function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =5; end % There are a total of 3 entries in each of the rate and state variable arrays. % There are a total of 13 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (minute)'); LEGEND_CONSTANTS(:,1) = strpad('POT in component non_muscle_autoregulatory_local_blood_flow_control (mmHg)'); LEGEND_CONSTANTS(:,10) = strpad('POD in component NM_autoregulatory_driving_force (mmHg)'); LEGEND_CONSTANTS(:,2) = strpad('POR in component parameter_values (mmHg)'); LEGEND_CONSTANTS(:,11) = strpad('POB in component NM_ST_sensitivity_control (mmHg)'); LEGEND_CONSTANTS(:,3) = strpad('POK in component parameter_values (dimensionless)'); LEGEND_ALGEBRAIC(:,1) = strpad('AR1 in component NM_ST_time_delay_and_damping (dimensionless)'); LEGEND_CONSTANTS(:,4) = strpad('A1K in component parameter_values (minute)'); LEGEND_STATES(:,1) = strpad('AR1T in component NM_ST_time_delay_and_damping (dimensionless)'); LEGEND_CONSTANTS(:,12) = strpad('POA in component NM_I_sensitivity_control (mmHg)'); LEGEND_CONSTANTS(:,5) = strpad('PON in component parameter_values (dimensionless)'); LEGEND_ALGEBRAIC(:,2) = strpad('AR2 in component NM_I_time_delay_and_limit (dimensionless)'); LEGEND_CONSTANTS(:,6) = strpad('A2K in component parameter_values (minute)'); LEGEND_STATES(:,2) = strpad('AR2T in component NM_I_time_delay_and_limit (dimensionless)'); LEGEND_CONSTANTS(:,13) = strpad('POC in component NM_LT_sensitivity_control (mmHg)'); LEGEND_CONSTANTS(:,7) = strpad('POZ in component parameter_values (dimensionless)'); LEGEND_ALGEBRAIC(:,3) = strpad('AR3 in component NM_LT_time_delay_and_limit (dimensionless)'); LEGEND_CONSTANTS(:,8) = strpad('A3K in component parameter_values (minute)'); LEGEND_STATES(:,3) = strpad('AR3T in component NM_LT_time_delay_and_limit (dimensionless)'); LEGEND_ALGEBRAIC(:,4) = strpad('ARM1 in component total_NM_autoregulation (dimensionless)'); LEGEND_ALGEBRAIC(:,5) = strpad('ARM in component global_NM_blood_flow_autoregulation_output (dimensionless)'); LEGEND_CONSTANTS(:,9) = strpad('AUTOSN in component parameter_values (dimensionless)'); LEGEND_RATES(:,1) = strpad('d/dt AR1T in component NM_ST_time_delay_and_damping (dimensionless)'); LEGEND_RATES(:,2) = strpad('d/dt AR2T in component NM_I_time_delay_and_limit (dimensionless)'); LEGEND_RATES(:,3) = strpad('d/dt AR3T in component NM_LT_time_delay_and_limit (dimensionless)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; CONSTANTS(:,1) = 35.1148; CONSTANTS(:,2) = 35; CONSTANTS(:,3) = 0.1; CONSTANTS(:,4) = 0.5; STATES(:,1) = 1.02127; CONSTANTS(:,5) = 0.1; CONSTANTS(:,6) = 60; STATES(:,2) = 1.01179; CONSTANTS(:,7) = 2; CONSTANTS(:,8) = 40000; STATES(:,3) = 1.1448; CONSTANTS(:,9) = 0.9; CONSTANTS(:,10) = CONSTANTS(:,1) - CONSTANTS(:,2); CONSTANTS(:,11) = CONSTANTS(:,10).*CONSTANTS(:,3)+1.00000; CONSTANTS(:,12) = CONSTANTS(:,5).*CONSTANTS(:,10)+1.00000; CONSTANTS(:,13) = CONSTANTS(:,7).*CONSTANTS(:,10)+1.00000; if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end RATES(:,1) = ( CONSTANTS(:,11).*1.00000 - STATES(:,1))./CONSTANTS(:,4); RATES(:,2) = ( CONSTANTS(:,12).*1.00000 - STATES(:,2))./CONSTANTS(:,6); RATES(:,3) = ( CONSTANTS(:,13).*1.00000 - STATES(:,3))./CONSTANTS(:,8); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,1) = piecewise({STATES(:,1)<0.500000, 0.500000 }, STATES(:,1)); ALGEBRAIC(:,2) = piecewise({STATES(:,2)<0.500000, 0.500000 }, STATES(:,2)); ALGEBRAIC(:,3) = piecewise({STATES(:,3)<0.300000, 0.300000 }, STATES(:,3)); ALGEBRAIC(:,4) = ALGEBRAIC(:,1).*ALGEBRAIC(:,2).*ALGEBRAIC(:,3); ALGEBRAIC(:,5) = (ALGEBRAIC(:,4) - 1.00000).*CONSTANTS(:,9)+1.00000; end % Compute result of a piecewise function function x = piecewise(cases, default) set = [0]; for i = 1:2:length(cases) if (length(cases{i+1}) == 1) x(cases{i} & ~set,:) = cases{i+1}; else x(cases{i} & ~set,:) = cases{i+1}(cases{i} & ~set); end set = set | cases{i}; if(set), break, end end if (length(default) == 1) x(~set,:) = default; else x(~set,:) = default(~set); end end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end