/* There are a total of 10 entries in the algebraic variable array. There are a total of 5 entries in each of the rate and state variable arrays. There are a total of 27 entries in the constant variable array. */ /* * VOI is time in component environment (second). * CONSTANTS[0] is k_0 in component Constants (flux). * CONSTANTS[1] is k_1 in component Constants (per_second). * CONSTANTS[2] is k_2 in component Constants (per_second). * CONSTANTS[3] is k_3 in component Constants (per_second). * CONSTANTS[4] is k_4 in component Constants (per_second). * CONSTANTS[5] is k_5 in component Constants (per_second). * CONSTANTS[6] is k_6 in component Constants (per_second). * CONSTANTS[7] is k_7 in component Constants (per_second). * CONSTANTS[8] is k_8 in component Constants (flux). * CONSTANTS[9] is k_9 in component Constants (flux). * CONSTANTS[10] is k_10 in component Constants (flux). * CONSTANTS[11] is k_11 in component Constants (flux). * CONSTANTS[12] is C_PLC_T in component Constants (micromolar). * CONSTANTS[13] is K_D in component Constants (micromolar). * CONSTANTS[14] is K_P in component Constants (micromolar). * CONSTANTS[15] is K_R in component Constants (micromolar). * CONSTANTS[16] is K_G in component Constants (micromolar). * CONSTANTS[17] is K_S in component Constants (micromolar). * CONSTANTS[18] is K_ER in component Constants (micromolar). * CONSTANTS[19] is K_C1 in component Constants (micromolar). * CONSTANTS[20] is K_C2 in component Constants (micromolar). * CONSTANTS[21] is beta in component Constants (dimensionless). * CONSTANTS[22] is lambda in component Constants (dimensionless). * CONSTANTS[23] is rho in component Constants (dimensionless). * CONSTANTS[24] is n in component Constants (dimensionless). * CONSTANTS[25] is m in component Constants (dimensionless). * CONSTANTS[26] is w in component Constants (dimensionless). * ALGEBRAIC[0] is R_APLC in component R_values (dimensionless). * ALGEBRAIC[8] is R_PKC in component R_values (dimensionless). * ALGEBRAIC[1] is R_G in component R_values (dimensionless). * ALGEBRAIC[9] is R_DG in component R_values (dimensionless). * ALGEBRAIC[2] is R_IP_3 in component R_values (dimensionless). * ALGEBRAIC[3] is R_Cyt1 in component R_values (dimensionless). * ALGEBRAIC[4] is R_Cyt2 in component R_values (dimensionless). * ALGEBRAIC[5] is R_ER in component R_values (dimensionless). * STATES[0] is APLC in component APLC (micromolar). * ALGEBRAIC[7] is DG in component DG (micromolar). * STATES[1] is C_cyt in component C_cyt (micromolar). * STATES[2] is G in component G_GTP (micromolar). * STATES[3] is IP_3 in component IP_3 (micromolar). * STATES[4] is C_ER in component C_ER (micromolar). * ALGEBRAIC[6] is PLC in component APLC (micromolar). * RATES[2] is d/dt G in component G_GTP (micromolar). * RATES[0] is d/dt APLC in component APLC (micromolar). * RATES[3] is d/dt IP_3 in component IP_3 (micromolar). * RATES[1] is d/dt C_cyt in component C_cyt (micromolar). * RATES[4] is d/dt C_ER in component C_ER (micromolar). * There are a total of 0 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 1e-4; CONSTANTS[1] = 3.4; CONSTANTS[2] = 4; CONSTANTS[3] = 4.5; CONSTANTS[4] = 1.2; CONSTANTS[5] = 0.12; CONSTANTS[6] = 14; CONSTANTS[7] = 2; CONSTANTS[8] = 10.5; CONSTANTS[9] = 0.6; CONSTANTS[10] = 3; CONSTANTS[11] = 0.26; CONSTANTS[12] = 0.01; CONSTANTS[13] = 0.01; CONSTANTS[14] = 0.004; CONSTANTS[15] = 0.2; CONSTANTS[16] = 0.025; CONSTANTS[17] = 0.025; CONSTANTS[18] = 0.075; CONSTANTS[19] = 1; CONSTANTS[20] = 2; CONSTANTS[21] = 0.05; CONSTANTS[22] = 0.001; CONSTANTS[23] = 0.2; CONSTANTS[24] = 4; CONSTANTS[25] = 2; CONSTANTS[26] = 3; STATES[0] = 0.001; STATES[1] = 0.2; STATES[2] = 0.001; STATES[3] = 0.001; STATES[4] = 1; RATES[2] = 0.1001; RATES[0] = 0.1001; RATES[3] = 0.1001; RATES[1] = 0.1001; RATES[4] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[2] - ((CONSTANTS[0]+ CONSTANTS[1]*STATES[2]) - CONSTANTS[2]*ALGEBRAIC[0]*STATES[2]) - CONSTANTS[3]*ALGEBRAIC[8]*STATES[2]; resid[1] = RATES[0] - CONSTANTS[4]*ALGEBRAIC[1]*ALGEBRAIC[9]*ALGEBRAIC[6] - CONSTANTS[5]*STATES[0]; resid[2] = RATES[3] - CONSTANTS[6]*STATES[0] - CONSTANTS[7]*STATES[3]; resid[3] = RATES[1] - CONSTANTS[21]*(( CONSTANTS[23]*( CONSTANTS[8]*ALGEBRAIC[2]*ALGEBRAIC[5] - CONSTANTS[9]*ALGEBRAIC[3]) - CONSTANTS[10]*ALGEBRAIC[4])+CONSTANTS[11]); resid[4] = RATES[4] - CONSTANTS[22]*( - CONSTANTS[8]*ALGEBRAIC[2]*ALGEBRAIC[5]+ CONSTANTS[9]*ALGEBRAIC[3]); } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = STATES[0]/(CONSTANTS[14]+STATES[0]); ALGEBRAIC[1] = pow(STATES[2], CONSTANTS[24])/(pow(CONSTANTS[16], CONSTANTS[24])+pow(STATES[2], CONSTANTS[24])); ALGEBRAIC[2] = pow(STATES[3], 3.00000)/(pow(CONSTANTS[17], 3.00000)+pow(STATES[3], 3.00000)); ALGEBRAIC[3] = STATES[1]/(CONSTANTS[19]+STATES[1]); ALGEBRAIC[4] = STATES[1]/(CONSTANTS[20]+STATES[1]); ALGEBRAIC[5] = pow(STATES[4], CONSTANTS[26])/(pow(CONSTANTS[18], CONSTANTS[26])+pow(STATES[4], CONSTANTS[26])); ALGEBRAIC[6] = CONSTANTS[12] - STATES[0]; ALGEBRAIC[7] = STATES[3]; ALGEBRAIC[8] = ( (ALGEBRAIC[7]/(CONSTANTS[13]+ALGEBRAIC[7]))*STATES[1])/(CONSTANTS[15]+STATES[1]); ALGEBRAIC[9] = pow(ALGEBRAIC[7], CONSTANTS[25])/(pow(CONSTANTS[13], CONSTANTS[25])+pow(ALGEBRAIC[7], CONSTANTS[25])); } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; SI[4] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { }