function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =9; end % There are a total of 7 entries in each of the rate and state variable arrays. % There are a total of 26 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component Environment (second)'); LEGEND_ALGEBRAIC(:,1) = strpad('P_L in component PluralPressureFunction (mmHg)'); LEGEND_ALGEBRAIC(:,2) = strpad('dP_Ldt in component PluralPressureFunction (mmHg_per_second)'); LEGEND_CONSTANTS(:,1) = strpad('P_m in component PluralPressureFunction (mmHg)'); LEGEND_CONSTANTS(:,24) = strpad('R in component PluralPressureFunction (mmHg_second_per_litre)'); LEGEND_CONSTANTS(:,2) = strpad('omega in component PluralPressureFunction (radian_per_second)'); LEGEND_CONSTANTS(:,3) = strpad('V_T in component PluralPressureFunction (litre)'); LEGEND_CONSTANTS(:,4) = strpad('E in component PluralPressureFunction (mmHg_per_second)'); LEGEND_CONSTANTS(:,5) = strpad('P_m in component lungMechanics (mmHg)'); LEGEND_STATES(:,1) = strpad('V_A in component lungMechanics (litre)'); LEGEND_CONSTANTS(:,6) = strpad('E in component lungMechanics (mmHg_per_second)'); LEGEND_STATES(:,2) = strpad('P_A in component lungMechanics (mmHg)'); LEGEND_CONSTANTS(:,7) = strpad('R in component lungMechanics (mmHg_second_per_litre)'); LEGEND_ALGEBRAIC(:,7) = strpad('Q_A in component gasExchange (litre_per_second)'); LEGEND_ALGEBRAIC(:,4) = strpad('q in component lungMechanics (litre_per_second)'); LEGEND_CONSTANTS(:,8) = strpad('D_o in component gasExchange (mole_per_second_mmHg)'); LEGEND_STATES(:,3) = strpad('f_o in component gasExchange (dimensionless)'); LEGEND_ALGEBRAIC(:,8) = strpad('f_oi in component gasExchange (dimensionless)'); LEGEND_CONSTANTS(:,9) = strpad('D_c in component gasExchange (mole_per_second_mmHg)'); LEGEND_STATES(:,4) = strpad('f_c in component gasExchange (dimensionless)'); LEGEND_ALGEBRAIC(:,9) = strpad('f_ci in component gasExchange (dimensionless)'); LEGEND_CONSTANTS(:,10) = strpad('P_w in component gasExchange (mmHg)'); LEGEND_ALGEBRAIC(:,5) = strpad('p_ao in component gasExchange (mmHg)'); LEGEND_STATES(:,5) = strpad('p_o in component gasTransport (mmHg)'); LEGEND_ALGEBRAIC(:,6) = strpad('p_ac in component gasExchange (mmHg)'); LEGEND_CONSTANTS(:,11) = strpad('f_om in component gasExchange (dimensionless)'); LEGEND_CONSTANTS(:,12) = strpad('f_cm in component gasExchange (dimensionless)'); LEGEND_STATES(:,6) = strpad('p_c in component gasTransport (mmHg)'); LEGEND_CONSTANTS(:,13) = strpad('V_D in component gasExchange (litre)'); LEGEND_CONSTANTS(:,14) = strpad('V_T in component gasExchange (litre)'); LEGEND_ALGEBRAIC(:,3) = strpad('df_satdp in component gasTransport (dimensionless)'); LEGEND_CONSTANTS(:,15) = strpad('L in component gasTransport (dimensionless)'); LEGEND_CONSTANTS(:,16) = strpad('K_T in component gasTransport (litre_per_mole)'); LEGEND_CONSTANTS(:,17) = strpad('K_R in component gasTransport (litre_per_mole)'); LEGEND_CONSTANTS(:,18) = strpad('sigma in component gasTransport (mole_per_litre_mmHg)'); LEGEND_CONSTANTS(:,19) = strpad('V_c in component gasTransport (litre)'); LEGEND_CONSTANTS(:,20) = strpad('T_h in component gasTransport (mole_per_litre)'); LEGEND_CONSTANTS(:,25) = strpad('delta in component gasTransport (dimensionless)'); LEGEND_CONSTANTS(:,26) = strpad('h in component gasTransport (mole_per_litre)'); LEGEND_CONSTANTS(:,21) = strpad('l_2 in component gasTransport (litre_per_second_mole)'); LEGEND_CONSTANTS(:,22) = strpad('r_2 in component gasTransport (per_second)'); LEGEND_CONSTANTS(:,23) = strpad('sigma_c in component gasTransport (mole_per_litre_mmHg)'); LEGEND_STATES(:,7) = strpad('z in component gasTransport (dimensionless)'); LEGEND_RATES(:,2) = strpad('d/dt P_A in component lungMechanics (mmHg)'); LEGEND_RATES(:,1) = strpad('d/dt V_A in component lungMechanics (litre)'); LEGEND_RATES(:,3) = strpad('d/dt f_o in component gasExchange (dimensionless)'); LEGEND_RATES(:,4) = strpad('d/dt f_c in component gasExchange (dimensionless)'); LEGEND_RATES(:,5) = strpad('d/dt p_o in component gasTransport (mmHg)'); LEGEND_RATES(:,6) = strpad('d/dt p_c in component gasTransport (mmHg)'); LEGEND_RATES(:,7) = strpad('d/dt z in component gasTransport (dimensionless)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; CONSTANTS(:,1) = 760; CONSTANTS(:,2) = 1.256637; CONSTANTS(:,3) = 0.41; CONSTANTS(:,4) = 2.5; CONSTANTS(:,5) = 760; STATES(:,1) = 1; CONSTANTS(:,6) = 2.5; STATES(:,2) = 760; CONSTANTS(:,7) = 1; CONSTANTS(:,8) = 0.0000156; STATES(:,3) = 0.1368; CONSTANTS(:,9) = 0.0000316; STATES(:,4) = 0.05263; CONSTANTS(:,10) = 47; STATES(:,5) = 40; CONSTANTS(:,11) = 0.21; CONSTANTS(:,12) = 0; STATES(:,6) = 46; CONSTANTS(:,13) = 0.151; CONSTANTS(:,14) = 0.41; CONSTANTS(:,15) = 171200000; CONSTANTS(:,16) = 10000; CONSTANTS(:,17) = 3600000; CONSTANTS(:,18) = 0.0000014; CONSTANTS(:,19) = 0.071; CONSTANTS(:,20) = 0.002; CONSTANTS(:,21) = 164000; CONSTANTS(:,22) = 0.12; CONSTANTS(:,23) = 0.000033; STATES(:,7) = 0.00000044219; CONSTANTS(:,24) = ( 2.00000.* pi.*1.00000)./5.00000; CONSTANTS(:,25) = power(10.0000, 1.90000); CONSTANTS(:,26) = 1.00000.*power(10.0000, - 7.40000); if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end RATES(:,7) = ( CONSTANTS(:,25).*CONSTANTS(:,22).*CONSTANTS(:,23).*STATES(:,6))./1.00000 - CONSTANTS(:,25).*CONSTANTS(:,21).*CONSTANTS(:,26).*STATES(:,7); ALGEBRAIC(:,1) = (CONSTANTS(:,1) - (( CONSTANTS(:,24).*CONSTANTS(:,2).*CONSTANTS(:,3))./2.00000).* sin(( CONSTANTS(:,2).*VOI)./1.00000)) - CONSTANTS(:,4).*(2.50000 - (( CONSTANTS(:,3).*1.00000)./2.00000).*cos(( CONSTANTS(:,2).*VOI)./1.00000)); RATES(:,1) = ((CONSTANTS(:,5) - ALGEBRAIC(:,1)) - ( STATES(:,1).*CONSTANTS(:,6))./1.00000)./CONSTANTS(:,7); ALGEBRAIC(:,3) = ( ( CONSTANTS(:,15).*power(1.00000+ CONSTANTS(:,16).*CONSTANTS(:,18).*STATES(:,5), 4.00000)+power(1.00000+ CONSTANTS(:,17).*CONSTANTS(:,18).*STATES(:,5), 4.00000)).*( 3.00000.*CONSTANTS(:,15).*power(CONSTANTS(:,16), 2.00000).*power(CONSTANTS(:,18), 2.00000).*STATES(:,5).*1.00000.*power(1.00000+ CONSTANTS(:,16).*CONSTANTS(:,18).*STATES(:,5), 2.00000)+ CONSTANTS(:,15).*CONSTANTS(:,16).*CONSTANTS(:,18).*1.00000.*power(1.00000+ CONSTANTS(:,16).*CONSTANTS(:,18).*STATES(:,5), 3.00000)+ 3.00000.*power(CONSTANTS(:,17), 2.00000).*power(CONSTANTS(:,18), 2.00000).*STATES(:,5).*1.00000.*power(1.00000+ CONSTANTS(:,17).*CONSTANTS(:,18).*STATES(:,5), 2.00000)+ CONSTANTS(:,17).*CONSTANTS(:,18).*1.00000.*power(1.00000+ CONSTANTS(:,17).*CONSTANTS(:,18).*STATES(:,5), 3.00000)) - ( CONSTANTS(:,15).*CONSTANTS(:,16).*CONSTANTS(:,18).*STATES(:,5).*power(1.00000+ CONSTANTS(:,16).*CONSTANTS(:,18).*STATES(:,5), 3.00000)+ CONSTANTS(:,17).*CONSTANTS(:,18).*STATES(:,5).*power(1.00000+ CONSTANTS(:,17).*CONSTANTS(:,18).*STATES(:,5), 3.00000)).*( 4.00000.*CONSTANTS(:,15).*CONSTANTS(:,16).*CONSTANTS(:,18).*1.00000.*power(1.00000+ CONSTANTS(:,16).*CONSTANTS(:,18).*STATES(:,5), 3.00000)+ 4.00000.*CONSTANTS(:,17).*CONSTANTS(:,18).*1.00000.*power(1.00000+ CONSTANTS(:,17).*CONSTANTS(:,18).*STATES(:,5), 3.00000)))./power( CONSTANTS(:,15).*power(1.00000+ CONSTANTS(:,16).*CONSTANTS(:,18).*STATES(:,5), 4.00000)+power(1.00000+ CONSTANTS(:,17).*CONSTANTS(:,18).*STATES(:,5), 4.00000), 2.00000); RATES(:,5) = (CONSTANTS(:,8)./( CONSTANTS(:,18).*CONSTANTS(:,19))).*power(1.00000+ (( 4.00000.*CONSTANTS(:,20))./CONSTANTS(:,18)).*ALGEBRAIC(:,3), - 1.00000).*( STATES(:,3).*(STATES(:,2) - CONSTANTS(:,10)) - STATES(:,5)); ALGEBRAIC(:,6) = STATES(:,4).*(STATES(:,2) - CONSTANTS(:,10)); RATES(:,6) = ( (CONSTANTS(:,9)./( CONSTANTS(:,23).*CONSTANTS(:,19))).*(ALGEBRAIC(:,6) - STATES(:,6))+ (( 1.00000.*CONSTANTS(:,25).*CONSTANTS(:,21))./CONSTANTS(:,23)).*CONSTANTS(:,26).*STATES(:,7)) - CONSTANTS(:,25).*CONSTANTS(:,22).*STATES(:,6); ALGEBRAIC(:,2) = (( - CONSTANTS(:,24).*power(CONSTANTS(:,2), 2.00000).*CONSTANTS(:,3))./( 2.00000.*1.00000)).*cos(( CONSTANTS(:,2).*VOI)./1.00000) - CONSTANTS(:,4).*(2.50000 - (CONSTANTS(:,3)./2.00000).* sin(( CONSTANTS(:,2).*VOI)./1.00000)); ALGEBRAIC(:,4) = (CONSTANTS(:,5) - STATES(:,2))./CONSTANTS(:,7); ALGEBRAIC(:,5) = STATES(:,3).*(STATES(:,2) - CONSTANTS(:,10)); ALGEBRAIC(:,7) = ALGEBRAIC(:,4)+ 1.00000.*CONSTANTS(:,9).*(STATES(:,6) - ALGEBRAIC(:,6))+ 1.00000.*CONSTANTS(:,8).*(STATES(:,5) - ALGEBRAIC(:,5)); RATES(:,2) = ( CONSTANTS(:,5).*CONSTANTS(:,6).*ALGEBRAIC(:,7))./( STATES(:,2).*1.00000)+ALGEBRAIC(:,2); ALGEBRAIC(:,8) = piecewise({CONSTANTS(:,14)>=CONSTANTS(:,13), ( STATES(:,3).*CONSTANTS(:,13)+ CONSTANTS(:,11).*(CONSTANTS(:,14) - CONSTANTS(:,13)))./CONSTANTS(:,14) }, STATES(:,3)); RATES(:,3) = (1.00000./STATES(:,1)).*(( 1.00000.*CONSTANTS(:,8).*(STATES(:,5) - ALGEBRAIC(:,5))+ (ALGEBRAIC(:,8) - STATES(:,3)).*ALGEBRAIC(:,4)) - STATES(:,3).*( 1.00000.*CONSTANTS(:,9).*(STATES(:,6) - ALGEBRAIC(:,6))+ 1.00000.*CONSTANTS(:,8).*(STATES(:,5) - ALGEBRAIC(:,5)))); ALGEBRAIC(:,9) = piecewise({CONSTANTS(:,14)>=CONSTANTS(:,13), ( STATES(:,4).*CONSTANTS(:,13)+ CONSTANTS(:,12).*(CONSTANTS(:,14) - CONSTANTS(:,13)))./CONSTANTS(:,14) }, STATES(:,4)); RATES(:,4) = (1.00000./STATES(:,1)).*(( 1.00000.*CONSTANTS(:,9).*(STATES(:,6) - ALGEBRAIC(:,6))+ (ALGEBRAIC(:,9) - STATES(:,4)).*ALGEBRAIC(:,4)) - STATES(:,4).*( 1.00000.*CONSTANTS(:,8).*(STATES(:,5) - ALGEBRAIC(:,5))+ 1.00000.*CONSTANTS(:,9).*(STATES(:,6) - ALGEBRAIC(:,6)))); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,1) = (CONSTANTS(:,1) - (( CONSTANTS(:,24).*CONSTANTS(:,2).*CONSTANTS(:,3))./2.00000).* sin(( CONSTANTS(:,2).*VOI)./1.00000)) - CONSTANTS(:,4).*(2.50000 - (( CONSTANTS(:,3).*1.00000)./2.00000).*cos(( CONSTANTS(:,2).*VOI)./1.00000)); ALGEBRAIC(:,3) = ( ( CONSTANTS(:,15).*power(1.00000+ CONSTANTS(:,16).*CONSTANTS(:,18).*STATES(:,5), 4.00000)+power(1.00000+ CONSTANTS(:,17).*CONSTANTS(:,18).*STATES(:,5), 4.00000)).*( 3.00000.*CONSTANTS(:,15).*power(CONSTANTS(:,16), 2.00000).*power(CONSTANTS(:,18), 2.00000).*STATES(:,5).*1.00000.*power(1.00000+ CONSTANTS(:,16).*CONSTANTS(:,18).*STATES(:,5), 2.00000)+ CONSTANTS(:,15).*CONSTANTS(:,16).*CONSTANTS(:,18).*1.00000.*power(1.00000+ CONSTANTS(:,16).*CONSTANTS(:,18).*STATES(:,5), 3.00000)+ 3.00000.*power(CONSTANTS(:,17), 2.00000).*power(CONSTANTS(:,18), 2.00000).*STATES(:,5).*1.00000.*power(1.00000+ CONSTANTS(:,17).*CONSTANTS(:,18).*STATES(:,5), 2.00000)+ CONSTANTS(:,17).*CONSTANTS(:,18).*1.00000.*power(1.00000+ CONSTANTS(:,17).*CONSTANTS(:,18).*STATES(:,5), 3.00000)) - ( CONSTANTS(:,15).*CONSTANTS(:,16).*CONSTANTS(:,18).*STATES(:,5).*power(1.00000+ CONSTANTS(:,16).*CONSTANTS(:,18).*STATES(:,5), 3.00000)+ CONSTANTS(:,17).*CONSTANTS(:,18).*STATES(:,5).*power(1.00000+ CONSTANTS(:,17).*CONSTANTS(:,18).*STATES(:,5), 3.00000)).*( 4.00000.*CONSTANTS(:,15).*CONSTANTS(:,16).*CONSTANTS(:,18).*1.00000.*power(1.00000+ CONSTANTS(:,16).*CONSTANTS(:,18).*STATES(:,5), 3.00000)+ 4.00000.*CONSTANTS(:,17).*CONSTANTS(:,18).*1.00000.*power(1.00000+ CONSTANTS(:,17).*CONSTANTS(:,18).*STATES(:,5), 3.00000)))./power( CONSTANTS(:,15).*power(1.00000+ CONSTANTS(:,16).*CONSTANTS(:,18).*STATES(:,5), 4.00000)+power(1.00000+ CONSTANTS(:,17).*CONSTANTS(:,18).*STATES(:,5), 4.00000), 2.00000); ALGEBRAIC(:,6) = STATES(:,4).*(STATES(:,2) - CONSTANTS(:,10)); ALGEBRAIC(:,2) = (( - CONSTANTS(:,24).*power(CONSTANTS(:,2), 2.00000).*CONSTANTS(:,3))./( 2.00000.*1.00000)).*cos(( CONSTANTS(:,2).*VOI)./1.00000) - CONSTANTS(:,4).*(2.50000 - (CONSTANTS(:,3)./2.00000).* sin(( CONSTANTS(:,2).*VOI)./1.00000)); ALGEBRAIC(:,4) = (CONSTANTS(:,5) - STATES(:,2))./CONSTANTS(:,7); ALGEBRAIC(:,5) = STATES(:,3).*(STATES(:,2) - CONSTANTS(:,10)); ALGEBRAIC(:,7) = ALGEBRAIC(:,4)+ 1.00000.*CONSTANTS(:,9).*(STATES(:,6) - ALGEBRAIC(:,6))+ 1.00000.*CONSTANTS(:,8).*(STATES(:,5) - ALGEBRAIC(:,5)); ALGEBRAIC(:,8) = piecewise({CONSTANTS(:,14)>=CONSTANTS(:,13), ( STATES(:,3).*CONSTANTS(:,13)+ CONSTANTS(:,11).*(CONSTANTS(:,14) - CONSTANTS(:,13)))./CONSTANTS(:,14) }, STATES(:,3)); ALGEBRAIC(:,9) = piecewise({CONSTANTS(:,14)>=CONSTANTS(:,13), ( STATES(:,4).*CONSTANTS(:,13)+ CONSTANTS(:,12).*(CONSTANTS(:,14) - CONSTANTS(:,13)))./CONSTANTS(:,14) }, STATES(:,4)); end % Compute result of a piecewise function function x = piecewise(cases, default) set = [0]; for i = 1:2:length(cases) if (length(cases{i+1}) == 1) x(cases{i} & ~set,:) = cases{i+1}; else x(cases{i} & ~set,:) = cases{i+1}(cases{i} & ~set); end set = set | cases{i}; if(set), break, end end if (length(default) == 1) x(~set,:) = default; else x(~set,:) = default(~set); end end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end