This model has been curated by Penny Noble
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134
Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes
14(1)
Richard
Lawson
James
Department of Physiology, Anatomy & Genetics, University of Oxford
Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes (Stretch Model)
Lawson
James
Richard
P
Kohl
keyword
P
Noble
excitation-contraction coupling
guinea-pig
diadic space
calcium dynamics
Penny
J
Noble
2007-12-04T15:11:55+13:00
James Lawson
J
Penny
Noble
cardiac
ventricular myocyte
electrophysiology
Penny Noble was informed by a community member that INaCads was not included in the dCads/dt ODE and hence the system was out of balance. This has been fixed in version 07. An alteration was also made to the model to remove two differential expressions in the intracellular_calcium concentration component to allow PCEnv 0.2 to run the model.
D
Noble
Note that the missing i_NCX_ds component was added to the dCai/dt rather than the dCads/dt equation in order to achieve balance in the model.
This version was created by Penny Noble and is known to read into COR. James Lawson fixed an error (19/04/07) that prevented it reading in PCEnv (unsupported predefined operator diff in component intracellular_calcium_concentration. This variant of version 06 is the STRETCH model, which includes acetylcholine dependent modulation and the electromechanical processes simulated by Variant 02, and also includes simulation of stretch and fibroblasts. This model is parameterised the same as the BASIC model, with all additional variables set to zero.
To simulate multiple action potentials with this model the following integrator parameters must be used: max step size must be 0.001 or less, max point density must be 10,000 or more.
Several variables have been given cmeta:id's to allow creation of a PCEnv session file.
This file is a CellML description of Noble, Carghese, Kohl and Noble's 1998 extension of their 1991 guinea pig ventricular cell model. This model incorporates a diadic space, IKr and IKs currents, and length and tension dependent processes. Variant 3 is parameterised for the 'stretch' model.
Penny
Noble
Department of Physiology, Anatomy & Genetics
Oxford University
9487284
Richard
Lawson
James
Penny
J
Noble
2008-05-14T03:16:52+12:00
A
Varghese
Canadian Journal of Cardiology
penny.noble@dpag.ox.ac.uk
2007-06-22T13:59:26+12:00
Changed stim_end in stimulus protocol from 10.1 to 1,000,000 seconds
100000
0.001
bdf15
Units checked, curated.
0.001
50000
James Lawson
2007-09-06T13:01:21+12:00
1998-01-00 00:00
2007-02-06T13:00:00+13:00
2006-05-03T00:00:00+00:00
2007-07-18T12:59:52+12:00