C C There are a total of 6 entries in the algebraic variable array. C There are a total of 4 entries in each of the rate and state variable arrays. C There are a total of 22 entries in the constant variable array. C C C VOI is time in component environment (minute). C STATES(1) is m in component m (micromolar). C CONSTS(1) is kM_plus in component m (fourth_order_rate_constant). C CONSTS(2) is kM_minus in component m (first_order_rate_constant). C CONSTS(3) is CaMtotal in component m (micromolar). C STATES(2) is x in component x (micromolar). C ALGBRC(1) is dmdt in component m (flux). C STATES(3) is z in component z (micromolar). C CONSTS(4) is kN_plus in component z (second_order_rate_constant). C CONSTS(5) is kN_minus in component z (first_order_rate_constant). C CONSTS(6) is CaNtotal in component z (micromolar). C ALGBRC(2) is dzdt in component z (flux). C STATES(4) is h in component h (dimensionless). C CONSTS(7) is d in component h (first_order_rate_constant). C CONSTS(8) is f in component h (first_order_rate_constant). C ALGBRC(4) is phi in component phi (dimensionless). C CONSTS(9) is lamda in component model_parameters (dimensionless). C CONSTS(22) is L0 in component model_parameters (dimensionless). C ALGBRC(3) is y in component model_parameters (dimensionless). C CONSTS(10) is N in component model_parameters (dimensionless). C ALGBRC(5) is psi in component psi (dimensionless). C CONSTS(11) is Vx in component x (flux). C CONSTS(12) is Kx in component x (micromolar). C CONSTS(13) is V1 in component x (flux). C CONSTS(14) is K1 in component x (micromolar). C CONSTS(15) is V2 in component x (flux). C CONSTS(16) is K2 in component x (micromolar). C CONSTS(17) is V3 in component x (flux). C CONSTS(18) is K3 in component x (micromolar). C CONSTS(19) is kc in component x (dimensionless). C CONSTS(20) is alpha in component x (first_order_rate_constant). C CONSTS(21) is Caex in component x (micromolar). C ALGBRC(6) is dxdt in component x (flux). C RATES(1) is d/dt m in component m (micromolar). C RATES(3) is d/dt z in component z (micromolar). C RATES(4) is d/dt h in component h (dimensionless). C RATES(2) is d/dt x in component x (micromolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 0.0 CONSTS(1) = 500.0 CONSTS(2) = 100.0 CONSTS(3) = 25.0 STATES(2) = 0.0 STATES(3) = 1.0E-8 CONSTS(4) = 5.0 CONSTS(5) = 5.0 CONSTS(6) = 25.0 STATES(4) = 0.0 CONSTS(7) = 0.4 CONSTS(8) = 0.1 CONSTS(9) = 5.0 CONSTS(10) = 13.0 CONSTS(11) = 1000.0 CONSTS(12) = 500.0 CONSTS(13) = 30000.0 CONSTS(14) = 4.3 CONSTS(15) = 100.0 CONSTS(16) = 0.1 CONSTS(17) = 10000.0 CONSTS(18) = 100.0 CONSTS(19) = 10.0 CONSTS(20) = 0.006 CONSTS(21) = 1.0 CONSTS(22) = 10.0000 ** - (CONSTS(10)/2.00000) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(1) = CONSTS(1)*(CONSTS(3) - STATES(1))*STATES(2) ** 3.00000 - CONSTS(2)*STATES(1) RATES(3) = CONSTS(4)*(CONSTS(6) - STATES(3))*STATES(1) - CONSTS(5)*STATES(3) ALGBRC(3) = 1.00000/STATES(3) ALGBRC(4) = 1.00000/(1.00000+( CONSTS(22)*( CONSTS(9)*ALGBRC(3) ** CONSTS(10)+1.00000 - 1.00000))/( ( CONSTS(9)*ALGBRC(3) - 1.00000)*((ALGBRC(3) - 1.00000)/(ALGBRC(3) ** CONSTS(10)+1.00000 - 1.00000)))) RATES(4) = CONSTS(7)*ALGBRC(4)*(1.00000/STATES(3))*(1.00000 - STATES(4)) - CONSTS(8)*(1.00000 - ALGBRC(4)*(1.00000/STATES(3)))*STATES(4) ALGBRC(5) = (1.00000+CONSTS(22))/((ALGBRC(3) ** CONSTS(10)+1.00000 - 1.00000)/(ALGBRC(3) - 1.00000)+ CONSTS(22)*(( CONSTS(9)*ALGBRC(3) ** CONSTS(10)+1.00000 - 1.00000)/( CONSTS(9)*ALGBRC(3) - 1.00000))) RATES(2) = ( CONSTS(11)*CONSTS(21))/(CONSTS(12)+CONSTS(21)) - ( STATES(4)*ALGBRC(5)*(1.00000/STATES(3))*(( CONSTS(13)*STATES(2))/(CONSTS(14)+STATES(2)))+ STATES(4)*ALGBRC(5)*(1.00000/STATES(3))*(( CONSTS(15)*STATES(2))/(CONSTS(16)+STATES(2)))+ (1.00000/(1.00000+ CONSTS(19)*STATES(3)))*(( CONSTS(17)*STATES(2))/(CONSTS(18)+STATES(2)))+ CONSTS(20)*STATES(2)) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(3) = 1.00000/STATES(3) ALGBRC(4) = 1.00000/(1.00000+( CONSTS(22)*( CONSTS(9)*ALGBRC(3) ** CONSTS(10)+1.00000 - 1.00000))/( ( CONSTS(9)*ALGBRC(3) - 1.00000)*((ALGBRC(3) - 1.00000)/(ALGBRC(3) ** CONSTS(10)+1.00000 - 1.00000)))) ALGBRC(5) = (1.00000+CONSTS(22))/((ALGBRC(3) ** CONSTS(10)+1.00000 - 1.00000)/(ALGBRC(3) - 1.00000)+ CONSTS(22)*(( CONSTS(9)*ALGBRC(3) ** CONSTS(10)+1.00000 - 1.00000)/( CONSTS(9)*ALGBRC(3) - 1.00000))) ALGBRC(1) = CONSTS(1)*(CONSTS(3) - STATES(1))*STATES(2) ** 3.00000 - CONSTS(2)*STATES(1) ALGBRC(2) = CONSTS(4)*(CONSTS(6) - STATES(3))*STATES(1) - CONSTS(5)*STATES(3) ALGBRC(6) = ( CONSTS(11)*CONSTS(21))/(CONSTS(12)+CONSTS(21)) - ( STATES(4)*ALGBRC(5)*(1.00000/STATES(3))*(( CONSTS(13)*STATES(2))/(CONSTS(14)+STATES(2)))+ STATES(4)*ALGBRC(5)*(1.00000/STATES(3))*(( CONSTS(15)*STATES(2))/(CONSTS(16)+STATES(2)))+ (1.00000/(1.00000+ CONSTS(19)*STATES(3)))*(( CONSTS(17)*STATES(2))/(CONSTS(18)+STATES(2)))+ CONSTS(20)*STATES(2)) RETURN END