A mathematical model of metabolic insulin signaling pathways
E1101
E1084
283
Sherman
Arthur
insulin input
x1
concentration of phosphorylated once-bound intracellular receptors
x8
percentage of PI(3,4)P2 out of the total lipid population
x15
x7
concentration of phosphorylated twice-bound intracellular receptors
0.01
x11
concentration of unactivated PI 3-kinase
percentage of activated Akt
x17
x14
percentage of PI(4,5)P2 out of the total lipid population
c.lloyd@auckland.ac.nz
This is the CellML descripition of Sedaghat, Sherman and Quon's 2002
mathematical model of metabolic insulin signaling pathways.
keyword
concentration of unphosphorylated IRS-1
x9
A mathematical model of metabolic insulin signaling pathways (without feedback)
The University of Auckland, Bioengineering Institute
Sedaghat, Sherman and Quon's 2002 mathematical model of metabolic insulin signaling pathways.
percentage of intracellular GLUT4
x20
The University of Auckland
Auckland Bioengineering Institute
concentration of unphosphorylated once-bound surface receptors
x3
concentration of phosphorylated once-bound surface receptors
x5
concentration of unbound unphosphorylated intracellular receptors
x6
percentage of unactivated Akt
x16
The new version of this model has been re-coded to remove the reaction element and replace it with a simple MathML description of the model reaction kinetics. This is thought to be truer to the original publication, and information regarding the enzyme kinetics etc will later be added to the metadata through use of an ontology.
signal transduction
insulin
metabolism
x21
percentage of cell surface GLUT4
2007-06-05T10:44:09+12:00
x13
percentage of PI(3,4,5)P3 out of the total lipid population
Catherine
May
Lloyd
2007-05-30T00:00:00+00:00
concentration of tyrosine-phosphorylated IRS-1/activated PI 3-kinase complex
x12
Quon
J
Michael
x19
percentage of activated PKC-zeta
12376338
concentration of phosphorylated twice-bound surface receptors
x4
concentration of unbound surface insulin receptors
x2
2002-11
x18
percentage of unactivated PKC-zeta
Lloyd
Catherine
May
R
Ahmad
Sedaghat
concentration of tyrosine-phosphorylated IRS-1
x10
Catherine Lloyd
American Journal of Physiology