONSTS(10)*(STATES(1) ** 2.00000/(CONSTS(11) ** 2.00000+STATES(1) ** 2.00000))*(STATES(2) - STATES(1)) ALGBRC(5) = CONSTS(12)*(STATES(2) - STATES(1)) ALGBRC(3) = CONSTS(9)*STATES(1) ALGBRC(1) = CONSTS(1) - (STATES(1)+ (CONSTS(2)/CONSTS(3))*STATES(2)+ (CONSTS(4)/CONSTS(5))*STATES(3)) ALGBRC(2) = CONSTS(6) - ALGBRC(1) ALGBRC(7) = ( CONSTS(15)*(STATES(1) ** 2.00000/(CONSTS(17) ** 2.00000+STATES(1) ** 2.00000))+CONSTS(16))*STATES(3) ALGBRC(6) = CONSTS(13)*(STATES(1) ** 8.00000/(CONSTS(14) ** 8.00000+STATES(1) ** 8.00000)) RETURN END