function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =51; end % There are a total of 23 entries in each of the rate and state variable arrays. % There are a total of 69 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (second)'); LEGEND_CONSTANTS(:,1) = strpad('R in component cell_parameters (millijoule_per_mole_kelvin)'); LEGEND_CONSTANTS(:,2) = strpad('T in component cell_parameters (kelvin)'); LEGEND_CONSTANTS(:,3) = strpad('F in component cell_parameters (coulomb_per_mole)'); LEGEND_CONSTANTS(:,4) = strpad('Cm in component cell_parameters (microF)'); LEGEND_CONSTANTS(:,5) = strpad('v_i in component cell_parameters (microlitre)'); LEGEND_CONSTANTS(:,6) = strpad('v_SR in component cell_parameters (microlitre)'); LEGEND_CONSTANTS(:,7) = strpad('Na_o in component cell_parameters (millimolar)'); LEGEND_CONSTANTS(:,8) = strpad('K_o in component cell_parameters (millimolar)'); LEGEND_CONSTANTS(:,9) = strpad('Ca_o in component cell_parameters (millimolar)'); LEGEND_STATES(:,1) = strpad('V in component membrane_potential (millivolt)'); LEGEND_ALGEBRAIC(:,22) = strpad('i_Na in component fast_sodium_current (nanoA)'); LEGEND_ALGEBRAIC(:,24) = strpad('i_K1 in component time_independent_potassium_current (nanoA)'); LEGEND_ALGEBRAIC(:,25) = strpad('i_to in component transient_outward_current (nanoA)'); LEGEND_ALGEBRAIC(:,23) = strpad('i_K in component time_dependent_rectifier_potassium_current (nanoA)'); LEGEND_ALGEBRAIC(:,29) = strpad('i_Ca_L in component L_type_Ca_channel (nanoA)'); LEGEND_ALGEBRAIC(:,33) = strpad('i_NaK in component sodium_potassium_pump (nanoA)'); LEGEND_ALGEBRAIC(:,31) = strpad('i_NaCa in component sodium_calcium_exchanger (nanoA)'); LEGEND_ALGEBRAIC(:,40) = strpad('i_b_Na in component sodium_background_current (nanoA)'); LEGEND_ALGEBRAIC(:,37) = strpad('i_b_K in component potassium_background_current (nanoA)'); LEGEND_ALGEBRAIC(:,36) = strpad('i_b_Ca in component calcium_background_current (nanoA)'); LEGEND_ALGEBRAIC(:,1) = strpad('i_Stim in component membrane_potential (nanoA)'); LEGEND_CONSTANTS(:,10) = strpad('stim_start in component membrane_potential (second)'); LEGEND_CONSTANTS(:,11) = strpad('stim_end in component membrane_potential (second)'); LEGEND_CONSTANTS(:,12) = strpad('stim_period in component membrane_potential (second)'); LEGEND_CONSTANTS(:,13) = strpad('stim_duration in component membrane_potential (second)'); LEGEND_CONSTANTS(:,14) = strpad('stim_amplitude in component membrane_potential (nanoA)'); LEGEND_ALGEBRAIC(:,9) = strpad('E_Na in component reversal_potentials (millivolt)'); LEGEND_ALGEBRAIC(:,16) = strpad('E_K in component reversal_potentials (millivolt)'); LEGEND_ALGEBRAIC(:,20) = strpad('E_Ca in component reversal_potentials (millivolt)'); LEGEND_ALGEBRAIC(:,21) = strpad('E_mh in component reversal_potentials (millivolt)'); LEGEND_STATES(:,2) = strpad('K_i in component intracellular_potassium_concentration (millimolar)'); LEGEND_STATES(:,3) = strpad('Na_i in component intracellular_sodium_concentration (millimolar)'); LEGEND_STATES(:,4) = strpad('Ca_i in component intracellular_calcium_concentration (millimolar)'); LEGEND_CONSTANTS(:,15) = strpad('g_Na in component fast_sodium_current (microS)'); LEGEND_STATES(:,5) = strpad('m in component fast_sodium_current_m_gate (dimensionless)'); LEGEND_STATES(:,6) = strpad('h in component fast_sodium_current_h_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,10) = strpad('alpha_m in component fast_sodium_current_m_gate (per_second)'); LEGEND_ALGEBRAIC(:,17) = strpad('beta_m in component fast_sodium_current_m_gate (per_second)'); LEGEND_CONSTANTS(:,16) = strpad('delta_m in component fast_sodium_current_m_gate (millivolt)'); LEGEND_ALGEBRAIC(:,2) = strpad('E0_m in component fast_sodium_current_m_gate (millivolt)'); LEGEND_ALGEBRAIC(:,3) = strpad('alpha_h in component fast_sodium_current_h_gate (per_second)'); LEGEND_ALGEBRAIC(:,11) = strpad('beta_h in component fast_sodium_current_h_gate (per_second)'); LEGEND_CONSTANTS(:,17) = strpad('shift_h in component fast_sodium_current_h_gate (millivolt)'); LEGEND_CONSTANTS(:,18) = strpad('i_Kmax in component time_dependent_rectifier_potassium_current (nanoA)'); LEGEND_STATES(:,7) = strpad('x in component time_dependent_rectifier_potassium_current_x_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,4) = strpad('alpha_x in component time_dependent_rectifier_potassium_current_x_gate (per_second)'); LEGEND_ALGEBRAIC(:,12) = strpad('beta_x in component time_dependent_rectifier_potassium_current_x_gate (per_second)'); LEGEND_CONSTANTS(:,19) = strpad('K_mk1 in component time_independent_potassium_current (millimolar)'); LEGEND_CONSTANTS(:,20) = strpad('g_K1 in component time_independent_potassium_current (microS)'); LEGEND_CONSTANTS(:,21) = strpad('g_to in component transient_outward_current (microS)'); LEGEND_STATES(:,8) = strpad('s in component transient_outward_current_s_gate (dimensionless)'); LEGEND_STATES(:,9) = strpad('r in component transient_outward_current_r_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,5) = strpad('alpha_s in component transient_outward_current_s_gate (per_second)'); LEGEND_ALGEBRAIC(:,13) = strpad('beta_s in component transient_outward_current_s_gate (per_second)'); LEGEND_ALGEBRAIC(:,28) = strpad('i_Ca_L_Na in component L_type_Ca_channel (nanoA)'); LEGEND_ALGEBRAIC(:,27) = strpad('i_Ca_L_K in component L_type_Ca_channel (nanoA)'); LEGEND_ALGEBRAIC(:,26) = strpad('i_Ca_L_Ca in component L_type_Ca_channel (nanoA)'); LEGEND_CONSTANTS(:,22) = strpad('P_Ca_L_Ca in component L_type_Ca_channel (nanoA_per_millimolar)'); LEGEND_STATES(:,10) = strpad('d in component L_type_Ca_channel_d_gate (dimensionless)'); LEGEND_STATES(:,11) = strpad('f in component L_type_Ca_channel_f_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,14) = strpad('alpha_d in component L_type_Ca_channel_d_gate (per_second)'); LEGEND_ALGEBRAIC(:,18) = strpad('beta_d in component L_type_Ca_channel_d_gate (per_second)'); LEGEND_ALGEBRAIC(:,6) = strpad('E0_d in component L_type_Ca_channel_d_gate (millivolt)'); LEGEND_CONSTANTS(:,23) = strpad('speed_d in component L_type_Ca_channel_d_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,15) = strpad('alpha_f in component L_type_Ca_channel_f_gate (per_second)'); LEGEND_ALGEBRAIC(:,19) = strpad('beta_f in component L_type_Ca_channel_f_gate (per_second)'); LEGEND_CONSTANTS(:,24) = strpad('speed_f in component L_type_Ca_channel_f_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,7) = strpad('E0_f in component L_type_Ca_channel_f_gate (millivolt)'); LEGEND_CONSTANTS(:,25) = strpad('i_NaCa_max in component sodium_calcium_exchanger (nanoA_per_millimolar4)'); LEGEND_CONSTANTS(:,26) = strpad('gamma in component sodium_calcium_exchanger (dimensionless)'); LEGEND_CONSTANTS(:,27) = strpad('i_NaK_max in component sodium_potassium_pump (nanoA)'); LEGEND_CONSTANTS(:,28) = strpad('K_mK in component sodium_potassium_pump (millimolar)'); LEGEND_CONSTANTS(:,29) = strpad('K_mNa in component sodium_potassium_pump (millimolar)'); LEGEND_CONSTANTS(:,30) = strpad('g_b_Ca in component calcium_background_current (microS)'); LEGEND_CONSTANTS(:,31) = strpad('g_b_K in component potassium_background_current (microS)'); LEGEND_CONSTANTS(:,32) = strpad('g_b_Na in component sodium_background_current (microS)'); LEGEND_STATES(:,12) = strpad('F_CaMK in component CaMKII_factor (dimensionless)'); LEGEND_ALGEBRAIC(:,8) = strpad('Inf_CaMK in component CaMKII_factor (dimensionless)'); LEGEND_CONSTANTS(:,33) = strpad('Tau_CaMK in component CaMKII_factor (second)'); LEGEND_STATES(:,13) = strpad('Cmdn_Ca in component calmodulin (millimolar)'); LEGEND_ALGEBRAIC(:,42) = strpad('j_rel in component RyR (millimolar_per_second)'); LEGEND_ALGEBRAIC(:,41) = strpad('K_rel in component RyR (per_second)'); LEGEND_ALGEBRAIC(:,38) = strpad('F_rel in component RyR (dimensionless)'); LEGEND_STATES(:,14) = strpad('Ca_SR in component SR_calcium_concentration (millimolar)'); LEGEND_CONSTANTS(:,34) = strpad('K_rel_max in component RyR (per_second)'); LEGEND_STATES(:,15) = strpad('F_SRCa_RyR in component RyR (millimolar)'); LEGEND_CONSTANTS(:,35) = strpad('Tau_SRCa_RyR in component RyR (second)'); LEGEND_ALGEBRAIC(:,30) = strpad('N_CaMK in component RyR (dimensionless)'); LEGEND_CONSTANTS(:,36) = strpad('gain_k1 in component RyR (dimensionless)'); LEGEND_CONSTANTS(:,37) = strpad('gain_k2 in component RyR (dimensionless)'); LEGEND_CONSTANTS(:,38) = strpad('gain_k3 in component RyR (dimensionless)'); LEGEND_CONSTANTS(:,39) = strpad('gain_k4 in component RyR (dimensionless)'); LEGEND_ALGEBRAIC(:,32) = strpad('k_1 in component RyR (per_second)'); LEGEND_ALGEBRAIC(:,34) = strpad('k_2 in component RyR (per_second)'); LEGEND_ALGEBRAIC(:,35) = strpad('k_3 in component RyR (per_second)'); LEGEND_CONSTANTS(:,54) = strpad('k_4 in component RyR (per_second)'); LEGEND_STATES(:,16) = strpad('F_1 in component RyR (dimensionless)'); LEGEND_STATES(:,17) = strpad('F_2 in component RyR (dimensionless)'); LEGEND_ALGEBRAIC(:,39) = strpad('F_3 in component RyR (dimensionless)'); LEGEND_CONSTANTS(:,40) = strpad('K_leak_rate in component RyR (per_second)'); LEGEND_ALGEBRAIC(:,45) = strpad('j_up in component SERCA (millimolar_per_second)'); LEGEND_CONSTANTS(:,41) = strpad('V_max_f in component SERCA (millimolar_per_second)'); LEGEND_CONSTANTS(:,42) = strpad('V_max_r in component SERCA (millimolar_per_second)'); LEGEND_ALGEBRAIC(:,43) = strpad('f_b in component SERCA (dimensionless)'); LEGEND_ALGEBRAIC(:,44) = strpad('r_b in component SERCA (dimensionless)'); LEGEND_CONSTANTS(:,43) = strpad('Cmdn_tot in component calmodulin (millimolar)'); LEGEND_CONSTANTS(:,44) = strpad('alpha_cmdn in component calmodulin (per_millimolar_per_second)'); LEGEND_CONSTANTS(:,45) = strpad('beta_cmdn in component calmodulin (per_second)'); LEGEND_ALGEBRAIC(:,46) = strpad('dCmdn_Ca_dtime in component calmodulin (millimolar_per_second)'); LEGEND_STATES(:,18) = strpad('Trpn_Ca in component troponin (millimolar)'); LEGEND_CONSTANTS(:,46) = strpad('Trpn_tot in component troponin (millimolar)'); LEGEND_CONSTANTS(:,47) = strpad('alpha_trpn in component troponin (per_millimolar_per_second)'); LEGEND_CONSTANTS(:,48) = strpad('beta_trpn in component troponin (per_second)'); LEGEND_ALGEBRAIC(:,49) = strpad('Force_norm in component Force (dimensionless)'); LEGEND_ALGEBRAIC(:,50) = strpad('dTrpn_Ca_dtime in component troponin (millimolar_per_second)'); LEGEND_ALGEBRAIC(:,51) = strpad('Force in component Force (N_per_mm2)'); LEGEND_CONSTANTS(:,49) = strpad('zeta in component Force (N_per_mm2)'); LEGEND_CONSTANTS(:,69) = strpad('Force_max in component Force (dimensionless)'); LEGEND_CONSTANTS(:,55) = strpad('phi_SL in component Force (dimensionless)'); LEGEND_CONSTANTS(:,66) = strpad('P_1_max in component Force (dimensionless)'); LEGEND_CONSTANTS(:,67) = strpad('P_2_max in component Force (dimensionless)'); LEGEND_CONSTANTS(:,68) = strpad('P_3_max in component Force (dimensionless)'); LEGEND_CONSTANTS(:,65) = strpad('sigma_paths in component Force (dimensionless)'); LEGEND_STATES(:,19) = strpad('N_0 in component Force (dimensionless)'); LEGEND_STATES(:,20) = strpad('P_0 in component Force (dimensionless)'); LEGEND_STATES(:,21) = strpad('P_1 in component Force (dimensionless)'); LEGEND_STATES(:,22) = strpad('P_2 in component Force (dimensionless)'); LEGEND_STATES(:,23) = strpad('P_3 in component Force (dimensionless)'); LEGEND_ALGEBRAIC(:,48) = strpad('N_1 in component Force (dimensionless)'); LEGEND_ALGEBRAIC(:,47) = strpad('alpha_tm in component Force (per_second)'); LEGEND_CONSTANTS(:,50) = strpad('beta_tm in component Force (per_second)'); LEGEND_CONSTANTS(:,58) = strpad('K_tm in component Force (dimensionless)'); LEGEND_CONSTANTS(:,59) = strpad('N_tm in component Force (dimensionless)'); LEGEND_CONSTANTS(:,51) = strpad('SL in component Force (micrometre)'); LEGEND_CONSTANTS(:,56) = strpad('SL_norm in component Force (dimensionless)'); LEGEND_CONSTANTS(:,57) = strpad('f_01 in component Force (per_second)'); LEGEND_CONSTANTS(:,60) = strpad('f_12 in component Force (per_second)'); LEGEND_CONSTANTS(:,64) = strpad('f_23 in component Force (per_second)'); LEGEND_CONSTANTS(:,61) = strpad('g_01 in component Force (per_second)'); LEGEND_CONSTANTS(:,62) = strpad('g_12 in component Force (per_second)'); LEGEND_CONSTANTS(:,63) = strpad('g_23 in component Force (per_second)'); LEGEND_CONSTANTS(:,52) = strpad('f_XB in component Force (per_second)'); LEGEND_CONSTANTS(:,53) = strpad('g_XB in component Force (per_second)'); LEGEND_RATES(:,1) = strpad('d/dt V in component membrane_potential (millivolt)'); LEGEND_RATES(:,5) = strpad('d/dt m in component fast_sodium_current_m_gate (dimensionless)'); LEGEND_RATES(:,6) = strpad('d/dt h in component fast_sodium_current_h_gate (dimensionless)'); LEGEND_RATES(:,7) = strpad('d/dt x in component time_dependent_rectifier_potassium_current_x_gate (dimensionless)'); LEGEND_RATES(:,8) = strpad('d/dt s in component transient_outward_current_s_gate (dimensionless)'); LEGEND_RATES(:,9) = strpad('d/dt r in component transient_outward_current_r_gate (dimensionless)'); LEGEND_RATES(:,10) = strpad('d/dt d in component L_type_Ca_channel_d_gate (dimensionless)'); LEGEND_RATES(:,11) = strpad('d/dt f in component L_type_Ca_channel_f_gate (dimensionless)'); LEGEND_RATES(:,12) = strpad('d/dt F_CaMK in component CaMKII_factor (dimensionless)'); LEGEND_RATES(:,16) = strpad('d/dt F_1 in component RyR (dimensionless)'); LEGEND_RATES(:,17) = strpad('d/dt F_2 in component RyR (dimensionless)'); LEGEND_RATES(:,15) = strpad('d/dt F_SRCa_RyR in component RyR (millimolar)'); LEGEND_RATES(:,13) = strpad('d/dt Cmdn_Ca in component calmodulin (millimolar)'); LEGEND_RATES(:,18) = strpad('d/dt Trpn_Ca in component troponin (millimolar)'); LEGEND_RATES(:,4) = strpad('d/dt Ca_i in component intracellular_calcium_concentration (millimolar)'); LEGEND_RATES(:,14) = strpad('d/dt Ca_SR in component SR_calcium_concentration (millimolar)'); LEGEND_RATES(:,3) = strpad('d/dt Na_i in component intracellular_sodium_concentration (millimolar)'); LEGEND_RATES(:,2) = strpad('d/dt K_i in component intracellular_potassium_concentration (millimolar)'); LEGEND_RATES(:,19) = strpad('d/dt N_0 in component Force (dimensionless)'); LEGEND_RATES(:,20) = strpad('d/dt P_0 in component Force (dimensionless)'); LEGEND_RATES(:,21) = strpad('d/dt P_1 in component Force (dimensionless)'); LEGEND_RATES(:,22) = strpad('d/dt P_2 in component Force (dimensionless)'); LEGEND_RATES(:,23) = strpad('d/dt P_3 in component Force (dimensionless)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; CONSTANTS(:,1) = 8314.472; CONSTANTS(:,2) = 310; CONSTANTS(:,3) = 96485.3415; CONSTANTS(:,4) = 9.5e-5; CONSTANTS(:,5) = 1.6404e-5; CONSTANTS(:,6) = 3.3477e-6; CONSTANTS(:,7) = 140; CONSTANTS(:,8) = 4; CONSTANTS(:,9) = 2; STATES(:,1) = -92.849333; CONSTANTS(:,10) = 0; CONSTANTS(:,11) = 1000; CONSTANTS(:,12) = 0.5; CONSTANTS(:,13) = 0.002; CONSTANTS(:,14) = -4; STATES(:,2) = 138.22; STATES(:,3) = 5.8041; STATES(:,4) = 9.91e-6; CONSTANTS(:,15) = 2.5; STATES(:,5) = 0.0013809; STATES(:,6) = 0.99569; CONSTANTS(:,16) = 1e-5; CONSTANTS(:,17) = 0; CONSTANTS(:,18) = 1; STATES(:,7) = 5.1127e-2; CONSTANTS(:,19) = 10; CONSTANTS(:,20) = 1; CONSTANTS(:,21) = 0.005; STATES(:,8) = 0.95854; STATES(:,9) = 1.5185e-8; CONSTANTS(:,22) = 0.25; STATES(:,10) = 1.7908e-8; STATES(:,11) = 1; CONSTANTS(:,23) = 3; CONSTANTS(:,24) = 0.5; CONSTANTS(:,25) = 0.0005; CONSTANTS(:,26) = 0.5; CONSTANTS(:,27) = 1.36; CONSTANTS(:,28) = 1; CONSTANTS(:,29) = 21.7; CONSTANTS(:,30) = 0.00025; CONSTANTS(:,31) = 0.0006; CONSTANTS(:,32) = 0.0006; STATES(:,12) = 1.028; CONSTANTS(:,33) = 0.8; STATES(:,13) = 3.9636e-6; STATES(:,14) = 0.24886; CONSTANTS(:,34) = 500; STATES(:,15) = 0.25089; CONSTANTS(:,35) = 0.05; CONSTANTS(:,36) = 1; CONSTANTS(:,37) = 1; CONSTANTS(:,38) = 1; CONSTANTS(:,39) = 1; STATES(:,16) = 0.5268; STATES(:,17) = 8.7508e-6; CONSTANTS(:,40) = 0; CONSTANTS(:,41) = 0.292; CONSTANTS(:,42) = 0.391; CONSTANTS(:,43) = 0.02; CONSTANTS(:,44) = 10000; CONSTANTS(:,45) = 500; STATES(:,18) = 2.7661e-4; CONSTANTS(:,46) = 0.07; CONSTANTS(:,47) = 80000; CONSTANTS(:,48) = 200; CONSTANTS(:,49) = 0.1; STATES(:,19) = 0.99917; STATES(:,20) = 9.8593e-5; STATES(:,21) = 1.3331e-4; STATES(:,22) = 2.3505e-4; STATES(:,23) = 1.5349e-4; CONSTANTS(:,50) = 40; CONSTANTS(:,51) = 2.15; CONSTANTS(:,52) = 10; CONSTANTS(:,53) = 30; CONSTANTS(:,54) = CONSTANTS(:,39).*1.80000; CONSTANTS(:,55) = piecewise({CONSTANTS(:,51)>=1.70000&CONSTANTS(:,51)<=2.00000, (CONSTANTS(:,51) - 0.600000)./1.40000 , CONSTANTS(:,51)>2.00000&CONSTANTS(:,51)<=2.20000, 1.00000 , CONSTANTS(:,51)>2.20000&CONSTANTS(:,51)<=2.30000, (3.60000 - CONSTANTS(:,51))./1.40000 }, NaN); CONSTANTS(:,56) = (CONSTANTS(:,51) - 1.70000)./0.700000; CONSTANTS(:,57) = 3.00000.*CONSTANTS(:,52); CONSTANTS(:,58) = 1.00000./(1.00000+(CONSTANTS(:,48)./CONSTANTS(:,47))./(0.00170000 - 0.000900000.*CONSTANTS(:,56))); CONSTANTS(:,59) = 3.50000+ 2.50000.*CONSTANTS(:,56); CONSTANTS(:,60) = 10.0000.*CONSTANTS(:,52); CONSTANTS(:,61) = CONSTANTS(:,53).*(2.00000 - CONSTANTS(:,56)); CONSTANTS(:,62) = 2.00000.*CONSTANTS(:,53).*(2.00000 - CONSTANTS(:,56)); CONSTANTS(:,63) = 3.00000.*CONSTANTS(:,53).*(2.00000 - CONSTANTS(:,56)); CONSTANTS(:,64) = 7.00000.*CONSTANTS(:,52); CONSTANTS(:,65) = 1.00000.*CONSTANTS(:,53).*2.00000.*CONSTANTS(:,53).*3.00000.*CONSTANTS(:,53)+ 1.00000.*CONSTANTS(:,57).*2.00000.*CONSTANTS(:,53).*3.00000.*CONSTANTS(:,53)+ 1.00000.*CONSTANTS(:,57).*1.00000.*CONSTANTS(:,60).*3.00000.*CONSTANTS(:,53)+ 1.00000.*CONSTANTS(:,57).*1.00000.*CONSTANTS(:,60).*1.00000.*CONSTANTS(:,64); CONSTANTS(:,66) = ( 1.00000.*CONSTANTS(:,57).*2.00000.*CONSTANTS(:,53).*3.00000.*CONSTANTS(:,53))./CONSTANTS(:,65); CONSTANTS(:,67) = ( 1.00000.*CONSTANTS(:,57).*1.00000.*CONSTANTS(:,60).*3.00000.*CONSTANTS(:,53))./CONSTANTS(:,65); CONSTANTS(:,68) = ( 1.00000.*CONSTANTS(:,57).*1.00000.*CONSTANTS(:,60).*1.00000.*CONSTANTS(:,64))./CONSTANTS(:,65); CONSTANTS(:,69) = CONSTANTS(:,66)+ 2.00000.*CONSTANTS(:,67)+ 3.00000.*CONSTANTS(:,68); if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end RATES(:,9) = 333.000.*(1.00000./(1.00000+exp( - (STATES(:,1)+4.00000)./5.00000)) - STATES(:,9)); RATES(:,15) = (STATES(:,14) - STATES(:,15))./CONSTANTS(:,35); RATES(:,13) = CONSTANTS(:,44).*(CONSTANTS(:,43) - STATES(:,13)).*STATES(:,4) - CONSTANTS(:,45).*STATES(:,13); RATES(:,22) = - (CONSTANTS(:,64)+CONSTANTS(:,62)).*STATES(:,22)+ CONSTANTS(:,60).*STATES(:,21)+ CONSTANTS(:,63).*STATES(:,23); RATES(:,23) = - CONSTANTS(:,63).*STATES(:,23)+ CONSTANTS(:,64).*STATES(:,22); ALGEBRAIC(:,8) = STATES(:,13)./5.00000e-05; RATES(:,12) = (ALGEBRAIC(:,8) - STATES(:,12))./CONSTANTS(:,33); ALGEBRAIC(:,3) = 20.0000.*exp( - 0.125000.*((STATES(:,1)+75.0000) - CONSTANTS(:,17))); ALGEBRAIC(:,11) = 2000.00./(1.00000+ 320.000.*exp( - 0.100000.*((STATES(:,1)+75.0000) - CONSTANTS(:,17)))); RATES(:,6) = ALGEBRAIC(:,3).*(1.00000 - STATES(:,6)) - ALGEBRAIC(:,11).*STATES(:,6); ALGEBRAIC(:,4) = ( 0.500000.*exp( 0.0826000.*(STATES(:,1)+50.0000)))./(1.00000+exp( 0.0570000.*(STATES(:,1)+50.0000))); ALGEBRAIC(:,12) = ( 1.30000.*exp( - 0.0600000.*(STATES(:,1)+20.0000)))./(1.00000+exp( - 0.0400000.*(STATES(:,1)+20.0000))); RATES(:,7) = ALGEBRAIC(:,4).*(1.00000 - STATES(:,7)) - ALGEBRAIC(:,12).*STATES(:,7); ALGEBRAIC(:,5) = 0.0330000.*exp( - STATES(:,1)./17.0000); ALGEBRAIC(:,13) = 33.0000./(1.00000+exp( - 0.125000.*(STATES(:,1)+10.0000))); RATES(:,8) = ALGEBRAIC(:,5).*(1.00000 - STATES(:,8)) - ALGEBRAIC(:,13).*STATES(:,8); ALGEBRAIC(:,2) = STATES(:,1)+41.0000; ALGEBRAIC(:,10) = piecewise({abs(ALGEBRAIC(:,2))=CONSTANTS(:,10)&VOI<=CONSTANTS(:,11)&(VOI - CONSTANTS(:,10)) - floor((VOI - CONSTANTS(:,10))./CONSTANTS(:,12)).*CONSTANTS(:,12)<=CONSTANTS(:,13), CONSTANTS(:,14) }, 0.00000); RATES(:,1) = ( - 1.00000./CONSTANTS(:,4)).*(ALGEBRAIC(:,22)+ALGEBRAIC(:,40)+ALGEBRAIC(:,24)+ALGEBRAIC(:,23)+ALGEBRAIC(:,25)+ALGEBRAIC(:,37)+ALGEBRAIC(:,29)+ALGEBRAIC(:,36)+ALGEBRAIC(:,31)+ALGEBRAIC(:,33)+ALGEBRAIC(:,1)); RATES(:,3) = - (ALGEBRAIC(:,22)+ALGEBRAIC(:,40)+ALGEBRAIC(:,28)+ 3.00000.*ALGEBRAIC(:,31)+ 3.00000.*ALGEBRAIC(:,33))./( CONSTANTS(:,5).*CONSTANTS(:,3)); ALGEBRAIC(:,41) = ( CONSTANTS(:,34).*STATES(:,15))./(STATES(:,15)+0.200000); ALGEBRAIC(:,38) = power(STATES(:,17)./(STATES(:,17)+0.250000), 2.00000); ALGEBRAIC(:,42) = ( ALGEBRAIC(:,41).*ALGEBRAIC(:,38)+CONSTANTS(:,40)).*(STATES(:,14) - STATES(:,4)); ALGEBRAIC(:,43) = power(STATES(:,4)./0.000240000, 2.00000); ALGEBRAIC(:,44) = power(STATES(:,14)./1.64000, 2.00000); ALGEBRAIC(:,45) = ( STATES(:,12).*CONSTANTS(:,41).*ALGEBRAIC(:,43) - CONSTANTS(:,42).*ALGEBRAIC(:,44))./(1.00000+ALGEBRAIC(:,43)+ALGEBRAIC(:,44)); RATES(:,14) = ( ALGEBRAIC(:,45).*CONSTANTS(:,5))./CONSTANTS(:,6) - ALGEBRAIC(:,42); ALGEBRAIC(:,47) = CONSTANTS(:,50).*power(STATES(:,18)./( CONSTANTS(:,46).*CONSTANTS(:,58)), CONSTANTS(:,59)); RATES(:,20) = - (CONSTANTS(:,50)+CONSTANTS(:,57)).*STATES(:,20)+ ALGEBRAIC(:,47).*STATES(:,19)+ CONSTANTS(:,61).*STATES(:,21); ALGEBRAIC(:,48) = 1.00000 - (STATES(:,19)+STATES(:,20)+STATES(:,21)+STATES(:,22)+STATES(:,23)); RATES(:,19) = ( CONSTANTS(:,50).*STATES(:,20) - ALGEBRAIC(:,47).*STATES(:,19))+ CONSTANTS(:,61).*ALGEBRAIC(:,48); RATES(:,21) = - (CONSTANTS(:,50)+CONSTANTS(:,60)+CONSTANTS(:,61)).*STATES(:,21)+ ALGEBRAIC(:,47).*ALGEBRAIC(:,48)+ CONSTANTS(:,57).*STATES(:,20)+ CONSTANTS(:,62).*STATES(:,22); ALGEBRAIC(:,49) = ( CONSTANTS(:,55).*(STATES(:,21)+ALGEBRAIC(:,48)+ 2.00000.*STATES(:,22)+ 3.00000.*STATES(:,23)))./CONSTANTS(:,69); RATES(:,18) = CONSTANTS(:,47).*(CONSTANTS(:,46) - STATES(:,18)).*STATES(:,4) - (( CONSTANTS(:,48).*(1.00000+ 2.00000.*(1.00000 - ALGEBRAIC(:,49))))./3.00000).*STATES(:,18); ALGEBRAIC(:,46) = CONSTANTS(:,44).*(CONSTANTS(:,43) - STATES(:,13)).*STATES(:,4) - CONSTANTS(:,45).*STATES(:,13); ALGEBRAIC(:,50) = CONSTANTS(:,47).*(CONSTANTS(:,46) - STATES(:,18)).*STATES(:,4) - (( CONSTANTS(:,48).*(1.00000+ 2.00000.*(1.00000 - ALGEBRAIC(:,49))))./3.00000).*STATES(:,18); RATES(:,4) = ((( - ((ALGEBRAIC(:,26)+ALGEBRAIC(:,36)) - 2.00000.*ALGEBRAIC(:,31))./( 2.00000.*CONSTANTS(:,5).*CONSTANTS(:,3)) - ALGEBRAIC(:,45))+( ALGEBRAIC(:,42).*CONSTANTS(:,6))./CONSTANTS(:,5)) - ALGEBRAIC(:,46)) - ALGEBRAIC(:,50); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,8) = STATES(:,13)./5.00000e-05; ALGEBRAIC(:,3) = 20.0000.*exp( - 0.125000.*((STATES(:,1)+75.0000) - CONSTANTS(:,17))); ALGEBRAIC(:,11) = 2000.00./(1.00000+ 320.000.*exp( - 0.100000.*((STATES(:,1)+75.0000) - CONSTANTS(:,17)))); ALGEBRAIC(:,4) = ( 0.500000.*exp( 0.0826000.*(STATES(:,1)+50.0000)))./(1.00000+exp( 0.0570000.*(STATES(:,1)+50.0000))); ALGEBRAIC(:,12) = ( 1.30000.*exp( - 0.0600000.*(STATES(:,1)+20.0000)))./(1.00000+exp( - 0.0400000.*(STATES(:,1)+20.0000))); ALGEBRAIC(:,5) = 0.0330000.*exp( - STATES(:,1)./17.0000); ALGEBRAIC(:,13) = 33.0000./(1.00000+exp( - 0.125000.*(STATES(:,1)+10.0000))); ALGEBRAIC(:,2) = STATES(:,1)+41.0000; ALGEBRAIC(:,10) = piecewise({abs(ALGEBRAIC(:,2))=CONSTANTS(:,10)&VOI<=CONSTANTS(:,11)&(VOI - CONSTANTS(:,10)) - floor((VOI - CONSTANTS(:,10))./CONSTANTS(:,12)).*CONSTANTS(:,12)<=CONSTANTS(:,13), CONSTANTS(:,14) }, 0.00000); ALGEBRAIC(:,41) = ( CONSTANTS(:,34).*STATES(:,15))./(STATES(:,15)+0.200000); ALGEBRAIC(:,38) = power(STATES(:,17)./(STATES(:,17)+0.250000), 2.00000); ALGEBRAIC(:,42) = ( ALGEBRAIC(:,41).*ALGEBRAIC(:,38)+CONSTANTS(:,40)).*(STATES(:,14) - STATES(:,4)); ALGEBRAIC(:,43) = power(STATES(:,4)./0.000240000, 2.00000); ALGEBRAIC(:,44) = power(STATES(:,14)./1.64000, 2.00000); ALGEBRAIC(:,45) = ( STATES(:,12).*CONSTANTS(:,41).*ALGEBRAIC(:,43) - CONSTANTS(:,42).*ALGEBRAIC(:,44))./(1.00000+ALGEBRAIC(:,43)+ALGEBRAIC(:,44)); ALGEBRAIC(:,47) = CONSTANTS(:,50).*power(STATES(:,18)./( CONSTANTS(:,46).*CONSTANTS(:,58)), CONSTANTS(:,59)); ALGEBRAIC(:,48) = 1.00000 - (STATES(:,19)+STATES(:,20)+STATES(:,21)+STATES(:,22)+STATES(:,23)); ALGEBRAIC(:,49) = ( CONSTANTS(:,55).*(STATES(:,21)+ALGEBRAIC(:,48)+ 2.00000.*STATES(:,22)+ 3.00000.*STATES(:,23)))./CONSTANTS(:,69); ALGEBRAIC(:,46) = CONSTANTS(:,44).*(CONSTANTS(:,43) - STATES(:,13)).*STATES(:,4) - CONSTANTS(:,45).*STATES(:,13); ALGEBRAIC(:,50) = CONSTANTS(:,47).*(CONSTANTS(:,46) - STATES(:,18)).*STATES(:,4) - (( CONSTANTS(:,48).*(1.00000+ 2.00000.*(1.00000 - ALGEBRAIC(:,49))))./3.00000).*STATES(:,18); ALGEBRAIC(:,51) = CONSTANTS(:,49).*ALGEBRAIC(:,49); end % Compute result of a piecewise function function x = piecewise(cases, default) set = [0]; for i = 1:2:length(cases) if (length(cases{i+1}) == 1) x(cases{i} & ~set,:) = cases{i+1}; else x(cases{i} & ~set,:) = cases{i+1}(cases{i} & ~set); end set = set | cases{i}; if(set), break, end end if (length(default) == 1) x(~set,:) = default; else x(~set,:) = default(~set); end end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end