C C There are a total of 13 entries in the algebraic variable array. C There are a total of 9 entries in each of the rate and state variable arrays. C There are a total of 19 entries in the constant variable array. C C C VOI is time in component environment (minute). C STATES(1) is S1 in component S1 (millimolar). C CONSTS(1) is Jo in component glucose_influx_rate (flux). C ALGBRC(4) is v1 in component v1 (flux). C STATES(2) is S2 in component S2 (millimolar). C ALGBRC(5) is v2 in component v2 (flux). C STATES(3) is S3 in component S3 (millimolar). C ALGBRC(6) is v3 in component v3 (flux). C ALGBRC(11) is v8 in component v8 (flux). C STATES(4) is S4 in component S4 (millimolar). C ALGBRC(7) is v4 in component v4 (flux). C STATES(5) is S5 in component S5 (millimolar). C ALGBRC(8) is v5 in component v5 (flux). C STATES(6) is S6 in component S6 (millimolar). C ALGBRC(10) is v6 in component v6 (flux). C ALGBRC(13) is J in component S6_flux_rate_across_the_plasma_membrane (flux). C STATES(7) is S6_ex in component S6_ex (millimolar). C CONSTS(2) is phi in component S6_ex (dimensionless). C ALGBRC(12) is v9 in component v9 (flux). C STATES(8) is A3 in component A3 (millimolar). C ALGBRC(9) is v7 in component v7 (flux). C CONSTS(3) is A in component A (millimolar). C ALGBRC(1) is A2 in component A (millimolar). C STATES(9) is N2 in component N2 (millimolar). C CONSTS(4) is N in component N (millimolar). C ALGBRC(2) is N1 in component N (millimolar). C CONSTS(5) is K_i in component v1 (millimolar). C CONSTS(6) is k_1 in component v1 (second_order_rate_constant). C CONSTS(7) is n in component v1 (dimensionless). C ALGBRC(3) is f_A3 in component v1 (dimensionless). C CONSTS(8) is k_2 in component v2 (first_order_rate_constant). C CONSTS(9) is k_GAPDH_plus in component v3 (second_order_rate_constant). C CONSTS(10) is k_GAPDH_minus in component v3 (second_order_rate_constant). C CONSTS(11) is k_PGK_plus in component v3 (second_order_rate_constant). C CONSTS(12) is k_PGK_minus in component v3 (second_order_rate_constant). C CONSTS(13) is k_4 in component v4 (second_order_rate_constant). C CONSTS(14) is k_5 in component v5 (first_order_rate_constant). C CONSTS(15) is k_6 in component v6 (second_order_rate_constant). C CONSTS(16) is k_7 in component v7 (first_order_rate_constant). C CONSTS(17) is k_8 in component v8 (second_order_rate_constant). C CONSTS(18) is k_9 in component v9 (first_order_rate_constant). C CONSTS(19) is k in component S6_flux_rate_across_the_plasma_membrane (first_order_rate_constant). C RATES(1) is d/dt S1 in component S1 (millimolar). C RATES(2) is d/dt S2 in component S2 (millimolar). C RATES(3) is d/dt S3 in component S3 (millimolar). C RATES(4) is d/dt S4 in component S4 (millimolar). C RATES(5) is d/dt S5 in component S5 (millimolar). C RATES(6) is d/dt S6 in component S6 (millimolar). C RATES(7) is d/dt S6_ex in component S6_ex (millimolar). C RATES(8) is d/dt A3 in component A3 (millimolar). C RATES(9) is d/dt N2 in component N2 (millimolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 1.57981839 CONSTS(1) = 50 STATES(2) = 4.8279999 STATES(3) = 0.468657507 STATES(4) = 0.589391932 STATES(5) = 8.210114438 STATES(6) = 0.078042624 STATES(7) = 0.025277594 CONSTS(2) = 0.1 STATES(8) = 1.972814237 CONSTS(3) = 4 STATES(9) = 0.384873894 CONSTS(4) = 1 CONSTS(5) = 1 CONSTS(6) = 550 CONSTS(7) = 4 CONSTS(8) = 9.8 CONSTS(9) = 323.8 CONSTS(10) = 57823.1 CONSTS(11) = 76411.1 CONSTS(12) = 23.7 CONSTS(13) = 80 CONSTS(14) = 9.7 CONSTS(15) = 2000 CONSTS(16) = 28 CONSTS(17) = 85.7 CONSTS(18) = 80 CONSTS(19) = 375 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(3) = 1.00000+STATES(8)/CONSTS(5) ** CONSTS(7) ** - 1.00000 ALGBRC(4) = CONSTS(6)*STATES(1)*STATES(8)*ALGBRC(3) RATES(1) = CONSTS(1) - ALGBRC(4) ALGBRC(5) = CONSTS(8)*STATES(2) RATES(2) = ALGBRC(4) - ALGBRC(5) ALGBRC(1) = CONSTS(3) - STATES(8) ALGBRC(2) = CONSTS(4) - STATES(9) ALGBRC(6) = ( CONSTS(9)*CONSTS(11)*STATES(3)*ALGBRC(2)*ALGBRC(1) - CONSTS(10)*CONSTS(12)*STATES(4)*STATES(8)*STATES(9))/( CONSTS(10)*STATES(9)+ CONSTS(11)*ALGBRC(1)) ALGBRC(7) = CONSTS(13)*STATES(4)*ALGBRC(1) RATES(4) = ALGBRC(6) - ALGBRC(7) ALGBRC(8) = CONSTS(14)*STATES(5) RATES(5) = ALGBRC(7) - ALGBRC(8) ALGBRC(9) = CONSTS(16)*STATES(8) RATES(8) = (ALGBRC(6)+ALGBRC(7)) - ( 2.00000*ALGBRC(4)+ALGBRC(9)) ALGBRC(11) = CONSTS(17)*STATES(3)*STATES(9) RATES(3) = 2.00000*ALGBRC(5) - (ALGBRC(6)+ALGBRC(11)) ALGBRC(10) = CONSTS(15)*STATES(6)*STATES(9) RATES(9) = ALGBRC(6) - (ALGBRC(10)+ALGBRC(11)) ALGBRC(13) = CONSTS(19)*(STATES(6) - STATES(7)) RATES(6) = ALGBRC(8) - (ALGBRC(10)+ALGBRC(13)) ALGBRC(12) = CONSTS(18)*STATES(7) RATES(7) = CONSTS(2)*ALGBRC(13) - ALGBRC(12) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(3) = 1.00000+STATES(8)/CONSTS(5) ** CONSTS(7) ** - 1.00000 ALGBRC(4) = CONSTS(6)*STATES(1)*STATES(8)*ALGBRC(3) ALGBRC(5) = CONSTS(8)*STATES(2) ALGBRC(1) = CONSTS(3) - STATES(8) ALGBRC(2) = CONSTS(4) - STATES(9) ALGBRC(6) = ( CONSTS(9)*CONSTS(11)*STATES(3)*ALGBRC(2)*ALGBRC(1) - CONSTS(10)*CONSTS(12)*STATES(4)*STATES(8)*STATES(9))/( CONSTS(10)*STATES(9)+ CONSTS(11)*ALGBRC(1)) ALGBRC(7) = CONSTS(13)*STATES(4)*ALGBRC(1) ALGBRC(8) = CONSTS(14)*STATES(5) ALGBRC(9) = CONSTS(16)*STATES(8) ALGBRC(11) = CONSTS(17)*STATES(3)*STATES(9) ALGBRC(10) = CONSTS(15)*STATES(6)*STATES(9) ALGBRC(13) = CONSTS(19)*(STATES(6) - STATES(7)) ALGBRC(12) = CONSTS(18)*STATES(7) RETURN END