/* There are a total of 21 entries in the algebraic variable array. There are a total of 11 entries in each of the rate and state variable arrays. There are a total of 19 entries in the constant variable array. */ /* * VOI is time in component environment (ms). * CONSTANTS[0] is R_gas_const in component parameters (millijoule_per_mole_kelvin). * CONSTANTS[1] is Temp in component parameters (kelvin). * CONSTANTS[2] is F in component parameters (coulomb_per_mole). * STATES[0] is R in component transmitter_release (dimensionless). * CONSTANTS[3] is kr_plus in component transmitter_release (per_uM_per_ms). * CONSTANTS[4] is kr_minus in component transmitter_release (per_ms). * ALGEBRAIC[19] is Ca in component calcium_concentration (uM). * ALGEBRAIC[0] is T in component transmitter_release (uM). * CONSTANTS[5] is T_bar in component transmitter_release (uM). * CONSTANTS[6] is Ca_ex in component calcium_concentration (uM). * ALGEBRAIC[8] is Ca_open in component calcium_concentration (uM). * CONSTANTS[7] is Dc in component calcium_concentration (micrometre2_per_second). * CONSTANTS[8] is r in component calcium_concentration (nanometre). * ALGEBRAIC[5] is sigma in component calcium_concentration (uM_per_ms). * ALGEBRAIC[1] is i_V in component calcium_concentration (uA). * CONSTANTS[9] is g_Ca in component calcium_concentration (pS). * CONSTANTS[10] is P in component calcium_concentration (mV_per_uM). * STATES[1] is V_post in component membrane_post (mV). * ALGEBRAIC[16] is O in component O (dimensionless). * ALGEBRAIC[10] is alpha in component rate_constants (per_ms). * ALGEBRAIC[12] is alpha_ in component rate_constants (per_ms). * ALGEBRAIC[14] is beta in component rate_constants (per_ms). * ALGEBRAIC[17] is beta_ in component rate_constants (per_ms). * ALGEBRAIC[20] is kG_plus in component rate_constants (per_ms). * STATES[2] is b in component rate_constants (dimensionless). * CONSTANTS[11] is kb_plus in component rate_constants (per_uM_per_ms). * CONSTANTS[12] is kb_minus in component rate_constants (per_ms). * CONSTANTS[13] is kG_minus in component rate_constants (per_ms). * CONSTANTS[14] is kG2_minus in component rate_constants (per_ms). * CONSTANTS[15] is kG3_minus in component rate_constants (per_ms). * STATES[3] is C1 in component C1 (dimensionless). * STATES[4] is C2 in component C2 (dimensionless). * STATES[5] is C_G1 in component C_G1 (dimensionless). * STATES[6] is C3 in component C3 (dimensionless). * STATES[7] is C_G2 in component C_G2 (dimensionless). * STATES[8] is C4 in component C4 (dimensionless). * STATES[9] is C_G3 in component C_G3 (dimensionless). * ALGEBRAIC[2] is C_G in component O (dimensionless). * CONSTANTS[16] is Cm in component membrane_post (uF_per_cm2). * ALGEBRAIC[3] is i_syn in component synaptic_current (uA_per_cm2). * ALGEBRAIC[15] is i_Na_post in component sodium_current_post (uA_per_cm2). * ALGEBRAIC[18] is i_K_post in component potassium_current_post (uA_per_cm2). * ALGEBRAIC[6] is i_leak_post in component leak_current_post (uA_per_cm2). * CONSTANTS[17] is g_syn in component synaptic_current (mS_per_cm2). * CONSTANTS[18] is V_syn in component synaptic_current (mV). * ALGEBRAIC[13] is x_infinity in component sodium_current_post (dimensionless). * ALGEBRAIC[9] is alpha_x in component sodium_current_post (dimensionless). * ALGEBRAIC[11] is beta_x in component sodium_current_post (dimensionless). * STATES[10] is n_post in component potassium_current_n_gate_post (dimensionless). * ALGEBRAIC[4] is alpha_n in component potassium_current_n_gate_post (per_ms). * ALGEBRAIC[7] is beta_n in component potassium_current_n_gate_post (per_ms). * RATES[0] is d/dt R in component transmitter_release (dimensionless). * RATES[2] is d/dt b in component rate_constants (dimensionless). * RATES[3] is d/dt C1 in component C1 (dimensionless). * RATES[4] is d/dt C2 in component C2 (dimensionless). * RATES[6] is d/dt C3 in component C3 (dimensionless). * RATES[8] is d/dt C4 in component C4 (dimensionless). * RATES[5] is d/dt C_G1 in component C_G1 (dimensionless). * RATES[7] is d/dt C_G2 in component C_G2 (dimensionless). * RATES[9] is d/dt C_G3 in component C_G3 (dimensionless). * RATES[1] is d/dt V_post in component membrane_post (mV). * RATES[10] is d/dt n_post in component potassium_current_n_gate_post (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 8314.41; CONSTANTS[1] = 310; CONSTANTS[2] = 96485; STATES[0] = 0; CONSTANTS[3] = 0.15; CONSTANTS[4] = 2.5; CONSTANTS[5] = 4000.0; CONSTANTS[6] = 2000.0; CONSTANTS[7] = 220; CONSTANTS[8] = 10; CONSTANTS[9] = 1.2; CONSTANTS[10] = 0.006; STATES[1] = -65; STATES[2] = 0; CONSTANTS[11] = 2000.0; CONSTANTS[12] = 1.0; CONSTANTS[13] = 0.00025; CONSTANTS[14] = 0.016; CONSTANTS[15] = 1.024; STATES[3] = 1; STATES[4] = 0; STATES[5] = 0; STATES[6] = 0; STATES[7] = 0; STATES[8] = 0; STATES[9] = 0; CONSTANTS[16] = 1.0; CONSTANTS[17] = 0.2; CONSTANTS[18] = 0; STATES[10] = 0; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[5]*STATES[0]; RATES[2] = CONSTANTS[11]*ALGEBRAIC[0]*(1.00000 - STATES[2]) - CONSTANTS[12]*STATES[2]; ALGEBRAIC[4] = ( 0.0200000*(STATES[1]+55.0000))/(1.00000 - exp(- (STATES[1]+55.0000)/10.0000)); ALGEBRAIC[7] = 0.250000*exp(- (STATES[1]+65.0000)/80.0000); RATES[10] = ALGEBRAIC[4]*(1.00000 - STATES[10]) - ALGEBRAIC[7]*STATES[10]; ALGEBRAIC[16] = ((((((1.00000 - STATES[3]) - STATES[4]) - STATES[6]) - STATES[8]) - STATES[5]) - STATES[7]) - STATES[9]; ALGEBRAIC[10] = 0.450000*exp(STATES[1]/22.0000); ALGEBRAIC[14] = 0.0150000*exp(- STATES[1]/14.0000); RATES[8] = ( 2.00000*ALGEBRAIC[10]*STATES[6]+ 4.00000*ALGEBRAIC[14]*ALGEBRAIC[16]) - STATES[8]*( 3.00000*ALGEBRAIC[14]+ALGEBRAIC[10]); ALGEBRAIC[3] = CONSTANTS[17]*STATES[2]*(STATES[1] - CONSTANTS[18]); ALGEBRAIC[9] = ( 0.200000*(STATES[1]+40.0000))/(1.00000 - 1.00000*exp(- (STATES[1]+40.0000)/10.0000)); ALGEBRAIC[11] = 8.00000*exp(1.00000/- (STATES[1]+65.0000/18.0000)); ALGEBRAIC[13] = ALGEBRAIC[9]/(ALGEBRAIC[9]+ALGEBRAIC[11]); ALGEBRAIC[15] = 120.000*pow(ALGEBRAIC[13], 3.00000)*(1.00000 - STATES[10])*(STATES[1] - 120.000); ALGEBRAIC[18] = 36.0000*pow(STATES[10], 4.00000)*(STATES[1]+77.0000); ALGEBRAIC[6] = 0.300000*(STATES[1]+54.0000); RATES[1] = - (ALGEBRAIC[15]+ALGEBRAIC[18]+ALGEBRAIC[6]+ALGEBRAIC[3])/CONSTANTS[16]; ALGEBRAIC[1] = ( (( CONSTANTS[9]*CONSTANTS[10]*2.00000*CONSTANTS[2]*STATES[1])/( CONSTANTS[0]*CONSTANTS[1]))*CONSTANTS[6])/(1.00000 - exp(( 2.00000*CONSTANTS[2]*STATES[1])/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[5] = - 5.18200*ALGEBRAIC[1]; ALGEBRAIC[8] = ALGEBRAIC[5]/( 2.00000*CONSTANTS[7]*CONSTANTS[8]* 3.14159265358979); ALGEBRAIC[19] = ALGEBRAIC[16]*ALGEBRAIC[8]+0.100000; RATES[0] = CONSTANTS[3]*ALGEBRAIC[19]*(1.00000 - STATES[0]) - CONSTANTS[4]*STATES[0]; ALGEBRAIC[20] = ( 3.00000*STATES[2])/(680.000+ 320.000*STATES[2]); RATES[3] = ( ALGEBRAIC[14]*STATES[4]+ CONSTANTS[13]*STATES[5]) - STATES[3]*( 4.00000*ALGEBRAIC[10]+ALGEBRAIC[20]); RATES[4] = ( 4.00000*ALGEBRAIC[10]*STATES[3]+ 2.00000*ALGEBRAIC[14]*STATES[6]+ CONSTANTS[14]*STATES[7]) - STATES[4]*(ALGEBRAIC[14]+ 3.00000*ALGEBRAIC[10]+ALGEBRAIC[20]); RATES[6] = ( 3.00000*ALGEBRAIC[10]*STATES[4]+ 3.00000*ALGEBRAIC[14]*STATES[8]+ CONSTANTS[15]*STATES[9]) - STATES[6]*( 2.00000*ALGEBRAIC[14]+ 2.00000*ALGEBRAIC[10]+ALGEBRAIC[20]); ALGEBRAIC[12] = ALGEBRAIC[10]/8.00000; ALGEBRAIC[17] = ALGEBRAIC[14]*8.00000; RATES[5] = ( ALGEBRAIC[17]*STATES[7]+ ALGEBRAIC[20]*STATES[3]) - STATES[5]*( 4.00000*ALGEBRAIC[12]+CONSTANTS[13]); RATES[7] = ( 4.00000*ALGEBRAIC[12]*STATES[5]+ 2.00000*ALGEBRAIC[17]*STATES[9]+ ALGEBRAIC[20]*STATES[4]) - STATES[7]*(ALGEBRAIC[17]+ 3.00000*ALGEBRAIC[12]+CONSTANTS[14]); RATES[9] = ( 3.00000*ALGEBRAIC[12]*STATES[7]+ ALGEBRAIC[20]*STATES[6]) - STATES[9]*( 2.00000*ALGEBRAIC[17]+CONSTANTS[15]); } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[5]*STATES[0]; ALGEBRAIC[4] = ( 0.0200000*(STATES[1]+55.0000))/(1.00000 - exp(- (STATES[1]+55.0000)/10.0000)); ALGEBRAIC[7] = 0.250000*exp(- (STATES[1]+65.0000)/80.0000); ALGEBRAIC[16] = ((((((1.00000 - STATES[3]) - STATES[4]) - STATES[6]) - STATES[8]) - STATES[5]) - STATES[7]) - STATES[9]; ALGEBRAIC[10] = 0.450000*exp(STATES[1]/22.0000); ALGEBRAIC[14] = 0.0150000*exp(- STATES[1]/14.0000); ALGEBRAIC[3] = CONSTANTS[17]*STATES[2]*(STATES[1] - CONSTANTS[18]); ALGEBRAIC[9] = ( 0.200000*(STATES[1]+40.0000))/(1.00000 - 1.00000*exp(- (STATES[1]+40.0000)/10.0000)); ALGEBRAIC[11] = 8.00000*exp(1.00000/- (STATES[1]+65.0000/18.0000)); ALGEBRAIC[13] = ALGEBRAIC[9]/(ALGEBRAIC[9]+ALGEBRAIC[11]); ALGEBRAIC[15] = 120.000*pow(ALGEBRAIC[13], 3.00000)*(1.00000 - STATES[10])*(STATES[1] - 120.000); ALGEBRAIC[18] = 36.0000*pow(STATES[10], 4.00000)*(STATES[1]+77.0000); ALGEBRAIC[6] = 0.300000*(STATES[1]+54.0000); ALGEBRAIC[1] = ( (( CONSTANTS[9]*CONSTANTS[10]*2.00000*CONSTANTS[2]*STATES[1])/( CONSTANTS[0]*CONSTANTS[1]))*CONSTANTS[6])/(1.00000 - exp(( 2.00000*CONSTANTS[2]*STATES[1])/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[5] = - 5.18200*ALGEBRAIC[1]; ALGEBRAIC[8] = ALGEBRAIC[5]/( 2.00000*CONSTANTS[7]*CONSTANTS[8]* 3.14159265358979); ALGEBRAIC[19] = ALGEBRAIC[16]*ALGEBRAIC[8]+0.100000; ALGEBRAIC[20] = ( 3.00000*STATES[2])/(680.000+ 320.000*STATES[2]); ALGEBRAIC[12] = ALGEBRAIC[10]/8.00000; ALGEBRAIC[17] = ALGEBRAIC[14]*8.00000; ALGEBRAIC[2] = STATES[5]+STATES[7]+STATES[9]; }