H
Bradley
Nuss
11440975
cardiac myocyte
electrophysiology
cardiac
kcne2
hreg
cardiac myocytes
long-qt syndrome
long-QT syndrome
The University of Auckland, Bioengineering Institute
C2
closed state 2
38
33
89
Molecular Interactions Between Two Long-QT Syndrome Gene Products,
HERG and KCNE2, Rationalized by In Vitro and In Silico Analysis
Greenstein
L
Joseph
C3
closed state 3
cardiac myocytes
Mazhari et al's model of the molecular interactions between two long-QT
syndrome gene products, HERG and KCNE2.
inactivated state
I
c.lloyd@auckland.ac.nz
closed state 1
C1
open state
O
Winslow
L
Richard
Catherine
Lloyd
May
Mazhari
Reza
Lloyd
May
Catherine
keyword
This is the CellML description of Mazhari et al's model of the molecular interactions between two long-QT syndrome gene products, HERG and KCNE2.
This model can be run in PCEnv but it gives a flat output. I suspect it needs to be embedded within a whole cell model in order to give a reasonable output.
Eduardo
Marban
2007-06-05T09:44:00+12:00
The new version of this model has been re-coded to remove the reaction element and replace it with a simple MathML description of the model reaction kinetics. This is thought to be truer to the original publication, and information regarding the enzyme kinetics etc will later be added to the metadata through use of an ontology.
The model runs in the PCEnv simulator but gives a flat output.
The University of Auckland
The Bioengineering Institute
2003-05-23T00:00:00+00:00
2001-07-06 00:00
Circulation Research
Catherine Lloyd