function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =40; end % There are a total of 7 entries in each of the rate and state variable arrays. % There are a total of 38 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (second)'); LEGEND_STATES(:,1) = strpad('V in component membrane (millivolt)'); LEGEND_CONSTANTS(:,1) = strpad('V_T in component membrane (millivolt)'); LEGEND_CONSTANTS(:,2) = strpad('V_S in component membrane (millivolt)'); LEGEND_CONSTANTS(:,3) = strpad('C_m in component membrane (mF_per_cm_squared)'); LEGEND_CONSTANTS(:,4) = strpad('F in component membrane (coulomb_per_mole)'); LEGEND_CONSTANTS(:,5) = strpad('R in component membrane (joule_per_mole_per_kelvin)'); LEGEND_CONSTANTS(:,6) = strpad('T in component membrane (kelvin)'); LEGEND_ALGEBRAIC(:,17) = strpad('I_leak in component I_leak (milliampere_per_cm_squared)'); LEGEND_ALGEBRAIC(:,22) = strpad('I_Na in component I_Na (milliampere_per_cm_squared)'); LEGEND_ALGEBRAIC(:,23) = strpad('I_KD in component I_KD (milliampere_per_cm_squared)'); LEGEND_ALGEBRAIC(:,24) = strpad('I_KM in component I_KM (milliampere_per_cm_squared)'); LEGEND_ALGEBRAIC(:,26) = strpad('I_CaL in component I_CaL (milliampere_per_cm_squared)'); LEGEND_ALGEBRAIC(:,40) = strpad('I_h in component I_h (milliampere_per_cm_squared)'); LEGEND_ALGEBRAIC(:,12) = strpad('I_app in component stimulus_protocol (milliampere_per_cm_squared)'); LEGEND_CONSTANTS(:,7) = strpad('i_stimStart in component stimulus_protocol (second)'); LEGEND_CONSTANTS(:,8) = strpad('i_stimEnd in component stimulus_protocol (second)'); LEGEND_CONSTANTS(:,9) = strpad('i_stimAmplitude in component stimulus_protocol (milliampere_per_cm_squared)'); LEGEND_ALGEBRAIC(:,6) = strpad('tau in component stimulus_protocol (second)'); LEGEND_CONSTANTS(:,10) = strpad('period in component stimulus_protocol (second)'); LEGEND_CONSTANTS(:,11) = strpad('g_leak in component I_leak (millisiemens_per_cm_squared)'); LEGEND_CONSTANTS(:,12) = strpad('E_leak in component I_leak (millivolt)'); LEGEND_CONSTANTS(:,13) = strpad('g_Na in component I_Na (millisiemens_per_cm_squared)'); LEGEND_CONSTANTS(:,14) = strpad('E_Na in component I_Na (millivolt)'); LEGEND_STATES(:,2) = strpad('m in component Na_m_gate (dimensionless)'); LEGEND_STATES(:,3) = strpad('h in component Na_h_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,1) = strpad('alpha in component Na_m_gate (per_second)'); LEGEND_ALGEBRAIC(:,7) = strpad('beta in component Na_m_gate (per_second)'); LEGEND_ALGEBRAIC(:,13) = strpad('tau_m in component Na_m_gate (second)'); LEGEND_ALGEBRAIC(:,18) = strpad('m_inf in component Na_m_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,2) = strpad('alpha_h in component Na_h_gate (per_second)'); LEGEND_ALGEBRAIC(:,8) = strpad('beta_h in component Na_h_gate (per_second)'); LEGEND_ALGEBRAIC(:,19) = strpad('h_inf in component Na_h_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,14) = strpad('tau_h in component Na_h_gate (second)'); LEGEND_CONSTANTS(:,15) = strpad('g_KD in component I_KD (millisiemens_per_cm_squared)'); LEGEND_CONSTANTS(:,16) = strpad('E_K in component I_KD (millivolt)'); LEGEND_STATES(:,4) = strpad('n in component KD_n_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,3) = strpad('alpha_n in component KD_n_gate (per_second)'); LEGEND_ALGEBRAIC(:,9) = strpad('beta_n in component KD_n_gate (per_second)'); LEGEND_ALGEBRAIC(:,15) = strpad('tau_n in component KD_n_gate (second)'); LEGEND_ALGEBRAIC(:,20) = strpad('n_inf in component KD_n_gate (dimensionless)'); LEGEND_CONSTANTS(:,17) = strpad('g_KM in component I_KM (millisiemens_per_cm_squared)'); LEGEND_STATES(:,5) = strpad('p in component KM_p_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,4) = strpad('p_inf in component KM_p_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,10) = strpad('tau_p in component KM_p_gate (second)'); LEGEND_CONSTANTS(:,18) = strpad('tau_max in component KM_p_gate (second)'); LEGEND_CONSTANTS(:,19) = strpad('P_Ca in component I_CaL (cm_per_second)'); LEGEND_ALGEBRAIC(:,25) = strpad('G in component G_nonlin (coulomb_per_cm_cubed)'); LEGEND_STATES(:,6) = strpad('q in component CaL_q_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,5) = strpad('alpha_q in component CaL_q_gate (per_second)'); LEGEND_ALGEBRAIC(:,11) = strpad('beta_q in component CaL_q_gate (per_second)'); LEGEND_ALGEBRAIC(:,16) = strpad('tau_q in component CaL_q_gate (second)'); LEGEND_ALGEBRAIC(:,21) = strpad('q_inf in component CaL_q_gate (dimensionless)'); LEGEND_CONSTANTS(:,20) = strpad('Z in component G_nonlin (dimensionless)'); LEGEND_CONSTANTS(:,21) = strpad('Ca_o in component G_nonlin (mM)'); LEGEND_STATES(:,7) = strpad('Ca_i in component dCa_i_dt (mM)'); LEGEND_CONSTANTS(:,22) = strpad('Ca_inf in component dCa_i_dt (mM)'); LEGEND_CONSTANTS(:,23) = strpad('tau_r in component dCa_i_dt (second)'); LEGEND_CONSTANTS(:,24) = strpad('d in component dCa_i_dt (centimeter)'); LEGEND_ALGEBRAIC(:,27) = strpad('drive_channel in component dCa_i_dt (mM_per_second)'); LEGEND_CONSTANTS(:,25) = strpad('k in component dCa_i_dt (fixer)'); LEGEND_ALGEBRAIC(:,39) = strpad('m in component I_h (dimensionless)'); LEGEND_CONSTANTS(:,26) = strpad('E_h in component I_h (millivolt)'); LEGEND_CONSTANTS(:,27) = strpad('g_hbar in component I_h (millisiemens_per_cm_squared)'); LEGEND_CONSTANTS(:,28) = strpad('cac in component I_h (mM)'); LEGEND_CONSTANTS(:,29) = strpad('V_S in component I_h (millivolt)'); LEGEND_ALGEBRAIC(:,36) = strpad('o_1 in component kinetic (dimensionless)'); LEGEND_ALGEBRAIC(:,37) = strpad('o_2 in component kinetic (dimensionless)'); LEGEND_CONSTANTS(:,30) = strpad('g_inc in component I_h (dimensionless)'); LEGEND_ALGEBRAIC(:,33) = strpad('p_0 in component kinetic (dimensionless)'); LEGEND_ALGEBRAIC(:,34) = strpad('p_1 in component kinetic (dimensionless)'); LEGEND_ALGEBRAIC(:,38) = strpad('c_1 in component kinetic (dimensionless)'); LEGEND_ALGEBRAIC(:,30) = strpad('alpha in component rate_constants (dimensionless)'); LEGEND_ALGEBRAIC(:,31) = strpad('beta in component rate_constants (dimensionless)'); LEGEND_ALGEBRAIC(:,32) = strpad('k_1Ca in component rate_constants (per_second)'); LEGEND_CONSTANTS(:,31) = strpad('k_2 in component rate_constants (per_second)'); LEGEND_ALGEBRAIC(:,35) = strpad('k_3p in component rate_constants (per_second)'); LEGEND_CONSTANTS(:,32) = strpad('k_4 in component rate_constants (per_second)'); LEGEND_ALGEBRAIC(:,28) = strpad('h_inf in component rate_constants (second)'); LEGEND_ALGEBRAIC(:,29) = strpad('tau_s in component rate_constants (second)'); LEGEND_CONSTANTS(:,33) = strpad('P_c in component rate_constants (dimensionless)'); LEGEND_CONSTANTS(:,34) = strpad('n_Ca in component rate_constants (dimensionless)'); LEGEND_CONSTANTS(:,35) = strpad('n_exp in component rate_constants (dimensionless)'); LEGEND_CONSTANTS(:,36) = strpad('p_C in component rate_constants (dimensionless)'); LEGEND_CONSTANTS(:,37) = strpad('Ca_c in component rate_constants (mM)'); LEGEND_CONSTANTS(:,38) = strpad('tau_m in component rate_constants (second)'); LEGEND_RATES(:,1) = strpad('d/dt V in component membrane (millivolt)'); LEGEND_RATES(:,2) = strpad('d/dt m in component Na_m_gate (dimensionless)'); LEGEND_RATES(:,3) = strpad('d/dt h in component Na_h_gate (dimensionless)'); LEGEND_RATES(:,4) = strpad('d/dt n in component KD_n_gate (dimensionless)'); LEGEND_RATES(:,5) = strpad('d/dt p in component KM_p_gate (dimensionless)'); LEGEND_RATES(:,6) = strpad('d/dt q in component CaL_q_gate (dimensionless)'); LEGEND_RATES(:,7) = strpad('d/dt Ca_i in component dCa_i_dt (mM)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; STATES(:,1) = -70; CONSTANTS(:,1) = -55; CONSTANTS(:,2) = 0; CONSTANTS(:,3) = 1e-3; CONSTANTS(:,4) = 96489; CONSTANTS(:,5) = 8.314; CONSTANTS(:,6) = 296.65; CONSTANTS(:,7) = 5; CONSTANTS(:,8) = 9; CONSTANTS(:,9) = -0.3; CONSTANTS(:,10) = 9; CONSTANTS(:,11) = 1; CONSTANTS(:,12) = -70; CONSTANTS(:,13) = 70; CONSTANTS(:,14) = 50; STATES(:,2) = 0; STATES(:,3) = 0; CONSTANTS(:,15) = 7; CONSTANTS(:,16) = -95; STATES(:,4) = 0; CONSTANTS(:,17) = 0.004; STATES(:,5) = 0; CONSTANTS(:,18) = 4; CONSTANTS(:,19) = 2.76e-4; STATES(:,6) = 0.00247262; CONSTANTS(:,20) = 2; CONSTANTS(:,21) = 2; STATES(:,7) = 100e-6; CONSTANTS(:,22) = 100e-6; CONSTANTS(:,23) = 17e-3; CONSTANTS(:,24) = 1e-4; CONSTANTS(:,25) = 0.1; CONSTANTS(:,26) = -20; CONSTANTS(:,27) = 0.02; CONSTANTS(:,28) = 0.006; CONSTANTS(:,29) = 0; CONSTANTS(:,30) = 2; CONSTANTS(:,31) = 0.1; CONSTANTS(:,32) = 1; CONSTANTS(:,33) = 0.01; CONSTANTS(:,34) = 4; CONSTANTS(:,35) = 1; CONSTANTS(:,36) = 0.01; CONSTANTS(:,37) = 0.006; CONSTANTS(:,38) = 20e-3; if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,4) = piecewise({ - (STATES(:,1)+35.0000)./10.0000<25.0000& - (STATES(:,1)+35.0000)./10.0000> - 25.0000, 1.00000./(1.00000+exp( - (STATES(:,1)+35.0000)./10.0000)) }, 1.00000); ALGEBRAIC(:,10) = piecewise({(STATES(:,1)+35.0000)./20.0000<25.0000&(STATES(:,1)+35.0000)./20.0000> - 25.0000, CONSTANTS(:,18)./( 3.30000.*exp((STATES(:,1)+35.0000)./20.0000)+exp( - (STATES(:,1)+35.0000)./20.0000)) }, 1.00000); RATES(:,5) = (ALGEBRAIC(:,4) - STATES(:,5))./ALGEBRAIC(:,10); ALGEBRAIC(:,1) = piecewise({abs(((13.0000+CONSTANTS(:,1)) - STATES(:,1))./4.00000)<1.00000e-06, 0.320000.*4.00000.*(1.00000 - ((13.0000+CONSTANTS(:,1)) - STATES(:,1))./( 2.00000.*4.00000)) }, ( 0.320000.*((13.0000+CONSTANTS(:,1)) - STATES(:,1)))./(exp(((13.0000+CONSTANTS(:,1)) - STATES(:,1))./4.00000) - 1.00000)); ALGEBRAIC(:,7) = piecewise({abs( - ((STATES(:,1) - CONSTANTS(:,1)) - 40.0000)./5.00000)<1.00000e-06, - 0.280000.*5.00000.*(1.00000 - - ((STATES(:,1) - CONSTANTS(:,1)) - 40.0000)./( 2.00000.*5.00000)) }, ( - 0.280000.*((STATES(:,1) - CONSTANTS(:,1)) - 40.0000))./(exp( - ((STATES(:,1) - CONSTANTS(:,1)) - 40.0000)./5.00000) - 1.00000)); ALGEBRAIC(:,13) = 1.00000./(ALGEBRAIC(:,1)+ALGEBRAIC(:,7)); ALGEBRAIC(:,18) = ALGEBRAIC(:,1)./(ALGEBRAIC(:,1)+ALGEBRAIC(:,7)); RATES(:,2) = (ALGEBRAIC(:,18) - STATES(:,2))./ALGEBRAIC(:,13); ALGEBRAIC(:,2) = 0.128000.*exp(((17.0000+CONSTANTS(:,1)+CONSTANTS(:,2)) - STATES(:,1))./18.0000); ALGEBRAIC(:,8) = 4.00000./(1.00000+exp(((40.0000+CONSTANTS(:,2)+CONSTANTS(:,1)) - STATES(:,1))./5.00000)); ALGEBRAIC(:,19) = ALGEBRAIC(:,2)./(ALGEBRAIC(:,2)+ALGEBRAIC(:,8)); ALGEBRAIC(:,14) = 1.00000./(ALGEBRAIC(:,2)+ALGEBRAIC(:,8)); RATES(:,3) = (ALGEBRAIC(:,19) - STATES(:,3))./ALGEBRAIC(:,14); ALGEBRAIC(:,3) = piecewise({abs(((STATES(:,1) - CONSTANTS(:,1)) - 15.0000)./5.00000)<1.00000e-06, - 0.0320000.*5.00000.*(1.00000 - ((STATES(:,1) - CONSTANTS(:,1)) - 15.0000)./( 2.00000.*5.00000)) }, ( - 0.0320000.*((STATES(:,1) - CONSTANTS(:,1)) - 15.0000))./(exp(((STATES(:,1) - CONSTANTS(:,1)) - 15.0000)./5.00000) - 1.00000)); ALGEBRAIC(:,9) = piecewise({abs( - ((STATES(:,1) - CONSTANTS(:,1)) - 10.0000)./40.0000)<1.00000e-06, 0.500000.*40.0000.*(1.00000+((STATES(:,1) - CONSTANTS(:,1)) - 10.0000)./( 2.00000.*40.0000)) }, ( 0.500000.* - ((STATES(:,1) - CONSTANTS(:,1)) - 10.0000))./(exp( - ((STATES(:,1) - CONSTANTS(:,1)) - 10.0000)./40.0000) - 1.00000)); ALGEBRAIC(:,15) = 1.00000./(ALGEBRAIC(:,3)+ALGEBRAIC(:,9)); ALGEBRAIC(:,20) = ALGEBRAIC(:,3)./(ALGEBRAIC(:,3)+ALGEBRAIC(:,9)); RATES(:,4) = (ALGEBRAIC(:,20) - STATES(:,4))./ALGEBRAIC(:,15); ALGEBRAIC(:,5) = 6.32000./(1.00000+exp( - (STATES(:,1) - 5.00000)./13.8900)); ALGEBRAIC(:,11) = piecewise({abs((1.31000 - STATES(:,1))./5.36000)<1.00000e-06, 0.0200000.*(5.36000+(1.31000 - STATES(:,1))./2.00000) }, ( 0.0200000.*(1.31000 - STATES(:,1)))./(1.00000 - exp((STATES(:,1) - 1.31000)./5.36000))); ALGEBRAIC(:,16) = 1.00000./(ALGEBRAIC(:,5)+ALGEBRAIC(:,11)); ALGEBRAIC(:,21) = 1.00000./(1.00000+exp((STATES(:,1)+10.0000)./ - 10.0000)); RATES(:,6) = (ALGEBRAIC(:,21) - STATES(:,6))./ALGEBRAIC(:,16); ALGEBRAIC(:,25) = ( (( power(CONSTANTS(:,20), 2.00000).*power(CONSTANTS(:,4), 2.00000).*0.00100000.*STATES(:,1))./( CONSTANTS(:,5).*CONSTANTS(:,6))).*1.00000e-06.*(STATES(:,7) - CONSTANTS(:,21).*exp(( CONSTANTS(:,20).*CONSTANTS(:,4).*0.00100000.*STATES(:,1))./( CONSTANTS(:,5).*CONSTANTS(:,6)))))./(1.00000 - exp(( 0.00100000.*CONSTANTS(:,20).*CONSTANTS(:,4).*STATES(:,1))./( CONSTANTS(:,5).*CONSTANTS(:,6)))); ALGEBRAIC(:,26) = 1000.00.*CONSTANTS(:,19).*power(STATES(:,6), 2.00000).*ALGEBRAIC(:,25); ALGEBRAIC(:,27) = ( CONSTANTS(:,25).*ALGEBRAIC(:,26))./( 2.00000.*CONSTANTS(:,4).*CONSTANTS(:,24)); RATES(:,7) = piecewise({ALGEBRAIC(:,27)<=0.00000, (CONSTANTS(:,22) - STATES(:,7))./CONSTANTS(:,23) }, ALGEBRAIC(:,27)+(CONSTANTS(:,22) - STATES(:,7))./CONSTANTS(:,23)); ALGEBRAIC(:,17) = 1000.00.*CONSTANTS(:,11).*(STATES(:,1) - CONSTANTS(:,12)); ALGEBRAIC(:,22) = 1000.00.*CONSTANTS(:,13).*power(STATES(:,2), 3.00000).*STATES(:,3).*(STATES(:,1) - CONSTANTS(:,14)); ALGEBRAIC(:,23) = 1000.00.*CONSTANTS(:,15).*power(STATES(:,4), 4.00000).*(STATES(:,1) - CONSTANTS(:,16)); ALGEBRAIC(:,24) = 1000.00.*CONSTANTS(:,17).*STATES(:,5).*(STATES(:,1) - CONSTANTS(:,16)); ALGEBRAIC(:,28) = 1.00000./(1.00000+exp(((STATES(:,1)+75.0000) - CONSTANTS(:,29))./5.50000)); ALGEBRAIC(:,29) = CONSTANTS(:,38)+1000.00./(exp(((STATES(:,1)+71.5500) - CONSTANTS(:,29))./14.2000)+exp( - ((STATES(:,1)+89.0000) - CONSTANTS(:,29))./11.6000)); ALGEBRAIC(:,30) = ALGEBRAIC(:,28)./ALGEBRAIC(:,29); ALGEBRAIC(:,31) = (1.00000 - ALGEBRAIC(:,28))./ALGEBRAIC(:,29); ALGEBRAIC(:,32) = CONSTANTS(:,31).*power(STATES(:,7)./CONSTANTS(:,37), CONSTANTS(:,34)); [CONSTANTS, STATES, ALGEBRAIC] = rootfind_0(VOI, CONSTANTS, STATES, ALGEBRAIC); ALGEBRAIC(:,35) = CONSTANTS(:,32).*power(ALGEBRAIC(:,34)./CONSTANTS(:,36), CONSTANTS(:,35)); [CONSTANTS, STATES, ALGEBRAIC] = rootfind_1(VOI, CONSTANTS, STATES, ALGEBRAIC); ALGEBRAIC(:,39) = ALGEBRAIC(:,36)+CONSTANTS(:,30)+ALGEBRAIC(:,37); ALGEBRAIC(:,40) = 1000.00.*CONSTANTS(:,27).*ALGEBRAIC(:,39).*(STATES(:,1) - CONSTANTS(:,26)); ALGEBRAIC(:,6) = VOI - CONSTANTS(:,10).*floor(VOI./CONSTANTS(:,10)); ALGEBRAIC(:,12) = piecewise({ALGEBRAIC(:,6)>=CONSTANTS(:,7)&ALGEBRAIC(:,6)<=CONSTANTS(:,8), CONSTANTS(:,9) }, 0.00000); RATES(:,1) = ( 0.00100000.*((((((ALGEBRAIC(:,12)+ - ALGEBRAIC(:,17)) - ALGEBRAIC(:,22)) - ALGEBRAIC(:,23)) - ALGEBRAIC(:,24)) - ALGEBRAIC(:,26)) - ALGEBRAIC(:,40)))./CONSTANTS(:,3); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,4) = piecewise({ - (STATES(:,1)+35.0000)./10.0000<25.0000& - (STATES(:,1)+35.0000)./10.0000> - 25.0000, 1.00000./(1.00000+exp( - (STATES(:,1)+35.0000)./10.0000)) }, 1.00000); ALGEBRAIC(:,10) = piecewise({(STATES(:,1)+35.0000)./20.0000<25.0000&(STATES(:,1)+35.0000)./20.0000> - 25.0000, CONSTANTS(:,18)./( 3.30000.*exp((STATES(:,1)+35.0000)./20.0000)+exp( - (STATES(:,1)+35.0000)./20.0000)) }, 1.00000); ALGEBRAIC(:,1) = piecewise({abs(((13.0000+CONSTANTS(:,1)) - STATES(:,1))./4.00000)<1.00000e-06, 0.320000.*4.00000.*(1.00000 - ((13.0000+CONSTANTS(:,1)) - STATES(:,1))./( 2.00000.*4.00000)) }, ( 0.320000.*((13.0000+CONSTANTS(:,1)) - STATES(:,1)))./(exp(((13.0000+CONSTANTS(:,1)) - STATES(:,1))./4.00000) - 1.00000)); ALGEBRAIC(:,7) = piecewise({abs( - ((STATES(:,1) - CONSTANTS(:,1)) - 40.0000)./5.00000)<1.00000e-06, - 0.280000.*5.00000.*(1.00000 - - ((STATES(:,1) - CONSTANTS(:,1)) - 40.0000)./( 2.00000.*5.00000)) }, ( - 0.280000.*((STATES(:,1) - CONSTANTS(:,1)) - 40.0000))./(exp( - ((STATES(:,1) - CONSTANTS(:,1)) - 40.0000)./5.00000) - 1.00000)); ALGEBRAIC(:,13) = 1.00000./(ALGEBRAIC(:,1)+ALGEBRAIC(:,7)); ALGEBRAIC(:,18) = ALGEBRAIC(:,1)./(ALGEBRAIC(:,1)+ALGEBRAIC(:,7)); ALGEBRAIC(:,2) = 0.128000.*exp(((17.0000+CONSTANTS(:,1)+CONSTANTS(:,2)) - STATES(:,1))./18.0000); ALGEBRAIC(:,8) = 4.00000./(1.00000+exp(((40.0000+CONSTANTS(:,2)+CONSTANTS(:,1)) - STATES(:,1))./5.00000)); ALGEBRAIC(:,19) = ALGEBRAIC(:,2)./(ALGEBRAIC(:,2)+ALGEBRAIC(:,8)); ALGEBRAIC(:,14) = 1.00000./(ALGEBRAIC(:,2)+ALGEBRAIC(:,8)); ALGEBRAIC(:,3) = piecewise({abs(((STATES(:,1) - CONSTANTS(:,1)) - 15.0000)./5.00000)<1.00000e-06, - 0.0320000.*5.00000.*(1.00000 - ((STATES(:,1) - CONSTANTS(:,1)) - 15.0000)./( 2.00000.*5.00000)) }, ( - 0.0320000.*((STATES(:,1) - CONSTANTS(:,1)) - 15.0000))./(exp(((STATES(:,1) - CONSTANTS(:,1)) - 15.0000)./5.00000) - 1.00000)); ALGEBRAIC(:,9) = piecewise({abs( - ((STATES(:,1) - CONSTANTS(:,1)) - 10.0000)./40.0000)<1.00000e-06, 0.500000.*40.0000.*(1.00000+((STATES(:,1) - CONSTANTS(:,1)) - 10.0000)./( 2.00000.*40.0000)) }, ( 0.500000.* - ((STATES(:,1) - CONSTANTS(:,1)) - 10.0000))./(exp( - ((STATES(:,1) - CONSTANTS(:,1)) - 10.0000)./40.0000) - 1.00000)); ALGEBRAIC(:,15) = 1.00000./(ALGEBRAIC(:,3)+ALGEBRAIC(:,9)); ALGEBRAIC(:,20) = ALGEBRAIC(:,3)./(ALGEBRAIC(:,3)+ALGEBRAIC(:,9)); ALGEBRAIC(:,5) = 6.32000./(1.00000+exp( - (STATES(:,1) - 5.00000)./13.8900)); ALGEBRAIC(:,11) = piecewise({abs((1.31000 - STATES(:,1))./5.36000)<1.00000e-06, 0.0200000.*(5.36000+(1.31000 - STATES(:,1))./2.00000) }, ( 0.0200000.*(1.31000 - STATES(:,1)))./(1.00000 - exp((STATES(:,1) - 1.31000)./5.36000))); ALGEBRAIC(:,16) = 1.00000./(ALGEBRAIC(:,5)+ALGEBRAIC(:,11)); ALGEBRAIC(:,21) = 1.00000./(1.00000+exp((STATES(:,1)+10.0000)./ - 10.0000)); ALGEBRAIC(:,25) = ( (( power(CONSTANTS(:,20), 2.00000).*power(CONSTANTS(:,4), 2.00000).*0.00100000.*STATES(:,1))./( CONSTANTS(:,5).*CONSTANTS(:,6))).*1.00000e-06.*(STATES(:,7) - CONSTANTS(:,21).*exp(( CONSTANTS(:,20).*CONSTANTS(:,4).*0.00100000.*STATES(:,1))./( CONSTANTS(:,5).*CONSTANTS(:,6)))))./(1.00000 - exp(( 0.00100000.*CONSTANTS(:,20).*CONSTANTS(:,4).*STATES(:,1))./( CONSTANTS(:,5).*CONSTANTS(:,6)))); ALGEBRAIC(:,26) = 1000.00.*CONSTANTS(:,19).*power(STATES(:,6), 2.00000).*ALGEBRAIC(:,25); ALGEBRAIC(:,27) = ( CONSTANTS(:,25).*ALGEBRAIC(:,26))./( 2.00000.*CONSTANTS(:,4).*CONSTANTS(:,24)); ALGEBRAIC(:,17) = 1000.00.*CONSTANTS(:,11).*(STATES(:,1) - CONSTANTS(:,12)); ALGEBRAIC(:,22) = 1000.00.*CONSTANTS(:,13).*power(STATES(:,2), 3.00000).*STATES(:,3).*(STATES(:,1) - CONSTANTS(:,14)); ALGEBRAIC(:,23) = 1000.00.*CONSTANTS(:,15).*power(STATES(:,4), 4.00000).*(STATES(:,1) - CONSTANTS(:,16)); ALGEBRAIC(:,24) = 1000.00.*CONSTANTS(:,17).*STATES(:,5).*(STATES(:,1) - CONSTANTS(:,16)); ALGEBRAIC(:,28) = 1.00000./(1.00000+exp(((STATES(:,1)+75.0000) - CONSTANTS(:,29))./5.50000)); ALGEBRAIC(:,29) = CONSTANTS(:,38)+1000.00./(exp(((STATES(:,1)+71.5500) - CONSTANTS(:,29))./14.2000)+exp( - ((STATES(:,1)+89.0000) - CONSTANTS(:,29))./11.6000)); ALGEBRAIC(:,30) = ALGEBRAIC(:,28)./ALGEBRAIC(:,29); ALGEBRAIC(:,31) = (1.00000 - ALGEBRAIC(:,28))./ALGEBRAIC(:,29); ALGEBRAIC(:,32) = CONSTANTS(:,31).*power(STATES(:,7)./CONSTANTS(:,37), CONSTANTS(:,34)); ALGEBRAIC(:,35) = CONSTANTS(:,32).*power(ALGEBRAIC(:,34)./CONSTANTS(:,36), CONSTANTS(:,35)); ALGEBRAIC(:,39) = ALGEBRAIC(:,36)+CONSTANTS(:,30)+ALGEBRAIC(:,37); ALGEBRAIC(:,40) = 1000.00.*CONSTANTS(:,27).*ALGEBRAIC(:,39).*(STATES(:,1) - CONSTANTS(:,26)); ALGEBRAIC(:,6) = VOI - CONSTANTS(:,10).*floor(VOI./CONSTANTS(:,10)); ALGEBRAIC(:,12) = piecewise({ALGEBRAIC(:,6)>=CONSTANTS(:,7)&ALGEBRAIC(:,6)<=CONSTANTS(:,8), CONSTANTS(:,9) }, 0.00000); end % Functions required for solving differential algebraic equation function [CONSTANTS, STATES, ALGEBRAIC] = rootfind_0(VOI, CONSTANTS_IN, STATES_IN, ALGEBRAIC_IN) ALGEBRAIC = ALGEBRAIC_IN; CONSTANTS = CONSTANTS_IN; STATES = STATES_IN; global initialGuess_0; if (length(initialGuess_0) ~= 2), initialGuess_0 = [0.1,0.1];, end options = optimset('Display', 'off', 'TolX', 1E-6); if length(VOI) == 1 residualfn = @(algebraicCandidate)residualSN_0(algebraicCandidate, ALGEBRAIC, VOI, CONSTANTS, STATES); soln = fsolve(residualfn, initialGuess_0, options); initialGuess_0 = soln; ALGEBRAIC(:,33) = soln(1); ALGEBRAIC(:,34) = soln(2); else SET_ALGEBRAIC(:,33) = logical(1); SET_ALGEBRAIC(:,34) = logical(1); for i=1:length(VOI) residualfn = @(algebraicCandidate)residualSN_0(algebraicCandidate, ALGEBRAIC(i,:), VOI(i), CONSTANTS, STATES(i,:)); soln = fsolve(residualfn, initialGuess_0, options); initialGuess_0 = soln; TEMP_ALGEBRAIC(:,33) = soln(1); TEMP_ALGEBRAIC(:,34) = soln(2); ALGEBRAIC(i,SET_ALGEBRAIC) = TEMP_ALGEBRAIC(SET_ALGEBRAIC); end end end function resid = residualSN_0(algebraicCandidate, ALGEBRAIC, VOI, CONSTANTS, STATES) ALGEBRAIC(:,33) = algebraicCandidate(1); ALGEBRAIC(:,34) = algebraicCandidate(2); resid(1) = ALGEBRAIC(:,33) - ( ALGEBRAIC(:,34).*CONSTANTS(:,31))./ALGEBRAIC(:,32); resid(2) = ALGEBRAIC(:,34) - (1.00000 - ALGEBRAIC(:,33)); end % Functions required for solving differential algebraic equation function [CONSTANTS, STATES, ALGEBRAIC] = rootfind_1(VOI, CONSTANTS_IN, STATES_IN, ALGEBRAIC_IN) ALGEBRAIC = ALGEBRAIC_IN; CONSTANTS = CONSTANTS_IN; STATES = STATES_IN; global initialGuess_1; if (length(initialGuess_1) ~= 3), initialGuess_1 = [0.1,0.1,0.1];, end options = optimset('Display', 'off', 'TolX', 1E-6); if length(VOI) == 1 residualfn = @(algebraicCandidate)residualSN_1(algebraicCandidate, ALGEBRAIC, VOI, CONSTANTS, STATES); soln = fsolve(residualfn, initialGuess_1, options); initialGuess_1 = soln; ALGEBRAIC(:,36) = soln(1); ALGEBRAIC(:,37) = soln(2); ALGEBRAIC(:,38) = soln(3); else SET_ALGEBRAIC(:,36) = logical(1); SET_ALGEBRAIC(:,37) = logical(1); SET_ALGEBRAIC(:,38) = logical(1); for i=1:length(VOI) residualfn = @(algebraicCandidate)residualSN_1(algebraicCandidate, ALGEBRAIC(i,:), VOI(i), CONSTANTS, STATES(i,:)); soln = fsolve(residualfn, initialGuess_1, options); initialGuess_1 = soln; TEMP_ALGEBRAIC(:,36) = soln(1); TEMP_ALGEBRAIC(:,37) = soln(2); TEMP_ALGEBRAIC(:,38) = soln(3); ALGEBRAIC(i,SET_ALGEBRAIC) = TEMP_ALGEBRAIC(SET_ALGEBRAIC); end end end function resid = residualSN_1(algebraicCandidate, ALGEBRAIC, VOI, CONSTANTS, STATES) ALGEBRAIC(:,36) = algebraicCandidate(1); ALGEBRAIC(:,37) = algebraicCandidate(2); ALGEBRAIC(:,38) = algebraicCandidate(3); resid(1) = ALGEBRAIC(:,38) - (ALGEBRAIC(:,31)./ALGEBRAIC(:,30)).*ALGEBRAIC(:,36); resid(2) = ALGEBRAIC(:,36) - (CONSTANTS(:,32)./ALGEBRAIC(:,35)).*ALGEBRAIC(:,37); resid(3) = ALGEBRAIC(:,37) - ((1.00000 - ALGEBRAIC(:,38)) - ALGEBRAIC(:,36)); end % Compute result of a piecewise function function x = piecewise(cases, default) set = [0]; for i = 1:2:length(cases) if (length(cases{i+1}) == 1) x(cases{i} & ~set,:) = cases{i+1}; else x(cases{i} & ~set,:) = cases{i+1}(cases{i} & ~set); end set = set | cases{i}; if(set), break, end end if (length(default) == 1) x(~set,:) = default; else x(~set,:) = default(~set); end end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end