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C C There are a total of 4 entries in the algebraic variable array. C There are a total of 5 entries in each of the rate and state variable arrays. C There are a total of 16 entries in the constant variable array. C C C VOI is time in component environment (second). C STATES(1) is P in component P (picomolar). C CONSTS(1) is k1 in component model_parameters (second_order_rate_constant). C CONSTS(2) is k1_ in component model_parameters (first_order_rate_constant). C CONSTS(3) is k2 in component model_parameters (second_order_rate_constant). C CONSTS(4) is k2_ in component model_parameters (first_order_rate_constant). C CONSTS(5) is kcl in component model_parameters (first_order_rate_constant). C ALGBRC(4) is D in component model_parameters (flux). C STATES(2) is Ca in component Ca (picomolar). C STATES(3) is Ci in component Ci (picomolar). C STATES(4) is Ra in component Ra (picomolar). C STATES(5) is Ri in component Ri (picomolar). C CONSTS(6) is k3 in component model_parameters (first_order_rate_constant). C CONSTS(7) is k3_ in component model_parameters (first_order_rate_constant). C CONSTS(8) is k4 in component model_parameters (first_order_rate_constant). C CONSTS(9) is k4_ in component model_parameters (first_order_rate_constant). C ALGBRC(2) is rho in component rho (dimensionless). C CONSTS(10) is De in component model_parameters (flux). C ALGBRC(3) is Dd in component model_parameters (flux). C CONSTS(11) is dmax in component model_parameters (flux). C CONSTS(12) is dmin in component model_parameters (flux). C CONSTS(13) is tau_on in component model_parameters (hour). C CONSTS(14) is tau_off in component model_parameters (hour). C CONSTS(16) is cycle_length in component model_parameters (hour). C CONSTS(15) is j in component model_parameters (dimensionless). C ALGBRC(1) is time_hour in component model_parameters (hour). C RATES(1) is d/dt P in component P (picomolar). C RATES(4) is d/dt Ra in component Ra (picomolar). C RATES(5) is d/dt Ri in component Ri (picomolar). C RATES(2) is d/dt Ca in component Ca (picomolar). C RATES(3) is d/dt Ci in component Ci (picomolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 3 CONSTS(1) = 1e-6 CONSTS(2) = 1e-3 CONSTS(3) = 1e-7 CONSTS(4) = 1e-3 CONSTS(5) = 5e-3 STATES(2) = 4e-4 STATES(3) = 0.05 STATES(4) = 16.9 STATES(5) = 1.7 CONSTS(6) = 1e-3 CONSTS(7) = 1e-4 CONSTS(8) = 2e-3 CONSTS(9) = 0.4 CONSTS(10) = 0 CONSTS(11) = 7.5 CONSTS(12) = 0 CONSTS(13) = 0.5 CONSTS(14) = 0.5 CONSTS(15) = 9 CONSTS(16) = CONSTS(13)+CONSTS(14) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(4) = ( CONSTS(2)*STATES(2)+ CONSTS(6)*STATES(5)) - ( CONSTS(1)*STATES(4)*STATES(1)+ CONSTS(7)*STATES(4)) RATES(5) = ( CONSTS(4)*STATES(3)+ CONSTS(7)*STATES(4)) - ( CONSTS(3)*STATES(5)*STATES(1)+ CONSTS(6)*STATES(5)) RATES(2) = ( CONSTS(1)*STATES(4)*STATES(1)+ CONSTS(8)*STATES(3)) - ( CONSTS(2)*STATES(2)+ CONSTS(9)*STATES(2)) RATES(3) = ( CONSTS(3)*STATES(5)*STATES(1)+ CONSTS(9)*STATES(2)) - ( CONSTS(4)*STATES(3)+ CONSTS(8)*STATES(3)) ALGBRC(1) = ( VOI*1.00000)/3600.00 ALGBRC(3) = TERNRY(ALGBRC(1)/CONSTS(16).GE.CONSTS(15), CONSTS(12), TERNRY(ALGBRC(1) - INT(ALGBRC(1)/CONSTS(16))*CONSTS(16).GE.0.00000.AND.ALGBRC(1) - INT(ALGBRC(1)/CONSTS(16))*CONSTS(16).LT.CONSTS(13), CONSTS(11), TERNRY(ALGBRC(1) - INT(ALGBRC(1)/CONSTS(16))*CONSTS(16).GE.CONSTS(13).AND.ALGBRC(1) - INT(ALGBRC(1)/CONSTS(16))*CONSTS(16).LT.CONSTS(16), CONSTS(12), 0.0/0.0) ALGBRC(4) = CONSTS(10)+ALGBRC(3) RATES(1) = ( CONSTS(2)*STATES(2)+ CONSTS(4)*STATES(3)+ALGBRC(4)) - ( CONSTS(1)*STATES(4)*STATES(1)+ CONSTS(3)*STATES(5)*STATES(1)+ CONSTS(5)*STATES(1)) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = ( VOI*1.00000)/3600.00 ALGBRC(3) = TERNRY(ALGBRC(1)/CONSTS(16).GE.CONSTS(15), CONSTS(12), TERNRY(ALGBRC(1) - INT(ALGBRC(1)/CONSTS(16))*CONSTS(16).GE.0.00000.AND.ALGBRC(1) - INT(ALGBRC(1)/CONSTS(16))*CONSTS(16).LT.CONSTS(13), CONSTS(11), TERNRY(ALGBRC(1) - INT(ALGBRC(1)/CONSTS(16))*CONSTS(16).GE.CONSTS(13).AND.ALGBRC(1) - INT(ALGBRC(1)/CONSTS(16))*CONSTS(16).LT.CONSTS(16), CONSTS(12), 0.0/0.0) ALGBRC(4) = CONSTS(10)+ALGBRC(3) ALGBRC(2) = (STATES(4)+STATES(2))/(STATES(4)+STATES(2)+STATES(5)+STATES(3)) RETURN END REAL FUNCTION TERNRY(TEST, VALA, VALB) LOGICAL TEST REAL VALA, VALB IF (TEST) THEN TERNRY = VALA ELSE TERNRY = VALB ENDIF RETURN END