C C There are a total of 3 entries in the algebraic variable array. C There are a total of 5 entries in each of the rate and state variable arrays. C There are a total of 18 entries in the constant variable array. C C C VOI is time in component environment (day). C STATES(1) is T in component T (per_ml). C CONSTS(1) is lamda in component T (second_order_rate_constant). C CONSTS(2) is d in component T (first_order_rate_constant). C CONSTS(3) is k in component kinetic_parameters (flux). C STATES(2) is VI in component VI (per_ml). C STATES(3) is T_ in component T_ (per_ml). C CONSTS(4) is tau in component T_ (first_order_rate_constant). C CONSTS(5) is m in component T_ (first_order_rate_constant). C CONSTS(6) is delta in component kinetic_parameters (first_order_rate_constant). C CONSTS(7) is N in component kinetic_parameters (dimensionless). C CONSTS(8) is c in component kinetic_parameters (first_order_rate_constant). C ALGBRC(1) is epsilon_PI in component epsilon_PI (dimensionless). C STATES(4) is VNI in component VNI (per_ml). C CONSTS(9) is IC50 in component epsilon_PI (mg_per_ml). C STATES(5) is Cc in component Cc (mg_per_ml). C ALGBRC(2) is Cb in component Cb (mg_per_ml). C CONSTS(10) is Vd in component Cb (ml). C CONSTS(11) is F in component Cb (dimensionless). C CONSTS(12) is D in component Cb (mg). C CONSTS(13) is ka in component kinetic_parameters (first_order_rate_constant). C CONSTS(14) is ke in component kinetic_parameters (first_order_rate_constant). C CONSTS(15) is kacell in component Cc (first_order_rate_constant). C CONSTS(16) is kecell in component Cc (first_order_rate_constant). C ALGBRC(3) is Cx in component Cx (mg_per_ml). C CONSTS(17) is H in component Cx (dimensionless). C CONSTS(18) is fb in component Cx (dimensionless). C RATES(1) is d/dt T in component T (per_ml). C RATES(3) is d/dt T_ in component T_ (per_ml). C RATES(2) is d/dt VI in component VI (per_ml). C RATES(4) is d/dt VNI in component VNI (per_ml). C RATES(5) is d/dt Cc in component Cc (mg_per_ml). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 1e6 CONSTS(1) = 1e4 CONSTS(2) = 0.01 CONSTS(3) = 2.4e-8 STATES(2) = 1 STATES(3) = 1 CONSTS(4) = 1.5 CONSTS(5) = 0.01 CONSTS(6) = 0.01 CONSTS(7) = 2500 CONSTS(8) = 23 STATES(4) = 2 CONSTS(9) = 9e-7 STATES(5) = 0 CONSTS(10) = 28000 CONSTS(11) = 1 CONSTS(12) = 600 CONSTS(13) = 14.64 CONSTS(14) = 6.86 CONSTS(15) = 24000 CONSTS(16) = 1.1 CONSTS(17) = 0.052 CONSTS(18) = 0.99 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(1) = CONSTS(1) - ( CONSTS(2)*STATES(1)+ CONSTS(3)*STATES(1)*STATES(2)) RATES(3) = CONSTS(3)*STATES(1)*(VOI - CONSTS(4))*STATES(2)*(VOI - CONSTS(4))*EXP( - CONSTS(5)*CONSTS(4)) - CONSTS(6)*STATES(3) ALGBRC(1) = STATES(5)/(CONSTS(9)+STATES(5)) RATES(2) = CONSTS(7)*CONSTS(6)*STATES(3)*(1.00000 - ALGBRC(1)) - CONSTS(8)*STATES(2) RATES(4) = CONSTS(7)*CONSTS(6)*STATES(3)*ALGBRC(1) - CONSTS(8)*STATES(4) ALGBRC(2) = (( CONSTS(11)*CONSTS(12))/CONSTS(10))*(CONSTS(13)/(CONSTS(14) - CONSTS(13)))*(EXP( - CONSTS(13)*VOI) - EXP( - CONSTS(14)*VOI)) ALGBRC(3) = TERNRY( (1.00000 - CONSTS(18))*CONSTS(17)*ALGBRC(2) - STATES(5).GT.0.00000, (1.00000 - CONSTS(18))*CONSTS(17)*ALGBRC(2) - STATES(5), 0.00000) RATES(5) = CONSTS(15)*ALGBRC(3) - CONSTS(16)*STATES(5) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = STATES(5)/(CONSTS(9)+STATES(5)) ALGBRC(2) = (( CONSTS(11)*CONSTS(12))/CONSTS(10))*(CONSTS(13)/(CONSTS(14) - CONSTS(13)))*(EXP( - CONSTS(13)*VOI) - EXP( - CONSTS(14)*VOI)) ALGBRC(3) = TERNRY( (1.00000 - CONSTS(18))*CONSTS(17)*ALGBRC(2) - STATES(5).GT.0.00000, (1.00000 - CONSTS(18))*CONSTS(17)*ALGBRC(2) - STATES(5), 0.00000) RETURN END REAL FUNCTION TERNRY(TEST, VALA, VALB) LOGICAL TEST REAL VALA, VALB IF (TEST) THEN TERNRY = VALA ELSE TERNRY = VALB ENDIF RETURN END