function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =0; end % There are a total of 1 entries in each of the rate and state variable arrays. % There are a total of 19 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (minute)'); LEGEND_CONSTANTS(:,1) = strpad('ADHC in component thirst_drinking_and_salt_appetite (dimensionless)'); LEGEND_CONSTANTS(:,2) = strpad('ANM in component thirst_drinking_and_salt_appetite (dimensionless)'); LEGEND_CONSTANTS(:,3) = strpad('POT in component thirst_drinking_and_salt_appetite (mmHg)'); LEGEND_CONSTANTS(:,13) = strpad('STH in component effect_of_salt_appetite_stimulation_on_thirst (dimensionless)'); LEGEND_CONSTANTS(:,4) = strpad('ANMSLT in component parameter_values (dimensionless)'); LEGEND_CONSTANTS(:,5) = strpad('Z10 in component parameter_values (mmHg)'); LEGEND_CONSTANTS(:,6) = strpad('Z11 in component parameter_values (per_mmHg2)'); LEGEND_CONSTANTS(:,11) = strpad('ANMSML in component effect_of_salt_appetite_stimulation_on_thirst (dimensionless)'); LEGEND_CONSTANTS(:,12) = strpad('STH1 in component effect_of_salt_appetite_stimulation_on_thirst (dimensionless)'); LEGEND_CONSTANTS(:,14) = strpad('AHCM in component effect_of_antidiuretic_hormone_on_thirst (dimensionless)'); LEGEND_CONSTANTS(:,7) = strpad('AHTHM in component parameter_values (dimensionless)'); LEGEND_CONSTANTS(:,15) = strpad('ANMTH in component effect_of_angiotensin_on_thirst (dimensionless)'); LEGEND_CONSTANTS(:,8) = strpad('ANMTM in component parameter_values (dimensionless)'); LEGEND_STATES(:,1) = strpad('TVD in component rate_of_fluid_intake (L_per_minute)'); LEGEND_CONSTANTS(:,9) = strpad('DR in component parameter_values (L_per_minute)'); LEGEND_CONSTANTS(:,10) = strpad('TVDDL in component parameter_values (minute)'); LEGEND_CONSTANTS(:,17) = strpad('AHTH in component rate_of_fluid_intake (dimensionless)'); LEGEND_CONSTANTS(:,16) = strpad('AHTH1 in component rate_of_fluid_intake (dimensionless)'); LEGEND_CONSTANTS(:,19) = strpad('TVZ in component rate_of_fluid_intake (L_per_minute)'); LEGEND_CONSTANTS(:,18) = strpad('TVZ1 in component rate_of_fluid_intake (L_per_minute)'); LEGEND_RATES(:,1) = strpad('d/dt TVD in component rate_of_fluid_intake (L_per_minute)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; CONSTANTS(:,1) = 1.0; CONSTANTS(:,2) = 0.987545; CONSTANTS(:,3) = 35.1148; CONSTANTS(:,4) = 2; CONSTANTS(:,5) = 45; CONSTANTS(:,6) = 0.01; CONSTANTS(:,7) = 2; CONSTANTS(:,8) = 1.5; STATES(:,1) = 0.000980838; CONSTANTS(:,9) = 0; CONSTANTS(:,10) = 30; CONSTANTS(:,11) = (CONSTANTS(:,2) - 1.00000).*CONSTANTS(:,4)+1.00000; CONSTANTS(:,12) = power(CONSTANTS(:,5) - CONSTANTS(:,3), 2.00000).*CONSTANTS(:,6).*CONSTANTS(:,11); CONSTANTS(:,13) = piecewise({CONSTANTS(:,12)<0.800000, 0.800000 , CONSTANTS(:,12)>8.00000, 8.00000 }, CONSTANTS(:,12)); CONSTANTS(:,14) = (CONSTANTS(:,1) - 1.00000).*CONSTANTS(:,7)+1.00000; CONSTANTS(:,15) = (CONSTANTS(:,2) - 1.00000).*CONSTANTS(:,8).*0.00100000; CONSTANTS(:,16) = CONSTANTS(:,14).*CONSTANTS(:,13).*0.00100000; CONSTANTS(:,17) = piecewise({CONSTANTS(:,16)<0.00000, 0.00000 }, CONSTANTS(:,16)); CONSTANTS(:,18) = (CONSTANTS(:,15)+CONSTANTS(:,17)).*1.00000; CONSTANTS(:,19) = piecewise({CONSTANTS(:,18)<0.00000, 0.00000 }, CONSTANTS(:,18)); if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end RATES(:,1) = ((CONSTANTS(:,19)+CONSTANTS(:,9)) - STATES(:,1))./CONSTANTS(:,10); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end end % Compute result of a piecewise function function x = piecewise(cases, default) set = [0]; for i = 1:2:length(cases) if (length(cases{i+1}) == 1) x(cases{i} & ~set,:) = cases{i+1}; else x(cases{i} & ~set,:) = cases{i+1}(cases{i} & ~set); end set = set | cases{i}; if(set), break, end end if (length(default) == 1) x(~set,:) = default; else x(~set,:) = default(~set); end end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end