/* There are a total of 3 entries in the algebraic variable array. There are a total of 3 entries in each of the rate and state variable arrays. There are a total of 18 entries in the constant variable array. */ /* * VOI is time in component environment (day). * ALGEBRAIC[2] is S in component population_pharmacodynamics_model (units). * CONSTANTS[0] is S0 in component population_pharmacodynamics_model (units). * CONSTANTS[1] is alpha in component population_pharmacodynamics_model (units_per_day). * CONSTANTS[2] is epsilon in component population_pharmacodynamics_model (units). * ALGEBRAIC[0] is ADAS_Cog_p in component placebo_response_model (units). * CONSTANTS[14] is PD_CeA in component drug_response_model (units). * CONSTANTS[3] is beta_P in component placebo_response_model (units). * CONSTANTS[15] is Keq_p in component placebo_response_model (per_day). * CONSTANTS[16] is Kel_p in component placebo_response_model (per_day). * CONSTANTS[4] is t_half_el_p in component placebo_response_model (day). * CONSTANTS[5] is t_half_eq_p in component placebo_response_model (day). * CONSTANTS[17] is CL in component pharmacokinetic_model (litre_per_day). * CONSTANTS[6] is smk in component pharmacokinetic_model (dimensionless). * CONSTANTS[7] is age in component pharmacokinetic_model (year). * ALGEBRAIC[1] is Sv in component drop_out_model (dimensionless). * CONSTANTS[8] is beta_a in component drug_response_model (units_ml_per_ng). * CONSTANTS[9] is CeA in component drug_response_model (ng_per_ml). * STATES[0] is CC in component drug_clearance (mg_per_litre). * STATES[1] is PC in component drug_clearance (mg_per_litre). * CONSTANTS[10] is Vc in component drug_clearance (litre). * CONSTANTS[11] is Vp in component drug_clearance (litre). * STATES[2] is A_in in component drug_clearance (mg). * CONSTANTS[12] is k_ab in component drug_clearance (per_day). * CONSTANTS[13] is CL_ic in component drug_clearance (litre_per_day). * RATES[0] is d/dt CC in component drug_clearance (mg_per_litre). * RATES[1] is d/dt PC in component drug_clearance (mg_per_litre). * RATES[2] is d/dt A_in in component drug_clearance (mg). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 30; CONSTANTS[1] = 0.0164; CONSTANTS[2] = 0.0; CONSTANTS[3] = -3; CONSTANTS[4] = 7; CONSTANTS[5] = 6; CONSTANTS[6] = 1; CONSTANTS[7] = 40; CONSTANTS[8] = -0.047; CONSTANTS[9] = 25; STATES[0] = 0; STATES[1] = 0; CONSTANTS[10] = 172; CONSTANTS[11] = 222; STATES[2] = 25; CONSTANTS[12] = 115.44; CONSTANTS[13] = 763.2; CONSTANTS[14] = CONSTANTS[8]*CONSTANTS[9]; CONSTANTS[15] = log(2.00000)/CONSTANTS[5]; CONSTANTS[16] = log(2.00000)/CONSTANTS[4]; CONSTANTS[17] = 2268.00*exp( - 0.0135000*(CONSTANTS[7] - 40.0000))*CONSTANTS[6]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { RATES[0] = ( CONSTANTS[12]*STATES[2] - ( CONSTANTS[17]*STATES[0]+ CONSTANTS[13]*(STATES[0] - STATES[1])))/CONSTANTS[10]; RATES[1] = ( CONSTANTS[13]*(STATES[0] - STATES[1]))/CONSTANTS[11]; RATES[2] = - 115.440*STATES[2]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = (( CONSTANTS[3]*CONSTANTS[15])/(CONSTANTS[15] - CONSTANTS[16]))*(exp( - CONSTANTS[16]*VOI) - exp( - CONSTANTS[15]*VOI)); ALGEBRAIC[1] = exp( - 0.00145000*VOI); ALGEBRAIC[2] = CONSTANTS[0]+ CONSTANTS[1]*VOI+ALGEBRAIC[0]+CONSTANTS[14]+CONSTANTS[2]; }