/* There are a total of 5 entries in the algebraic variable array. There are a total of 1 entries in each of the rate and state variable arrays. There are a total of 28 entries in the constant variable array. */ /* * VOI is time in component environment (second). * CONSTANTS[0] is k_p1 in component SERCA (second_order_rate_constant). * CONSTANTS[1] is k_p2 in component SERCA (first_order_rate_constant). * CONSTANTS[2] is k_p3 in component SERCA (first_order_rate_constant). * CONSTANTS[3] is k_m1 in component SERCA (first_order_rate_constant). * CONSTANTS[4] is k_m2 in component SERCA (second_order_rate_constant). * CONSTANTS[5] is k_m3 in component SERCA (second_order_rate_constant). * CONSTANTS[18] is kdatp in component SERCA (millimolar). * CONSTANTS[6] is kdcai in component SERCA (millimolar). * CONSTANTS[7] is kdcasr in component SERCA (millimolar). * CONSTANTS[8] is kdh1 in component SERCA (millimolar). * CONSTANTS[9] is kdhi in component SERCA (millimolar_squared). * CONSTANTS[10] is kdhsr in component SERCA (millimolar_squared). * CONSTANTS[11] is kdh in component SERCA (millimolar). * CONSTANTS[12] is n in component SERCA (dimensionless). * CONSTANTS[13] is Ca_i in component SERCA (millimolar). * CONSTANTS[14] is Ca_sr in component SERCA (millimolar). * CONSTANTS[15] is H_i in component SERCA (millimolar). * STATES[0] is ATP in component SERCA (millimolar). * CONSTANTS[16] is ADP in component SERCA (millimolar). * CONSTANTS[17] is P_i in component SERCA (millimolar). * ALGEBRAIC[0] is T_ATP in component SERCA (dimensionless). * CONSTANTS[19] is T_Cai in component SERCA (dimensionless). * CONSTANTS[20] is T_Casr in component SERCA (dimensionless). * CONSTANTS[21] is T_H1 in component SERCA (dimensionless). * CONSTANTS[22] is T_Hi in component SERCA (dimensionless). * CONSTANTS[23] is T_Hsr in component SERCA (dimensionless). * CONSTANTS[24] is T_H in component SERCA (dimensionless). * ALGEBRAIC[1] is a_p1 in component SERCA (first_order_rate_constant). * CONSTANTS[25] is a_p2 in component SERCA (first_order_rate_constant). * CONSTANTS[26] is a_m1 in component SERCA (first_order_rate_constant). * ALGEBRAIC[2] is a_m2 in component SERCA (first_order_rate_constant). * ALGEBRAIC[3] is s2 in component SERCA (first_order_rate_constant). * ALGEBRAIC[4] is v_cycle in component SERCA (first_order_rate_constant). * RATES[0] is d/dt ATP in component SERCA (millimolar). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 25900; CONSTANTS[1] = 2540; CONSTANTS[2] = 20.5; CONSTANTS[3] = 2; CONSTANTS[4] = 67200; CONSTANTS[5] = 149; CONSTANTS[6] = 0.9; CONSTANTS[7] = 2.24; CONSTANTS[8] = 1.09e-5; CONSTANTS[9] = 3.54e-3; CONSTANTS[10] = 1.05e-8; CONSTANTS[11] = 7.24e-5; CONSTANTS[12] = 2; CONSTANTS[13] = 1e-3; CONSTANTS[14] = 1; CONSTANTS[15] = 1e-4; STATES[0] = 0.01; CONSTANTS[16] = 20e-3; CONSTANTS[17] = 1; CONSTANTS[18] = CONSTANTS[3]/CONSTANTS[0]; CONSTANTS[19] = CONSTANTS[13]/CONSTANTS[6]; CONSTANTS[27] = 0.100000; CONSTANTS[20] = CONSTANTS[14]/CONSTANTS[7]; CONSTANTS[21] = CONSTANTS[15]/CONSTANTS[8]; CONSTANTS[22] = pow(CONSTANTS[15], CONSTANTS[12])/CONSTANTS[9]; CONSTANTS[23] = pow(CONSTANTS[15], CONSTANTS[12])/CONSTANTS[10]; CONSTANTS[24] = CONSTANTS[15]/CONSTANTS[11]; CONSTANTS[25] = ( CONSTANTS[2]*CONSTANTS[23])/( CONSTANTS[23]*(1.00000+CONSTANTS[24])+ CONSTANTS[24]*(1.00000+pow(CONSTANTS[20], 2.00000))); CONSTANTS[26] = ( CONSTANTS[4]*CONSTANTS[16]*pow(CONSTANTS[20], 2.00000)*CONSTANTS[24])/( CONSTANTS[23]*(1.00000+CONSTANTS[24])+ CONSTANTS[24]*(1.00000+pow(CONSTANTS[20], 2.00000))); } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { RATES[0] = CONSTANTS[27]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = STATES[0]/CONSTANTS[18]; ALGEBRAIC[1] = ( CONSTANTS[1]*ALGEBRAIC[0]*pow(CONSTANTS[19], 2.00000))/( ALGEBRAIC[0]*pow(CONSTANTS[19], 2.00000)+ CONSTANTS[22]*(1.00000+ ALGEBRAIC[0]*(1.00000+CONSTANTS[21]+pow(CONSTANTS[19], 2.00000)))); ALGEBRAIC[2] = ( CONSTANTS[5]*CONSTANTS[17]*CONSTANTS[22])/( ALGEBRAIC[0]*pow(CONSTANTS[19], 2.00000)+ CONSTANTS[22]*(1.00000+ ALGEBRAIC[0]*(1.00000+CONSTANTS[21]+pow(CONSTANTS[19], 2.00000)))); ALGEBRAIC[3] = ALGEBRAIC[1]+CONSTANTS[25]+CONSTANTS[26]+ALGEBRAIC[2]; ALGEBRAIC[4] = ( ALGEBRAIC[1]*CONSTANTS[25] - CONSTANTS[26]*ALGEBRAIC[2])/ALGEBRAIC[3]; }