/* There are a total of 15 entries in the algebraic variable array. There are a total of 7 entries in each of the rate and state variable arrays. There are a total of 40 entries in the constant variable array. */ /* * VOI is time in component environment (second). * CONSTANTS[0] is cap in component parameters (nanofarad). * CONSTANTS[1] is cc1lin in component parameters (per_second). * CONSTANTS[2] is cc_2 in component parameters (per_second). * CONSTANTS[3] is ck1lin in component parameters (per_second). * CONSTANTS[4] is ck_2 in component parameters (per_second). * CONSTANTS[5] is clmax in component parameters (nanosiemens). * CONSTANTS[6] is cnmax in component parameters (nanosiemens). * CONSTANTS[7] is cx1lin in component parameters (per_second). * CONSTANTS[8] is cx2 in component parameters (per_second). * CONSTANTS[9] is ef in component parameters (per_second). * CONSTANTS[10] is gl in component parameters (nanosiemens). * CONSTANTS[11] is hmc_1 in component parameters (uM). * CONSTANTS[12] is hmc_2 in component parameters (uM). * CONSTANTS[13] is inf in component parameters (uM_per_picocoulomb). * CONSTANTS[14] is inhmax in component parameters (dimensionless). * CONSTANTS[15] is k_1 in component parameters (per_uM_per_second). * CONSTANTS[16] is k_2 in component parameters (per_second). * CONSTANTS[17] is kI in component parameters (uM). * CONSTANTS[18] is kinh in component parameters (uM). * CONSTANTS[19] is kinhcng in component parameters (uM). * CONSTANTS[20] is n_1 in component parameters (dimensionless). * CONSTANTS[21] is n_2 in component parameters (dimensionless). * CONSTANTS[22] is nI in component parameters (dimensionless). * CONSTANTS[23] is ninh in component parameters (dimensionless). * CONSTANTS[24] is ninhcng in component parameters (dimensionless). * CONSTANTS[25] is pd in component parameters (per_second). * CONSTANTS[26] is r_1 in component parameters (per_second). * CONSTANTS[27] is r_2 in component parameters (per_second). * CONSTANTS[28] is smax in component parameters (uM_per_second). * CONSTANTS[29] is V_Cl in component parameters (millivolt). * CONSTANTS[30] is V_cng in component parameters (millivolt). * CONSTANTS[31] is V_l in component parameters (millivolt). * CONSTANTS[39] is F_vol in component parameters (picocoulomb_per_uM). * CONSTANTS[32] is F in component parameters (coulombs_per_mole). * CONSTANTS[33] is C_vol in component parameters (liter). * ALGEBRAIC[2] is O_stim in component O_stim (uM). * CONSTANTS[34] is od in component O_stim (uM). * CONSTANTS[35] is t_0 in component O_stim (second). * CONSTANTS[36] is t_1 in component O_stim (second). * ALGEBRAIC[0] is H_0 in component O_stim (dimensionless). * ALGEBRAIC[1] is H_1 in component O_stim (dimensionless). * STATES[0] is bLR in component bLR (dimensionless). * CONSTANTS[37] is R_tot in component bLR (dimensionless). * STATES[1] is aG in component aG (dimensionless). * CONSTANTS[38] is G_tot in component aG (dimensionless). * ALGEBRAIC[3] is k_G in component k_G (per_second). * ALGEBRAIC[4] is r_G in component r_G (per_second). * STATES[2] is cAMP in component cAMP (uM). * ALGEBRAIC[5] is synth in component synth (uM_per_second). * ALGEBRAIC[6] is degrad in component degrad (uM_per_second). * STATES[3] is aCaMK in component aCaMK (uM). * STATES[4] is Ca in component Ca (uM). * ALGEBRAIC[13] is I_CNG in component I_CNG (nanoampere). * ALGEBRAIC[11] is J_NCX in component J_NCX (uM_per_second). * ALGEBRAIC[7] is cc_1 in component cc_1 (uM_per_second). * STATES[5] is CaCaM in component CaCaM (uM). * ALGEBRAIC[8] is ck_1 in component ck_1 (uM_per_second). * STATES[6] is V in component V (millivolt). * ALGEBRAIC[10] is I_ClCa in component I_ClCa (nanoampere). * ALGEBRAIC[14] is I_NCX in component I_NCX (nanoampere). * ALGEBRAIC[12] is I_other in component I_other (nanoampere). * ALGEBRAIC[9] is inhcng in component inhcng (dimensionless). * RATES[0] is d/dt bLR in component bLR (dimensionless). * RATES[1] is d/dt aG in component aG (dimensionless). * RATES[2] is d/dt cAMP in component cAMP (uM). * RATES[4] is d/dt Ca in component Ca (uM). * RATES[5] is d/dt CaCaM in component CaCaM (uM). * RATES[3] is d/dt aCaMK in component aCaMK (uM). * RATES[6] is d/dt V in component V (millivolt). * There are a total of 2 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 0.004; CONSTANTS[1] = 0.88; CONSTANTS[2] = 26; CONSTANTS[3] = 13; CONSTANTS[4] = 0.9; CONSTANTS[5] = 1; CONSTANTS[6] = 1; CONSTANTS[7] = 1; CONSTANTS[8] = 13; CONSTANTS[9] = 2; CONSTANTS[10] = 6; CONSTANTS[11] = 2; CONSTANTS[12] = 3; CONSTANTS[13] = 1.9; CONSTANTS[14] = 5; CONSTANTS[15] = 0.06; CONSTANTS[16] = 20; CONSTANTS[17] = 0.7; CONSTANTS[18] = 2; CONSTANTS[19] = 1; CONSTANTS[20] = 2; CONSTANTS[21] = 2; CONSTANTS[22] = 2; CONSTANTS[23] = 1.5; CONSTANTS[24] = 1.3; CONSTANTS[25] = 20; CONSTANTS[26] = 10; CONSTANTS[27] = 5; CONSTANTS[28] = 71; CONSTANTS[29] = -50; CONSTANTS[30] = 0; CONSTANTS[31] = -70; CONSTANTS[32] = 9.649e4; CONSTANTS[33] = 1e-13; CONSTANTS[34] = 20; CONSTANTS[35] = 0.5; CONSTANTS[36] = 1.5; STATES[0] = 0; CONSTANTS[37] = 1; STATES[1] = 0; CONSTANTS[38] = 1; STATES[2] = 1.35648992164649e-88; STATES[3] = 6.60756525051462e-8; STATES[4] = 5.09073088043779e-12; STATES[5] = 1.86113118246926e-13; STATES[6] = -70; CONSTANTS[39] = (1.00000e+12/1.00000)*(1.00000/1000.00)*CONSTANTS[32]*CONSTANTS[33]; RATES[0] = 0.1001; RATES[1] = 0.1001; RATES[2] = 0.1001; RATES[4] = 0.1001; RATES[5] = 0.1001; RATES[3] = 0.1001; RATES[6] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[0] - CONSTANTS[15]*ALGEBRAIC[2]*(CONSTANTS[37] - STATES[0]) - CONSTANTS[26]*STATES[0]; resid[1] = RATES[1] - ALGEBRAIC[3]*(CONSTANTS[38] - STATES[1]) - ALGEBRAIC[4]; resid[2] = RATES[2] - ALGEBRAIC[5] - ALGEBRAIC[6]; resid[3] = RATES[4] - ( (1000.00/1.00000)*CONSTANTS[13]*ALGEBRAIC[13] - ALGEBRAIC[11]) - (ALGEBRAIC[7] - CONSTANTS[2]*STATES[5]); resid[4] = RATES[5] - ALGEBRAIC[7] - CONSTANTS[2]*STATES[5]; resid[5] = RATES[3] - ALGEBRAIC[8] - CONSTANTS[4]*STATES[3]; resid[6] = RATES[6] - (1000.00/1.00000)*(1.00000/CONSTANTS[0])*(ALGEBRAIC[13]+ALGEBRAIC[10]+ALGEBRAIC[14]+ALGEBRAIC[12]); } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = (CONDVAR[0]<0.00000 ? 0.00000 : 1.00000); ALGEBRAIC[1] = (CONDVAR[1]<0.00000 ? 0.00000 : 1.00000); ALGEBRAIC[2] = CONSTANTS[34]*(ALGEBRAIC[0] - ALGEBRAIC[1]); ALGEBRAIC[3] = CONSTANTS[16]*STATES[0]; ALGEBRAIC[4] = CONSTANTS[27]*STATES[1]; ALGEBRAIC[5] = ( STATES[1]*CONSTANTS[28])/(1.00000+pow(STATES[3]/CONSTANTS[18], CONSTANTS[23])); ALGEBRAIC[6] = CONSTANTS[25]*STATES[2]; ALGEBRAIC[7] = CONSTANTS[1]*STATES[4]; ALGEBRAIC[8] = CONSTANTS[3]*STATES[5]; ALGEBRAIC[10] = (( CONSTANTS[5]*pow(STATES[4], CONSTANTS[21]))/(pow(STATES[4], CONSTANTS[21])+pow(CONSTANTS[12], CONSTANTS[21])))*(1.00000/1000.00)*(CONSTANTS[29] - STATES[6]); ALGEBRAIC[11] = CONSTANTS[9]*STATES[4]; ALGEBRAIC[12] = CONSTANTS[10]*(1.00000/1000.00)*(CONSTANTS[31] - STATES[6]); ALGEBRAIC[9] = 1.00000+( (CONSTANTS[14] - 1.00000)*pow(STATES[5], CONSTANTS[24]))/(pow(STATES[5], CONSTANTS[24])+pow(CONSTANTS[19], CONSTANTS[24])); ALGEBRAIC[13] = (( CONSTANTS[6]*pow(STATES[2], CONSTANTS[20]))/(pow(STATES[2], CONSTANTS[20])+pow( ALGEBRAIC[9]*CONSTANTS[11], CONSTANTS[20])))*(1.00000/1000.00)*(CONSTANTS[30] - STATES[6]); ALGEBRAIC[14] = (1.00000/1000.00)*CONSTANTS[39]*ALGEBRAIC[11]; } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; SI[4] = 1.0; SI[5] = 1.0; SI[6] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { CONDVAR[0] = VOI - CONSTANTS[35]; CONDVAR[1] = VOI - CONSTANTS[36]; }