/* There are a total of 33 entries in the algebraic variable array. There are a total of 7 entries in each of the rate and state variable arrays. There are a total of 47 entries in the constant variable array. */ /* * VOI is time in component Environment (ms). * STATES[0] is NADHm in component Mitochondrial_variables (mM). * ALGEBRAIC[15] is Jpdh in component J_variables (uM_per_ms). * ALGEBRAIC[8] is Jo in component J_variables (uM_per_ms). * CONSTANTS[0] is gamma in component Mitochondrial_variables (dimensionless). * ALGEBRAIC[0] is NADm in component Mitochondrial_variables (mM). * STATES[1] is ADPm in component Mitochondrial_variables (mM). * STATES[2] is PSIm in component Mitochondrial_variables (mV). * STATES[3] is Cam in component Mitochondrial_variables (uM). * CONSTANTS[1] is NADtot in component Mitochondrial_variables (mM). * CONSTANTS[2] is fm in component Mitochondrial_variables (dimensionless). * CONSTANTS[3] is Cmito in component Mitochondrial_variables (uM_per_mV). * CONSTANTS[4] is Amtot in component Mitochondrial_variables (mM). * ALGEBRAIC[1] is ATPm in component Mitochondrial_variables (mM). * ALGEBRAIC[5] is RATm in component Mitochondrial_variables (dimensionless). * ALGEBRAIC[32] is Jant in component J_variables (uM_per_ms). * ALGEBRAIC[31] is Jf1f0 in component J_variables (uM_per_ms). * ALGEBRAIC[25] is Jh_res in component J_variables (uM_per_ms). * ALGEBRAIC[29] is Jh_atp in component J_variables (uM_per_ms). * ALGEBRAIC[20] is Jh_leak in component J_variables (uM_per_ms). * ALGEBRAIC[18] is Jnaca in component J_variables (uM_per_ms). * ALGEBRAIC[16] is Juni in component J_variables (uM_per_ms). * ALGEBRAIC[21] is Jmito in component J_variables (uM_per_ms). * STATES[4] is c in component Clamp_protocol (uM). * ALGEBRAIC[9] is ATPc in component Cytosol (mM). * STATES[5] is ADPc in component Cytosol (uM). * CONSTANTS[5] is Ac_tot in component Cytosol (uM). * CONSTANTS[6] is khyd in component Cytosol (dimensionless). * CONSTANTS[7] is Jhydbas in component Cytosol (mM). * ALGEBRAIC[13] is Jh_yd in component Cytosol (mM). * CONSTANTS[46] is delta in component Cytosol (dimensionless). * ALGEBRAIC[10] is Fproto in component Clamp_parameters (uM). * ALGEBRAIC[28] is Cproto in component Clamp_parameters (uM). * STATES[6] is FBP in component Clamp_protocol (uM). * CONSTANTS[8] is Fhold in component Clamp_parameters (uM). * CONSTANTS[9] is Ftest in component Clamp_parameters (uM). * CONSTANTS[10] is Fton in component Clamp_parameters (ms). * CONSTANTS[11] is Ftoff in component Clamp_parameters (ms). * CONSTANTS[12] is Chold in component Clamp_parameters (uM). * CONSTANTS[13] is Ctest in component Clamp_parameters (uM). * CONSTANTS[14] is Cton1 in component Clamp_parameters (ms). * CONSTANTS[15] is Cton2 in component Clamp_parameters (ms). * CONSTANTS[16] is Cton3 in component Clamp_parameters (ms). * CONSTANTS[17] is Ctoff1 in component Clamp_parameters (ms). * CONSTANTS[18] is Ctoff2 in component Clamp_parameters (ms). * CONSTANTS[19] is Ctoff3 in component Clamp_parameters (ms). * ALGEBRAIC[17] is pulse1 in component Clamp_parameters (uM). * ALGEBRAIC[22] is pulse2 in component Clamp_parameters (uM). * ALGEBRAIC[26] is pulse3 in component Clamp_parameters (uM). * ALGEBRAIC[2] is heav_on in component Clamp_parameters (dimensionless). * ALGEBRAIC[6] is heav_off in component Clamp_parameters (dimensionless). * ALGEBRAIC[3] is heav_Cton1 in component Clamp_parameters (dimensionless). * ALGEBRAIC[7] is heav_Cton2 in component Clamp_parameters (dimensionless). * ALGEBRAIC[11] is heav_Cton3 in component Clamp_parameters (dimensionless). * ALGEBRAIC[14] is heav_Ctoff1 in component Clamp_parameters (dimensionless). * ALGEBRAIC[19] is heav_Ctoff2 in component Clamp_parameters (dimensionless). * ALGEBRAIC[24] is heav_Ctoff3 in component Clamp_parameters (dimensionless). * ALGEBRAIC[12] is Jgpdh in component J_variables (uM_per_ms). * CONSTANTS[20] is p1 in component Parameters (dimensionless). * CONSTANTS[21] is p2 in component Parameters (dimensionless). * CONSTANTS[22] is p3 in component Parameters (uM). * CONSTANTS[23] is p21 in component Parameters (per_uM_per_ms_per_mV). * CONSTANTS[24] is p22 in component Parameters (per_uM_per_ms). * CONSTANTS[25] is p23 in component Parameters (uM_per_ms). * CONSTANTS[26] is p24 in component Parameters (per_mV). * CONSTANTS[27] is p4 in component Parameters (uM_per_ms). * CONSTANTS[28] is p5 in component Parameters (mM). * CONSTANTS[29] is p6 in component Parameters (mV). * CONSTANTS[30] is p7 in component Parameters (mV). * CONSTANTS[31] is p8 in component Parameters (uM_per_ms). * CONSTANTS[32] is p9 in component Parameters (mM). * CONSTANTS[33] is p10 in component Parameters (mV). * CONSTANTS[34] is p11 in component Parameters (mV). * CONSTANTS[35] is p12 in component Parameters (uM_per_ms). * CONSTANTS[36] is p13 in component Parameters (mM). * CONSTANTS[37] is p14 in component Parameters (mV). * CONSTANTS[38] is p15 in component Parameters (mV). * CONSTANTS[39] is p16 in component Parameters (uM_per_ms). * CONSTANTS[40] is p17 in component Parameters (uM_per_ms_per_mV). * CONSTANTS[41] is p18 in component Parameters (uM_per_ms). * CONSTANTS[42] is p19 in component Parameters (uM_per_ms). * CONSTANTS[43] is p20 in component Parameters (dimensionless). * ALGEBRAIC[4] is MM1 in component J_variables (uM_per_ms). * ALGEBRAIC[23] is MM2 in component J_variables (uM_per_ms). * ALGEBRAIC[27] is b13 in component J_variables (uM_per_ms). * ALGEBRAIC[30] is b2 in component J_variables (uM_per_ms). * CONSTANTS[44] is FRT in component J_variables (per_mV). * CONSTANTS[45] is kgpdh in component J_variables (uM_per_ms). * RATES[0] is d/dt NADHm in component Mitochondrial_variables (mM). * RATES[1] is d/dt ADPm in component Mitochondrial_variables (mM). * RATES[2] is d/dt PSIm in component Mitochondrial_variables (mV). * RATES[3] is d/dt Cam in component Mitochondrial_variables (uM). * RATES[5] is d/dt ADPc in component Cytosol (uM). * RATES[6] is d/dt FBP in component Clamp_protocol (uM). * RATES[4] is d/dt c in component Clamp_protocol (uM). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 0.6; CONSTANTS[0] = 0.001; STATES[1] = 7.4; STATES[2] = 93; STATES[3] = 0.1; CONSTANTS[1] = 10; CONSTANTS[2] = 0.01; CONSTANTS[3] = 1.8; CONSTANTS[4] = 15; STATES[4] = 0.1; STATES[5] = 1850; CONSTANTS[5] = 2500; CONSTANTS[6] = 0.00005; CONSTANTS[7] = 0.00005; STATES[6] = 0.5; CONSTANTS[8] = 1; CONSTANTS[9] = 5; CONSTANTS[10] = 90000; CONSTANTS[11] = 330000; CONSTANTS[12] = 0.1; CONSTANTS[13] = 0.1; CONSTANTS[14] = 120000; CONSTANTS[15] = 180000; CONSTANTS[16] = 240000; CONSTANTS[17] = 150000; CONSTANTS[18] = 210000; CONSTANTS[19] = 270000; CONSTANTS[20] = 400; CONSTANTS[21] = 1; CONSTANTS[22] = 0.01; CONSTANTS[23] = 0.01; CONSTANTS[24] = 1.1; CONSTANTS[25] = 0.001; CONSTANTS[26] = 0.016; CONSTANTS[27] = 0.6; CONSTANTS[28] = 0.1; CONSTANTS[29] = 177; CONSTANTS[30] = 5; CONSTANTS[31] = 7; CONSTANTS[32] = 0.1; CONSTANTS[33] = 177; CONSTANTS[34] = 5; CONSTANTS[35] = 120; CONSTANTS[36] = 10; CONSTANTS[37] = 190; CONSTANTS[38] = 8.5; CONSTANTS[39] = 35; CONSTANTS[40] = 0.002; CONSTANTS[41] = -0.03; CONSTANTS[42] = 0.35; CONSTANTS[43] = 2; CONSTANTS[44] = 0.037; CONSTANTS[45] = 0.0005; CONSTANTS[46] = 3.90000/53.2000; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[2] = (VOI - CONSTANTS[10]>=0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[6] = (VOI - CONSTANTS[11]>=0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[10] = CONSTANTS[8]+ (CONSTANTS[9] - CONSTANTS[8])*(ALGEBRAIC[2] - ALGEBRAIC[6]); RATES[6] = (ALGEBRAIC[10] - STATES[6])/0.100000; ALGEBRAIC[0] = CONSTANTS[1] - STATES[0]; ALGEBRAIC[12] = CONSTANTS[45]* pow((STATES[6]/1.00000), 1.0 / 2); ALGEBRAIC[15] = (CONSTANTS[20]/(CONSTANTS[21]+STATES[0]/ALGEBRAIC[0]))*(STATES[3]/(CONSTANTS[22]+STATES[3]))*ALGEBRAIC[12]; ALGEBRAIC[4] = ( CONSTANTS[27]*STATES[0])/(CONSTANTS[28]+STATES[0]); ALGEBRAIC[8] = ALGEBRAIC[4]/(1.00000+exp((STATES[2] - CONSTANTS[29])/CONSTANTS[30])); RATES[0] = CONSTANTS[0]*(ALGEBRAIC[15] - ALGEBRAIC[8]); ALGEBRAIC[18] = (( CONSTANTS[25]*STATES[3])/STATES[4])*exp( CONSTANTS[26]*STATES[2]); ALGEBRAIC[16] = ( CONSTANTS[23]*STATES[2] - CONSTANTS[24])*pow(STATES[4], 2.00000); ALGEBRAIC[21] = ALGEBRAIC[18] - ALGEBRAIC[16]; RATES[3] = - CONSTANTS[2]*ALGEBRAIC[21]; ALGEBRAIC[3] = (VOI - CONSTANTS[14]>=0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[14] = (VOI - CONSTANTS[17]>=0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[17] = (CONSTANTS[13] - CONSTANTS[12])*(ALGEBRAIC[3] - ALGEBRAIC[14]); ALGEBRAIC[7] = (VOI - CONSTANTS[15]>=0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[19] = (VOI - CONSTANTS[18]>=0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[22] = (CONSTANTS[13] - CONSTANTS[12])*(ALGEBRAIC[7] - ALGEBRAIC[19]); ALGEBRAIC[11] = (VOI - CONSTANTS[16]>=0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[24] = (VOI - CONSTANTS[19]>=0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[26] = (CONSTANTS[13] - CONSTANTS[12])*(ALGEBRAIC[11] - ALGEBRAIC[24]); ALGEBRAIC[28] = CONSTANTS[12]+ALGEBRAIC[17]+ALGEBRAIC[22]+ALGEBRAIC[26]; RATES[4] = (ALGEBRAIC[28] - STATES[4])/0.100000; ALGEBRAIC[1] = CONSTANTS[4] - STATES[1]; ALGEBRAIC[5] = ALGEBRAIC[1]/STATES[1]; ALGEBRAIC[32] = (( CONSTANTS[42]*ALGEBRAIC[5])/(ALGEBRAIC[5]+CONSTANTS[43]))/exp( - 0.500000*CONSTANTS[44]*STATES[2]); ALGEBRAIC[30] = ( CONSTANTS[39]*CONSTANTS[36])/(CONSTANTS[36]+ALGEBRAIC[1]); ALGEBRAIC[31] = ALGEBRAIC[30]/(1.00000+exp((CONSTANTS[37] - STATES[2])/CONSTANTS[38])); RATES[1] = CONSTANTS[0]*(ALGEBRAIC[32] - ALGEBRAIC[31]); ALGEBRAIC[23] = ( CONSTANTS[31]*STATES[0])/(CONSTANTS[32]+STATES[0]); ALGEBRAIC[25] = ALGEBRAIC[23]/(1.00000+exp((STATES[2] - CONSTANTS[33])/CONSTANTS[34])); ALGEBRAIC[27] = ( CONSTANTS[35]*CONSTANTS[36])/(CONSTANTS[36]+ALGEBRAIC[1]); ALGEBRAIC[29] = ALGEBRAIC[27]/(1.00000+exp((CONSTANTS[37] - STATES[2])/CONSTANTS[38])); ALGEBRAIC[20] = CONSTANTS[40]*STATES[2]+CONSTANTS[41]; RATES[2] = (((((ALGEBRAIC[25] - ALGEBRAIC[29]) - ALGEBRAIC[32]) - ALGEBRAIC[20]) - ALGEBRAIC[18]) - ALGEBRAIC[16]*2.00000)/CONSTANTS[3]; ALGEBRAIC[9] = CONSTANTS[5] - STATES[5]; ALGEBRAIC[13] = ( ( CONSTANTS[6]*STATES[4]+CONSTANTS[7])*ALGEBRAIC[9])/1.00000; RATES[5] = - CONSTANTS[46]*ALGEBRAIC[32]+ ALGEBRAIC[13]*1.00000; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[2] = (VOI - CONSTANTS[10]>=0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[6] = (VOI - CONSTANTS[11]>=0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[10] = CONSTANTS[8]+ (CONSTANTS[9] - CONSTANTS[8])*(ALGEBRAIC[2] - ALGEBRAIC[6]); ALGEBRAIC[0] = CONSTANTS[1] - STATES[0]; ALGEBRAIC[12] = CONSTANTS[45]* pow((STATES[6]/1.00000), 1.0 / 2); ALGEBRAIC[15] = (CONSTANTS[20]/(CONSTANTS[21]+STATES[0]/ALGEBRAIC[0]))*(STATES[3]/(CONSTANTS[22]+STATES[3]))*ALGEBRAIC[12]; ALGEBRAIC[4] = ( CONSTANTS[27]*STATES[0])/(CONSTANTS[28]+STATES[0]); ALGEBRAIC[8] = ALGEBRAIC[4]/(1.00000+exp((STATES[2] - CONSTANTS[29])/CONSTANTS[30])); ALGEBRAIC[18] = (( CONSTANTS[25]*STATES[3])/STATES[4])*exp( CONSTANTS[26]*STATES[2]); ALGEBRAIC[16] = ( CONSTANTS[23]*STATES[2] - CONSTANTS[24])*pow(STATES[4], 2.00000); ALGEBRAIC[21] = ALGEBRAIC[18] - ALGEBRAIC[16]; ALGEBRAIC[3] = (VOI - CONSTANTS[14]>=0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[14] = (VOI - CONSTANTS[17]>=0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[17] = (CONSTANTS[13] - CONSTANTS[12])*(ALGEBRAIC[3] - ALGEBRAIC[14]); ALGEBRAIC[7] = (VOI - CONSTANTS[15]>=0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[19] = (VOI - CONSTANTS[18]>=0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[22] = (CONSTANTS[13] - CONSTANTS[12])*(ALGEBRAIC[7] - ALGEBRAIC[19]); ALGEBRAIC[11] = (VOI - CONSTANTS[16]>=0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[24] = (VOI - CONSTANTS[19]>=0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[26] = (CONSTANTS[13] - CONSTANTS[12])*(ALGEBRAIC[11] - ALGEBRAIC[24]); ALGEBRAIC[28] = CONSTANTS[12]+ALGEBRAIC[17]+ALGEBRAIC[22]+ALGEBRAIC[26]; ALGEBRAIC[1] = CONSTANTS[4] - STATES[1]; ALGEBRAIC[5] = ALGEBRAIC[1]/STATES[1]; ALGEBRAIC[32] = (( CONSTANTS[42]*ALGEBRAIC[5])/(ALGEBRAIC[5]+CONSTANTS[43]))/exp( - 0.500000*CONSTANTS[44]*STATES[2]); ALGEBRAIC[30] = ( CONSTANTS[39]*CONSTANTS[36])/(CONSTANTS[36]+ALGEBRAIC[1]); ALGEBRAIC[31] = ALGEBRAIC[30]/(1.00000+exp((CONSTANTS[37] - STATES[2])/CONSTANTS[38])); ALGEBRAIC[23] = ( CONSTANTS[31]*STATES[0])/(CONSTANTS[32]+STATES[0]); ALGEBRAIC[25] = ALGEBRAIC[23]/(1.00000+exp((STATES[2] - CONSTANTS[33])/CONSTANTS[34])); ALGEBRAIC[27] = ( CONSTANTS[35]*CONSTANTS[36])/(CONSTANTS[36]+ALGEBRAIC[1]); ALGEBRAIC[29] = ALGEBRAIC[27]/(1.00000+exp((CONSTANTS[37] - STATES[2])/CONSTANTS[38])); ALGEBRAIC[20] = CONSTANTS[40]*STATES[2]+CONSTANTS[41]; ALGEBRAIC[9] = CONSTANTS[5] - STATES[5]; ALGEBRAIC[13] = ( ( CONSTANTS[6]*STATES[4]+CONSTANTS[7])*ALGEBRAIC[9])/1.00000; }