circadian rhythms
oscillator
signal transduction
circadian rhythm
drosophila
Drosophila
Ueda et al.'s mathematical model of circadian rhythms in Drosophila.
10000
0.1
1000
CC_n
nuclear Clk-Cyc protein complex
Catherine Lloyd
11403560
Added simulation metadata and cmeta:id's to some variables
Lloyd
Catherine
May
Masatoshi
Hagiwara
This is the CellML description of Ueda et al.'s mathematical model of circadian rhythms in Drosophila.
keyword
Kitano
Hiroaki
The University of Auckland
Auckland Bioengineering Institute
c.lloyd@auckland.ac.nz
Clk_c
cytosolic Clk protein
cytosolic Clk-Cyc protein complex
CC_c
cytosolic Tim protein
Tim_c
Cyc_c
cytosolic Cyc protein
Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm
406
401
210
Journal of Theoretical Biology
May
Lloyd
Catherine
Catherine Lloyd
The University of Auckland, Auckland Bioengineering Institute
Per_c
cytosolic Per protein
Ueda
Hiroki
R
Lawson
James
Richard
Tim_m
Tim mRNA
nuclear Per-Tim protein complex
PT_n
Added initial conditions to all the substrates (these were based on the values used in the corresponding SBML model in the BioModels database), and fixed a typo in the equation for dPTc/dt such that the first term in this equation now reads V1*Perc*Timc rather than V1*Perc*PTc.
cytosolic Per-Tim protein complex
PT_c
This CellML model is known to run in both PCEnv and COR to replicate the published results. The units have been checked and they are consistent.
2001-06-21
Clk_m
Clk mRNA
Per mRNA
Per_m
2003-09-23T00:00:00+00:00
2008-10-14T15:10:39+13:00
2008-10-20T14:24:23+13:00