<?xml version="1.0"?>
<!-- FILE : hynne_model_2001.xml
CREATED : 18th September 2003
LAST MODIFIED : 18th September 2003
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/1/02 CellML Metadata 1.0 Specification.
DESCRIPTION : This file contains a CellML description of Hynee et al's 2001 full scale model of glycolysis in Saccharomyces cerevisiae
CHANGES:
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="hynne_2001" name="hynne_2001">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Full-scale model of glycolysis in Saccharomyces cerevisiae</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This model runs in both OpenCell and COR to replicate the published results (figure 6). The units have been checked and they are consistent. This CellML model translation is based on the curated SBML model in the BioModels database (BIOMD0000000061.xml). Note that in order to replicate figure 6 the model has to be run for at least 100 seconds first to allow all the oscillations to stabilise.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
ABSTRACT: We present a powerful, general method of fitting a model of a biochemical pathway to experimental substrate concentrations and dynamical properties measured at a stationary state, when the mechanism is largely known but kinetic parameters are lacking. Rate constants and maximum velocities are calculated from the experimental data by simple algebra without integration of kinetic equations. Using this direct approach, we fit a comprehensive model of glycolysis and glycolytic oscillations in intact yeast cells to data measured on a suspension of living cells of Saccharomyces cerevisiae near a Hopf bifurcation, and to a large set of stationary concentrations and other data estimated from comparable batch experiments. The resulting model agrees with almost all experimentally known stationary concentrations and metabolic fluxes, with the frequency of oscillation and with the majority of other experimentally known kinetic and dynamical variables. The functional forms of the rate equations have not been optimized.
</para>
<para>
The original paper reference is cited below:
</para>
<para>
Full-scale model of glycolysis in <emphasis>Saccharomyces cerevisiae</emphasis>, F. Hynne, S. Dano, and P. G. Sorensen , 2001, <emphasis>Biophysical Chemistry</emphasis>
, 94, 121-163. <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/11744196">PubMed ID: 11744196</ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>reaction diagram</title>
</objectinfo>
<imagedata fileref="hynne_2001.png"/>
</imageobject>
</mediaobject>
<caption>The glycolysis pathway described by the mathematical model.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<units name="millimolar">
<unit prefix="milli" units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="millimolar2">
<unit exponent="2" units="millimolar"/>
</units>
<units name="minute">
<unit multiplier="60.0" units="second"/>
</units>
<units name="flux">
<unit units="millimolar"/>
<unit exponent="-1" units="minute"/>
</units>
<units name="first_order_rate_constant">
<unit exponent="-1" units="minute"/>
</units>
<units name="second_order_rate_constant">
<unit exponent="-1" units="millimolar"/>
<unit exponent="-1" units="minute"/>
</units>
<component name="environment">
<variable cmeta:id="environment_time" name="time" public_interface="out" units="minute"/>
</component>
<component cmeta:id="Glc_x_0" name="Glc_x_0">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Glc_x_0">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Glc_x_0</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">mixed flow glucose</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable initial_value="24.0" name="Glc_x_0" public_interface="out" units="millimolar"/>
</component>
<component cmeta:id="Glc_x" name="Glc_x">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Glc_x">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Glc_x</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">extracellular glucose</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="Glc_x_Glc_x" initial_value="6.7" name="Glc_x" public_interface="out" units="millimolar"/>
<variable name="GlcTrans" public_interface="in" units="flux"/>
<variable name="inGlc" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Glc_x</ci>
</apply>
<apply>
<minus/>
<ci>inGlc</ci>
<ci>GlcTrans</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="Glc" name="Glc">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Glc">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Glc</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">cytosolic glucose</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="Glc_Glc" initial_value="0.573074" name="Glc" public_interface="out" units="millimolar"/>
<variable name="GlcTrans" public_interface="in" units="flux"/>
<variable name="HK" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Glc</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 59 </cn>
<ci>GlcTrans</ci>
</apply>
<ci>HK</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="G6P" name="G6P">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#G6P">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">G6P</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">glucose-6-phopshate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="G6P_G6P" initial_value="4.2" name="G6P" public_interface="out" units="millimolar"/>
<variable name="PGI" public_interface="in" units="flux"/>
<variable name="HK" public_interface="in" units="flux"/>
<variable name="storage" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>G6P</ci>
</apply>
<apply>
<minus/>
<ci>HK</ci>
<apply>
<plus/>
<ci>PGI</ci>
<ci>storage</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="F6P" name="F6P">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#F6P">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">F6P</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">fructose-6 phopshate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="F6P_F6P" initial_value="0.49" name="F6P" public_interface="out" units="millimolar"/>
<variable name="PGI" public_interface="in" units="flux"/>
<variable name="PFK" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>F6P</ci>
</apply>
<apply>
<minus/>
<ci>PGI</ci>
<ci>PFK</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="FBP" name="FBP">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#FBP">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">FBP</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">fructose-1,6 bisphopshate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="FBP_FBP" initial_value="4.64" name="FBP" public_interface="out" units="millimolar"/>
<variable name="PFK" public_interface="in" units="flux"/>
<variable name="ALD" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>FBP</ci>
</apply>
<apply>
<minus/>
<ci>PFK</ci>
<ci>ALD</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="GAP" name="GAP">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#GAP">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">GAP</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">glyceraldehyde-3-phopshate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="GAP_GAP" initial_value="0.115" name="GAP" public_interface="out" units="millimolar"/>
<variable name="GAPDH" public_interface="in" units="flux"/>
<variable name="ALD" public_interface="in" units="flux"/>
<variable name="TIM" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>GAP</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ALD</ci>
<ci>TIM</ci>
</apply>
<ci>GAPDH</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="DHAP" name="DHAP">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#DHAP">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">DHAP</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">1,3-diphosphoglycerate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="DHAP_DHAP" initial_value="2.95" name="DHAP" public_interface="out" units="millimolar"/>
<variable name="ALD" public_interface="in" units="flux"/>
<variable name="TIM" public_interface="in" units="flux"/>
<variable name="lpGlyc" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>DHAP</ci>
</apply>
<apply>
<minus/>
<ci>ALD</ci>
<apply>
<plus/>
<ci>TIM</ci>
<ci>lpGlyc</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="BPG" name="BPG">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#BPG">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">BPG</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">1,3-bisphosphoglycerate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="BPG_BPG" initial_value="0.00027" name="BPG" public_interface="out" units="millimolar"/>
<variable name="lpPEP" public_interface="in" units="flux"/>
<variable name="GAPDH" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>BPG</ci>
</apply>
<apply>
<minus/>
<ci>GAPDH</ci>
<ci>lpPEP</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="PEP" name="PEP">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#PEP">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">PEP</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">phosphoenolpyruvate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="PEP_PEP" initial_value="0.04" name="PEP" public_interface="out" units="millimolar"/>
<variable name="lpPEP" public_interface="in" units="flux"/>
<variable name="PK" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PEP</ci>
</apply>
<apply>
<minus/>
<ci>lpPEP</ci>
<ci>PK</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="Pyr" name="Pyr">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Pyr">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Pyr</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">pyruvate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="Pyr_Pyr" initial_value="8.7" name="Pyr" public_interface="out" units="millimolar"/>
<variable name="PK" public_interface="in" units="flux"/>
<variable name="PDC" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Pyr</ci>
</apply>
<apply>
<minus/>
<ci>PK</ci>
<ci>PDC</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="ATP" name="ATP">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#ATP">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">ATP</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">adenosine triphosphate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="ATP_ATP" initial_value="2.1" name="ATP" public_interface="out" units="millimolar"/>
<variable name="HK" public_interface="in" units="flux"/>
<variable name="lpPEP" public_interface="in" units="flux"/>
<variable name="PFK" public_interface="in" units="flux"/>
<variable name="PK" public_interface="in" units="flux"/>
<variable name="storage" public_interface="in" units="flux"/>
<variable name="consum" public_interface="in" units="flux"/>
<variable name="AK" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ATP</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>PK</ci>
<ci>lpPEP</ci>
</apply>
<apply>
<plus/>
<ci>PFK</ci>
<ci>storage</ci>
<ci>HK</ci>
<ci>consum</ci>
<ci>AK</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="ADP" name="ADP">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#ADP">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">ADP</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">adenosine diphosphate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="ADP_ADP" initial_value="1.5" name="ADP" public_interface="out" units="millimolar"/>
<variable name="HK" public_interface="in" units="flux"/>
<variable name="lpPEP" public_interface="in" units="flux"/>
<variable name="PFK" public_interface="in" units="flux"/>
<variable name="PK" public_interface="in" units="flux"/>
<variable name="storage" public_interface="in" units="flux"/>
<variable name="consum" public_interface="in" units="flux"/>
<variable name="AK" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ADP</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>PFK</ci>
<ci>storage</ci>
<ci>HK</ci>
<ci>consum</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2 </cn>
<ci>AK</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>PK</ci>
<ci>lpPEP</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="AMP" name="AMP">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#AMP">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">AMP</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">adenosine monophosphate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable initial_value="0.33" name="AMP" public_interface="out" units="millimolar"/>
<variable name="AK" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>AMP</ci>
</apply>
<apply>
<minus/>
<ci>AK</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="CN_x_0" name="CN_x_0">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#CN_x_0">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">CN_x_0</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">mixed flow concentration of cyanide</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable initial_value="5.60" name="CN_x_0" public_interface="out" units="millimolar"/>
</component>
<component cmeta:id="CN_x" name="CN_x">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#CN_x">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">CN_x</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">total concentration of adenosine phosphates</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="CN_x_CN_x" initial_value="5.20358" name="CN_x" public_interface="out" units="millimolar"/>
<variable name="lacto" public_interface="in" units="flux"/>
<variable name="inCN" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CN_x</ci>
</apply>
<apply>
<minus/>
<ci>inCN</ci>
<ci>lacto</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="ACA" name="ACA">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#ACA">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">ACA</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">cytosolic acetaldehyde</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="ACA_ACA" initial_value="1.48153" name="ACA" public_interface="out" units="millimolar"/>
<variable name="difACA" public_interface="in" units="flux"/>
<variable name="PDC" public_interface="in" units="flux"/>
<variable name="ADH" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ACA</ci>
</apply>
<apply>
<minus/>
<ci>PDC</ci>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 59 </cn>
<ci>difACA</ci>
</apply>
<ci>ADH</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="ACA_x" name="ACA_x">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#ACA_x">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">ACA_x</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">extracellular acetaldehyde</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="ACA_x_ACA_x" initial_value="1.28836" name="ACA_x" public_interface="out" units="millimolar"/>
<variable name="lacto" public_interface="in" units="flux"/>
<variable name="difACA" public_interface="in" units="flux"/>
<variable name="outACA" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ACA_x</ci>
</apply>
<apply>
<minus/>
<ci>difACA</ci>
<apply>
<plus/>
<ci>lacto</ci>
<ci>outACA</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="EtOH" name="EtOH">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#EtOH">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">EtOH</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">cytosolic ethanol</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="EtOH_EtOH" initial_value="19.2379" name="EtOH" public_interface="out" units="millimolar"/>
<variable name="difEtOH" public_interface="in" units="flux"/>
<variable name="ADH" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>EtOH</ci>
</apply>
<apply>
<minus/>
<ci>ADH</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 59 </cn>
<ci>difEtOH</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="EtOH_x" name="EtOH_x">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#EtOH_x">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">EtOH_x</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">extracellular ethanol</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="EtOH_x_EtOH_x" initial_value="16.4514" name="EtOH_x" public_interface="out" units="millimolar"/>
<variable name="difEtOH" public_interface="in" units="flux"/>
<variable name="outEtOH" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>EtOH_x</ci>
</apply>
<apply>
<minus/>
<ci>difEtOH</ci>
<ci>outEtOH</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="Glyc" name="Glyc">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Glyc">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Glyc</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">cytosolic glycogen</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable initial_value="4.196" name="Glyc" public_interface="out" units="millimolar"/>
<variable name="difGlyc" public_interface="in" units="flux"/>
<variable name="lpGlyc" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Glyc</ci>
</apply>
<apply>
<minus/>
<ci>lpGlyc</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 59 </cn>
<ci>difGlyc</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="Glyc_x" name="Glyc_x">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Glyc_x">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Glyc_x</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">extracellular glycogen</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable initial_value="1.68478" name="Glyc_x" public_interface="out" units="millimolar"/>
<variable name="difGlyc" public_interface="in" units="flux"/>
<variable name="outGlyc" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Glyc_x</ci>
</apply>
<apply>
<minus/>
<ci>difGlyc</ci>
<ci>outGlyc</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="NADH" name="NADH">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#NADH">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">NADH</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">nicotinamide adenine dinucleotide</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="NADH_NADH" initial_value="0.33" name="NADH" public_interface="out" units="millimolar"/>
<variable name="GAPDH" public_interface="in" units="flux"/>
<variable name="ADH" public_interface="in" units="flux"/>
<variable name="lpGlyc" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>NADH</ci>
</apply>
<apply>
<minus/>
<ci>GAPDH</ci>
<apply>
<plus/>
<ci>ADH</ci>
<ci>lpGlyc</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="NAD" name="NAD">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#NAD">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">NAD</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">positive nicotinamide adenine dinucleotide</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="NAD_NAD" initial_value="0.65" name="NAD" public_interface="out" units="millimolar"/>
<variable name="GAPDH" public_interface="in" units="flux"/>
<variable name="ADH" public_interface="in" units="flux"/>
<variable name="lpGlyc" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>NAD</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ADH</ci>
<ci>lpGlyc</ci>
</apply>
<ci>GAPDH</ci>
</apply>
</apply>
</math>
</component>
<!--
The following components describe the reactions of the model.
-->
<component cmeta:id="inGlc" name="inGlc">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#inGlc">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">inGlc</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">glucose mixed flow to extracellular medium</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="inGlc" public_interface="out" units="flux"/>
<variable name="Glc_x_0" public_interface="in" units="millimolar"/>
<variable name="Glc_x" public_interface="in" units="millimolar"/>
<variable name="k0" public_interface="in" units="first_order_rate_constant"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="inGlc_calculation">
<eq/>
<ci> inGlc </ci>
<apply>
<times/>
<ci> k0 </ci>
<apply>
<minus/>
<ci> Glc_x_0 </ci>
<ci> Glc_x </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="GlcTrans" name="GlcTrans">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#GlcTrans">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">GlcTrans</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">glucose uptake</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="GlcTrans" public_interface="out" units="flux"/>
<variable name="Glc_x" public_interface="in" units="millimolar"/>
<variable name="Glc" public_interface="in" units="millimolar"/>
<variable name="G6P" public_interface="in" units="millimolar"/>
<variable initial_value="1.7" name="K2_Glc" units="millimolar"/>
<variable initial_value="1.2" name="K2_IG6P" units="millimolar"/>
<variable initial_value="7.2" name="K2_IIG6P" units="millimolar"/>
<variable initial_value="1014.96" name="V_2m" units="flux"/>
<variable initial_value="1.0" name="P2" units="dimensionless"/>
<variable name="y_vol" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="GlcTrans_calculation">
<eq/>
<ci> GlcTrans </ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> V_2m </ci>
<ci> y_vol </ci>
</apply>
<apply>
<divide/>
<apply>
<divide/>
<ci> Glc_x </ci>
<ci> K2_Glc </ci>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> Glc_x </ci>
<ci> K2_Glc </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci> P2 </ci>
<apply>
<divide/>
<ci> Glc_x </ci>
<ci> K2_Glc </ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> P2 </ci>
<apply>
<divide/>
<ci> Glc </ci>
<ci> K2_Glc </ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> Glc </ci>
<ci> K2_Glc </ci>
</apply>
<apply>
<divide/>
<ci> G6P </ci>
<ci> K2_IG6P </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> Glc </ci>
<ci> G6P </ci>
</apply>
<apply>
<times/>
<ci> K2_Glc </ci>
<ci> K2_IIG6P </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> V_2m </ci>
<ci> y_vol </ci>
</apply>
<apply>
<divide/>
<apply>
<divide/>
<ci> Glc </ci>
<ci> K2_Glc </ci>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> Glc </ci>
<ci> K2_Glc </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci> P2 </ci>
<apply>
<divide/>
<ci> Glc </ci>
<ci> K2_Glc </ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> P2 </ci>
<apply>
<divide/>
<ci> Glc_x </ci>
<ci> K2_Glc </ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> Glc_x </ci>
<ci> K2_Glc </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci> G6P </ci>
<ci> K2_IG6P </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> Glc </ci>
<ci> G6P </ci>
</apply>
<apply>
<times/>
<ci> K2_Glc </ci>
<ci> K2_IIG6P </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="HK" name="HK">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#HK">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">HK</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">hexokinase</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="HK" public_interface="out" units="flux"/>
<variable name="Glc" public_interface="in" units="millimolar"/>
<variable name="ATP" public_interface="in" units="millimolar"/>
<variable initial_value="0.37" name="K3_DGlc" units="millimolar"/>
<variable initial_value="0.0" name="K3_Glc" units="millimolar"/>
<variable initial_value="0.1" name="K3_ATP" units="millimolar"/>
<variable initial_value="51.7547" name="V_3m" units="flux"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="HK_calculation">
<eq/>
<ci> HK </ci>
<apply>
<divide/>
<apply>
<times/>
<ci> V_3m </ci>
<ci> ATP </ci>
<ci> Glc </ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> K3_DGlc </ci>
<ci> K3_ATP </ci>
</apply>
<apply>
<times/>
<ci> K3_Glc </ci>
<ci> ATP </ci>
</apply>
<apply>
<times/>
<ci> K3_ATP </ci>
<ci> Glc </ci>
</apply>
<apply>
<times/>
<ci> Glc </ci>
<ci> ATP </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="PGI" name="PGI">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#PGI">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">PGI</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">phosphoglucoisomerase</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="PGI" public_interface="out" units="flux"/>
<variable name="G6P" public_interface="in" units="millimolar"/>
<variable name="F6P" public_interface="in" units="millimolar"/>
<variable initial_value="496.042" name="V_4m" units="flux"/>
<variable initial_value="0.8" name="K4_G6P" units="millimolar"/>
<variable initial_value="0.15" name="K4_F6P" units="millimolar"/>
<variable initial_value="0.13" name="K4_eq" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="PGI_calculation">
<eq/>
<ci> PGI </ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> V_4m </ci>
<ci> G6P </ci>
</apply>
<apply>
<plus/>
<ci> K4_G6P </ci>
<ci> G6P </ci>
<apply>
<times/>
<apply>
<divide/>
<ci> K4_G6P </ci>
<ci> K4_F6P </ci>
</apply>
<ci> F6P </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> V_4m </ci>
<apply>
<divide/>
<ci> F6P </ci>
<ci> K4_eq </ci>
</apply>
</apply>
<apply>
<plus/>
<ci> K4_G6P </ci>
<ci> G6P </ci>
<apply>
<times/>
<apply>
<divide/>
<ci> K4_G6P </ci>
<ci> K4_F6P </ci>
</apply>
<ci> F6P </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="PFK" name="PFK">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#PFK">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">PFK</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">phosphofructokinase</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="PFK" public_interface="out" units="flux"/>
<variable name="F6P" public_interface="in" units="millimolar"/>
<variable name="ATP" public_interface="in" units="millimolar"/>
<variable name="AMP" public_interface="in" units="millimolar"/>
<variable initial_value="0.021" name="K5" units="millimolar2"/>
<variable initial_value="0.15" name="kappa5" units="dimensionless"/>
<variable initial_value="45.4327" name="V_5m" units="flux"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="PFK_calculation">
<eq/>
<ci> PFK </ci>
<apply>
<divide/>
<apply>
<times/>
<ci> V_5m </ci>
<apply>
<power/>
<ci> F6P </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> K5 </ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<times/>
<ci> kappa5 </ci>
<apply>
<divide/>
<ci> ATP </ci>
<ci> AMP </ci>
</apply>
<apply>
<divide/>
<ci> ATP </ci>
<ci> AMP </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci> F6P </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="ALD" name="ALD">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#ALD">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">ALD</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">aldolase</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="ALD" public_interface="out" units="flux"/>
<variable name="GAP" public_interface="in" units="millimolar"/>
<variable name="DHAP" public_interface="in" units="millimolar"/>
<variable name="FBP" public_interface="in" units="millimolar"/>
<variable initial_value="0.081" name="K6_eq" units="millimolar"/>
<variable initial_value="0.3" name="K6_FBP" units="millimolar"/>
<variable initial_value="2.0" name="K6_DHAP" units="millimolar"/>
<variable initial_value="4.0" name="K6_GAP" units="millimolar"/>
<variable initial_value="10.0" name="K6_IGAP" units="millimolar"/>
<variable initial_value="1.10391E4" name="V_6r" units="flux"/>
<variable initial_value="2.20782E3" name="V_6f" units="flux"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="ALD_calculation">
<eq/>
<ci> ALD </ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> V_6f </ci>
<ci> FBP </ci>
</apply>
<apply>
<plus/>
<ci> K6_FBP </ci>
<ci> FBP </ci>
<apply>
<divide/>
<apply>
<times/>
<ci> GAP </ci>
<ci> K6_DHAP </ci>
<ci> V_6f </ci>
</apply>
<apply>
<times/>
<ci> K6_eq </ci>
<ci> V_6r </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> DHAP </ci>
<ci> K6_GAP </ci>
<ci> V_6f </ci>
</apply>
<apply>
<times/>
<ci> K6_eq </ci>
<ci> V_6r </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> FBP </ci>
<ci> GAP </ci>
</apply>
<ci> K6_IGAP </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> GAP </ci>
<ci> DHAP </ci>
<ci> V_6f </ci>
</apply>
<apply>
<times/>
<ci> K6_eq </ci>
<ci> V_6r </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> V_6f </ci>
<apply>
<divide/>
<apply>
<times/>
<ci> GAP </ci>
<ci> DHAP </ci>
</apply>
<ci> K6_eq </ci>
</apply>
</apply>
<apply>
<plus/>
<ci> K6_FBP </ci>
<ci> FBP </ci>
<apply>
<divide/>
<apply>
<times/>
<ci> GAP </ci>
<ci> K6_DHAP </ci>
<ci> V_6f </ci>
</apply>
<apply>
<times/>
<ci> K6_eq </ci>
<ci> V_6r </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> DHAP </ci>
<ci> K6_GAP </ci>
<ci> V_6f </ci>
</apply>
<apply>
<times/>
<ci> K6_eq </ci>
<ci> V_6r </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> FBP </ci>
<ci> GAP </ci>
</apply>
<ci> K6_IGAP </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> GAP </ci>
<ci> DHAP </ci>
<ci> V_6f </ci>
</apply>
<apply>
<times/>
<ci> K6_eq </ci>
<ci> V_6r </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="TIM" name="TIM">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#TIM">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">TIM</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">triosephosphate isomerase</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="TIM" public_interface="out" units="flux"/>
<variable name="GAP" public_interface="in" units="millimolar"/>
<variable name="DHAP" public_interface="in" units="millimolar"/>
<variable initial_value="0.055" name="K7_eq" units="dimensionless"/>
<variable initial_value="1.23" name="K7_DHAP" units="millimolar"/>
<variable initial_value="1.27" name="K7_GAP" units="millimolar"/>
<variable initial_value="1.16365E2" name="V_7m" units="flux"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="TIM_calculation">
<eq/>
<ci> TIM </ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> V_7m </ci>
<ci> DHAP </ci>
</apply>
<apply>
<plus/>
<ci> K7_DHAP </ci>
<ci> DHAP </ci>
<apply>
<times/>
<apply>
<divide/>
<ci> K7_DHAP </ci>
<ci> K7_GAP </ci>
</apply>
<ci> GAP </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> V_7m </ci>
<apply>
<divide/>
<ci> GAP </ci>
<ci> K7_eq </ci>
</apply>
</apply>
<apply>
<plus/>
<ci> K7_DHAP </ci>
<ci> DHAP </ci>
<apply>
<times/>
<apply>
<divide/>
<ci> K7_DHAP </ci>
<ci> K7_GAP </ci>
</apply>
<ci> GAP </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="GAPDH" name="GAPDH">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#GAPDH">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">GAPDH</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">glyceraldehyde 3-phosphate dehydrogenase</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="GAPDH" public_interface="out" units="flux"/>
<variable name="GAP" public_interface="in" units="millimolar"/>
<variable name="NAD" public_interface="in" units="millimolar"/>
<variable name="NADH" public_interface="in" units="millimolar"/>
<variable name="BPG" public_interface="in" units="millimolar"/>
<variable initial_value="0.1" name="K8_NAD" units="millimolar"/>
<variable initial_value="0.06" name="K8_NADH" units="millimolar"/>
<variable initial_value="0.6" name="K8_GAP" units="millimolar"/>
<variable initial_value="0.01" name="K8_BPG" units="millimolar"/>
<variable initial_value="0.0055" name="K8_eq" units="dimensionless"/>
<variable initial_value="8.33858E2" name="V_8m" units="flux"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="GAPDH_calculation">
<eq/>
<ci> GAPDH </ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> V_8m </ci>
<ci> GAP </ci>
<ci> NAD </ci>
</apply>
<apply>
<times/>
<ci> K8_GAP </ci>
<ci> K8_NAD </ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> GAP </ci>
<ci> K8_GAP </ci>
</apply>
<apply>
<divide/>
<ci> BPG </ci>
<ci> K8_BPG </ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> NAD </ci>
<ci> K8_NAD </ci>
</apply>
<apply>
<divide/>
<ci> NADH </ci>
<ci> K8_NADH </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> V_8m </ci>
<apply>
<divide/>
<apply>
<times/>
<ci> BPG </ci>
<ci> NADH </ci>
</apply>
<ci> K8_eq </ci>
</apply>
</apply>
<apply>
<times/>
<ci> K8_GAP </ci>
<ci> K8_NAD </ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> GAP </ci>
<ci> K8_GAP </ci>
</apply>
<apply>
<divide/>
<ci> BPG </ci>
<ci> K8_BPG </ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> NAD </ci>
<ci> K8_NAD </ci>
</apply>
<apply>
<divide/>
<ci> NADH </ci>
<ci> K8_NADH </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="lpPEP" name="lpPEP">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#lpPEP">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">lpPEP</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">phosphoenolpyruvate synthesis</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="lpPEP" public_interface="out" units="flux"/>
<variable name="PEP" public_interface="in" units="millimolar"/>
<variable name="ADP" public_interface="in" units="millimolar"/>
<variable name="ATP" public_interface="in" units="millimolar"/>
<variable name="BPG" public_interface="in" units="millimolar"/>
<variable initial_value="4.43866E5" name="k9f" units="second_order_rate_constant"/>
<variable initial_value="1.52862E3" name="k9r" units="second_order_rate_constant"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="lpPEP_calculation">
<eq/>
<ci> lpPEP </ci>
<apply>
<minus/>
<apply>
<times/>
<ci> k9f </ci>
<ci> BPG </ci>
<ci> ADP </ci>
</apply>
<apply>
<times/>
<ci> k9r </ci>
<ci> PEP </ci>
<ci> ATP </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="PK" name="PK">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#PK">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">PK</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">pyruvate kinase</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="PK" public_interface="out" units="flux"/>
<variable name="PEP" public_interface="in" units="millimolar"/>
<variable name="ADP" public_interface="in" units="millimolar"/>
<variable initial_value="0.2" name="K10_PEP" units="millimolar"/>
<variable initial_value="0.17" name="K10_ADP" units="millimolar"/>
<variable initial_value="3.43096E2" name="V_10m" units="flux"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="PK_calculation">
<eq/>
<ci> PK </ci>
<apply>
<divide/>
<apply>
<times/>
<ci> V_10m </ci>
<ci> ADP </ci>
<ci> PEP </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci> K10_PEP </ci>
<ci> PEP </ci>
</apply>
<apply>
<plus/>
<ci> K10_ADP </ci>
<ci> ADP </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="PDC" name="PDC">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#PDC">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">PDC</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">pyruvate decarboxylase</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="PDC" public_interface="out" units="flux"/>
<variable name="Pyr" public_interface="in" units="millimolar"/>
<variable initial_value="0.3" name="K11" units="millimolar"/>
<variable initial_value="5.31328E1" name="V_11m" units="flux"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="PDC_calculation">
<eq/>
<ci> PDC </ci>
<apply>
<divide/>
<apply>
<times/>
<ci> V_11m </ci>
<ci> Pyr </ci>
</apply>
<apply>
<plus/>
<ci> K11 </ci>
<ci> Pyr </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="ADH" name="ADH">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#ADH">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">ADH</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">alcohol dehydrogenase</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="ADH" public_interface="out" units="flux"/>
<variable name="NADH" public_interface="in" units="millimolar"/>
<variable name="ACA" public_interface="in" units="millimolar"/>
<variable initial_value="0.1" name="K12_NADH" units="millimolar"/>
<variable initial_value="0.71" name="K12_ACA" units="millimolar"/>
<variable initial_value="8.98023E1" name="V_12m" units="flux"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="ADH_calculation">
<eq/>
<ci> ADH </ci>
<apply>
<divide/>
<apply>
<times/>
<ci> V_12m </ci>
<ci> ACA </ci>
<ci> NADH </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci> K12_NADH </ci>
<ci> NADH </ci>
</apply>
<apply>
<plus/>
<ci> K12_ACA </ci>
<ci> ACA </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="outEtOH" name="outEtOH">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#outEtOH">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">outEtOH</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">ethanol flow</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="outEtOH" public_interface="out" units="flux"/>
<variable name="EtOH_x" public_interface="in" units="millimolar"/>
<variable name="k0" public_interface="in" units="first_order_rate_constant"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="outEtOH_calculation">
<eq/>
<ci> outEtOH </ci>
<apply>
<times/>
<ci> k0 </ci>
<ci> EtOH_x </ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="difEtOH" name="difEtOH">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#difEtOH">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">difEtOH</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">ethanol out</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="difEtOH" public_interface="out" units="flux"/>
<variable initial_value="16.72" name="k13" units="first_order_rate_constant"/>
<variable name="EtOH_x" public_interface="in" units="millimolar"/>
<variable name="EtOH" public_interface="in" units="millimolar"/>
<variable name="y_vol" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="difEtOH_calculation">
<eq/>
<ci> difEtOH </ci>
<apply>
<times/>
<apply>
<divide/>
<ci> k13 </ci>
<ci> y_vol </ci>
</apply>
<apply>
<minus/>
<ci> EtOH </ci>
<ci> EtOH_x </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="lpGlyc" name="lpGlyc">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#lpGlyc">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">lpGlyc</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">glycerol synthesis</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="lpGlyc" public_interface="out" units="flux"/>
<variable name="NAD" public_interface="in" units="millimolar"/>
<variable name="NADH" public_interface="in" units="millimolar"/>
<variable name="DHAP" public_interface="in" units="millimolar"/>
<variable initial_value="0.13" name="K15_NADH" units="millimolar"/>
<variable initial_value="0.034" name="K15_INADH" units="millimolar"/>
<variable initial_value="0.13" name="K15_INAD" units="millimolar"/>
<variable initial_value="25.0" name="K15_DHAP" units="millimolar"/>
<variable initial_value="8.14797E1" name="V_15m" units="flux"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="lpGlyc_calculation">
<eq/>
<ci> lpGlyc </ci>
<apply>
<divide/>
<apply>
<times/>
<ci> V_15m </ci>
<ci> DHAP </ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> K15_DHAP </ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<times/>
<apply>
<divide/>
<ci> K15_INADH </ci>
<ci> NADH </ci>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> NAD </ci>
<ci> K15_INAD </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> DHAP </ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<times/>
<apply>
<divide/>
<ci> K15_NADH </ci>
<ci> NADH </ci>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> NAD </ci>
<ci> K15_INAD </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="outGlyc" name="outGlyc">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#outGlyc">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">outGlyc</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">glycerol flow</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="outGlyc" public_interface="out" units="flux"/>
<variable name="Glyc_x" public_interface="in" units="millimolar"/>
<variable name="k0" public_interface="in" units="first_order_rate_constant"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="outGlyc_calculation">
<eq/>
<ci> outGlyc </ci>
<apply>
<times/>
<ci> k0 </ci>
<ci> Glyc_x </ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="difGlyc" name="difGlyc">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#difGlyc">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">difGlyc</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">glycerol out</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="difGlyc" public_interface="out" units="flux"/>
<variable initial_value="1.9" name="k16" units="first_order_rate_constant"/>
<variable name="Glyc_x" public_interface="in" units="millimolar"/>
<variable name="Glyc" public_interface="in" units="millimolar"/>
<variable name="y_vol" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="difGlyc_calculation">
<eq/>
<ci> difGlyc </ci>
<apply>
<times/>
<apply>
<divide/>
<ci> k16 </ci>
<ci> y_vol </ci>
</apply>
<apply>
<minus/>
<ci> Glyc </ci>
<ci> Glyc_x </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="outACA" name="outACA">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#outACA">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">outACA</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">acetaldehyde flow</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="outACA" public_interface="out" units="flux"/>
<variable name="ACA_x" public_interface="in" units="millimolar"/>
<variable name="k0" public_interface="in" units="first_order_rate_constant"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="outACA_calculation">
<eq/>
<ci> outACA </ci>
<apply>
<times/>
<ci> k0 </ci>
<ci> ACA_x </ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="difACA" name="difACA">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#difACA">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">difACA</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">acetaldehyde out</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="difACA" public_interface="out" units="flux"/>
<variable name="ACA" public_interface="in" units="millimolar"/>
<variable name="ACA_x" public_interface="in" units="millimolar"/>
<variable name="y_vol" public_interface="in" units="dimensionless"/>
<variable initial_value="24.7" name="k18" units="first_order_rate_constant"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="difACA_calculation">
<eq/>
<ci> difACA </ci>
<apply>
<times/>
<apply>
<divide/>
<ci> k18 </ci>
<ci> y_vol </ci>
</apply>
<apply>
<minus/>
<ci> ACA </ci>
<ci> ACA_x </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="lacto" name="lacto">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#lacto">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">lacto</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">cyanide-acetaldehyde flow</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="lacto" public_interface="out" units="flux"/>
<variable name="ACA_x" public_interface="in" units="millimolar"/>
<variable name="CN_x" public_interface="in" units="millimolar"/>
<variable initial_value="2.83828E-3" name="k20" units="second_order_rate_constant"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="lacto_calculation">
<eq/>
<ci> lacto </ci>
<apply>
<times/>
<ci> k20 </ci>
<ci> ACA_x </ci>
<ci> CN_x </ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="inCN" name="inCN">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#inCN">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">inCN</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">cyanide flow</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="inCN" public_interface="out" units="flux"/>
<variable name="CN_x_0" public_interface="in" units="millimolar"/>
<variable name="CN_x" public_interface="in" units="millimolar"/>
<variable name="k0" public_interface="in" units="first_order_rate_constant"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="inCN_calculation">
<eq/>
<ci> inCN </ci>
<apply>
<times/>
<ci> k0 </ci>
<apply>
<minus/>
<ci> CN_x_0 </ci>
<ci> CN_x </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="storage" name="storage">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#storage">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">storage</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">storage</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="storage" public_interface="out" units="flux"/>
<variable name="ATP" public_interface="in" units="millimolar"/>
<variable name="G6P" public_interface="in" units="millimolar"/>
<variable initial_value="2.25932" name="k22" units="second_order_rate_constant"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="storage_calculation">
<eq/>
<ci> storage </ci>
<apply>
<times/>
<ci> k22 </ci>
<ci> ATP </ci>
<ci> G6P </ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="consum" name="consum">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#consum">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">consum</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">ATP consumption</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="consum" public_interface="out" units="flux"/>
<variable name="ATP" public_interface="in" units="millimolar"/>
<variable initial_value="3.20760" name="k23" units="first_order_rate_constant"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="consum_calculation">
<eq/>
<ci> consum </ci>
<apply>
<times/>
<ci> k23 </ci>
<ci> ATP </ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="AK" name="AK">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#AK">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">AK</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">adenylate kinase</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="AK" public_interface="out" units="flux"/>
<variable name="ATP" public_interface="in" units="millimolar"/>
<variable name="ADP" public_interface="in" units="millimolar"/>
<variable name="AMP" public_interface="in" units="millimolar"/>
<variable initial_value="4.32900E2" name="k24f" units="second_order_rate_constant"/>
<variable initial_value="1.33333E2" name="k24r" units="second_order_rate_constant"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="AK_calculation">
<eq/>
<ci> AK </ci>
<apply>
<minus/>
<apply>
<times/>
<ci> k24f </ci>
<ci> AMP </ci>
<ci> ATP </ci>
</apply>
<apply>
<times/>
<ci> k24r </ci>
<apply>
<power/>
<ci> ADP </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="model_parameters">
<variable initial_value="59.0" name="y_vol" public_interface="out" units="dimensionless"/>
<variable initial_value="0.048" name="k0" public_interface="out" units="first_order_rate_constant"/>
</component>
<connection>
<map_components component_1="Glc_x_0" component_2="inGlc"/>
<map_variables variable_1="Glc_x_0" variable_2="Glc_x_0"/>
</connection>
<connection>
<map_components component_1="Glc_x" component_2="inGlc"/>
<map_variables variable_1="Glc_x" variable_2="Glc_x"/>
<map_variables variable_1="inGlc" variable_2="inGlc"/>
</connection>
<connection>
<map_components component_1="model_parameters" component_2="inGlc"/>
<map_variables variable_1="k0" variable_2="k0"/>
</connection>
<connection>
<map_components component_1="Glc_x" component_2="GlcTrans"/>
<map_variables variable_1="Glc_x" variable_2="Glc_x"/>
<map_variables variable_1="GlcTrans" variable_2="GlcTrans"/>
</connection>
<connection>
<map_components component_1="Glc" component_2="GlcTrans"/>
<map_variables variable_1="Glc" variable_2="Glc"/>
<map_variables variable_1="GlcTrans" variable_2="GlcTrans"/>
</connection>
<connection>
<map_components component_1="model_parameters" component_2="GlcTrans"/>
<map_variables variable_1="y_vol" variable_2="y_vol"/>
</connection>
<connection>
<map_components component_1="Glc" component_2="HK"/>
<map_variables variable_1="Glc" variable_2="Glc"/>
<map_variables variable_1="HK" variable_2="HK"/>
</connection>
<connection>
<map_components component_1="G6P" component_2="HK"/>
<map_variables variable_1="HK" variable_2="HK"/>
</connection>
<connection>
<map_components component_1="G6P" component_2="PGI"/>
<map_variables variable_1="G6P" variable_2="G6P"/>
<map_variables variable_1="PGI" variable_2="PGI"/>
</connection>
<connection>
<map_components component_1="G6P" component_2="GlcTrans"/>
<map_variables variable_1="G6P" variable_2="G6P"/>
</connection>
<connection>
<map_components component_1="G6P" component_2="storage"/>
<map_variables variable_1="G6P" variable_2="G6P"/>
<map_variables variable_1="storage" variable_2="storage"/>
</connection>
<connection>
<map_components component_1="F6P" component_2="PGI"/>
<map_variables variable_1="F6P" variable_2="F6P"/>
<map_variables variable_1="PGI" variable_2="PGI"/>
</connection>
<connection>
<map_components component_1="F6P" component_2="PFK"/>
<map_variables variable_1="F6P" variable_2="F6P"/>
<map_variables variable_1="PFK" variable_2="PFK"/>
</connection>
<connection>
<map_components component_1="FBP" component_2="PFK"/>
<map_variables variable_1="PFK" variable_2="PFK"/>
</connection>
<connection>
<map_components component_1="FBP" component_2="ALD"/>
<map_variables variable_1="FBP" variable_2="FBP"/>
<map_variables variable_1="ALD" variable_2="ALD"/>
</connection>
<connection>
<map_components component_1="GAP" component_2="ALD"/>
<map_variables variable_1="GAP" variable_2="GAP"/>
<map_variables variable_1="ALD" variable_2="ALD"/>
</connection>
<connection>
<map_components component_1="GAP" component_2="TIM"/>
<map_variables variable_1="GAP" variable_2="GAP"/>
<map_variables variable_1="TIM" variable_2="TIM"/>
</connection>
<connection>
<map_components component_1="GAP" component_2="GAPDH"/>
<map_variables variable_1="GAP" variable_2="GAP"/>
<map_variables variable_1="GAPDH" variable_2="GAPDH"/>
</connection>
<connection>
<map_components component_1="DHAP" component_2="ALD"/>
<map_variables variable_1="DHAP" variable_2="DHAP"/>
<map_variables variable_1="ALD" variable_2="ALD"/>
</connection>
<connection>
<map_components component_1="DHAP" component_2="TIM"/>
<map_variables variable_1="DHAP" variable_2="DHAP"/>
<map_variables variable_1="TIM" variable_2="TIM"/>
</connection>
<connection>
<map_components component_1="DHAP" component_2="lpGlyc"/>
<map_variables variable_1="DHAP" variable_2="DHAP"/>
<map_variables variable_1="lpGlyc" variable_2="lpGlyc"/>
</connection>
<connection>
<map_components component_1="Glyc" component_2="lpGlyc"/>
<map_variables variable_1="lpGlyc" variable_2="lpGlyc"/>
</connection>
<connection>
<map_components component_1="Glyc_x" component_2="outGlyc"/>
<map_variables variable_1="Glyc_x" variable_2="Glyc_x"/>
<map_variables variable_1="outGlyc" variable_2="outGlyc"/>
</connection>
<connection>
<map_components component_1="model_parameters" component_2="outGlyc"/>
<map_variables variable_1="k0" variable_2="k0"/>
</connection>
<connection>
<map_components component_1="Glyc_x" component_2="difGlyc"/>
<map_variables variable_1="Glyc_x" variable_2="Glyc_x"/>
<map_variables variable_1="difGlyc" variable_2="difGlyc"/>
</connection>
<connection>
<map_components component_1="Glyc" component_2="difGlyc"/>
<map_variables variable_1="Glyc" variable_2="Glyc"/>
<map_variables variable_1="difGlyc" variable_2="difGlyc"/>
</connection>
<connection>
<map_components component_1="model_parameters" component_2="difGlyc"/>
<map_variables variable_1="y_vol" variable_2="y_vol"/>
</connection>
<connection>
<map_components component_1="BPG" component_2="GAPDH"/>
<map_variables variable_1="GAPDH" variable_2="GAPDH"/>
<map_variables variable_1="BPG" variable_2="BPG"/>
</connection>
<connection>
<map_components component_1="BPG" component_2="lpPEP"/>
<map_variables variable_1="lpPEP" variable_2="lpPEP"/>
<map_variables variable_1="BPG" variable_2="BPG"/>
</connection>
<connection>
<map_components component_1="PEP" component_2="lpPEP"/>
<map_variables variable_1="PEP" variable_2="PEP"/>
<map_variables variable_1="lpPEP" variable_2="lpPEP"/>
</connection>
<connection>
<map_components component_1="PEP" component_2="PK"/>
<map_variables variable_1="PEP" variable_2="PEP"/>
<map_variables variable_1="PK" variable_2="PK"/>
</connection>
<connection>
<map_components component_1="Pyr" component_2="PK"/>
<map_variables variable_1="PK" variable_2="PK"/>
</connection>
<connection>
<map_components component_1="Pyr" component_2="PDC"/>
<map_variables variable_1="Pyr" variable_2="Pyr"/>
<map_variables variable_1="PDC" variable_2="PDC"/>
</connection>
<connection>
<map_components component_1="ACA" component_2="ADH"/>
<map_variables variable_1="ACA" variable_2="ACA"/>
<map_variables variable_1="ADH" variable_2="ADH"/>
</connection>
<connection>
<map_components component_1="ACA" component_2="PDC"/>
<map_variables variable_1="PDC" variable_2="PDC"/>
</connection>
<connection>
<map_components component_1="ACA_x" component_2="outACA"/>
<map_variables variable_1="ACA_x" variable_2="ACA_x"/>
<map_variables variable_1="outACA" variable_2="outACA"/>
</connection>
<connection>
<map_components component_1="model_parameters" component_2="outACA"/>
<map_variables variable_1="k0" variable_2="k0"/>
</connection>
<connection>
<map_components component_1="ACA_x" component_2="difACA"/>
<map_variables variable_1="ACA_x" variable_2="ACA_x"/>
<map_variables variable_1="difACA" variable_2="difACA"/>
</connection>
<connection>
<map_components component_1="ACA" component_2="difACA"/>
<map_variables variable_1="ACA" variable_2="ACA"/>
<map_variables variable_1="difACA" variable_2="difACA"/>
</connection>
<connection>
<map_components component_1="model_parameters" component_2="difACA"/>
<map_variables variable_1="y_vol" variable_2="y_vol"/>
</connection>
<connection>
<map_components component_1="EtOH_x" component_2="outEtOH"/>
<map_variables variable_1="EtOH_x" variable_2="EtOH_x"/>
<map_variables variable_1="outEtOH" variable_2="outEtOH"/>
</connection>
<connection>
<map_components component_1="model_parameters" component_2="outEtOH"/>
<map_variables variable_1="k0" variable_2="k0"/>
</connection>
<connection>
<map_components component_1="EtOH" component_2="difEtOH"/>
<map_variables variable_1="EtOH" variable_2="EtOH"/>
<map_variables variable_1="difEtOH" variable_2="difEtOH"/>
</connection>
<connection>
<map_components component_1="EtOH_x" component_2="difEtOH"/>
<map_variables variable_1="EtOH_x" variable_2="EtOH_x"/>
<map_variables variable_1="difEtOH" variable_2="difEtOH"/>
</connection>
<connection>
<map_components component_1="model_parameters" component_2="difEtOH"/>
<map_variables variable_1="y_vol" variable_2="y_vol"/>
</connection>
<connection>
<map_components component_1="CN_x_0" component_2="inCN"/>
<map_variables variable_1="CN_x_0" variable_2="CN_x_0"/>
</connection>
<connection>
<map_components component_1="CN_x" component_2="inCN"/>
<map_variables variable_1="CN_x" variable_2="CN_x"/>
<map_variables variable_1="inCN" variable_2="inCN"/>
</connection>
<connection>
<map_components component_1="model_parameters" component_2="inCN"/>
<map_variables variable_1="k0" variable_2="k0"/>
</connection>
<connection>
<map_components component_1="CN_x" component_2="lacto"/>
<map_variables variable_1="CN_x" variable_2="CN_x"/>
<map_variables variable_1="lacto" variable_2="lacto"/>
</connection>
<connection>
<map_components component_1="ACA_x" component_2="lacto"/>
<map_variables variable_1="ACA_x" variable_2="ACA_x"/>
<map_variables variable_1="lacto" variable_2="lacto"/>
</connection>
<connection>
<map_components component_1="ATP" component_2="HK"/>
<map_variables variable_1="ATP" variable_2="ATP"/>
<map_variables variable_1="HK" variable_2="HK"/>
</connection>
<connection>
<map_components component_1="ADP" component_2="HK"/>
<map_variables variable_1="HK" variable_2="HK"/>
</connection>
<connection>
<map_components component_1="ADP" component_2="PFK"/>
<map_variables variable_1="PFK" variable_2="PFK"/>
</connection>
<connection>
<map_components component_1="ATP" component_2="storage"/>
<map_variables variable_1="ATP" variable_2="ATP"/>
<map_variables variable_1="storage" variable_2="storage"/>
</connection>
<connection>
<map_components component_1="ADP" component_2="storage"/>
<map_variables variable_1="storage" variable_2="storage"/>
</connection>
<connection>
<map_components component_1="ATP" component_2="PFK"/>
<map_variables variable_1="ATP" variable_2="ATP"/>
<map_variables variable_1="PFK" variable_2="PFK"/>
</connection>
<connection>
<map_components component_1="AMP" component_2="PFK"/>
<map_variables variable_1="AMP" variable_2="AMP"/>
</connection>
<connection>
<map_components component_1="ATP" component_2="PK"/>
<map_variables variable_1="PK" variable_2="PK"/>
</connection>
<connection>
<map_components component_1="ADP" component_2="PK"/>
<map_variables variable_1="ADP" variable_2="ADP"/>
<map_variables variable_1="PK" variable_2="PK"/>
</connection>
<connection>
<map_components component_1="ATP" component_2="lpPEP"/>
<map_variables variable_1="ATP" variable_2="ATP"/>
<map_variables variable_1="lpPEP" variable_2="lpPEP"/>
</connection>
<connection>
<map_components component_1="ADP" component_2="lpPEP"/>
<map_variables variable_1="ADP" variable_2="ADP"/>
<map_variables variable_1="lpPEP" variable_2="lpPEP"/>
</connection>
<connection>
<map_components component_1="ATP" component_2="AK"/>
<map_variables variable_1="ATP" variable_2="ATP"/>
<map_variables variable_1="AK" variable_2="AK"/>
</connection>
<connection>
<map_components component_1="ADP" component_2="AK"/>
<map_variables variable_1="ADP" variable_2="ADP"/>
<map_variables variable_1="AK" variable_2="AK"/>
</connection>
<connection>
<map_components component_1="AMP" component_2="AK"/>
<map_variables variable_1="AMP" variable_2="AMP"/>
<map_variables variable_1="AK" variable_2="AK"/>
</connection>
<connection>
<map_components component_1="ATP" component_2="consum"/>
<map_variables variable_1="ATP" variable_2="ATP"/>
<map_variables variable_1="consum" variable_2="consum"/>
</connection>
<connection>
<map_components component_1="ADP" component_2="consum"/>
<map_variables variable_1="consum" variable_2="consum"/>
</connection>
<connection>
<map_components component_1="NAD" component_2="GAPDH"/>
<map_variables variable_1="NAD" variable_2="NAD"/>
<map_variables variable_1="GAPDH" variable_2="GAPDH"/>
</connection>
<connection>
<map_components component_1="NADH" component_2="GAPDH"/>
<map_variables variable_1="NADH" variable_2="NADH"/>
<map_variables variable_1="GAPDH" variable_2="GAPDH"/>
</connection>
<connection>
<map_components component_1="NAD" component_2="ADH"/>
<map_variables variable_1="ADH" variable_2="ADH"/>
</connection>
<connection>
<map_components component_1="EtOH" component_2="ADH"/>
<map_variables variable_1="ADH" variable_2="ADH"/>
</connection>
<connection>
<map_components component_1="NADH" component_2="ADH"/>
<map_variables variable_1="NADH" variable_2="NADH"/>
<map_variables variable_1="ADH" variable_2="ADH"/>
</connection>
<connection>
<map_components component_1="NAD" component_2="lpGlyc"/>
<map_variables variable_1="NAD" variable_2="NAD"/>
<map_variables variable_1="lpGlyc" variable_2="lpGlyc"/>
</connection>
<connection>
<map_components component_1="NADH" component_2="lpGlyc"/>
<map_variables variable_1="NADH" variable_2="NADH"/>
<map_variables variable_1="lpGlyc" variable_2="lpGlyc"/>
</connection>
<connection>
<map_components component_1="Glc_x" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Glc" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="G6P" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="F6P" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="FBP" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="GAP" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="DHAP" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Glyc" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Glyc_x" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="BPG" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="PEP" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Pyr" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ACA" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ACA_x" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ATP" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ADP" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="AMP" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="CN_x" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="EtOH" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="EtOH_x" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="NAD" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="NADH" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Seq rdf:about="rdf:#432ac3cd-a7a2-4cd4-9620-0576ff866e2c">
<rdf:li rdf:resource="rdf:#655968ec-91a3-4cd2-aba4-891403c42ed3"/>
<rdf:li rdf:resource="rdf:#bf789ce6-4e4e-4454-a15f-5ff437a896fe"/>
<rdf:li rdf:resource="rdf:#ae1dbb9b-4ee5-4eeb-bd98-c794c552be2f"/>
</rdf:Seq>
<rdf:Description rdf:about="rdf:#201f8866-53e2-45c3-be9d-a1f85a1b86e7">
<bqs:subject_type xmlns:bqs="http://www.cellml.org/bqs/1.0#">keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>metabolism</rdf:li>
<rdf:li>glycolysis</rdf:li>
<rdf:li>yeast</rdf:li>
</rdf:Bag>
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#436e437b-4a95-426d-8134-b30b2fc02891">
<dc:subject xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#201f8866-53e2-45c3-be9d-a1f85a1b86e7"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#4f94a8b0-0fb6-46b4-9acb-e5ae49ebac60">
<vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3780b5d9-427d-4597-b6b4-eb392e89a809">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">F</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Hynne</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#59043ea1-39a9-491c-b730-8663f2c1b0f6">
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#3e792e34-8f27-43ac-9059-32014a4dcbe1"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e42dfd78-6fcf-4022-90d0-1d5cc13d1493">
<vCard:ORG xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#72020d28-7a47-4133-ac04-3918fbb4b23f"/>
<vCard:EMAIL xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#2d3aec9c-4aa8-4a5b-9bde-0ca7a70d5d1a"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#1161bc15-f55a-49ec-b246-4d4d29b04476"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#1170af5e-77c1-4689-8162-af76bbd70292">
<dcterms:modified xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#2d2cc897-f391-4876-99b7-4a46dccc817e"/>
<rdf:value>Fixed semicolons in listed links.</rdf:value>
<cmeta:modifier rdf:resource="rdf:#59043ea1-39a9-491c-b730-8663f2c1b0f6"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#162df6e7-3284-4d87-ab43-fe5e6894bd9c">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#4f94a8b0-0fb6-46b4-9acb-e5ae49ebac60"/>
<rdf:value/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#655968ec-91a3-4cd2-aba4-891403c42ed3">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#3780b5d9-427d-4597-b6b4-eb392e89a809"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#5d645444-a248-4a7e-862f-4d00d698e5cb">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#432ac3cd-a7a2-4cd4-9620-0576ff866e2c"/>
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Full-scale model of glycolysis in Saccharomyces cerevisiae</dc:title>
<bqs:volume xmlns:bqs="http://www.cellml.org/bqs/1.0#">94</bqs:volume>
<bqs:first_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">121</bqs:first_page>
<bqs:Journal xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#2c8a54bb-ca1f-4647-a28b-a5c7b956bf61"/>
<dcterms:issued xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#2befbbbd-2492-46ab-bc5f-16a7236e85ac"/>
<bqs:last_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">163</bqs:last_page>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3e792e34-8f27-43ac-9059-32014a4dcbe1">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Lloyd</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">May</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="#hynne_2001">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">
Hynne et al's 2001 full scale model of glycolysis in Saccharomyces
cerevisiae.
</dc:title>
<cmeta:comment rdf:resource="rdf:#3b03f92f-2a4b-4e49-a4a1-2a2f4355e63d"/>
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#436e437b-4a95-426d-8134-b30b2fc02891"/>
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#31a745a5-1749-4826-975a-4737deed41ce"/>
<cmeta:species>Saccharomyces cerevisae</cmeta:species>
</rdf:Description>
<rdf:Description rdf:about="rdf:#1161bc15-f55a-49ec-b246-4d4d29b04476">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Lloyd</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">May</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2c8a54bb-ca1f-4647-a28b-a5c7b956bf61">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Biophysical Chemistry</dc:title>
</rdf:Description>
<rdf:Description rdf:about="rdf:#72020d28-7a47-4133-ac04-3918fbb4b23f">
<vCard:Orgname xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">The University of Auckland</vCard:Orgname>
<vCard:Orgunit xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Auckland Bioengineering Institute</vCard:Orgunit>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2befbbbd-2492-46ab-bc5f-16a7236e85ac">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2001-12-11</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#c9f78085-56cd-477c-9b2a-a8dcfb9809db">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2003-09-18T00:00:00+00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#bf789ce6-4e4e-4454-a15f-5ff437a896fe">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#e6f0489b-cf59-4e07-8185-9d7c7bed78c4"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2d3aec9c-4aa8-4a5b-9bde-0ca7a70d5d1a">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value>c.lloyd@auckland.ac.nz</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e6f0489b-cf59-4e07-8185-9d7c7bed78c4">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">S</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Dano</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#31a745a5-1749-4826-975a-4737deed41ce">
<bqs:Pubmed_id xmlns:bqs="http://www.cellml.org/bqs/1.0#">12050011</bqs:Pubmed_id>
<bqs:JournalArticle xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#5d645444-a248-4a7e-862f-4d00d698e5cb"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ae1dbb9b-4ee5-4eeb-bd98-c794c552be2f">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#474f6c6b-5ee3-484e-a480-19823b563f32"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#474f6c6b-5ee3-484e-a480-19823b563f32">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">P</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Sorensen</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">G</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2d2cc897-f391-4876-99b7-4a46dccc817e">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2007-06-14T12:08:49+12:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="">
<dc:publisher xmlns:dc="http://purl.org/dc/elements/1.1/">The University of Auckland, Auckland Bioengineering Institute</dc:publisher>
<cmeta:comment rdf:resource="rdf:#162df6e7-3284-4d87-ab43-fe5e6894bd9c"/>
<dcterms:created xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#c9f78085-56cd-477c-9b2a-a8dcfb9809db"/>
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#e42dfd78-6fcf-4022-90d0-1d5cc13d1493"/>
<cmeta:modification rdf:resource="rdf:#1170af5e-77c1-4689-8162-af76bbd70292"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3b03f92f-2a4b-4e49-a4a1-2a2f4355e63d">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#7de24052-47a8-4b72-9ac0-95dcec69d32c"/>
<rdf:value>This is the CellML description of Hynne et al's 2001 full scale model
of glycolysis in Saccharomyces cerevisiae.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#7de24052-47a8-4b72-9ac0-95dcec69d32c">
<vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine Lloyd</vCard:FN>
</rdf:Description>
</rdf:RDF>
</model>
